Uptown 2026 Holidays & City Breaks | Flight + Hotel

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Top hotels in Uptown

Clayton Plaza Hotel & Extended Stay

7750 Carondelet Avenue St. Louis MO

Fully refundableReserve now, pay when you stay

€95

11 Oct - 12 Oct

includes taxes & fees

8.8/10 Excellent! (3,441 reviews)

"Aron at guest services was very nice but hotel was dirtier then used to be about a year ago. Found a roach in bathroom in my room. Garbage and towels outside one of the rooms was there for two days. Parking lot area entrance dirty ."

Reviewed on 27 Sept 2026

Hyatt Regency St. Louis at The Arch

315 Chestnut St St. Louis MO

Fully refundableReserve now, pay when you stay

€139

2 Oct - 3 Oct

includes taxes & fees

Drury Plaza Hotel St. Louis at the Arch

2 South 4th Street St. Louis MO

Fully refundableReserve now, pay when you stay

€139

2 Oct - 3 Oct

includes taxes & fees

9.6/10 Exceptional! (3,780 reviews)

"Can’t say enough how special this hotel, staff and site was for us. I’m a Drury Inn customer and found this site beyond my expectations. Room spotless, and food options great!"

Reviewed on 28 Sept 2026

See all 1,584 properties in Uptown

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Uptown attractions

World's Largest Catsup Bottle

8.4/10 (59 reviews)

Find out about the history of Collinsville when you take a trip to World's Largest Catsup Bottle. Discover the top-notch restaurants and great live music in this walkable area.

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