Cheap flights from Panama starting at €154

View €154 flight on Tue, 16 Sep 2025Opens in a new window

Popular airlines from Panama

  • United

    United

  • KLM

    KLM

  • American Airlines

    American Airlines

  • Delta

    Delta

  • Turkish Airlines

    Turkish Airlines

  • Iberia

    Iberia

  • Copa

    Copa

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Cheapest flights from Panama

These prices were available within the past 7 days. Prices quoted are per person, return, for the period specified. Prices and availability are subject to change. Additional terms apply.

Aeromexico
Fri, 12 Dec - Tue, 23 Dec
PTY
Panama City
CUN
Cancun
€275 Return, found 11 hours ago
€275
Return
found 11 hours ago
Select Aeromexico flight, departing Fri, 12 Dec from Panama City to Cancun, returning Tue, 23 Dec, priced at €275 found 11 hours ago
Copa
Fri, 22 Aug - Thu, 28 Aug
PTY
Panama City
MDE
Medellin
€277 Return, found 1 day ago
€277
Return
found 1 day ago
Select Copa flight, departing Fri, 22 Aug from Panama City to Medellin, returning Thu, 28 Aug, priced at €277 found 1 day ago
Copa
Fri, 22 Aug - Thu, 28 Aug
PTY
Panama City
MDE
Medellin
€311 Return, found 1 day ago
€311
Return
found 1 day ago
Select Copa flight, departing Fri, 22 Aug from Panama City to Medellin, returning Thu, 28 Aug, priced at €311 found 1 day ago
Delta
Wed, 29 Oct - Tue, 4 Nov
PTY
Panama City
MIA
Miami
€324 Return, found 3 days ago
€324
Return
found 3 days ago
Select Delta flight, departing Wed, 29 Oct from Panama City to Miami, returning Tue, 4 Nov, priced at €324 found 3 days ago
Copa
Wed, 30 Jul - Wed, 6 Aug
PTY
Panama City
MDE
Medellin
€332 Return, found 3 days ago
€332
Return
found 3 days ago
Select Copa flight, departing Wed, 30 Jul from Panama City to Medellin, returning Wed, 6 Aug, priced at €332 found 3 days ago
Copa
Fri, 22 Aug - Thu, 28 Aug
PTY
Panama City
MDE
Medellin
€340 Return, found 1 day ago
€340
Return
found 1 day ago
Select Copa flight, departing Fri, 22 Aug from Panama City to Medellin, returning Thu, 28 Aug, priced at €340 found 1 day ago
Copa
Wed, 30 Jul - Wed, 6 Aug
PTY
Panama City
MDE
Medellin
€340 Return, found 3 days ago
€340
Return
found 3 days ago
Select Copa flight, departing Wed, 30 Jul from Panama City to Medellin, returning Wed, 6 Aug, priced at €340 found 3 days ago
Copa
Fri, 22 Aug - Thu, 28 Aug
PTY
Panama City
MDE
Medellin
€345 Return, found 1 day ago
€345
Return
found 1 day ago
Select Copa flight, departing Fri, 22 Aug from Panama City to Medellin, returning Thu, 28 Aug, priced at €345 found 1 day ago
avianca
Fri, 22 Aug - Thu, 28 Aug
PTY
Panama City
MDE
Medellin
€358 Return, found 1 day ago
€358
Return
found 1 day ago
Select avianca flight, departing Fri, 22 Aug from Panama City to Medellin, returning Thu, 28 Aug, priced at €358 found 1 day ago
American Airlines
Sat, 13 Sep - Sun, 14 Sep
PTY
Panama City
MIA
Miami
€398 Return, found 3 days ago
€398
Return
found 3 days ago
Select American Airlines flight, departing Sat, 13 Sep from Panama City to Miami, returning Sun, 14 Sep, priced at €398 found 3 days ago
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