
Popular airlines from St. Louis to Panama City
- Delta
Delta
- United
United
- American Airlines
American Airlines
- Copa
Copa
- Avianca
Avianca
- Plan, book, fly with confidence
trending down icon Be in the knowGet alerts if flight prices drop or rise*bex rewards loyalty icon Book smarterSave up to 15% on select hotels after you book a flight*payments icon
Top Routes to Panama City
Expedia's Latest Trends
Hotels
- Hotels in Death Valley
- Costa Blanca - Playa Flamenca - apartment sea coast beach golf resort LA CALMA
- Hotel RH Princesa
- LGBT-Friendly Hotels in Peshawar
- Caravan Parks Liscannor
- The Siam
- Hotels in Arrecife
- Hotels in Montmartre
- Hotels in Old Town Bari
- 2 Bedroom Apartment Beside Merrion Square
- Hotels with Spa in County Meath
- Mythos Palace Resort - Adults only
- Ekati Mare Lifestyle Resort
- Hotels in Cork
- Hotels in Castletown-Geoghegan
- Hilton Birmingham Metropole
- 5 Star Hotels in Mallorca Island
Flights
Activities
Holiday Rentals
*Available to Expedia members.