Cheap flights from Guna Yala starting at €126

View €126 flight on Wed, 8 Apr 2026Opens in a new window

Popular airlines from Guna Yala

  • Avianca

  • United

  • American Airlines

  • Delta

  • Copa

  • Aeromexico

  • KLM

  • Be in the know

    Get alerts if flight prices drop or rise*

  • Book smarter

    Save up to 15% on select hotels after you book a flight*

  • Earn twice

    Earn your airline miles on top of our rewards
    Sign in

Cheapest flights from Guna Yala

These prices were available within the past 7 days. Prices quoted are per person, return, for the period specified. Prices and availability are subject to change. Additional terms apply.

Copa
Sat, 16 May - Tue, 19 May
PTY
Panama City
MDE
Medellin
€275 Return, found 1 day ago
€275
Return
found 1 day ago
Select Copa flight, departing Sat, 16 May from Panama City to Medellin, returning Tue, 19 May, priced at €275 found 1 day ago
Copa
Sat, 16 May - Tue, 19 May
PTY
Panama City
MDE
Medellin
€284 Return, found 1 day ago
€284
Return
found 1 day ago
Select Copa flight, departing Sat, 16 May from Panama City to Medellin, returning Tue, 19 May, priced at €284 found 1 day ago
Aeromexico
Wed, 7 Oct - Mon, 12 Oct
PTY
Panama City
CUN
Cancun
€289 Return, found 1 day ago
€289
Return
found 1 day ago
Select Aeromexico flight, departing Wed, 7 Oct from Panama City to Cancun, returning Mon, 12 Oct, priced at €289 found 1 day ago
Copa
Sat, 16 May - Tue, 19 May
PTY
Panama City
MDE
Medellin
€293 Return, found 1 day ago
€293
Return
found 1 day ago
Select Copa flight, departing Sat, 16 May from Panama City to Medellin, returning Tue, 19 May, priced at €293 found 1 day ago
avianca
Fri, 13 Nov - Mon, 16 Nov
PTY
Panama City
BOG
Bogotá
€294 Return, found 3 days ago
€294
Return
found 3 days ago
Select avianca flight, departing Fri, 13 Nov from Panama City to Bogotá, returning Mon, 16 Nov, priced at €294 found 3 days ago
Aeromexico
Wed, 7 Oct - Mon, 12 Oct
PTY
Panama City
CUN
Cancun
€313 Return, found 1 day ago
€313
Return
found 1 day ago
Select Aeromexico flight, departing Wed, 7 Oct from Panama City to Cancun, returning Mon, 12 Oct, priced at €313 found 1 day ago
avianca
Sat, 16 May - Tue, 19 May
PTY
Panama City
MDE
Medellin
€322 Return, found 1 day ago
€322
Return
found 1 day ago
Select avianca flight, departing Sat, 16 May from Panama City to Medellin, returning Tue, 19 May, priced at €322 found 1 day ago
Copa
Thu, 4 Jun - Sun, 7 Jun
PTY
Panama City
MDE
Medellin
€323 Return, found 3 days ago
€323
Return
found 3 days ago
Select Copa flight, departing Thu, 4 Jun from Panama City to Medellin, returning Sun, 7 Jun, priced at €323 found 3 days ago
Delta
Mon, 27 Apr - Fri, 1 May
PTY
Panama City
JFK
New York
€557 Return, found 1 day ago
€557
Return
found 1 day ago
Select Delta flight, departing Mon, 27 Apr from Panama City to New York, returning Fri, 1 May, priced at €557 found 1 day ago
American Airlines
Thu, 19 Mar - Sun, 22 Mar
PTY
Panama City
MIA
Miami
€568 Return, just found
€568
Return
just found
Select American Airlines flight, departing Thu, 19 Mar from Panama City to Miami, returning Sun, 22 Mar, priced at €568 just found
*Available to Expedia members.