
Popular airlines from McGhee Tyson Airport (TYS) to Chicago O'Hare Intl. Airport (ORD)
- American Airlines
American Airlines
- Delta
Delta
- United
United
- Southwest Airlines
Southwest Airlines
- Frontier Airlines
Frontier Airlines
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Cheap flights from Knoxville to Chicago (TYS-ORD)
Prices were available within the past 7 days and start at €112 for one-way flights and €211 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, 31 Oct - Mon, 3 Nov
TYS
Knoxville
ORD
Chicago
€211 Return, found 1 day ago
€211
Return
found 1 day ago

Fri, 31 Oct - Mon, 3 Nov
TYS
Knoxville
ORD
Chicago
€215 Return, found 1 day ago
€215
Return
found 1 day ago

Fri, 31 Oct - Mon, 3 Nov
TYS
Knoxville
ORD
Chicago
€219 Return, found 1 day ago
€219
Return
found 1 day ago

Fri, 31 Oct - Mon, 3 Nov
TYS
Knoxville
ORD
Chicago
€223 Return, found 1 day ago
€223
Return
found 1 day ago

Fri, 31 Oct - Mon, 3 Nov
TYS
Knoxville
ORD
Chicago
€224 Return, found 1 day ago
€224
Return
found 1 day ago

Fri, 31 Oct - Mon, 3 Nov
TYS
Knoxville
ORD
Chicago
€245 Return, found 1 day ago
€245
Return
found 1 day ago

Fri, 31 Oct - Mon, 3 Nov
TYS
Knoxville
ORD
Chicago
€249 Return, found 1 day ago
€249
Return
found 1 day ago

Fri, 31 Oct - Mon, 3 Nov
TYS
Knoxville
ORD
Chicago
€253 Return, found 1 day ago
€253
Return
found 1 day ago

Fri, 31 Oct - Mon, 3 Nov
TYS
Knoxville
ORD
Chicago
€258 Return, found 1 day ago
€258
Return
found 1 day ago

Fri, 31 Oct - Mon, 3 Nov
TYS
Knoxville
ORD
Chicago
€258 Return, found 1 day ago
€258
Return
found 1 day ago
Find the cheapest month to fly from Knoxville (TYS) to Chicago (ORD)
January is typically the cheapest month to fly
From €135 - €343 per traveller.
Frequently asked questions
Travel information
Origin airport | McGhee Tyson |
---|---|
Destination airport | O'Hare Intl. |
Airlines serving | American Airlines, Delta, United |
Return price | €210 |
Distance | 760 km |
Book with confidence
Perfect flights from Knoxville to Chicago
Embark on an unforgettable journey without breaking the bank with Expedia's incredible deals on cheap flights from Knoxville to Chicago. Whether you're aching for a romantic escape with your partner, craving an adventurous solo expedition, or yearning to immerse yourself in the local history and culture, we've got you covered.
Picture yourself strolling through the streets of Chicago, surrounded by breathtaking architecture and absorbing the vibrant atmosphere of this captivating city. Indulge in the mouth-watering local specialties, from tantalizing street food to exquisite fine dining. With Expedia, you can experience all of this and more, without sacrificing your budget.
Our flexible McGhee Tyson to O'Hare Intl. ticket options cater to your travel preferences, with incredible one-way fares from €112 and roundtrip prices from €211. Whether you're planning a short city break or a longer adventure, our dynamic pricing ensures that you find the best deals for your journey.
But the magic doesn't stop there. Expedia offers a range of partner services to enhance your trip. Rent a car at O'Hare Intl. and explore Chicago and its surrounding areas at your own pace. Discover hidden gems off the beaten path, and create unforgettable memories. We also provide a handpicked selection of accommodations, from charming bed and breakfasts to luxury hotels, ensuring that you have a comfortable and memorable stay.
Planning your next great adventure is a breeze with Expedia. Our user-friendly platform, unbeatable prices, and round-the-clock customer support are designed to make your travel experience seamless and stress-free. So, why wait? Book your TYS to ORD travel arrangements today and embark on the journey of a lifetime in Chicago.
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Top Routes from Knoxville
Top Routes to Chicago
- Newark Liberty Intl. Airport to Chicago (EWR - ORD)
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- Boston to Chicago (BOS - ORD)
- Cork to Chicago (ORK - ORD)
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- New York to Chicago (JFK - ORD)
- Dublin to Chicago (DUB - ORD)
- Budapest to Chicago (BUD - ORD)
- Shannon to Chicago (SNN - ORD)
- Frankfurt to Chicago (FRA - ORD)
- Vilnius to Chicago (VNO - ORD)
- London to Chicago (LHR - ORD)
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Expedia's Latest Trends
Flights
- Flights from New York (JFK) to Chicago (ORD)
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- Flights from Dublin (DUB) to Memphis (MEM)
- Flights from New York (LGA) to Nashville (BNA)
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