A colonial-style building with a bell tower, palm trees, and a paved walkway.

4 Star Hotels in Santa Cruz, Santa Cruz

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Check availability on Santa Cruz 4 Star Hotels

Tonight
16 Aug - 17 Aug
Tomorrow
17 Aug - 18 Aug
Next weekend
21 Aug - 23 Aug
In two weeks
28 Aug - 30 Aug

Our top choices for Santa Cruz 4-star hotels

1. TRYP by Wyndham Santa Cruz

TRYP by Wyndham Santa Cruz
Santa Cruz
United States
Pluetina
€85
17 Aug - 18 Aug
TRYP by Wyndham Santa Cruz

2. Camino Real Hotel

Camino Real Hotel
Santa Cruz
United States
Austin
€125
1 Sept - 2 Sept
Camino Real Hotel

3. Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
Santa Cruz
United States
imilse de
€64
27 Aug - 28 Aug
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

4. Swissôtel Santa Cruz De La Sierra

Swissôtel Santa Cruz De La Sierra
Santa Cruz
United States
GONZALO
€128
31 Aug - 1 Sept
Swissôtel Santa Cruz De La Sierra

5. Hotel Maywa

Hotel Maywa
Santa Cruz
United States
Alex
Hotel Maywa

6. Buganvillas Hotel Suites & Spa

Buganvillas Hotel Suites & Spa
Santa Cruz
Sweden
Charlotte
Buganvillas Hotel Suites & Spa

7. Royal Lodge Hotel

Royal Lodge Hotel
Santa Cruz
Argentina
Anonymous traveller
Royal Lodge Hotel
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Explore similar 5-star hotels

Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Santa Cruz.
Novotel Santa Cruz De La Sierra

Novotel Santa Cruz De La Sierra

AV ROCA CORONADO 901 Santa Cruz
€107
1 Sept - 2 Sept
Novotel Santa Cruz De La Sierra
Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel

4to Anillo Entre Radial 23 Santa Cruz Santa Cruz
€91
21 Aug - 22 Aug
9/10 Wonderful! (243 reviews)
Marriott Santa Cruz de la Sierra Hotel
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Santa Cruz

Tropical energy pulses through Plaza 24 de Septiembre, where locals gather under palm trees and the Metropolitan Cathedral's twin towers stand watch. Biocentro Güembé offers rainforest trails with butterfly gardens, while the massive Ventura Mall provides air-conditioned shopping when afternoon temperatures climb.

See all hotels in Santa Cruz
A colonial-style building with a bell tower, palm trees, and a paved walkway.

Top Santa Cruz Hotel Reviews

Frequently asked questions

What are the best 4-star hotels in Santa Cruz?
If you're seeking luxury comfort and loads of amenities during your Santa Cruz retreat, consider TRYP by Wyndham Santa Cruz. This 4-star hotel offers a spa tub and a terrace. Hampton by Hilton Santa Cruz/Equipetrol, Bolivia also gets stellar reviews from Expedia guests. Concierge services and a garden are among its conveniences.
How much does it cost to stay in a 4-star hotel in Santa Cruz?
Expedia can help you easily locate the perfect 4-star hotel for your holiday in Santa Cruz. Use our filter tool to tailor your search by things like price, conveniences and star rating and get access to terrific deals in a few clicks.
  • Search for the lowest price from €91
What's the difference between 5-star and 4-star hotels in Santa Cruz?
If you choose to spend your holiday at a 4-star hotel in Santa Cruz, you'll typically find plenty of conveniences to ensure you're comfortable, such as a restaurant, gym and pool. You can enjoy top-quality service and deluxe accommodation. Choose a 5-star hotel and you'll get a few extra perks — think concierge assistance, on-site spas and opulent turndown services. You're likely to get more amenities and premium services at a 5-star stay, but both are fabulous options for luxury travellers.

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