A bench, a bicycle, and a lake surrounded by trees.

4 Star Hotels in Upstate South Carolina, South Carolina

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Check availability on Upstate South Carolina 4 Star Hotels

Tonight
23 Oct - 24 Oct
Tomorrow
24 Oct - 25 Oct
This weekend
23 Oct - 25 Oct
Next weekend
30 Oct - 1 Nov

Our top choices for Upstate South Carolina 4-star hotels

A large, multi-story house with a prominent waterfall in the foreground, surrounded by lush greenery.
A modern interior with a stone fireplace, seating areas, and a unique ceiling design.
A modern interior with a fireplace, plush seating, and a stone accent wall.
A modern interior with a stone fireplace, leather sofas, and a wooden ceiling.

1. Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection
Greenville Downtown
United States
colleen
€353
includes taxes & fees
15 Nov - 16 Nov
Grand Bohemian Lodge Greenville, Autograph Collection
A dining area with a wooden table, chairs, and a vase of white flowers.
A modern hotel lobby with a chandelier, wooden shelving, a reception desk, and a view of the outdoors.
A modern living room with a fireplace, seating area, and a bar with shelves of bottles.
A large, two-story house with a symmetrical facade, large windows, and a central entrance.

2. Hotel Hartness

Hotel Hartness
Greenville
United States
Nicole
€195
includes taxes & fees
25 Oct - 26 Oct
Hotel Hartness
A hotel facade with arched windows, a fountain, and a sign for "The Westin."
A banquet hall with round tables, chandeliers, and ornate windows.
A grand lobby with a chandelier, multiple seating areas, and a checkered floor pattern.
A lobby with patterned flooring, a grand staircase, and elegant furniture.

3. The Westin Poinsett Greenville

The Westin Poinsett Greenville
Greenville Downtown
United States
BRITTANY
€163
includes taxes & fees
22 Nov - 23 Nov
The Westin Poinsett Greenville
A modern living room with a sofa, a coffee table, a TV, and a balcony with a view of buildings.
A modern kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, and a granite countertop. There are three white bar stools and two pendant lights.
A bedroom with a bed, bedside tables, a ceiling fan, and two windows with blinds.
A modern kitchen with white cabinets, a stainless steel refrigerator, and a bar area with white stools.

4. Mint House Greenville Downtown by Kasa

Mint House Greenville Downtown by Kasa
Greenville Downtown
United States
Michelle
€87
includes taxes & fees
23 Nov - 24 Nov
Mint House Greenville Downtown by Kasa
A modern lounge area with a brick accent wall, a fireplace, and comfortable seating.
A multi-story hotel with a prominent entrance, a parking lot, and a landscaped area with a small tree.
A bar area with a counter, multiple chairs, and a display of bottles and glasses.
A hotel room with a bed, a sofa, a dining table with chairs, a coffee machine, and a TV mounted on the wall.

5. The Abernathy of Clemson

The Abernathy of Clemson
Clemson
United States
Amy
€159
includes taxes & fees
17 Nov - 18 Nov
The Abernathy of Clemson
A multi-level interior with a spiral staircase, wooden railings, and a seating area with tables and chairs.
A spacious restaurant with high ceilings, wooden flooring, and a mix of modern and classic furniture.
A spacious living area with a sofa, ottoman, and chairs, a dining area with a table, and a kitchen in the background.
An outdoor patio with wicker furniture, a round table, and a fountain.

6. The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
Clemson
United States
Laurrie
€207
includes taxes & fees
28 Oct - 29 Oct
The Shepherd Hotel Downtown Clemson
A white BMW with "BMW Performance Driving School" text on the side, driving on a road with a cloud-covered sky in the background.
A spacious indoor venue with rows of white chairs adorned with purple sashes, large windows, and a modern ceiling design.
A bar area with multiple hanging decorative lights, a counter with bar stools, and a seating area with chairs.
A banquet hall with round tables set for dining, large windows, and a stage with curtains.

7. Greenville Marriott

Greenville Marriott
Greenville
United States
John
€115
includes taxes & fees
31 Oct - 1 Nov
Greenville Marriott
Bar (on property)
Snack bar
Bar (on property)
Ballroom

8. Doubletree By Hilton Greenville Airport

Doubletree By Hilton Greenville Airport
Greer
United States
Stephanie
€112
includes taxes & fees
16 Nov - 17 Nov
Doubletree By Hilton Greenville Airport
A modern building with outdoor seating and a garden.
A two-story house with a dark roof and siding, a front porch with four yellow chairs, and a well-maintained garden with shrubs and mulch.
A modern kitchen with white cabinetry, a wooden dining table, and a black chair. There is a window with a view of greenery outside.
A modern living room with a sofa, coffee table, and dining table. There is a TV mounted on the wall, a coffee machine, and a bookshelf.

9. The Station by Compo Hotels

The Station by Compo Hotels
Travelers Rest
United States
Anonymous traveller
€306
includes taxes & fees
22 Nov - 23 Nov
The Station by Compo Hotels
A two-story house with a tiled roof, a stone fire pit, and outdoor seating.
A swimming pool with lounge chairs and a building with balconies.
A spacious room with wooden beams, a large chandelier, and a cozy seating area with orange chairs and a white sofa.
A restaurant with a stone fireplace, hanging crystal chandelier, and multiple dining tables set with white tablecloths and wine glasses.

10. Hotel Domestique

Hotel Domestique
Travelers Rest
United States
Chuck
€411
includes taxes & fees
25 Oct - 26 Oct
Hotel Domestique
A spacious living room with a stone fireplace, wooden beams, and a chandelier.
A modern kitchen with white cabinetry, dark blue walls, and a patterned floor.
A modern kitchen with dark wood cabinets, a black refrigerator, a microwave, and a stainless steel sink. There are two bar stools at the island, and a flat-screen TV mounted on the wall.
A modern kitchen with dark cabinetry, a stainless steel range, and a granite countertop.

11. Landing Apartments Greer - Sugar Creek

Landing Apartments Greer - Sugar Creek
Greer
United States
Amanda
Landing Apartments Greer - Sugar Creek
A bedroom with a bed, a chair, and a potted aloe plant on a table.
A multi-story building with a symmetrical facade, large windows, and two flags on top.
A modern kitchen with stainless steel appliances, dark wooden cabinets, a dining table with chairs, and a potted plant.
A modern kitchen with stainless steel appliances, a dining area with a table and chairs, and a TV mounted on a wooden cabinet.

12. Landing Furnished Apartments - Spartanburg, SC

Landing Furnished Apartments - Spartanburg, SC
Spartanburg
Landing Furnished Apartments - Spartanburg, SC
A cozy living room with a fireplace, leather armchair, and a large window.
A wooden gazebo with a roof, surrounded by trees, overlooking a lake.
A modern kitchen with stainless steel appliances, a granite countertop, and large windows offering a view of the outdoors.
A covered outdoor deck with wicker furniture and large windows offering views of a forest and a lake.

13. Designer Retreat w/ Pool, Golf + Beach Access!

Designer Retreat w/ Pool, Golf + Beach Access!
Salem
United States
Anonymous traveller
Designer Retreat w/ Pool, Golf + Beach Access!
A two-story yellow house with a front porch, a small garden, and a pathway leading to the entrance.
Interior
An indoor swimming pool with clear lanes, a covered roof, and a bench area.
A two-story yellow house with a front porch, surrounded by greenery and a driveway.

14. Wooded Keowee Key Retreat Near Golf & Trails

Wooded Keowee Key Retreat Near Golf & Trails
Salem
Wooded Keowee Key Retreat Near Golf & Trails
A swimming pool with a view of a lake and docked boats.
A marina with boats docked, a lifeguard station, and a dock with lounge chairs.
A multi-story hotel with a parking lot and a view of a lake.
A sandy beach with a calm lake surrounded by trees.

15. Lake Keowee Condo: Resort Pools & Lake Access!

Lake Keowee Condo: Resort Pools & Lake Access!
Salem
United States
Shawn
Lake Keowee Condo: Resort Pools & Lake Access!
A swimming pool with a view of the lake and docked boats.
A modern kitchen with a central island, stainless steel appliances, wooden cabinets, and a window providing natural light.
A spacious living area with a high ceiling, a large window with a view of trees, a kitchen with a bar, and a comfortable seating area with a sofa and ottomans.
A marina with boats docked, surrounded by greenery and trees.

16. Keowee Key Condo w/ Lake Access & Community Pools!

Keowee Key Condo w/ Lake Access & Community Pools!
Salem
Keowee Key Condo w/ Lake Access & Community Pools!
A wooden deck with a table and chairs, large windows, and a view of trees.
A swimming pool with a view of a lake and docked boats.
A dining area with a wooden table and chairs, a kitchen with white cabinets, and a staircase with a white railing.
A spacious living room with a fireplace, a television, and a staircase leading to an upper level.

17. Salem Vacation Rental w/ Lake Keowee Access!

Salem Vacation Rental w/ Lake Keowee Access!
Salem
Salem Vacation Rental w/ Lake Keowee Access!
A swimming pool with a view of the lake and docked boats.
A gazebo with a wooden roof and open sides, surrounded by trees and overlooking a body of water.
An aerial view of a residential area with houses, a golf course, and a lake in the background.
A marina with boats docked, a lifeguard station, and a view of a lake surrounded by trees.

18. Views, Pools & Marina: Lake Keowee Condo!

Views, Pools & Marina: Lake Keowee Condo!
Salem
Views, Pools & Marina: Lake Keowee Condo!
A multi-story wooden building with balconies, large windows, and a landscaped area with trees.
A modern building with a prominent wooden entrance canopy, stone pillars, and a clear sky.
A modern living room with a sofa, a coffee table, and a fireplace.
A modern kitchen with a stainless steel sink, pendant lighting, and a view to a living area with a sofa and a staircase.

19. Tee Times & Lake Days! Luxe Keowee Key Living

Tee Times & Lake Days! Luxe Keowee Key Living
Salem
Tee Times & Lake Days! Luxe Keowee Key Living
Interior
A hallway with a wooden bench, a chandelier, a door, and a wall with a sign.
A multi-story hotel with a parking lot and a view of a lake.
A kitchen with white cabinets, a stainless steel refrigerator, a microwave, and a sink.

20. Lake Keowee Condo w/ Balcony & Resort Amenities!

Lake Keowee Condo w/ Balcony & Resort Amenities!
Salem
United States
Kathleen
Lake Keowee Condo w/ Balcony & Resort Amenities!
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Learn more about Upstate South Carolina

Check out the local area in Upstate South Carolina—home to attractions like Discovery Island Water Park and Heritage Park.

See all hotels in Upstate South Carolina
A multi-tiered waterfall cascading over rocks in a forested area.
Photo by Ryan Watts

Top Upstate South Carolina Hotel Reviews

Mint House Greenville Downtown by Kasa

Mint House Greenville Downtown by Kasa

8/10 Good
"Great location and in vicinity/walking to Reedy Falls, shops, food & ice cream, and Grand Bohemian Lodge, too! Walk the pathway along the river and seeing the boulder water falls was exceptionally special! Balcony was a nice view of city life. Parking for a fee was conveniently located for access to the property. Kitchen was large and equipped well for simple dinner. The Laundry room with detergent was useful, too!"
Melissa 2-night trip
Posted 3 days ago
Mint House Greenville Downtown by Kasa

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