A bench, a bicycle, and a lake surrounded by trees.

4 Star Hotels in Upstate South Carolina, South Carolina

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Check availability on Upstate South Carolina 4 Star Hotels

Tonight
8 Sept - 9 Sept
Tomorrow
9 Sept - 10 Sept
This weekend
11 Sept - 13 Sept
Next weekend
18 Sept - 20 Sept

Our top choices for Upstate South Carolina 4-star hotels

A restaurant with a bar area, green upholstered seating, and a view of trees through large windows.
A large, two-story house with a symmetrical facade, large windows, and a central entrance.
A bar with multiple shelves of liquor bottles and glasses hanging above.
A modern hotel lobby with a chandelier, wooden shelving, a reception desk, and a view of the outdoors.

1. Hotel Hartness

Hotel Hartness
Greenville
United States
Cornelius
€177
includes taxes & fees
4 Oct - 5 Oct
Hotel Hartness
A large, multi-story house with a prominent waterfall in the foreground, surrounded by lush greenery.
An outdoor dining area with multiple tables and chairs, large windows, and a view of greenery.
A modern interior with a stone fireplace, leather sofas, and a wooden ceiling.
A modern interior with a fireplace, plush seating, and a stone accent wall.

2. Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection
Greenville Downtown
United States
David
€341
includes taxes & fees
4 Oct - 5 Oct
Grand Bohemian Lodge Greenville, Autograph Collection
A hotel facade with arched windows, a fountain, and a sign for "The Westin."
A grand lobby with a chandelier, multiple seating areas, and a checkered floor pattern.
A banquet hall with round tables, chandeliers, and ornate windows.

3. The Westin Poinsett Greenville

The Westin Poinsett Greenville
Greenville Downtown
United States
Karen
€197
includes taxes & fees
13 Sept - 14 Sept
The Westin Poinsett Greenville
A modern living room with a sofa, a coffee table, a TV, and a balcony with a view of buildings.
A modern kitchen with white cabinets, a stainless steel refrigerator, and a bar area with white stools.
A bedroom with a bed, bedside tables, a ceiling fan, and two windows with blinds.
A modern kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, and a granite countertop. There are three white bar stools and two pendant lights.

4. Mint House Greenville Downtown by Kasa

Mint House Greenville Downtown by Kasa
Greenville Downtown
United States
Channell
€123
includes taxes & fees
9 Sept - 10 Sept
Mint House Greenville Downtown by Kasa
A bar area with multiple hanging decorative lights, a counter with bar stools, and a seating area with chairs.
A banquet hall with round tables set for dining, large windows, and a stage with curtains.
A well-furnished living room with a chandelier, wooden furniture, and a view through a window.
A modern building with a large illuminated logo reading "TOPGOLF" on the facade.

5. Greenville Marriott

Greenville Marriott
Greenville
United States
richard
€119
includes taxes & fees
17 Sept - 18 Sept
Greenville Marriott
A multi-level interior with a spiral staircase, wooden railings, and a seating area with tables and chairs.
An outdoor patio with wicker furniture, a round table, and a fountain.
A spacious restaurant with high ceilings, wooden flooring, and a mix of modern and classic furniture.
A modern bar area with a wooden ceiling, green bar stools, and a bar counter.

6. The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
Clemson
United States
Laurrie
€228
includes taxes & fees
15 Sept - 16 Sept
The Shepherd Hotel Downtown Clemson
A modern lounge area with a brick accent wall, a fireplace, and comfortable seating.
A multi-story hotel with a prominent entrance, a parking lot, and a landscaped area with a small tree.
A modern living room with a sofa, two armchairs, a coffee table, and a potted plant.
A bar area with a counter, multiple chairs, and a display of bottles and glasses.

7. The Abernathy of Clemson

The Abernathy of Clemson
Clemson
United States
Robert
€154
includes taxes & fees
9 Sept - 10 Sept
The Abernathy of Clemson
A modern building with outdoor seating and a garden.
A modern kitchen with white cabinetry, a wooden dining table, and a black chair. There is a window with a view of greenery outside.
A modern living room with a sofa, coffee table, and dining table. There is a TV mounted on the wall, a coffee machine, and a bookshelf.
A two-story house with a dark roof and siding, a front porch with four yellow chairs, and a well-maintained garden with shrubs and mulch.

8. The Station by Compo Hotels

The Station by Compo Hotels
Travelers Rest
United States
Anonymous traveller
€285
includes taxes & fees
14 Sept - 15 Sept
The Station by Compo Hotels
A two-story house with a tiled roof, a stone fire pit, and outdoor seating.
A spacious room with wooden beams, a large chandelier, and a cozy seating area with orange chairs and a white sofa.
A bar with a large window view of mountains and a chandelier.
A swimming pool with lounge chairs and a building with balconies.

9. Hotel Domestique

Hotel Domestique
Travelers Rest
United States
Chuck
€397
includes taxes & fees
9 Sept - 10 Sept
Hotel Domestique
A spacious living room with a stone fireplace, wooden beams, and a chandelier.
A modern kitchen with dark wood cabinets, a black refrigerator, a microwave, and a stainless steel sink. There are two bar stools at the island, and a flat-screen TV mounted on the wall.
A multi-story residential building with balconies, a stone archway entrance, and a sign indicating it is part of Century Park at Taft Community.
A modern kitchen with dark cabinetry, a stainless steel range, and a granite countertop.

10. Landing Apartments Greer - Sugar Creek

Landing Apartments Greer - Sugar Creek
Greer
United States
Amanda
Landing Apartments Greer - Sugar Creek
A wooden gazebo with a roof and a table and chairs inside, surrounded by trees and overlooking a lake.
A modern kitchen with a stainless steel sink, pendant lighting, and a view to a living area with a sofa and a staircase.
A spacious hotel lobby with a bar area, seating arrangements, and large windows offering views.
A modern living room with a sofa, a coffee table, and a fireplace.

11. Tee Times & Lake Days! Luxe Keowee Key Living

Tee Times & Lake Days! Luxe Keowee Key Living
Salem
Tee Times & Lake Days! Luxe Keowee Key Living
A wooden gazebo with a roof, surrounded by trees, overlooking a lake.
A cozy living room with a fireplace, leather armchair, and a large window.
A spacious living area with a high ceiling, wooden beams, a grey sofa, a brown leather chair, and a dining table with a plant.
A modern kitchen with stainless steel appliances, a granite countertop, and large windows offering a view of the outdoors.

12. Designer Retreat w/ Pool, Golf + Beach Access!

Designer Retreat w/ Pool, Golf + Beach Access!
Salem
United States
Anonymous traveller
Designer Retreat w/ Pool, Golf + Beach Access!
A wooden deck with a table and chairs, surrounded by trees.
A spacious living room with a grey sofa, a wooden coffee table, and a blue rug. There is a dining area with a wooden table and chairs.

13. Wooded Keowee Key Retreat Near Golf & Trails

Wooded Keowee Key Retreat Near Golf & Trails
Salem
Wooded Keowee Key Retreat Near Golf & Trails
A bedroom with a bed, a chair, and a potted aloe plant on a table.
A modern kitchen with stainless steel appliances, dark wooden cabinets, a dining table with chairs, and a potted plant.
A modern living room with a flat-screen TV, two leather chairs, a wooden dining table, and a potted plant.
A multi-story building with a symmetrical facade, large windows, and two flags on top.

14. Landing Furnished Apartments - Spartanburg, SC

Landing Furnished Apartments - Spartanburg, SC
Spartanburg
Landing Furnished Apartments - Spartanburg, SC
A modern kitchen with a central island, stainless steel appliances, and pendant lighting.
A covered patio area with outdoor seating, large windows, and a white exterior.
A modern kitchen with white cabinets, stainless steel appliances, and a central island with bar stools.
A modern kitchen with white cabinets, a stainless steel refrigerator, and pendant lighting.

15. Steps to Lake Greenwood: Waterfront Gem w/ Patio

Steps to Lake Greenwood: Waterfront Gem w/ Patio
Greenwood
United States
Luetrina
Steps to Lake Greenwood: Waterfront Gem w/ Patio
A kitchen with white cabinets, a stainless steel refrigerator, a microwave, and a sink.
A marina with boats docked, a wooden pier, and a clear sky.
A multi-story hotel with a parking lot and a view of a lake.

16. Lake Keowee Condo w/ Balcony & Resort Amenities!

Lake Keowee Condo w/ Balcony & Resort Amenities!
Salem
Lake Keowee Condo w/ Balcony & Resort Amenities!
A swimming pool with a view of the lake and docked boats.
A modern kitchen with a central island, stainless steel appliances, wooden cabinets, and a window providing natural light.
A marina with boats docked, surrounded by greenery and trees.
A modern living room with a large window, a flat-screen TV, a leather sofa, a coffee table, and a bookshelf.

17. Keowee Key Condo w/ Lake Access & Community Pools!

Keowee Key Condo w/ Lake Access & Community Pools!
Salem
Keowee Key Condo w/ Lake Access & Community Pools!
A marina with boats docked, a lifeguard station, and a dock with lounge chairs.
A multi-story hotel with a parking lot and a view of a lake.
A sandy beach with a calm lake surrounded by trees.
A spacious dining area with a wooden table, chairs, and a chandelier. A cozy seating area with a sofa and chairs is visible in the background.

18. Lake Keowee Condo: Resort Pools & Lake Access!

Lake Keowee Condo: Resort Pools & Lake Access!
Salem
Lake Keowee Condo: Resort Pools & Lake Access!
A gazebo with a wooden roof and open sides, surrounded by trees and overlooking a body of water.
A dining area with a wooden table and chairs, a kitchen with white cabinets, and a staircase with a white railing.
A spacious living room with a fireplace, a television, and a staircase leading to an upper level.
A marina with boats docked, surrounded by greenery and trees.

19. Salem Vacation Rental w/ Lake Keowee Access!

Salem Vacation Rental w/ Lake Keowee Access!
Salem
Salem Vacation Rental w/ Lake Keowee Access!
A gazebo with a wooden roof and open sides, surrounded by trees and overlooking a body of water.
An aerial view of a residential area with houses, a golf course, and a lake in the background.
A marina with boats docked, a lifeguard station, and a view of a lake surrounded by trees.
A sandy beach with a calm lake surrounded by trees.

20. Views, Pools & Marina: Lake Keowee Condo!

Views, Pools & Marina: Lake Keowee Condo!
Salem
Views, Pools & Marina: Lake Keowee Condo!
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Learn more about Upstate South Carolina

Check out the local area in Upstate South Carolina—home to attractions like Heritage Park and CCNB Amphitheatre.

See all hotels in Upstate South Carolina
A multi-tiered waterfall cascading over rocks in a forested area.
Photo by Ryan Watts

Top Upstate South Carolina Hotel Reviews

The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson

10/10 Excellent
"Absolutely perfect in every way!"
Heather 1-night trip
Posted 16 hours ago
The Shepherd Hotel Downtown Clemson
Hotel Hartness

Hotel Hartness

10/10 Excellent
"This property was amazing, comfortable and with every amenity needed to be happy. Will definitely return to this unique property."
Elizabeth 1-night trip
Posted 1 day ago
Hotel Hartness
The Abernathy of Clemson

The Abernathy of Clemson

10/10 Excellent
"Perfect hotel on Clemson’s campus. Walkable to all campus activities and nightlife. Large rooms with a sitting area, kitchenette and walk-in shower."
Laura 2-night trip
Posted 2 days ago
The Abernathy of Clemson
Mint House Greenville Downtown by Kasa

Mint House Greenville Downtown by Kasa

10/10 Excellent
"Room was clean, huge, check in was easy. Especially if you’re introverted!"
Hannah 1-night trip
Posted 3 days ago
Mint House Greenville Downtown by Kasa
Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection

8/10 Good
"Nice property that is extremely well located relative to downtown Greenville. Staff and facilities were first rate but I found the decor slightly tacky."
Henry R 1-night trip
Posted 11 days ago
Grand Bohemian Lodge Greenville, Autograph Collection

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