Calle 50

Photo by Fabiola Tile
Photo by Fabiola Tile
Photo by Fabiola Tile
Photo by Fabiola Tile
Photo by Journey Of A Nomadic Family
Photo by Journey Of A Nomadic Family
Photo by Simon Gerald
Photo by Simon Gerald
Photo by Stefan Messing
Photo by Stefan Messing
Price found within the past 48 hours. Click for updated prices.
MARINN Tropical Vibes Hotel

MARINN Tropical Vibes Hotel

3.5 out of 5
Amador
per person
7 Sept - 12 Sept
found 1 day ago
Return direct flight included
Dublin (DUB) to Panama City (PTY)
8/10 Very Good! (111 reviews)
Friendly and knowledgeable staff, helpful with ideas and other travel needs. Very reassuring.

Reviewed on 29 Jul 2025

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
per person
7 Sept - 12 Sept
found 1 day ago
Return direct flight included
Dublin (DUB) to Panama City (PTY)
9/10 Wonderful! (956 reviews)
Nuestra experiencia en el hotel fue excelente. Las instalaciones se mantienen impecablemente limpias y bien cuidadas, lo que hace que la estadía sea muy agradable. El personal es sumamente atento y gentil, siempre dispuesto a ayudar y hacer sentir a los huéspedes bienvenidos. Nos encantó la música en vivo que ofrecen, creando un ambiente relajado y acogedor. Además, la ubicación es perfecta: está muy cerca de los principales lugares turísticos, lo que facilita explorar la zona sin complicaciones. ¡Definitivamente volveríamos!

Reviewed on 25 Jul 2025

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
per person
7 Sept - 12 Sept
found 1 day ago
Return direct flight included
Dublin (DUB) to Panama City (PTY)
8.4/10 Very Good! (936 reviews)
This hotel is very conveniently located. It offers easy access to all major highways, malls, casco viejo and restaurants.

Reviewed on 1 Aug 2025

Tours & day trips

See all 53 activities
Day Tour in San Blas Islands All Included Visiting 4 Islands

Day Tour in San Blas Islands All Included Visiting 4 Islands

Activity duration is 14 hours
9.4 out of 10 with 33 reviews
Free cancellation available
Price is €150 per adult
Day Tour in San Blas Islands All Included Visiting 4 IslandsOpens in new tab

Private & custom tours

See all 10 activities
Private Half-Day Panama City Tour And Panama Canal

Private Half-Day Panama City Tour And Panama Canal

Activity duration is 5 hours
10.0 out of 10 with 2 reviews
Free cancellation available
Price is €39 per adult
Private Half-Day Panama City Tour And Panama CanalOpens in new tab

Cruises & boat tours

See all 7 activities
Panama Canal Partial Transit

Panama Canal Partial Transit

Activity duration is 7 hours
8.4 out of 10 with 95 reviews
Free cancellation available
Price is €129 per adult
Panama Canal Partial TransitOpens in new tab

Popular places to visit

Soho City Center

Soho City Center

You can enjoy retail therapy at Soho City Center during your trip to Panama City. Discover the area's shops or seek out its local tours.

Soho City Center
Multiplaza Pacific Mall

Multiplaza Pacific Mall

4.5/5(8 reviews)

During your trip to Panama City, you can search for that perfect souvenir at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.

Multiplaza Pacific Mall
Avenida Balboa

Avenida Balboa

3.5/5(9 reviews)

You can browse for the perfect souvenirs at Avenida Balboa during your stay in Panama City. While you're in the area, wander around the natural setting.

Avenida Balboa
Uruguay Street

Uruguay Street

4/5(2 reviews)

During your visit to Panama City, you can search for that perfect souvenir at Uruguay Street. While in this family-friendly area, you can savour the top-notch restaurants.

Uruguay Street

Bingo 90

Why not roll the dice with a visit to Bingo 90 during your travels in Panama City? Visit the shops and casinos in this vibrant area.

Bingo 90

National Shrine of the Heart of Mary

You can learn about the history of Panama City with a trip to National Shrine of the Heart of Mary. Stroll along the seaside or visit the shops in this vibrant area.

National Shrine of the Heart of Mary

Top Hotel Deals

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella, Panama City, Panama
Hotel Riu Plaza Panama
Sheraton Grand Panama

Sheraton Grand Panama

4 out of 5
Via Israel And 77th Street, Panama City, Panama
Sheraton Grand Panama
Waymore Hotel Spa & Casino

Waymore Hotel Spa & Casino

4 out of 5
Calle Augusto Samuel Boyd y Calle Eusebi, Panama City
Waymore Hotel Spa & Casino
Principe Hotel and Suites

Principe Hotel and Suites

3 out of 5
Via Argentina, Panama City, Panama
Principe Hotel and Suites
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
Avenida Balboa, Panama City
Megapolis Hotel Panamá
Studio Coliving

Studio Coliving

4.5 out of 5
Av. Ricardo Arango y, Av. Federico Boyd, Panama City, Panama
Studio Coliving
JW Marriott Panama

JW Marriott Panama

5 out of 5
Calle Punta Colon, Punta Pacifica, Panama City, Panama
JW Marriott Panama
Ramada Plaza By Wyndham Panama Punta Pacífica

Ramada Plaza By Wyndham Panama Punta Pacífica

4 out of 5
Via Israel y Calle 71, San Francisco, Panama City, Panama
Ramada Plaza By Wyndham Panama Punta Pacífica
Decapolis Hotel Panama City

Decapolis Hotel Panama City

4 out of 5
Avenida Balboa Con Multicentro, Panama City, Panama
Decapolis Hotel Panama City
See all 1,458 properties in Calle 50
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.