Antigua Guatemala Hotel Guide - Casa Santo Domingo Museum hotels in Antigua Guatemala, Guatemala.

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Our top choices for Casa Santo Domingo Museum hotels

Hotel Aurora

3.5 star property
Historic Center, 0.2 km from Casa Santo Domingo Museum
9.6 out of 10, Exceptional, (386)
"Quiet and beautiful. "
United States
Richard
The price is €90
includes taxes & fees
11 Dec - 12 Dec
Hotel Aurora

Las Cruces Boutique Hotel

4.0 star property
Historic Center, 0.5 km from Casa Santo Domingo Museum
9.8 out of 10, Exceptional, (221)
"Great place!"
United States
Ragnar
The price is €262
includes taxes & fees
23 Dec - 24 Dec
Las Cruces Boutique Hotel

Casa Santa Rosa Hotel Boutique

3.5 star property
Historic Center, 0.4 km from Casa Santo Domingo Museum
9.6 out of 10, Exceptional, (317)
"I had an incredible stay. Estiben took care of all my needs including helping me with my Spanish and arranging for tours. The hiel is very quiet and peaceful with a stunningly beautiful garden and patio. It’s a short walk to the Santa Catalina arch and very close to the entry point for the hike to Cerro de la Cruz. "
United States
Siddique Ahmed Khan
The price is €134
includes taxes & fees
11 Dec - 12 Dec
Casa Santa Rosa Hotel Boutique

Posada San Sebastian

3.0 star property
Historic Center, 0.5 km from Casa Santo Domingo Museum
9.6 out of 10, Exceptional, (93)
"Great hotel on ideal location to explore the city. Very friendly and welcoming staff, our second stay & wouldn’t hesitate to stay there again "
United Kingdom
Stephen
The price is €82
includes taxes & fees
15 Dec - 16 Dec
Posada San Sebastian

Luna Maya Boutique Hotel

3.0 star property
0.4 km from Casa Santo Domingo Museum
9.6 out of 10, Exceptional, (21)
"Very helpful staff the breakfast was delicious and the room was super clean and comfortable."
Canada
Adam
The price is €77
includes taxes & fees
14 Dec - 15 Dec
Luna Maya Boutique Hotel

Hotel Museo Spa Casa Santo Domingo

4.5 star property
Barrio de La Concepción, < 0.1 km from Casa Santo Domingo Museum
9.2 out of 10, Wonderful, (1001)
"Great room, the food was awesome and the amenities are just amazing."
United States
Cesar Luis Sinclair
The price is €260
includes taxes & fees
4 Jan - 5 Jan 2026
Hotel Museo Spa Casa Santo Domingo

Hotel Posada de Don Rodrigo Antigua

3.5 star property
Historic Center, 0.7 km from Casa Santo Domingo Museum
9.4 out of 10, Exceptional, (643)
"Friendly staff, clean rooms the location was excellent. "
United States
Elias
The price is €205
includes taxes & fees
2 Jan - 3 Jan 2026
Hotel Posada de Don Rodrigo Antigua

El Convento Boutique Hotel

4.0 star property
Historic Center, 0.4 km from Casa Santo Domingo Museum
9.4 out of 10, Exceptional, (800)
"Great hotel to explore Antigua "
United States
vered
The price is €220
includes taxes & fees
4 Jan - 5 Jan 2026
El Convento Boutique Hotel

Hotel Camino Real Antigua

4.0 star property
Historic Center, 1 km from Casa Santo Domingo Museum
9.6 out of 10, Exceptional, (1000)
"Amazing hotel with beautiful gardens, great rooms, helpful staff and the top breakfast in Antigua. "
United States
Audrey
The price is €210
includes taxes & fees
15 Dec - 16 Dec
Hotel Camino Real Antigua

Hotel Casa Bansley

2.5 star property
1.3 km from Casa Santo Domingo Museum
9.8 out of 10, Exceptional, (46)
"Very nice boutique hotel"
United States
Aldo
The price is €108
includes taxes & fees
14 Dec - 15 Dec
Hotel Casa Bansley

Hostal Antigueño - Hostel

2.0 star property
0.3 km from Casa Santo Domingo Museum
9.2 out of 10, Wonderful, (30)
"Great place, great people! Highly recommend!"
Canada
Cody
Hostal Antigueño - Hostel

Mestizo Antigua

4.0 star property
Historic Center, 0.8 km from Casa Santo Domingo Museum
9.4 out of 10, Exceptional, (153)
"The hotel is well situated. The receptionist, Kelyn was amazing, she went out of her way to make my stay comfortable and enjoyable. "
United States
Mercedes
The price is €151
includes taxes & fees
5 Jan - 6 Jan 2026
Mestizo Antigua

Porta Hotel Antigua

4.5 star property
0.8 km from Casa Santo Domingo Museum
9.4 out of 10, Exceptional, (1003)
"Everything about this hotel was fantastic. The bed was so comfortable. "
United States
Raymond
The price is €194
includes taxes & fees
15 Dec - 16 Dec
Porta Hotel Antigua

All Suite El Marques de Antigua

3.5 star property
0.9 km from Casa Santo Domingo Museum
9.4 out of 10, Exceptional, (296)
"Great location and very clean"
United States
Saul
All Suite El Marques de Antigua

Good Hotel Antigua

4.0 star property
0.4 km from Casa Santo Domingo Museum
9.2 out of 10, Wonderful, (524)
"Very friendly staff and the room was as expected, clean and cozy. "
United States
Sayda
The price is €173
includes taxes & fees
5 Jan - 6 Jan 2026
Good Hotel Antigua

Pensativo House Hotel

4.5 star property
0.9 km from Casa Santo Domingo Museum
9.4 out of 10, Exceptional, (389)
"Great Staff! Very Clean and awesome views!"
United States
Bryan
Pensativo House Hotel

Las Camelias Inn

3.0 star property
Historic Center, 0.3 km from Casa Santo Domingo Museum
8.8 out of 10, Excellent, (575)
"Very good place for my stay in Antigua. They were so helpful in storing my luggages away even after check out for a whole day for free when I went for the volcano hike. "
Canada
Joel
The price is €100
includes taxes & fees
7 Jan - 8 Jan 2026
Las Camelias Inn

Los Pasos Boutique Hotel & Spa

4.5 star property
0.7 km from Casa Santo Domingo Museum
9.4 out of 10, Exceptional, (1002)
"Great place to stay. "
United States
tania
The price is €159
includes taxes & fees
14 Dec - 15 Dec
Los Pasos Boutique Hotel & Spa

Ojala

3.0 star property
Historic Center, 0.9 km from Casa Santo Domingo Museum
9.4 out of 10, Exceptional, (22)
"Fantastic stay, central to everything, would highly recommend"
Australia
Peter
The price is €69
includes taxes & fees
11 Dec - 12 Dec
Ojala

La Villa Serena

3.0 star property
1.5 km from Casa Santo Domingo Museum
9.6 out of 10, Exceptional, (109)
"room was very pretty and bed was extremely comfortable. "
United States
clara
The price is €83
includes taxes & fees
14 Dec - 15 Dec
La Villa Serena
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Casa Santo Domingo Museum Hotel Reviews

Hotels near other Casa Santo Domingo Museum attractions

Frequently asked questions

What's the area like around Casa Santo Domingo Museum?
Casa Santo Domingo Museum is located in a historic area of Antigua Guatemala known for its major shopping area. If you're looking for a convenient place to stay, take a look at the 499 hotels and other accommodation options you'll find within a mile.
What's the best hotel to stay close to Casa Santo Domingo Museum?
Adjacent to Casa Santo Domingo Museum, Hotel Museo Spa Casa Santo Domingo is one of the top choices for your stay based on our traveller data, and this hotel offers a full-service spa and 2 restaurants. Other good choices close by include Porta Hotel Antigua and Hotel Camino Real Antigua.
How many hotels are there near Casa Santo Domingo Museum?
Expedia has 499 hotels and other accommodation options within a mile from Casa Santo Domingo Museum.
If I need to cancel the hotel reservation for my stay near Casa Santo Domingo Museum, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If you have a reservation that's non-refundable, you might still have the option to cancel and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to review the best deals available near Casa Santo Domingo Museum.
What can I see and do near Casa Santo Domingo Museum?
You might want to spend some time browsing the exhibits at Antigua Guatemala Colonial Art Museum, Jade Maya Factory and Museum or La Azotea Cultural Center. Explore notable local landmarks like Las Capuchinas Convent, Santa Clara Convent and Santa Catalina Arch. Spend some time exploring the the natural beauty of Central Park, Tanque La Unión and El Reposo Spa.