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Check prices for these dates

In two weeks
5 Sept - 7 Sept
In two months
17 Oct - 19 Oct
In three months
14 Nov - 16 Nov
In four months
12 Dec - 14 Dec

Featured Apartments in Defiance and around

Our top choices for Defiance apartments

Amazing Renovated Historic Loft on Main Street
Fridge, microwave, oven, stovetop

Amazing Renovated Historic Loft on Main Street

10.0 out of 10, Exceptional, (53)
"The place was great, just as advertised. Location was close to everything and made for a nice weekend away from kids"
The price is €212
includes taxes & fees
25 Aug - 26 Aug
Amazing Renovated Historic Loft on Main Street
Wentzville One Bedroom Apartment by StayLage
TV

Wentzville One Bedroom Apartment by StayLage

9.8 out of 10, Exceptional, (7)
"Hadxa wonderful stay in Wentzville here. I am often in Missouri, i will definitely be back! "
Wentzville One Bedroom Apartment by StayLage
Studio on Historic Main by StayLage
1 bedroom, iron/ironing board, WiFi, bed sheets

Studio on Historic Main by StayLage

9.4 out of 10, Exceptional, (27)
"My wife and I stayed for her birthday weekend and had a great time. The property is located at the end of the strip so it was perfect to start the bar hoping. The apartment was very cozy and clean. Definitely recommend for the quick get a way!!"
The price is €186
includes taxes & fees
24 Aug - 25 Aug
Studio on Historic Main by StayLage
Sunny SparkingClean King bed Apt- CreveCoeurPark
Smart TV, books, music library, computer monitors

Sunny SparkingClean King bed Apt- CreveCoeurPark

9.8 out of 10, Exceptional, (12)
"Good Stay"
Sunny SparkingClean King bed Apt- CreveCoeurPark
1st Capitol Mansion - Suite 401
Private kitchen

1st Capitol Mansion - Suite 401

8.4 out of 10, Very good, (7)
"Nice property and a great location to all the shops and restaurants that St. Charles has to offer. The place was clean and nicely updated. Will definitely stay here again!"
1st Capitol Mansion - Suite 401
6th street 101 - Walk to Main St
Fridge, microwave, oven, stovetop

6th street 101 - Walk to Main St

6th street 101 - Walk to Main St
The Hidden Gem - 2BR Basement Apartment on 7 Acres
Fridge, microwave, oven, stovetop

The Hidden Gem - 2BR Basement Apartment on 7 Acres

10.0 out of 10, Exceptional, (11)
"Another great stay at The Hidden Gem. Easy access in a quiet location!"
The Hidden Gem - 2BR Basement Apartment on 7 Acres
Back Door Guest Suite, Zia My Retreat
1 bedroom, desk, iron/ironing board, WiFi

Back Door Guest Suite, Zia My Retreat

10.0 out of 10, Exceptional, (4)
"Beautiful relaxing place in adorable neighborhood! Quite the find!"
The price is €212
includes taxes & fees
6 Sept - 7 Sept
Back Door Guest Suite, Zia My Retreat
Duplex Hideaway in St. Charles, MO
Fridge, microwave, oven, stovetop

Duplex Hideaway in St. Charles, MO

10.0 out of 10, Exceptional, (4)
"Good location, comfortable bed, new interior, well equipped. Very clean and organized!"
The price is €234
includes taxes & fees
26 Aug - 27 Aug
Duplex Hideaway in St. Charles, MO
Private Basement Retreat w/ HOT TUB by StayLage
TV

Private Basement Retreat w/ HOT TUB by StayLage

9.0 out of 10, Wonderful, (7)
"My husband could not say enough about his stay. We not only recommend this place but will stay there again. Great communication and a beautiful space!"
Private Basement Retreat w/ HOT TUB by StayLage
The Lofts of North Main Street
Dining

The Lofts of North Main Street

9.6 out of 10, Exceptional, (144)
"Perfect location!"
The price is €221
includes taxes & fees
25 Aug - 26 Aug
The Lofts of North Main Street
Charming Duplex on Main
Fridge, microwave, stovetop, toaster

Charming Duplex on Main

10.0 out of 10, Exceptional, (15)
"Everything was awesome!!!!!!"
The price is €239
includes taxes & fees
31 Aug - 1 Sept
Charming Duplex on Main
Main Street Living! 2 Bedroom Unit right On Main!
Fridge, microwave, oven, stovetop

Main Street Living! 2 Bedroom Unit right On Main!

10.0 out of 10, Exceptional, (30)
"We had a great stay in St. Charles. 703 South Main Street is the perfect location for walking to Main Street shops and restaurants and only about 25 minutes from downtown St. Louis. I highly recommend this property for those looking for a comfortable retreat in the historical setting of St. Charles."
Main Street Living! 2 Bedroom Unit right On Main!
The Historic Bricks on Main
TV

The Historic Bricks on Main

9.0 out of 10, Wonderful, (12)
"Love how close it is to everything. Very clean. Would stay there again. "
The price is €213
includes taxes & fees
26 Aug - 27 Aug
The Historic Bricks on Main
Prime Loft of Main Street
Smart TV

Prime Loft of Main Street

9.8 out of 10, Exceptional, (96)
"The apartment had everything we needed for a quick getaway with family. Cute place and perfectly located. "
The price is €219
includes taxes & fees
25 Aug - 26 Aug
Prime Loft of Main Street
The FarmHouse 3bd/2ba B&B in MO Wine Country & Katy Trail
Smart TV

The FarmHouse 3bd/2ba B&B in MO Wine Country & Katy Trail

8.0 out of 10, Very good, (3)
"The unit was clean and comfortable, and easy to get in and out. Cooking was possible with a full setup kitchen, but there was also restaurants nearby as well. The host was responsive and took quick action on a small issue. I'd recommend this place for anyone wanting to visit the Katy trail."
The price is €491
includes taxes & fees
5 Sept - 6 Sept
The FarmHouse 3bd/2ba B&B in MO Wine Country & Katy Trail
Great for Business Travelers! Pool + Gym
Pool

Great for Business Travelers! Pool + Gym

Great for Business Travelers! Pool + Gym
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Defiance Hotel Reviews

Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

10/10 Excellent
"Wonderful"
Stephanie 1-night trip
Posted 15 hours ago
Hollywood Casino & Hotel St. Louis

Frequently asked questions

What's it like to stay at an apartment in Defiance?
You'll find 10 apartments to choose from in Defiance for your holiday.
Why would you choose apartments instead of traditional hotels?
An apartment is often more spacious than a traditional hotel room and comes with a kitchen, so you can cook some of your meals. Apartments are ideal for families who want the conveniences of home, and also for couples who want to stay away from the tourist areas.
What's the top apartment I should consider for a stay in Defiance?
Below are some of the more popular apartments in the area: 'The Chardonnay Chalet' Defiance Studio Trail!: Situated in Defiance , 0.3 mi/0.4 km from the heart of Defiance. Includes a patio . 'the Ruebling House': Bright, Modern, & Renovated!: Located 0.1 mi/0.2 km away in Defiance . The Merlot Bungalow Defiance Tiny Home on Trail: It's located in Defiance , 0.3 mi/0.4 km away. Overlook Main St. in this 2 Bedroom Owners Suite!: Located 18.5 mi/29.7 km away in St. Charles . A patio, a sofa bed and a Smart TV are included . Access to on-site laundry facilities is available on site . Prime Loft of Main Street: Located in St. Charles , 19.2 mi/30.9 km from Defiance. Includes free WiFi, a sofa bed and a Smart TV . Access to on-site laundry facilities is available on site .
How many apartments will I find in Defiance?
Expedia has 10 apartments to book in Defiance.
What can I expect from the weather in Defiance?
Weather is only one factor, but it can really affect your travel plans, especially if you are planning a longer stay in Defiance. The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 3°C. Average annual precipitation for Defiance is 1228 mm.
What are the must-see places to visit in Defiance?
August A. Busch Memorial Conservation Area and Missouri River are a couple of scenic spots to enjoy the outdoors, whereas Historic Daniel Boone Home and Heritage Center is one of the cultural attractions. While here, Yellow Farmhouse Winery and Chandler Hill Vineyards are other places worth a visit.
What's the best way to get to and around Defiance?
Knowing a bit about the transportation options can you save you a headache when you get to your destination. Fly into St. Louis, MO (SUS-Spirit of St. Louis), which is located 7.5 mi (12 km) from the heart of the city. Otherwise, look for flights into Lambert-St. Louis International Airport (STL), which is 23.5 mi (37.8 km) away. If you'd like to explore around the area, consider renting a car to explore more sights.