Defiance Hotels from €66 - Fully Refundable Options

A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

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Our top choices for Defiance hotels

A hotel room with a bed, a sofa, a coffee table, and wall art.

A restaurant with wooden tables and chairs, a blue wall with white floral patterns, and a counter with a coffee machine.

An indoor swimming pool with a clear view of the outside, a metal ladder, and a ceiling with recessed lighting.

A hotel lobby with a reception desk, seating area, and a large potted plant.

1. Sleep Inn & Suites O'Fallon MO - Technology Drive

O'Fallon

Tim

€83

includes taxes & fees

2 Nov - 3 Nov

A hotel room with two beds, a desk with a chair, a television, and a window with curtains.

A Holiday Inn Express hotel with a brick facade, a covered entrance, and a clear sky.

A reception desk with a modern design, featuring a blue geometric wall and a wooden finish.

A hotel lobby with a seating area, a reception desk, and a flat-screen TV mounted on the wall.

2. Holiday Inn Express St. Louis West - O'Fallon by IHG

O'Fallon

Greg

€98

includes taxes & fees

15 Oct - 16 Oct

A multi-story hotel with a central entrance featuring a covered patio area.

A hotel with a swimming pool, outdoor seating, and a covered patio area.

A hotel room with a sofa, armchair, bedside table, lamp, TV, and a bed with patterned bedding.

A hotel lobby with a sectional sofa, a fireplace, a flat-screen TV, and framed artwork on the walls.

3. Staybridge Suites O'Fallon Chesterfield by IHG

O'Fallon

Norman

€98

includes taxes & fees

14 Oct - 15 Oct

An outdoor patio area with a stone fire pit, wicker furniture, and a covered seating area with a view of the building's interior.

A multi-story hotel with a brick facade, a covered outdoor seating area with a fire feature, and a sign indicating it is a Marriott property.

A hotel room with a sofa, a side table, a lamp, a flat-screen TV, and a bed with a red blanket.

A hotel room with a large bed, bedside lamps, a TV, a desk, and a bathroom.

4. TownePlace Suites by Marriott St. Louis Chesterfield

Chesterfield

Bobbi jo

€134

includes taxes & fees

20 Oct - 21 Oct

A modern dining area with a brick fireplace, yellow and blue chairs, and a blue sofa.

A hotel with a brick facade, multiple parking spaces, and a grassy area in the foreground.

A gym with a treadmill, elliptical, stationary bike, and a rack of dumbbells.

A desk with a desktop computer, a printer, and a chair.

5. Comfort Inn & Suites Chesterfield - St. Louis

Chesterfield

Brenda

€91

includes taxes & fees

19 Oct - 20 Oct

A hotel with a prominent tower, a fountain in the courtyard, and a well-maintained garden.

A hotel room with a large bed, a bedside lamp, a telephone, a mirror, and a bathroom with a sink and towel rack.

A spacious living area with a staircase, a large painting, and a chandelier.

A modern bathroom with a large mirror, white vanity, and a bathtub.

6. The Wildwood Hotel

Wildwood

Ryan

€86

includes taxes & fees

9 Nov - 10 Nov

A spacious lobby with a stone fireplace, seating area, and a bar with high stools.

A hotel lobby with a seating area featuring two armchairs, a round coffee table, and a flat-screen TV mounted on a wooden wall.

A hotel pantry stocked with beverages and snacks, a refrigerated display case, and a sign reading "The Market".

A modern living room with a fireplace, a flat-screen TV, a sofa, a coffee table, and a dining area.

7. Residence Inn by Marriott O'Fallon

O'Fallon

Rianna

€138

includes taxes & fees

30 Oct - 31 Oct

A spacious lobby with a high ceiling, a central seating area with sofas and a coffee table, and a large window providing natural light.

A spacious lobby with a fireplace, comfortable seating, a large painting, and a view of the kitchen area.

A spacious lobby with a sofa, a coffee station, and a reception desk.

A shop with a variety of snacks and beverages, including a refrigerated section with drinks and a display of packaged snacks.

8. Hilton Garden Inn St. Louis/O'Fallon MO

O'Fallon

Kassie

€117

includes taxes & fees

1 Nov - 2 Nov

An outdoor patio area with wicker furniture and a central fire feature.

A modern hotel lobby with a bar area, seating arrangements, and a reception desk.

A modern hotel lobby with a reception desk, seating area, and a television screen displaying a map.

A Courtyard Marriott hotel with a parking lot and a green shuttle service.

9. Courtyard by Marriott St. Louis Chesterfield

Chesterfield

Kelly

€125

includes taxes & fees

26 Oct - 27 Oct

Two people in a swimming pool with colorful inflatable rings.

A lobby with a grand staircase, two patterned sofas, a glass coffee table, and a large mirror.

A hotel room with a large bed, a desk, a TV, and a view of a pool through the glass door.

A spacious lobby with a stone fireplace, a chandelier, and a staircase.

10. Holiday Inn St. Louis West Six Flags by IHG

Eureka

Rob

€132

includes taxes & fees

9 Nov - 10 Nov

A modern kitchen with a bar area, wooden cabinets, and pendant lighting.

A swimming pool with a tiled deck, a sunlit room with a view, and a seating area with chairs.

A hotel room with two beds, a sofa, a small table, a lamp, and a framed abstract painting on the wall.

A hotel room with three computer workstations, each with a monitor, keyboard, and a lamp.

11. Hyatt Place St. Louis/Chesterfield

Chesterfield

Debbie

€125

includes taxes & fees

18 Oct - 19 Oct

A modern kitchen area with a breakfast bar, a coffee machine, and a refrigerator displaying menu options.

A hotel room with two beds, a blue sofa, a small table, and a kitchenette.

A coffee station with two coffee machines and a display of coffee pods and cups.

A Holiday Inn Express & Suites building with a brick facade, a covered entrance, and a numbered address.

12. Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

Chesterfield

Terry

€114

includes taxes & fees

18 Oct - 19 Oct

A spacious lobby with a central round table, two sofas, and a chandelier.

A Drury Plaza hotel with a modern design, featuring a curved facade, large windows, and a Drury Plaza sign on the top.

A buffet setup with various food items and a decorative vase of flowers.

A hotel room with two beds, a patterned wall, and a view of the city through sheer curtains.

13. Drury Plaza Hotel St. Louis Chesterfield

Chesterfield

Chasity

€135

includes taxes & fees

18 Oct - 19 Oct

A spacious lobby with a high ceiling, a dining area, and a kitchen in the background.

A modern hotel lobby with a computer desk, a flat-screen TV, and a ceiling fan.

A lobby with a checkered carpet, a marble coffee table, two armchairs with patterned cushions, a sofa, and a dining table with chairs.

A hotel room with a bathroom, a bed, a nightstand, and a window.

14. Quality Inn Near Six Flags St. Louis

Pacific

Chantelle

€92

includes taxes & fees

9 Nov - 10 Nov

An indoor swimming pool with a hot tub, clear signage, and a view of the outside through large windows.

A modern dining area with yellow and blue chairs, a flat-screen TV, and a kitchen area with appliances.

A spacious living area with a blue wall, yellow armchairs, a blue sofa, and a wooden coffee table.

A hotel room with two beds, a desk with a TV, a chair, and a lamp.

15. Comfort Inn Near Six Flags St. Louis

Pacific

Gail

€92

includes taxes & fees

9 Nov - 10 Nov

A courtyard with a central seating area, surrounded by trees and a building with a pitched roof.

A modern dining area with a long table, multiple chairs, and pendant lighting.

A reception desk with a "WELCOME TO THE SHOW ME STATE" sign, a wooden counter, and a Hilton Honors sign.

A store interior with a 'Treats' sign, snack shelves, and a chalkboard with a welcome message.

16. Hampton Inn & Suites St. Louis/Chesterfield

Chesterfield

Vijay

€123

includes taxes & fees

1 Nov - 2 Nov

A Super 8 hotel with a flat facade, multiple windows, and a parking lot.

A hotel room with a bed, a desk, a chair, a nightstand, a lamp, and a large cityscape artwork on the wall.

A bathroom with a shower, a small white stool, and a towel rack.

A breakfast area with wooden cabinets, a coffee station, and a dining table with chairs.

17. Super 8 by Wyndham Eureka/Six Flags Nearby

Eureka

Claire

€66

includes taxes & fees

8 Nov - 9 Nov

A spacious living room with a large painting, a fireplace, a staircase, and modern furniture.

A hotel room with a dining area, a fireplace, and a view of the outdoors.

A swimming pool with tiled edges and a hot tub area, surrounded by windows and chairs.

A hotel room with a large bed, two sofas, a desk, and a TV.

18. Best Western Plus Washington Hotel

Washington

Shawn

€136

includes taxes & fees

18 Oct - 19 Oct

A spacious lobby with a high ceiling, a dining area, and a seating area with sofas and a coffee table.

An indoor swimming pool with clear blue water, a tiled floor, and a ceiling with square vents.

An outdoor patio area with a table and chairs, a glass door entrance, and a visible interior with a dining area.

A spacious lobby with a blue sofa, round coffee table, and blue chairs. There is a reception desk and a seating area with a high ceiling and large windows.

19. Drury Inn & Suites St. Louis St. Peters

St. Peters

Ashley

€113

includes taxes & fees

18 Oct - 19 Oct

A multi-story hotel with a stone facade and a covered entrance.

A modern living room with a wooden dining table, grey chairs, a sofa, and a coffee machine.

A compact hotel room with two beds, a desk with a chair, a television, a microwave, and a refrigerator.

A modern living room with a blue accent wall, a gray sofa, a dining table with chairs, and a coffee table.

20. WoodSpring Suites St Peters-OFallon

St. Peters

Thomas

€81

includes taxes & fees

13 Oct - 14 Oct

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Stay near popular Defiance attractions

A glass of red wine on a wooden table with a vineyard in the background.

Chandler Hill Vineyards

7.8/10 (7 reviews)

This elegant Missouri winery showcases local and California wines from its hillside setting. Savour varietals on the expansive terrace while enjoying vineyard views and seasonal cuisine from their full-service kitchen.

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A wooden dock extending into a pond with lily pads, surrounded by lush greenery and a clear blue sky.

August A. Busch Memorial Conservation Area

8.6/10 (7 reviews)

This sprawling conservation area features over 30 lakes and historic WWII bunkers amid diverse habitats. Explore well-maintained trails while watching for migratory birds and wildlife in their natural environment.

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Sugar Creek Winery

8.0/10 (1 review)

Sip award-winning Missouri wines at this hillside vineyard along the scenic Katy Trail. Relax on covered decks with your own picnic while enjoying live weekend music and panoramic countryside views.

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Historic Daniel Boone Home and Heritage Center

9.6/10 (4 reviews)

Step into the limestone home where Daniel Boone's son Nathan crafted a frontier masterpiece with seven fireplaces. Explore the surrounding historic village for an authentic glimpse into 19th-century pioneer life.

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Broemmelsiek Park

This 494-acre natural playground offers nine miles of trails through forests and around serene lakes. Attend a monthly stargazing event at the astronomy viewing area for a uniquely celestial park experience.

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Yellow Farmhouse Winery

This boutique winery in Defiance, Missouri was known for its distinctive unfiltered wines and relaxed atmosphere. Visitors could enjoy tastings with live music while picnicking on scenic grounds with vineyard views.

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Matson Hill Park Trailhead

Wander through 475 acres of rugged forest terrain with challenging hiking paths and gravity-flow mountain bike trails. The historic 1830s Hays Home offers a glimpse into pioneer life amid the natural splendour.

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Hamburg Trail Trailhead

This moderate 6.9-mile loop winds through the scenic Weldon Spring Conservation Area, connecting to the Katy Trail State Park. Spot native wildlife while traversing diverse landscapes of shaded woodlands and open fields.

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Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

See all hotels in Defiance

Top Defiance Hotel Reviews

Drury Inn & Suites Southwest St. Louis

10/10 Excellent

"Great stay always at Drury"

Drury Plaza Hotel St. Louis Chesterfield

10/10 Excellent

"We really enjoyed our stay. The room was very clean. The staff were very pleasant and cheerful. The day we were leaving my husband went to get breakfast. The staff said they were not open yet, but told him he could have a tray and take the food to his room. Great place to stay!!"

Hampton Inn St. Charles St. Peters

10/10 Excellent

"Last minute, short stay but well worth it. Very clean and comfortable. Good breakfast."

Sonesta ES Suites St. Louis - Chesterfield

8/10 Good

"Walls were thin. Too much noise."

The Wildwood Hotel

10/10 Excellent

"The room was super clean and the jacuzzi was such a fun touch!"

Drury Plaza Hotel St. Louis Creve Coeur

10/10 Excellent

"Nice stay overall"

La Quinta Inn & Suites by Wyndham St. Louis Westport

10/10 Excellent

"Good Customer Services thanks"

Hyatt Place St. Louis/Chesterfield

10/10 Excellent

"What a wonderful spot! The breakfast was delicious and offered plenty of variety. No matter their role, every staff member was super friendly."

Ameristar Casino Resort and Spa

8/10 Good

"Wonderful stay for a small bachelorette party. Had a wonderful time!"

More cheap stays in Defiance

Quality Inn Foristell

12 Highway W Foristell MO

€80

9 Nov - 10 Nov

includes taxes & fees

8.2/10 Very good! (1,004 reviews)

Sleep Inn & Suites O'Fallon MO - Technology Drive

1147 Technology Drive O'Fallon MO

€83

2 Nov - 3 Nov

includes taxes & fees

Country Inn & Suites by Radisson, St. Peters, MO

3877 Veterans Memorial Pkwy St. Charles MO

€84

1 Nov - 2 Nov

includes taxes & fees

Comfort Suites St Charles - St Louis

1400 S 5th St St. Charles MO

€97

18 Oct - 19 Oct

includes taxes & fees

Hampton Inn St. Charles St. Peters

3720 W Clay St St. Charles MO

€122

25 Oct - 26 Oct

includes taxes & fees

8.2/10 Very good! (1,007 reviews)

Country Inn & Suites by Radisson, St. Charles Historic District

1190 S Main St St. Charles MO

€138

1 Nov - 2 Nov

includes taxes & fees

Frequently asked questions

What's the best place to stay in Defiance?

Hollywood Casino & Hotel St. Louis, located 18.1 mi (29.2 km) from the heart of Defiance, is a top choice for your stay, based on our traveller data. Two other options for your visit to the area are Sonesta ES Suites St. Louis - Chesterfield and Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham. See all available top hotels, or vacation rentals in Defiance.

What are some of the best holiday rentals that Defiance has to offer?

HotTub-2br2b-near Historic Main Street: This holiday home rental outside of Defiance offers a patio, a garden and a BBQ to help you feel perfectly comfortable in your new surroundings. Kitchen amenities include a dishwasher, a fridge and a stovetop. Make the most of Access to hot tub in this rental home to help you unwind. See all vacation rentals in Defiance.

If I need to cancel my hotel reservation in Defiance, will I receive a refund?

Yes! The majority of room reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you have a reservation that's non-refundable, you might be able to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.

What are some accommodation options with pools in Defiance?

Sonesta ES Suites St. Louis - Chesterfield: Offers daily, a seasonal outdoor pool and free self parking. Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham and Ameristar Casino Resort and Spa are two additional hotels with an on-site pool. View all hotels with pools in Defiance.

How is it staying in Defiance?

Visitors can enjoy all that Defiance has to offer, including the wineries and parks. Top sights in the area include St. Louis Union Station and St. Louis Zoo. In Defiance, there are 19 hotels and other accommodation options to choose from. Find out more about Defiance.

What should I do while I'm visiting Defiance?

Natural beauty is on display at August A. Busch Memorial Conservation Area, Missouri River and Matson Hill Park Trailhead. A couple of additional sights to add to your itinerary are Yellow Farmhouse Winery and Chandler Hill Vineyards. Take a look at what more there is to see and do in Expedia's Defiance guide.

What's the weather like in Defiance?

The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 3°C. Average annual precipitation for Defiance is 1228 mm.

Defiance Hotels

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Defiance

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Defiance hotels

1. Sleep Inn & Suites O'Fallon MO - Technology Drive

2. Holiday Inn Express St. Louis West - O'Fallon by IHG

3. Staybridge Suites O'Fallon Chesterfield by IHG

4. TownePlace Suites by Marriott St. Louis Chesterfield

5. Comfort Inn & Suites Chesterfield - St. Louis

6. The Wildwood Hotel

7. Residence Inn by Marriott O'Fallon

8. Hilton Garden Inn St. Louis/O'Fallon MO

9. Courtyard by Marriott St. Louis Chesterfield

10. Holiday Inn St. Louis West Six Flags by IHG

11. Hyatt Place St. Louis/Chesterfield

12. Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

13. Drury Plaza Hotel St. Louis Chesterfield

14. Quality Inn Near Six Flags St. Louis

15. Comfort Inn Near Six Flags St. Louis

16. Hampton Inn & Suites St. Louis/Chesterfield

17. Super 8 by Wyndham Eureka/Six Flags Nearby

18. Best Western Plus Washington Hotel

19. Drury Inn & Suites St. Louis St. Peters

20. WoodSpring Suites St Peters-OFallon

Stay near popular Defiance attractions

Chandler Hill Vineyards

August A. Busch Memorial Conservation Area

Sugar Creek Winery

Historic Daniel Boone Home and Heritage Center

Broemmelsiek Park

Yellow Farmhouse Winery

Matson Hill Park Trailhead

Hamburg Trail Trailhead

Learn more about Defiance

Top Defiance Hotel Reviews

Drury Inn & Suites Southwest St. Louis

Drury Plaza Hotel St. Louis Chesterfield

Hampton Inn St. Charles St. Peters

Sonesta ES Suites St. Louis - Chesterfield

The Wildwood Hotel

Drury Plaza Hotel St. Louis Creve Coeur

La Quinta Inn & Suites by Wyndham St. Louis Westport

Hyatt Place St. Louis/Chesterfield

Ameristar Casino Resort and Spa

More cheap stays in Defiance

Quality Inn Foristell

Sleep Inn & Suites O'Fallon MO - Technology Drive

Country Inn & Suites by Radisson, St. Peters, MO

Comfort Suites St Charles - St Louis

Hampton Inn St. Charles St. Peters

Country Inn & Suites by Radisson, St. Charles Historic District

Frequently asked questions

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