St. Charles Luxury Hotels, St. Louis: St. Charles Hotel Guide

Check availability on St. Charles Luxury Hotels

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Our top choices for St. Charles luxury hotels

A modern lobby with orange seating, a flat-screen TV, and a stone accent wall.

1. Drury Plaza Hotel St. Louis St. Charles

St. Charles

Madhusudhana Rao

includes taxes & fees

14 Dec - 15 Dec

A modern kitchen with a central island, breakfast bar, and various appliances.

2. Hampton Inn & Suites St. Charles Old Town Area

St. Charles

Sara

includes taxes & fees

6 Dec - 7 Dec

A multi-level hotel lobby with numerous seating areas, a central water feature, and a variety of plants.

3. Embassy Suites by Hilton St. Louis St. Charles

St. Charles

Elyse

includes taxes & fees

29 Nov - 30 Nov

An indoor swimming pool with clear glass walls, metal railings, and a tiled floor.

4. Ameristar Casino Resort and Spa

St. Charles

Carter

includes taxes & fees

30 Nov - 1 Dec

5. Tru by Hilton St. Charles St. Louis, MO

St. Charles

Alissa

includes taxes & fees

22 Nov - 23 Nov

A hotel with a prominent 'Comfort Suites' sign, a covered entrance with columns, and a parking lot.

6. Comfort Suites St Charles - St Louis

St. Charles

Shawna

includes taxes & fees

6 Dec - 7 Dec

A spacious living room with a large sectional sofa, a coffee table, and a fireplace. There is a television mounted on the wall and a chandelier hanging from the ceiling.

7. Best Western Plus The Charles Hotel

St. Charles

Steven

includes taxes & fees

18 Nov - 19 Nov

8. Candlewood Suites St Louis St Charles by IHG

St. Charles

Jeffrey

includes taxes & fees

29 Nov - 30 Nov

A spacious lobby with a reception desk, seating area, and a fireplace.

9. Americas Best Value Inn & Suites St. Louis, St. Charles Inn

St. Charles

Gonzalo

includes taxes & fees

14 Dec - 15 Dec

A hotel room with a large bed, two bedside tables with lamps, a desk with a chair, a door, and a wall with a road map mural.

10. Super 8 by Wyndham St Charles

St. Charles

Dana

includes taxes & fees

6 Dec - 7 Dec

A swimming pool area with red and white lounge chairs, a glass table, and a blue and yellow ceiling.

11. Hampton Inn St. Charles St. Peters

St. Charles

Catherine

includes taxes & fees

13 Dec - 14 Dec

A Holiday Inn Express & Suites hotel with a covered entrance and a brick facade.

12. Holiday Inn Express Hotel and Suites St. Charles by IHG

St. Charles

Tia

includes taxes & fees

27 Nov - 28 Nov

A reception desk with a wooden counter, a computer, a telephone, and a small plant. There are three pendant lights above the desk.

13. Country Inn & Suites by Radisson, St. Peters, MO

St. Charles

Heather

includes taxes & fees

6 Dec - 7 Dec

A hotel room with a bed, a bedside table, and a window with curtains.

14. Relax Inn Saint Charles

St. Charles

Chris

includes taxes & fees

19 Nov - 20 Nov

A modern living room with a sofa, armchair, and coffee table. A flat-screen TV is mounted on a stand, and a staircase is visible in the background.

15. Sleep Inn Saint Charles North

St. Charles

Christine

includes taxes & fees

13 Dec - 14 Dec

A multi-story hotel with a central entrance and a sign reading 'WOODSPRING SUITES'.

16. WoodSpring Suites St Louis St Charles

St. Charles

Erica

includes taxes & fees

15 Nov - 16 Nov

A hotel room with a large bed, a desk, and a television.

17. Home2 Suites by Hilton St. Charles St.Louis

St. Charles

includes taxes & fees

13 Dec - 14 Dec

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Top St. Charles Hotel Reviews

Ameristar Casino Resort and Spa

10/10 Excellent

"Great room great stay! Would definitely recommend and visit again!"

Country Inn & Suites by Radisson, St. Charles Historic District

10/10 Excellent

"3 night stay in early Nov-2026. Location is very walkable to historic St. Charles and waterfront. Check in was great-there was a large group of people in front of me when I arrived and the desk clerk saw me and flagged me to the counter to help me around the group. She also suggested Salt & Smoke for dinner which I tried and it was good. Room and facilities were very clean, and the bed and pillows were very comfortable. It was very quiet, no street noise; this time of year may be less noisy than it would be in the summertime. Complimentary breakfast was good; when it was getting close to closing time the person managing the food actually asked me if I needed anything else before she shut down which was very considerate. Warm cookies in lobby were good. I recommend Napoli restarurant just a short drive away-very good!"

Frequently asked questions

Are you looking for a luxury hotel for your stay in St. Charles?

During your visit, you might want to enjoy the casinos and shopping which St. Charles is known for.

What's the best luxury hotel in St. Charles?

Ameristar Casino Resort and Spa is a luxury hotel with 6 restaurants and 2 bars, and it's a popular choice for Expedia travellers looking for an elegant place to stay.

When can I expect good weather in St. Charles?

Planning for the weather is an important factor for making your trip to St. Charles a success, especially when you're splurging. The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 3°C. Average annual precipitation for St. Charles is 1172 mm.

What's there to see and do in St. Charles?

When you're in St. Charles, enjoy exploring the sights and attractions here including Historic Main Street, Katy Trail and Lewis & Clark Boathouse and Nature Center. If you have a little extra time during your trip, you might want to make a stop at St Charles Convention Center and Ameristar Casino St. Charles.

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Check availability on St. Charles Luxury Hotels

Our top choices for St. Charles luxury hotels

1. Drury Plaza Hotel St. Louis St. Charles

2. Hampton Inn & Suites St. Charles Old Town Area