€121 Cheap Flights Knoxville to St. Louis (TYS-STL)

View €121 flight on Thu, 4 Dec 2025Opens in a new window

Popular airlines from McGhee Tyson Airport (TYS) to St. Louis Lambert Intl. Airport (STL)

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Cheap flights from Knoxville to St. Louis (TYS-STL)

Prices were available within the past 7 days and start at €121 for one-way flights and €215 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Thu, 4 Dec - Sat, 13 Dec
TYS
Knoxville
STL
St. Louis
€215 Return, found 2 days ago
€215
Return
found 2 days ago
Select American Airlines flight, departing Thu, 4 Dec from Knoxville to St. Louis, returning Sat, 13 Dec, priced at €215 found 2 days ago
Delta
Thu, 4 Dec - Sat, 13 Dec
TYS
Knoxville
STL
St. Louis
€230 Return, found 2 days ago
€230
Return
found 2 days ago
Select Delta flight, departing Thu, 4 Dec from Knoxville to St. Louis, returning Sat, 13 Dec, priced at €230 found 2 days ago
Delta
Thu, 4 Dec - Sat, 13 Dec
TYS
Knoxville
STL
St. Louis
€247 Return, found 2 days ago
€247
Return
found 2 days ago
Select Delta flight, departing Thu, 4 Dec from Knoxville to St. Louis, returning Sat, 13 Dec, priced at €247 found 2 days ago
American Airlines
Thu, 4 Dec - Sat, 13 Dec
TYS
Knoxville
STL
St. Louis
€253 Return, found 2 days ago
€253
Return
found 2 days ago
Select American Airlines flight, departing Thu, 4 Dec from Knoxville to St. Louis, returning Sat, 13 Dec, priced at €253 found 2 days ago
Delta
Thu, 4 Dec - Sat, 13 Dec
TYS
Knoxville
STL
St. Louis
€267 Return, found 2 days ago
€267
Return
found 2 days ago
Select Delta flight, departing Thu, 4 Dec from Knoxville to St. Louis, returning Sat, 13 Dec, priced at €267 found 2 days ago
Delta
Thu, 4 Dec - Sat, 13 Dec
TYS
Knoxville
STL
St. Louis
€280 Return, found 2 days ago
€280
Return
found 2 days ago
Select Delta flight, departing Thu, 4 Dec from Knoxville to St. Louis, returning Sat, 13 Dec, priced at €280 found 2 days ago
Delta
Thu, 4 Dec - Sat, 13 Dec
TYS
Knoxville
STL
St. Louis
€281 Return, found 2 days ago
€281
Return
found 2 days ago
Select Delta flight, departing Thu, 4 Dec from Knoxville to St. Louis, returning Sat, 13 Dec, priced at €281 found 2 days ago
Delta
Thu, 4 Dec - Sat, 13 Dec
TYS
Knoxville
STL
St. Louis
€284 Return, found 2 days ago
€284
Return
found 2 days ago
Select Delta flight, departing Thu, 4 Dec from Knoxville to St. Louis, returning Sat, 13 Dec, priced at €284 found 2 days ago
American Airlines
Thu, 4 Dec - Sat, 13 Dec
TYS
Knoxville
STL
St. Louis
€293 Return, found 2 days ago
€293
Return
found 2 days ago
Select American Airlines flight, departing Thu, 4 Dec from Knoxville to St. Louis, returning Sat, 13 Dec, priced at €293 found 2 days ago
United
Thu, 4 Dec - Sat, 13 Dec
TYS
Knoxville
STL
St. Louis
€344 Return, found 2 days ago
€344
Return
found 2 days ago
Select United flight, departing Thu, 4 Dec from Knoxville to St. Louis, returning Sat, 13 Dec, priced at €344 found 2 days ago

Find the cheapest month to fly from Knoxville (TYS) to St. Louis (STL)

May is typically the cheapest month to fly

From €169 - €408 per traveller.

Frequently asked questions

How much is a flight from McGhee Tyson Airport (TYS) to Lambert Field?
Round-trip journeys from Knoxville Airport to Lambert Field start from €215. This price is based on fares advertised within the last 7 days on Expedia for flights departing within the next year — make your booking ASAP so you don't miss out. Prices and availability are subject to change. Additional terms apply.
Do I need to pay a cancellation fee if I cancel my flight from TYS to Lambert-St. Louis Intl. Airport (STL)?
Most flights can be conveniently cancelled online, but whether you incur a fee differs between airlines. If you do have to cancel your break, follow the easy instructions in the Customer Service Portal.
How do I find cheap flights from TYS to STL that have flexible change policies?
Many airlines offer the option to reschedule your flight without a change fee. All you pay is the difference between the original flight and the new flight. When you're searching for TYS to Lambert-St. Louis Intl. Airport (STL) flights, you'll see a "no change fees" filter for you to select.
How far is the flight from TYS to Lambert Field?
That new movie you've been wanting to see will have to wait — the flight distance between TYS and St. Louis Lambert International Airport is only 650 kilometres. The captain will be asking you to buckle up for touchdown before you know it.
Which airlines fly direct from McGhee Tyson Airport (TYS) to Lambert Field?
There are no direct flights, so you'll have to make at least one stop between McGhee Tyson Airport (TYS) and Lambert Field. Use the layover time to stretch your legs and freshen up.
Are TYS to St. Louis Lambert International Airport flight tickets cheaper when they're purchased at the last minute?
Flight prices change all the time, so there are no guarantees. While last-minute flight deals between McGhee Tyson Airport (TYS) and Lambert-St. Louis Intl. Airport (STL) are possible, it's also a good idea to monitor prices well before you fly. In fact, some carriers advertise their prices up to 12 months before the departure date. Expedia is continuously updating the best bargains around, so check back often and be ready to grab your seat when the price is low.

Travel information

Origin airport
McGhee Tyson
Destination airport
Lambert-St. Louis Intl.
Return price
€214
Distance
647 km

Book with confidence

Perfect flights from Knoxville to St. Louis

Embark on an unforgettable journey without breaking the bank with Expedia's incredible deals on cheap flights from Knoxville to St. Louis. Whether you're aching for a romantic escape with your partner, craving an adventurous solo expedition, or yearning to immerse yourself in the local history and culture, we've got you covered.
 
Picture yourself strolling through the streets of , surrounded by breathtaking architecture and absorbing the vibrant atmosphere of this captivating city. Indulge in the mouth-watering local specialties, from tantalizing street food to exquisite fine dining. With Expedia, you can experience all of this and more, without sacrificing your budget.
 
Our flexible McGhee Tyson to Lambert-St. Louis Intl. ticket options cater to your travel preferences, with incredible one-way fares from €121 and roundtrip prices from €215. Whether you're planning a short city break or a longer adventure, our dynamic pricing ensures that you find the best deals for your journey.
 
But the magic doesn't stop there. Expedia offers a range of partner services to enhance your trip. Rent a car at Lambert-St. Louis Intl. and explore and its surrounding areas at your own pace. Discover hidden gems off the beaten path, and create unforgettable memories. We also provide a handpicked selection of accommodations, from charming bed and breakfasts to luxury hotels, ensuring that you have a comfortable and memorable stay.
 
Planning your next great adventure is a breeze with Expedia. Our user-friendly platform, unbeatable prices, and round-the-clock customer support are designed to make your travel experience seamless and stress-free. So, why wait? Book your to travel arrangements today and embark on the journey of a lifetime in St. Louis.
Perfect flights from Knoxville to St. Louis

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