Defiance Hotel Guide - Historic Daniel Boone Home and Heritage Center hotels in Defiance, United States of America.

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Tonight
25 Dec - 26 Dec
Tomorrow
26 Dec - 27 Dec
This weekend
26 Dec - 28 Dec
Next weekend
2 Jan - 4 Jan

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Our top choices for Historic Daniel Boone Home and Heritage Center hotels

Exterior
Holiday Inn Express & Suites Wentzville St Louis West by IHG

Holiday Inn Express & Suites Wentzville St Louis West by IHG

Holiday Inn Express & Suites Wentzville St Louis West by IHG
2.5 star property
17.3 km from Historic Daniel Boone Home and Heritage Center
9.4 out of 10, Exceptional, (849)
"Excellent location, very clean and comfortable, great hot breakfast, and amazing staff!"
United States
Shannon
The price is €112
includes taxes & fees
3 Jan - 4 Jan 2026
Holiday Inn Express & Suites Wentzville St Louis West by IHG
Property amenity
TownePlace Suites by Marriott Wentzville

TownePlace Suites by Marriott Wentzville

TownePlace Suites by Marriott Wentzville
3.0 star property
17 km from Historic Daniel Boone Home and Heritage Center
9.4 out of 10, Exceptional, (48)
"Great property, would recommend!!"
United States
Karen
The price is €151
includes taxes & fees
28 Dec - 29 Dec
TownePlace Suites by Marriott Wentzville
Lobby
Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive
2.5 star property
14.7 km from Historic Daniel Boone Home and Heritage Center
9.0 out of 10, Wonderful, (1001)
"Wonderful stay. Checkin was easy and host was very accommodating. "
United States
Teresa
The price is €78
includes taxes & fees
2 Jan - 3 Jan 2026
Sleep Inn & Suites O'Fallon MO - Technology Drive
Egyptian cotton sheets, premium bedding, pillow-top beds, desk
Best Western Plus Washington Hotel

Best Western Plus Washington Hotel

Best Western Plus Washington Hotel
2.5 star property
16.2 km from Historic Daniel Boone Home and Heritage Center
9.0 out of 10, Wonderful, (638)
"One of our favorites! This hotel is very clean, breakfast is very good and the kids love the indoor pool."
United States
Debra
The price is €120
includes taxes & fees
28 Dec - 29 Dec
Best Western Plus Washington Hotel
Lobby sitting area
Hilton Garden Inn St. Louis/O'Fallon MO

Hilton Garden Inn St. Louis/O'Fallon MO

Hilton Garden Inn St. Louis/O'Fallon MO
3.0 star property
14.2 km from Historic Daniel Boone Home and Heritage Center
8.8 out of 10, Excellent, (719)
"Clean room, quiet"
United States
Laura
The price is €95
includes taxes & fees
23 Jan - 24 Jan 2026
Hilton Garden Inn St. Louis/O'Fallon MO
Reception
Hampton Inn St. Louis Wentzville

Hampton Inn St. Louis Wentzville

Hampton Inn St. Louis Wentzville
2.5 star property
16.9 km from Historic Daniel Boone Home and Heritage Center
9.0 out of 10, Wonderful, (638)
"The room was clean and quiet The staff was very nice the temperature was perfect"
United States
candice
The price is €119
includes taxes & fees
4 Jan - 5 Jan 2026
Hampton Inn St. Louis Wentzville
Property amenity
TownePlace Suites by Marriott St. Louis Chesterfield

TownePlace Suites by Marriott St. Louis Chesterfield

TownePlace Suites by Marriott St. Louis Chesterfield
3.0 star property
16.7 km from Historic Daniel Boone Home and Heritage Center
9.0 out of 10, Wonderful, (271)
"lady at the desk that works 2 jobs 7 days a wk DAMN!!! Shes great."
United States
nigel e
The price is €111
includes taxes & fees
28 Dec - 29 Dec
TownePlace Suites by Marriott St. Louis Chesterfield
Lobby lounge
Fairfield Inn & Suites Wentzville

Fairfield Inn & Suites Wentzville

Fairfield Inn & Suites Wentzville
2.5 star property
17.9 km from Historic Daniel Boone Home and Heritage Center
9.0 out of 10, Wonderful, (643)
"Clean room, friendly and professional staff, plus the included breakfast was a great perk."
United States
Marlene
The price is €124
includes taxes & fees
29 Dec - 30 Dec
Fairfield Inn & Suites Wentzville
Balcony view
The Inn at Elijah McLeans

The Inn at Elijah McLeans

The Inn at Elijah McLeans
4.0 star property
17.3 km from Historic Daniel Boone Home and Heritage Center
8.8 out of 10, Excellent, (134)
"Great place for a weekend getaway! The Inn was clean, staff is extremely helpful. The Inn is within walking distance with unique shops, restaurants, anything you needed."
United States
Angelia
The price is €130
includes taxes & fees
31 Dec - 1 Jan 2026
The Inn at Elijah McLeans
Exterior
Staybridge Suites O'Fallon Chesterfield by IHG

Staybridge Suites O'Fallon Chesterfield by IHG

Staybridge Suites O'Fallon Chesterfield by IHG
3.0 star property
14.7 km from Historic Daniel Boone Home and Heritage Center
8.4 out of 10, Very good, (409)
"Simple excellent place to stay"
United States
Hussam
The price is €110
includes taxes & fees
26 Dec - 27 Dec
Staybridge Suites O'Fallon Chesterfield by IHG
Exterior
Holiday Inn Express St. Louis West - O'Fallon by IHG

Holiday Inn Express St. Louis West - O'Fallon by IHG

Holiday Inn Express St. Louis West - O'Fallon by IHG
2.5 star property
14.6 km from Historic Daniel Boone Home and Heritage Center
8.6 out of 10, Excellent, (846)
"A very nice stay with very pleasant staff"
United States
Clifford
The price is €91
includes taxes & fees
4 Jan - 5 Jan 2026
Holiday Inn Express St. Louis West - O'Fallon by IHG
Lobby
Residence Inn by Marriott O'Fallon

Residence Inn by Marriott O'Fallon

Residence Inn by Marriott O'Fallon
3.0 star property
15.2 km from Historic Daniel Boone Home and Heritage Center
8.4 out of 10, Very good, (454)
"Love the stay great for families!"
United States
jeriece
The price is €119
includes taxes & fees
2 Jan - 3 Jan 2026
Residence Inn by Marriott O'Fallon
Room, 2 Queen Beds, Non Smoking
Super 8 by Wyndham Washington

Super 8 by Wyndham Washington

Super 8 by Wyndham Washington
2.0 star property
18.4 km from Historic Daniel Boone Home and Heritage Center
8.4 out of 10, Very good, (699)
"The staff was extremely nice & accommodating."
United States
Brenda
The price is €82
includes taxes & fees
3 Jan - 4 Jan 2026
Super 8 by Wyndham Washington
Standard Room, 2 Queen Beds, Non Smoking
Comfort Inn & Suites Chesterfield - St. Louis

Comfort Inn & Suites Chesterfield - St. Louis

Comfort Inn & Suites Chesterfield - St. Louis
2.5 star property
17.7 km from Historic Daniel Boone Home and Heritage Center
8.0 out of 10, Very good, (1003)
"Great place to stay"
United States
Dawn
The price is €78
includes taxes & fees
4 Jan - 5 Jan 2026
Comfort Inn & Suites Chesterfield - St. Louis
Lobby
Economy Inn Wentzville

Economy Inn Wentzville

Economy Inn Wentzville
2.0 star property
17.4 km from Historic Daniel Boone Home and Heritage Center
6.4 out of 10, (508)
"The Building has a nice exterior"
United States
Christopher
The price is €58
includes taxes & fees
26 Dec - 27 Dec
Economy Inn Wentzville
Exterior
LAKEVIEWINN

LAKEVIEWINN

LAKEVIEWINN
2.5 star property
18.4 km from Historic Daniel Boone Home and Heritage Center
5.6 out of 10, (30)
"I enjoyed it! And the owners were so sweet and understanding. I would absolutely stay there again!"
United States
Evelyn
The price is €65
includes taxes & fees
8 Jan - 9 Jan 2026
LAKEVIEWINN
Exterior
Wine Country Getaway | JZ Vacation Rentals

Wine Country Getaway | JZ Vacation Rentals

Wine Country Getaway | JZ Vacation Rentals
3.5 star property
17.3 km from Historic Daniel Boone Home and Heritage Center
8.0 out of 10, Very good, (1)
"Great communication, had a couple of leaks and shower flooded but the maintenance came right away to fix it. Overall clean, AC/Heat unit in each room, big kitchen, wonderful sitting area and decor."
United States
Stacy
The price is €344
includes taxes & fees
5 Jan - 6 Jan 2026
Wine Country Getaway | JZ Vacation Rentals
Luxury Suite | Exterior
2nd St Loft

2nd St Loft

2nd St Loft
2.0 star property
17.2 km from Historic Daniel Boone Home and Heritage Center
The price is €152
includes taxes & fees
24 Jan - 25 Jan 2026
2nd St Loft
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Historic Daniel Boone Home and Heritage Center Hotel Reviews

The Wildwood Hotel

The Wildwood Hotel

10/10 Excellent
"Very nice, clean hotel in a great area. "
Kimberly 1-night trip
Posted 2 days ago
The Wildwood Hotel

Hotels near other Historic Daniel Boone Home and Heritage Center attractions

Chandler Hill Vineyards

You can enjoy a tasting or tour at Chandler Hill Vineyards during your travels to Defiance. While in this romantic area, you can savour the top-notch restaurants.
See properties

Matson Hill Park Trailhead

You can take time to visit Matson Hill Park Trailhead during your travels to Defiance. While you're in the area, wander around the parks.
See properties

Frequently asked questions

What's the area like around Historic Daniel Boone Home and Heritage Center?
Historic Daniel Boone Home and Heritage Center is located in a welcoming area of Defiance that travellers like for its lakeside setting and hiking. You'll find 25 hotels and other accommodations within a few miles for a convenient home base.
What's the best hotel to stay close to Historic Daniel Boone Home and Heritage Center?
Holiday Inn Express St. Louis West - O'Fallon by IHG is one of the top choices for your stay based on our traveller data, and this hotel offers free breakfast and an indoor pool. You'll find it 9.1 mi (14.6 km) from Historic Daniel Boone Home and Heritage Center. Other good choices around the area include Hilton Garden Inn St. Louis/O'Fallon MO and Sleep Inn & Suites O'Fallon MO - Technology Drive.
How many hotels should I expect to find close to Historic Daniel Boone Home and Heritage Center?
Expedia has 25 hotels and other accommodation options a few miles from Historic Daniel Boone Home and Heritage Center.
If I need to cancel the hotel reservation for my stay near Historic Daniel Boone Home and Heritage Center, will I receive a refund?
Yes, the majority of hotel room reservations are refundable provided that you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of check in. If you booked a non-refundable reservation, you might be able to still cancel and be given a refund within a 24-hour period of booking. Enter dates in and click on "Search", then use the "fully refundable" filter to review top deals close to Historic Daniel Boone Home and Heritage Center.