Hotels in Cape Girardeau County - Expedia.ie

Skip to main content

Stays
Flights
Cars
Packages
Things to do

Deals
Groups & meetings

Open app
List your property
Support
Trips
Members save 10% or more on over 100,000 hotels worldwide when you’re signed in
- Sign in
- Learn about Expedia Rewards
- Feedback

Cape Girardeau County
Missouri
United States of America
Hotels
Expedia.ie

Holiday Rentals in Cape Girardeau County Cape Girardeau County Car Hire Cape Girardeau County Holidays

A rocky stream surrounded by trees and foliage.

A rocky stream surrounded by trees and foliage.

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Top Cities in Cape Girardeau County

A calm body of water, a sandy beach, and a forested area in the distance.

A river, a large white building, and a cityscape.

A tree with white blossoms in a grassy area surrounded by trees.

Check prices for these dates

Tonight

8 Sept - 9 Sept

Tomorrow

9 Sept - 10 Sept

This weekend

11 Sept - 13 Sept

Next weekend

18 Sept - 20 Sept

Filter by

Star rating

1 star

2 stars

3 stars

4 stars

5 stars

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Good 7+

Very good 8+

Wonderful 9+

Any

Our top choices for Cape Girardeau County hotels

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.

A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.

An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.

1. Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3.0 star property

Cape Girardeau

9.6 out of 10, Exceptional, (1,000 reviews)

9.6/10

Exceptional

(1,000 reviews)

"The stay was great"

"The stay was great"

United States

Sandra

The price is €97

€97

includes taxes & fees

13 Sept - 14 Sept

Drury Plaza Hotel Cape Girardeau Conference Center

A spacious lobby with a curved staircase, large windows, and a seating area with a rug.

A modern outdoor seating area with a glass-top table and a fire feature, overlooking a sunset view.

A modern living room with a large sectional sofa, a flat-screen TV, and a view of the sea through large windows.

A hotel room with two beds, a desk, a chair, and a view of the city.

2. The Riverview

4.0 star property

Cape Girardeau

9.4 out of 10, Exceptional, (659 reviews)

9.4/10

Exceptional

(659 reviews)

"Very clean rooms, nice hotel."

"Very clean rooms, nice hotel."

United States

Alyssa

The price is €111

€111

includes taxes & fees

13 Sept - 14 Sept

A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.

A hotel room with a bed, desk, chair, TV, and a small kitchenette area.

An indoor swimming pool with a clear view of the pool area, including the pool's edge, a set of stairs leading into the pool, and a few lounge chairs and tables around the pool.

A living room with a stone fireplace, a television mounted above it, and a large sofa with cushions.

3. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 star property

Cape Girardeau

9.4 out of 10, Exceptional, (1,000 reviews)

9.4/10

Exceptional

(1,000 reviews)

"Good breakfast ( a bit crowded), roomy suite, good location, good value for a weekend stay"

"Good breakfast ( a bit crowded), roomy suite, good location, good value for a weekend stay"

United States

ELAINE

The price is €99

€99

includes taxes & fees

13 Sept - 14 Sept

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.

A modern dining area with wooden tables and chairs, a kitchen area with a tiled backsplash, and framed pictures on the wall.

A reception area with a wooden reception desk, two blue armchairs with orange cushions, a patterned side table, and a wall-mounted lamp.

A hotel room with two beds, a window with curtains, an air conditioning unit, and a lamp on a nightstand.

4. Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

2.5 star property

Cape Girardeau

9.2 out of 10, Wonderful, (1,007 reviews)

9.2/10

Wonderful

(1,007 reviews)

"Good location and reasonable prices"

"Good location and reasonable prices"

Canada

Raidas

The price is €70

€70

includes taxes & fees

13 Sept - 14 Sept

Pear Tree Inn Cape Girardeau West

A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.

A breakfast setting with waffles, scrambled eggs, toast, a glass of orange juice, and a white mug on a table with a green placemat.

A hotel room with a large bed, two bedside tables, a desk with a chair, and two lamps.

A bowl of cereal with raisins and milk, a half orange, and a sandwich on a table with a yellow napkin.

5. Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

3.0 star property

Cape Girardeau

9.4 out of 10, Exceptional, (1,005 reviews)

9.4/10

Exceptional

(1,005 reviews)

"Pleasant stay."

"Pleasant stay."

United States

Cheryl

The price is €87

€87

includes taxes & fees

13 Sept - 14 Sept

Drury Inn & Suites Cape Girardeau

A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.

A Drury Inn & Suites building with a traditional architectural style, featuring a covered entrance and multiple windows.

A hotel room with two beds, a brick wall, and a wooden headboard.

An indoor swimming pool with a wooden ceiling, lounge chairs, and a lifeguard chair.

6. Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

3.0 star property

Jackson

9.6 out of 10, Exceptional, (1,008 reviews)

9.6/10

Exceptional

(1,008 reviews)

"This hotel was so clean and comfy! The breakfast was awesome too!"

"This hotel was so clean and comfy! The breakfast was awesome too!"

United States

Jamie

The price is €74

€74

includes taxes & fees

21 Sept - 22 Sept

Drury Inn & Suites Jackson MO

A hotel with a modern design, featuring a prominent sign for Candlewood Suites. There are multiple parking spaces visible in front of the building.

A hotel patio with a gazebo, outdoor seating, and a view of the road.

A hotel room with a bed, a TV, a desk, and a chair.

An indoor swimming pool with tiled flooring, a seating area with chairs, and a staircase leading to a door.

7. Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG

2.5 star property

Cape Girardeau

8.0 out of 10, Very good, (1,002 reviews)

8.0/10

Very good

(1,002 reviews)

"Very enjoyable stay, great staff."

"Very enjoyable stay, great staff."

United States

Samuel

The price is €84

€84

includes taxes & fees

4 Oct - 5 Oct

Candlewood Suites Cape Girardeau by IHG

A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.

A breakfast bar with a coffee machine, waffle maker, toaster, and various food items.

A reception desk with a large mural of a bridge, wooden reception area, and a potted plant.

An outdoor patio with tables and chairs, a stone wall, and large windows.

8. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3.0 star property

Jackson

9.0 out of 10, Wonderful, (843 reviews)

9.0/10

Wonderful

(843 reviews)

"Nice place"

"Nice place"

United States

Andrew

The price is €86

€86

includes taxes & fees

13 Sept - 14 Sept

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

A spacious living area with a high ceiling, a green accent wall, and a wooden balcony railing.

A restaurant with multiple tables and chairs, an exit sign, a television, and a counter with food items.

A hotel room with a large bathtub, a bed with a wooden headboard, a nightstand with a lamp, and a painting of a building on the wall.

A reception desk with a green wall, a wooden door, and a sign that reads 'QUALITY INN.'

9. Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North

2.5 star property

Cape Girardeau

7.0 out of 10, Good, (794 reviews)

7.0/10

Good

(794 reviews)

"The motel was attractive from the road and easily accessible. The facilities were clean and seemed to be in good condition. Our room was spacious and comfortable. The staff was helpful. The breakfast was meager, yet decent."

"The motel was attractive from the road and easily accessible. The facilities were clean and seemed to be in good condition. Our room was spacious and comfortable. The staff was helpful. The breakfast was meager, yet decent."

United States

Stephen

The price is €58

€58

includes taxes & fees

20 Sept - 21 Sept

Quality Inn Cape Girardeau North

A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.

A Fairfield by Marriott hotel with a modern design, featuring a stone facade, multiple floors, and a well-lit entrance.

An indoor swimming pool with lounge chairs and tables, large windows, and a view of the outside.

A reception area with a wooden reception desk, a glass door leading to a storage room, and a decorative wall piece.

10. Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau

3.0 star property

Cape Girardeau

9.4 out of 10, Exceptional, (227 reviews)

9.4/10

Exceptional

(227 reviews)

"Good breakfast selection"

"Good breakfast selection"

Canada

Chevonne

The price is €98

€98

includes taxes & fees

17 Sept - 18 Sept

Fairfield Inn & Suites by Marriott Cape Girardeau

A modern retail area with a display of local items and snacks.

An outdoor patio area with seating arrangements, including a sofa and chairs, and a table.

A modern indoor seating area with blue sofas and tables, a patterned carpet, and large windows offering a view of the outdoors.

A modern lounge area with seating options including sofas, chairs, and a hanging chair, with large windows providing a view of the outdoors.

11. Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau

2.5 star property

Cape Girardeau

9.6 out of 10, Exceptional, (175 reviews)

9.6/10

Exceptional

(175 reviews)

"Staff was friendly and welcoming."

"Staff was friendly and welcoming."

United States

Darlene

The price is €88

€88

includes taxes & fees

20 Sept - 21 Sept

Tru By Hilton Cape Girardeau

A spacious lobby with marble flooring, elegant seating, and a grand staircase.

A Courtyard by Marriott hotel with a modern brick facade, large windows, and a covered entrance area.

A lobby with seating areas, a reception desk, and a bar.

A modern hotel lobby with a framed advertisement for breakfast at the new Bistro, a seating area with sofas and a coffee table, and a decorative mirror reflecting the space.

12. Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown

3.0 star property

Cape Girardeau

9.6 out of 10, Exceptional, (549 reviews)

9.6/10

Exceptional

(549 reviews)

"Perfect place and location for our girls trip. The staff was excellent!"

"Perfect place and location for our girls trip. The staff was excellent!"

United States

Kristin

The price is €122

€122

includes taxes & fees

20 Sept - 21 Sept

Courtyard by Marriott Cape Girardeau Downtown

A hotel room with a bed, desk, chair, television, and two wall-mounted lamps.

A motel with multiple floors, a parking lot, and a staircase leading to the upper floors.

A hotel room with a large bed, two bedside tables, a nightstand, a telephone, and two wall-mounted lamps.

A bathroom with a marble wall and a white bathtub.

13. Town House Inn Cape Giradreau

Town House Inn Cape Giradreau

2.5 star property

Cape Girardeau

6.2 out of 10, (239 reviews)

6.2/10

(239 reviews)

"Good atat"

"Good atat"

United States

Joshua

The price is €75

€75

includes taxes & fees

10 Oct - 11 Oct

Town House Inn Cape Giradreau

A spacious dining area with high ceilings, large windows, and modern lighting fixtures.

An outdoor patio with stone walls, wicker furniture, and large windows.

A hotel room with a bed, a desk with a television, a chair, a suitcase, and a map on the wall.

A gym with exercise equipment, a treadmill, and a wall-mounted TV.

14. Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East

2.5 star property

Cape Girardeau

9.6 out of 10, Exceptional, (844 reviews)

9.6/10

Exceptional

(844 reviews)

"Clean rooms and friendly staff"

"Clean rooms and friendly staff"

United States

Rebekah

The price is €103

€103

includes taxes & fees

20 Sept - 21 Sept

Hampton Inn Cape Girardeau I 55 East

A spacious lobby with large windows, comfortable seating, and a modern ceiling design.

A breakfast bar with coffee machines, a cereal dispenser, and a fruit display.

A gym with treadmills, an elliptical, a bench, and a rack of dumbbells.

A room with large windows, two red upholstered chairs, a small table, and a potted plant.

15. Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau

2.5 star property

Jackson

8.2 out of 10, Very good, (779 reviews)

8.2/10

Very good

(779 reviews)

"Our room was clean and spacious. We had icy cold A/C and it was quiet there for the night!"

"Our room was clean and spacious. We had icy cold A/C and it was quiet there for the night!"

United States

VICTORIA

The price is €74

€74

includes taxes & fees

4 Oct - 5 Oct

Comfort Suites Jackson-Cape Girardeau

A living room with a TV, a fireplace, a sofa, and wall art.

A compact kitchen with a microwave, a dining table with chairs, a ceiling fan, and a television on a stand.

A compact kitchen with a sink, countertop, and wooden cabinets.

A residential house with a red door, a front porch, and two trees in the yard.

16. Little Blue Cottage on Spanish

Little Blue Cottage on Spanish

Cape Girardeau

8.4 out of 10, Very good, (58 reviews)

8.4/10

Very good

(58 reviews)

"Great cute place. "

"Great cute place. "

United States

Jeremy W.

The price is €105

€105

includes taxes & fees

7 Oct - 8 Oct

Little Blue Cottage on Spanish

A kitchen with dark wooden cabinets, a stainless steel refrigerator, a black stove, a microwave, and a sink.

A trophy labeled "Town House Inn" with "Cape Girardeau County, Missouri" and "2025" on it.

A bathroom with a granite countertop sink, a mirror, two hair dryers mounted on the wall, and a trash bin.

17. Town House Inn

2.5 star property

Jackson

7.6 out of 10, Good, (446 reviews)

7.6/10

Good

(446 reviews)

"Adequately comfortable "

"Adequately comfortable "

United States

Taylor

The price is €66

€66

includes taxes & fees

10 Sept - 11 Sept

A kitchen with wooden cabinets, a black refrigerator, a microwave, a stove, and a ceiling fan. There are three stools at the island.

A bathroom with a marble sink, a mirror, and a light fixture above the mirror.

A neatly made bed with white linens, a bedside lamp, and two framed pictures on the wall.

A kitchen with wooden cabinets, a granite countertop, a stove, and a dining area with wooden chairs and a table.

18. Relax in the country at Countryside Villas! - Villa A

Relax in the country at Countryside Villas! - Villa A

Jackson

10.0 out of 10, Exceptional, (37 reviews)

10/10

Exceptional

(37 reviews)

"Great place to stay, felt like home away from home. "

"Great place to stay, felt like home away from home. "

United States

Brittany

Relax in the country at Countryside Villas! - Villa A

A modern living room with a wooden ceiling, a stone fireplace, a TV mounted on the wall, and a bar area with stools.

A hot tub on a wooden deck with a view of trees.

A modern kitchen with wooden cabinetry, a built-in island with bar stools, and large windows with blinds.

A wooden cabin elevated on stilts in a forest, with a gravel driveway leading to it.

19. The Twisted Sassafras Treehouse

The Twisted Sassafras Treehouse

Cape Girardeau

10.0 out of 10, Exceptional, (36 reviews)

10/10

Exceptional

(36 reviews)

"Amazing stay! Everything was perfect."

"Amazing stay! Everything was perfect."

United States

Wayne F.

The Twisted Sassafras Treehouse

A two-story house with a covered porch, a large window, and a chimney.

A dining table with a glass top, decorated with a floral table runner, a plate of strawberries, a bowl of blackberries, and a stack of plates.

A spacious living area with a piano, a rocking chair, and a staircase with wooden railings.

A living room with a piano, a fireplace, a rocking chair, and a dining area with a table and chairs.

20. “Brickyard”-Recently Remodeled Dutch Colonial Revival in Downtown Cape Girardeau

“Brickyard”-Recently Remodeled Dutch Colonial Revival in Downtown Cape Girardeau

Cape Girardeau

10.0 out of 10, Exceptional, (45 reviews)

10/10

Exceptional

(45 reviews)

"Spectacular place and great host! Highly recommend!"

"Spectacular place and great host! Highly recommend!"

United States

Eric P.

“Brickyard”-Recently Remodeled Dutch Colonial Revival in Downtown Cape Girardeau

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

View all properties

Save an average of 15% on thousands of hotels when you're signed in

Sign up, it's free

Top Cape Girardeau County Hotel Reviews

Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau

10/10 Excellent

"The receptionist was very courteous. Helped answer all my questions. We loved the room. And we had a great breakfast before we left."

David 1-night trip

Posted 4 hours ago

Fairfield Inn & Suites by Marriott Cape Girardeau

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

8/10 Good

"Great"

chantell 1-night trip

Posted 5 hours ago

Drury Plaza Hotel Cape Girardeau Conference Center

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

10/10 Excellent

"."

Floyd 1-night trip

Posted 12 hours ago

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East

10/10 Excellent

"I really enjoyed my stay. Everything was clean and accessible. Cozy. TV was easy to use. Staff was friendly. I was traveling alone and felt safe. Breakfast was good enough, but Cracker Barrel is so close next door, you can literally throw a rock and hit it. Central location to tons of shopping. Highly recommend."

Nicole 3-night trip

Posted 13 hours ago

Hampton Inn Cape Girardeau I 55 East

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

10/10 Excellent

"Was overall great place to stay"

Ronnie 1-night trip

Posted 1 day ago

Pear Tree Inn Cape Girardeau West

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

10/10 Excellent

"Such a great place to stay! Clean friendly delicious breakfast!"

Sharra 1-night trip

Posted 2 days ago

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

10/10 Excellent

"Comfortable and convenient"

Holly 3-night trip

Posted 2 days ago

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

10/10 Excellent

"Nice place! Breakfast was amazing!"

Rebecca 2-night trip

Posted 3 days ago

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

10/10 Excellent

"Great experience! Great property! Great stay! Great food! Water slide was excellent surprise!!! Lol"

roger 2-night trip

Posted 3 days ago

Drury Inn & Suites Jackson MO

Explore a world of travel with Expedia

Accommodation
Flights
Packages
Cars

Flights from Akron (CAK) to Cape Girardeau (CGI)
Flights from Larsen Bay (KLN) to Cape Girardeau (CGI)
Flights from Laredo (LRD) to Cape Girardeau (CGI)

Arcadia Holidays
Visit Bernie
Visit Bloomsdale
Dexter Holidays
Eden Spa & Salon
Visit Fredericktown
Visit New Madrid
Visit Old Appleton
Visit Ozora
Visit Park Hills
Walnut Hollow Lake
Visit Wappapello

Ace New Zealand Rental Cars in Doe Run
Ada Rental Cars in New Offenburg
Addcar rental Rental Cars in Fruitland
Apex Car Rentals Rental Cars in Southeast Missouri
Car hire Catron
Sicily By Car Rental Cars in Delta

Go further with the Expedia app

Save on select hotels and earn double points when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go.

Scan the QR code with your device camera and download our app

QR code to download the app

Company

About
Jobs
List your property
Partnerships
Newsroom
Advertising

Explore

Ireland travel guide
Hotels in Ireland
Holiday rentals in Ireland
Holiday packages in Ireland
Domestic flights
Car rentals in Ireland
All accommodation types

Policies

General terms and conditions (excluding Vrbo bookings)
Vrbo terms and conditions
Accessibility
Privacy Statement
Cookie Statement
Terms of use
Legal information / Contact us
Content guidelines and reporting content

Help

Support
Change or cancel your booking
Refund process and timelines
Book a flight using an airline credit
International travel documents

Expedia, Inc. is not responsible for content on external Web sites.

© 2026 Expedia, Inc., an Expedia Group company. All rights reserved. Expedia and the Expedia Logo are trademarks or registered trademarks of Expedia, Inc.

9a2d85f5-2dda-45bf-99eb-edfaad07de35a5878b7d-9ba3-4231-98f3-d4c207b8474d