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Visitors to this part of Hessen rub shoulders with about 650,000 local residents.
Berlin, the national capital, is situated 260 miles northeast of Frankfurt, while Niederdorfelden lies 8 miles to the northeast.
Hang out with the kids at the German Film Museum and Titus Thermen. For even more fun, head onwards to Wasserpark and the Kinder Museum.
Animals of all shapes and sizes await at the Frankfurt Zoological Garden and the Zoo Vivarium Darmstadt. When you add in the Zoo Frankfurt, the family are sure to have an amazing zoological adventure.
From beautiful flowers to magical, meandering garden pathways, the treasures of the Palmengarten are just waiting to be discovered. The Botanical Gardens and the Frankfurt Botanical Garden are also worth a look.
When the weather is fine, grab some lunch and make your way over to one of the pleasant green spaces, such as Martin Luther King Park and Herrengarten. You'll also find plenty of space to lay about on the grass at the Prinz-Georg-Garten and Prinz-Emil-Garten.
Surrounded by woody trees and scrubby grass, Grosse Woog is a nice escape for birdlife and travelers alike.
Do you want to take some time out by the sea? Load up a bag with some goodies and find a nice little spot at Langener Waldsee.
Need to get away from the stresses of modern life? Head on over to Riedwiesen Nature Reserve and Naturpark Hochtaunus. Nature lovers will also have a great time at Alter Flugplatz and Stadtwald.
See the world in a different light with a trip to one of the area's wonderfully curated cultural institutions. The Jewish Museum and the German Architecture Museum offer a range of collections that are bound to spark your curiosity. Another two worth considering are the Klingspor Museum and the Museum for Communication.
Some travelers think of natural museums as a place to take the children, but the alluring collections at the Senckenberg Museum and the Hessisches Landesmuseum prove that there's enough to keep the adults busy too. The Haus der Stadtgeschichte and the Frankfurt Archeologic Museum are also well worth a visit.
Are you an art aficionado? You'll find galleries of all varieties here. Pop in to the Museum of Modern Art and the Staedel Museum for the best of what this creative enclave has to offer. If these leave you feeling energized, finish up your day at the Liebieghaus and the Museum of Applied Arts.
There's always something new to learn about the past at the Historical Museum. If you like that, you should also check out the variety of interesting items on display at the Historical Museum and the Bibelhaus.
To find out more about the area's rich and fascinating past, consider visiting its many remaining historical sites. Start your history tour at the Roemer or the Goethe University Frankfurt Campus Bockenheim. You might also like to take a few photos at Messel Pit Fossil Site and the Technical University Darmstadt.
The stately manors and palaces of the region are always popular with tourists. Admire artworks and lavish furnishings and take some time in the courtyards and gardens at Darmstadt Palace, Rumpenheim Palace and Schlossmuseum.
After spending an afternoon at Burgruine or Burg Kronberg, you may just feel like you've traveled back to the days of knights and dames! For even more intersting views and historical stories, go forth and explore Schloss Rumpenheim and Schonhof.
Whether you consider yourself spiritual or not, you're sure to have a pleasant time at Frankfurt Cathedral and St. Paul's Church. St. Catharine's Church and Russian Chapel are also recommended religious sites.
Frankfurt's most acclaimed sights can overshadow its lesser-known, but equally rewarding activities. The Stadtbibliothek Offenbach and Jugendstilbad are two recommended options. Also, think about checking out the BraunSammlung and Holbeinsteg if you have time.
This family-friendly Frankfurt hotel is located in Frankfurt Airport Area, within 1 mi (2 km) of The Squaire and Lufthansa Flight Training Center. Hoechst Castle and Commerzbank-Arena are also within 6 miles (10 km).
This family-friendly Frankfurt hotel is located near the airport, within a 10-minute walk of Staedel Museum, Frankfurt Opera House and Liebieghaus. Roemer and Frankfurt Cathedral are also within 1 mi (2 km).
Located in Bockenheim, this spa hotel is within 3 miles (5 km) of Congress Center Messe Frankfurt, Senckenberg Museum and Palmengarten. Alte Oper and Maintower are also within 3 miles (5 km).
Located in Frankfurt Airport Area, this eco-friendly hotel is 1.2 mi (2 km) from The Squaire and 2.2 mi (3.5 km) from Lufthansa Flight Training Center. Commerzbank-Arena and Langener Waldsee are also within 6 miles (10 km).
This family-friendly Frankfurt hotel is located in Frankfurt Airport Area, within 1 mi (2 km) of The Squaire and Lufthansa Flight Training Center. Hoechst Castle and Commerzbank-Arena are also within 16 mi (25 km).
Located in Frankfurt Airport Area, this luxury hotel is 1.4 mi (2.2 km) from The Squaire and 2.3 mi (3.7 km) from Lufthansa Flight Training Center. Commerzbank-Arena and Langener Waldsee are also within 6 miles (10 km).
Located in Bahnhofsviertel, this hotel is within a 10-minute walk of English Theatre, Frankfurt Opera House and Maintower. Staedel Museum and St. Paul's Church are also within 15 minutes.
Located in Frankfurt Airport Area, this hotel is 2.1 mi (3.4 km) from Lufthansa Flight Training Center and within 9 miles (15 km) of Commerzbank-Arena and Congress Center Messe Frankfurt. Staedel Museum and Frankfurt Opera House are also within 9 miles (15 km).