A river with a bridge, a town, and a forested hillside.

Hannibal Hotel Guide - Hotels with Spa in Hannibal, Missouri

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Hannibal Hotels with Spa

Tonight
29 Sept - 30 Sept
Tomorrow
30 Sept - 1 Oct
This weekend
2 Oct - 4 Oct
Next weekend
9 Oct - 11 Oct

Our top choices for Hannibal hotels with a spa

A wooden interior with a hot tub, a wheelchair-accessible bench, and a window.
An indoor swimming pool with wooden walls, a tiled floor, and a sign indicating no diving is allowed.
A hotel reception area with a wooden reception desk, a red chair, and a carpeted floor.
A hotel room with a bed, a sofa, a desk, and a lamp.

1. Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal
Hannibal
  • Serene spa sanctuary awaits in the heart of Hannibal with rejuvenating hot tub, indoor pool, and hydromassage showers.
€77
includes taxes & fees
11 Oct - 12 Oct
Comfort Inn & Suites - Hannibal
A modern reception area with a marble counter, a wooden panel with a light fixture, a fireplace, and a seating area with a sofa and chairs.
A Holiday Inn hotel with a modern facade, a covered entrance, and landscaped areas with shrubs.
A hotel room with a sofa, armchair, lamp, and a large mirror.
A spacious lobby with a fireplace, seating area, and large windows.

2. Holiday Inn Quincy East by IHG

Holiday Inn Quincy East by IHG
Quincy
  • Revitalising spa treatments await at this hotel, where an indoor pool, cosy pillow menus, and attentive staff create a relaxing retreat.
€135
includes taxes & fees
18 Oct - 19 Oct
Holiday Inn Quincy East by IHG
View all properties

Choose what matters most at spa hotels in Hannibal

Pool
Breakfast included
Hot tub
4 stars
5 stars

Top Hannibal Hotel Reviews

Best Western On The River

Best Western On The River

10/10 Excellent
"The hotel is sleek and modern without being fancy. The location was fantastic, the staff was very helpful, and the pool was a lovely way to start or end the day."
Sonia 1-night trip
Posted 17 hours ago
Best Western On The River
Quality Inn & Suites Hannibal West

Quality Inn & Suites Hannibal West

8/10 Good
"This was a great stop on our Mississippi River travels"
Mary 2-night trip
Posted 2 days ago
Quality Inn & Suites Hannibal West

Frequently asked questions

Looking to holiday at a spa hotel in Hannibal?
Forget the stress of everyday life and book yourself a hotel with a spa. Travellers recommend the gourmet restaurants in Hannibal. Enjoy the shops and riverfront during your holiday. Spa hotels are a great way to break away from your routine and add a layer of luxury to your holiday.
What is the best spa hotel in Hannibal?
Comfort Inn & Suites - Hannibal is a top spa hotel featuring a 24-hour fitness centre and an indoor pool. Kick back and relax in the Hot tub.
How many spa hotels are there in Hannibal?
Among Expedia's 54 accommodation options in Hannibal, there is 1 spa hotel.
What's there to see and do in Hannibal?
Take in the sights and attractions that Hannibal offers with a visit to Rockcliffe Mansion, Mark Twain Boyhood Home and Museum and Mark Twain Memorial Lighthouse. If you have a little extra time during your trip, you might want to check out Lovers Leap and Mark Twain Cave.
What is a Hannibal spa hotel?
Spa hotels in Hannibal provide lodging and have an on-site spa offering services such as massages as well as beauty treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation and relaxation.

Explore a world of travel with Expedia