Jacksonville Hotel Guide. Hotels in Isle of Palms South, Jacksonville, United States of America

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Our top choices for Isle of Palms South hotels

Quality Inn Atlantic Beach - Mayo Clinic Jax Area

Quality Inn Atlantic Beach - Mayo Clinic Jax Area
2.5 star property
9.1 km from Isle of Palms South
7.8 out of 10, Good, (1001)
"This was a spectacular stay"
United States
Lance
The price is €89
includes taxes & fees
5 Jan - 6 Jan 2026
Quality Inn Atlantic Beach - Mayo Clinic Jax Area

Holiday Inn Express & Suites Jacksonville - Atlantic Beach by IHG

Holiday Inn Express & Suites Jacksonville - Atlantic Beach by IHG
2.5 star property
7.9 km from Isle of Palms South
8.6 out of 10, Excellent, (1002)
"Great location "
United States
Jose D
The price is €99
includes taxes & fees
2 Jan - 3 Jan 2026
Holiday Inn Express & Suites Jacksonville - Atlantic Beach by IHG

The Hotel Palms

The Hotel Palms
3.5 star property
6.6 km from Isle of Palms South
9.6 out of 10, Exceptional, (291)
"stayed here for an event and it was awesome"
United States
clayton
The price is €163
includes taxes & fees
1 Jan - 2 Jan 2026
The Hotel Palms

Best Western Mayport Inn & Suites

Best Western Mayport Inn & Suites
2.5 star property
8.9 km from Isle of Palms South
7.8 out of 10, Good, (723)
"The check in person was the best!"
United States
Scott
The price is €95
includes taxes & fees
4 Jan - 5 Jan 2026
Best Western Mayport Inn & Suites

Salt Air Inn & Suites

Salt Air Inn & Suites
2.5 star property
6.6 km from Isle of Palms South
9.8 out of 10, Exceptional, (415)
"Great stay , convenient locations , friendly staff and well priced "
United States
Grant
Salt Air Inn & Suites

Candlewood Suites Jacksonville - Mayport by IHG

Candlewood Suites Jacksonville - Mayport by IHG
2.5 star property
8.1 km from Isle of Palms South
9.0 out of 10, Wonderful, (252)
"It's location was perfect and not too far from the places that I needed to go."
United States
Ian
The price is €105
includes taxes & fees
4 Jan - 5 Jan 2026
Candlewood Suites Jacksonville - Mayport by IHG

One Ocean Resort and Spa

One Ocean Resort and Spa
4.5 star property
6.8 km from Isle of Palms South
8.8 out of 10, Excellent, (1002)
"Need to rethink having guests in middle of this major renovation. Refresh definitely needed. Wouldn’t stay here again until renovation is complete. Staff was accommodating. "
United States
karen
The price is €163
includes taxes & fees
30 Dec - 31 Dec
One Ocean Resort and Spa

Courtyard by Marriott Jacksonville Beach Oceanfront

Courtyard by Marriott Jacksonville Beach Oceanfront
3.0 star property
5.2 km from Isle of Palms South
8.4 out of 10, Very good, (1004)
"Perfect time thanks again marriot"
United States
BRANDON
The price is €163
includes taxes & fees
4 Jan - 5 Jan 2026
Courtyard by Marriott Jacksonville Beach Oceanfront

TownePlace Suites by Marriott® Jacksonville Mayport

TownePlace Suites by Marriott® Jacksonville Mayport
3.0 star property
9.7 km from Isle of Palms South
9.8 out of 10, Exceptional, (67)
"This was an awesome place to stay."
United States
Christine
The price is €112
includes taxes & fees
4 Jan - 5 Jan 2026
TownePlace Suites by Marriott® Jacksonville Mayport

Seahorse Oceanfront Inn

Seahorse Oceanfront Inn
2.5 star property
6.8 km from Isle of Palms South
9.0 out of 10, Wonderful, (612)
"The location was ideal if you enjoy shopping eating and entertainment in walking distance ."
United States
Alethia
Seahorse Oceanfront Inn

Hampton Inn Jacksonville Beach/Oceanfront

Hampton Inn Jacksonville Beach/Oceanfront
3.0 star property
5.1 km from Isle of Palms South
9.2 out of 10, Wonderful, (2615)
"The room was clean, staff was friendly and we loved the location. "
United States
Diane
The price is €130
includes taxes & fees
11 Jan - 12 Jan 2026
Hampton Inn Jacksonville Beach/Oceanfront

Holiday Inn Express Jacksonville Beach by IHG

Holiday Inn Express Jacksonville Beach by IHG
3.0 star property
3.5 km from Isle of Palms South
9.2 out of 10, Wonderful, (1001)
"Great location "
United States
Angel
The price is €111
includes taxes & fees
6 Jan - 7 Jan 2026
Holiday Inn Express Jacksonville Beach by IHG

Four Points by Sheraton Jacksonville Beachfront

Four Points by Sheraton Jacksonville Beachfront
3.0 star property
4.5 km from Isle of Palms South
9.0 out of 10, Wonderful, (1000)
"Easy to walk to the beach and local restaurant"
United States
Allen D
The price is €172
includes taxes & fees
4 Jan - 5 Jan 2026
Four Points by Sheraton Jacksonville Beachfront

Fairfield Inn & Suites by Marriott Jacksonville Beach

Fairfield Inn & Suites by Marriott Jacksonville Beach
2.5 star property
5.2 km from Isle of Palms South
8.6 out of 10, Excellent, (892)
"Great place to stay highly recommend it"
United States
Taryn
The price is €106
includes taxes & fees
4 Jan - 5 Jan 2026
Fairfield Inn & Suites by Marriott Jacksonville Beach

Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach
2.5 star property
4.8 km from Isle of Palms South
9.0 out of 10, Wonderful, (3442)
"Nice stay!"
United States
Mark
The price is €129
includes taxes & fees
30 Dec - 31 Dec
Margaritaville Jacksonville Beach

Ponte Vedra Inn & Club

Ponte Vedra Inn & Club
5.0 star property
6.1 km from Isle of Palms South
9.4 out of 10, Exceptional, (813)
"Wonderful place to visit to relax. Very clean, very friendly and courteous staff. Great view from the balcony."
United States
Greg
The price is €403
includes taxes & fees
4 Jan - 5 Jan 2026
Ponte Vedra Inn & Club

Casa Marina Hotel

Casa Marina Hotel
3.0 star property
4.7 km from Isle of Palms South
8.4 out of 10, Very good, (1000)
"Room and hotel was very clean. Great old hotel with charm! Loved the roof top bar, views amazing. Location is perfect! "
Canada
Wayne
Casa Marina Hotel

Embassy Suites by Hilton Jacksonville Baymeadows

Embassy Suites by Hilton Jacksonville Baymeadows
3.5 star property
14 km from Isle of Palms South
8.4 out of 10, Very good, (1308)
"Nice stay "
United States
Carsi
The price is €118
includes taxes & fees
3 Jan - 4 Jan 2026
Embassy Suites by Hilton Jacksonville Baymeadows

Springhill Suites By Marriott Jacksonville Beach Oceanfront

Springhill Suites By Marriott Jacksonville Beach Oceanfront
4.0 star property
4.7 km from Isle of Palms South
9.0 out of 10, Wonderful, (623)
"The room was great and the staff was exceptional. Would stay here again in a heartbeat. "
United States
Michael
The price is €159
includes taxes & fees
4 Jan - 5 Jan 2026
Springhill Suites By Marriott Jacksonville Beach Oceanfront

Hyatt Regency Jacksonville

Hyatt Regency Jacksonville
4.0 star property
22.1 km from Isle of Palms South
9.0 out of 10, Wonderful, (1405)
"Great stay "
United States
terria
The price is €166
includes taxes & fees
1 Jan - 2 Jan 2026
Hyatt Regency Jacksonville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Isle of Palms South

Find the best Isle of Palms South areas for the activities you enjoy most.

Downtown Jacksonville

The picturesque St. Johns River meanders through the center of this hub of skyscrapers, cultural landmarks and exciting nightlife.

Amelia City

While visiting Amelia City, you might make a stop by sights like American Beach and Fernandina Beach.

Southside

If you're spending some time in Southside, St. Johns Town Center and Orange Park Place Shopping Center are top sights worth seeing.

Sawgrass

Beaches and riverfront are just a few things travellers like about Sawgrass. A stop by Mickler Beach is also recommended if you've got time to explore the area.

Northwest

While visiting Northwest, you might make a stop by sights like Cummer Museum of Art and Gardens and Jacksonville-Baldwin Rail Trail.

Top Isle of Palms South Hotel Reviews

Frequently asked questions

What is Isle of Palms South like?
Travellers will be sure to find plenty to entertain them in Jacksonville Beach's Isle of Palms South neighbourhood.
How many hotels can I expect to find in Isle of Palms South?
Expedia has 9 Isle of Palms South hotels and other accommodation options, and one might make a good home base for venturing out into the greater Jacksonville Beach area.
If I need to cancel my hotel reservation in Isle of Palms South, will I receive a refund?
Yes, the majority of hotel reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If you have a non-refundable reservation, you might be able to still cancel and receive a refund within a 24-hour period of booking. Enter dates in and click on "Search", then you can filter by "fully refundable" to view the best deals in Isle of Palms South.
What are the top things to see and do in Isle of Palms South?
Adventure Landing, Cradle Creek Preserve and Windsor Parke Golf Club are just a few of the places to visit in and around Isle of Palms South. Jacksonville Beach Golf Club and Windsor Commons Shopping Center are also worth a visit when you're out sightseeing in Jacksonville Beach.

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