Jacksonville Hotel Guide. Hotels in Isle of Palms South, Jacksonville, United States of America
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Our top choices for Isle of Palms South hotels
1. Residence Inn By Marriott Jacksonville - Mayo Clinic Area
Residence Inn By Marriott Jacksonville - Mayo Clinic AreaIsle of Palms, 2 km from Isle of Palms South
9.4 out of 10, Exceptional, (584 reviews)
"Great stay"
Michaelanne
The price is €134
includes taxes & fees
29 Aug - 30 Aug
2. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches1.5 km from Isle of Palms South
8.4 out of 10, Very good, (794 reviews)
"Nice hotel for the money."
Troy
The price is €149
includes taxes & fees
22 Aug - 23 Aug
3. TownePlace Suites by Marriott Jacksonville East
TownePlace Suites by Marriott Jacksonville East2.9 km from Isle of Palms South
9.2 out of 10, Wonderful, (649 reviews)
"Clean place"
Anonymous traveller
The price is €104
includes taxes & fees
6 Sept - 7 Sept
4. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic2.9 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,003 reviews)
"Great place to stay."
Patsy
The price is €125
includes taxes & fees
23 Aug - 24 Aug
5. Holiday Inn Express Jacksonville Beach by IHG
Holiday Inn Express Jacksonville Beach by IHG3.5 km from Isle of Palms South
9.2 out of 10, Wonderful, (1,003 reviews)
"The location is great walking distance restaurants and free parking."
Salvador
The price is €112
includes taxes & fees
30 Aug - 31 Aug
6. Hilton Jacksonville at Mayo Clinic near Beaches
Hilton Jacksonville at Mayo Clinic near Beaches1.9 km from Isle of Palms South
9.4 out of 10, Exceptional, (322 reviews)
"Enjoyed my stay here we definitely come back!"
Mercedes
The price is €148
includes taxes & fees
7 Sept - 8 Sept
7. Margaritaville Jacksonville Beach
Margaritaville Jacksonville BeachOceanfront, 4.8 km from Isle of Palms South
9.0 out of 10, Wonderful, (4,354 reviews)
"Lovely and beautiful place for the family."
Noelia
The price is €146
includes taxes & fees
18 Aug - 19 Aug
8. Best Western Oceanfront
Best Western OceanfrontOceanfront, 4.6 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,009 reviews)
"The location was great."
Shawna
The price is €129
includes taxes & fees
23 Aug - 24 Aug
9. Casa Marina Hotel
Casa Marina HotelOceanfront, 4.8 km from Isle of Palms South
8.4 out of 10, Very good, (1,011 reviews)
"Hotel needs a total renovation."
William
The price is €124
includes taxes & fees
20 Aug - 21 Aug
10. Fairfield Inn & Suites by Marriott Jacksonville Beach
Fairfield Inn & Suites by Marriott Jacksonville BeachOceanfront, 5.2 km from Isle of Palms South
8.6 out of 10, Excellent, (971 reviews)
"Very close to the beach, plenty of restaurants and shopping within a close distance. We will definitely be back there!"
Xaviera
The price is €124
includes taxes & fees
30 Aug - 31 Aug
11. Courtyard by Marriott Jacksonville Beach Oceanfront
Courtyard by Marriott Jacksonville Beach OceanfrontOceanfront, 5.2 km from Isle of Palms South
8.6 out of 10, Excellent, (1,005 reviews)
"great stay."
victoria
The price is €162
includes taxes & fees
24 Aug - 25 Aug
12. Element by Marriott Jacksonville Beach
Element by Marriott Jacksonville BeachOceanfront, 4.4 km from Isle of Palms South
9.6 out of 10, Exceptional, (574 reviews)
"Best hotel ever 😊"
Tablo
The price is €141
includes taxes & fees
30 Aug - 31 Aug
13. Hyatt Studios Jacksonville/St Johns Town Center
Hyatt Studios Jacksonville/St Johns Town Center8.7 km from Isle of Palms South
9.4 out of 10, Exceptional, (173 reviews)
"Clean , convenient, wonderful staff."
Alicia
The price is €108
includes taxes & fees
1 Sept - 2 Sept
14. Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area3.8 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,202 reviews)
"Clean and staff very attentive."
Hannah
The price is €116
includes taxes & fees
13 Sept - 14 Sept
15. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG3.7 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,018 reviews)
"Very helpful staff and nice view to the golf course."
Jorge
The price is €108
includes taxes & fees
13 Sept - 14 Sept
16. Four Points by Sheraton Jacksonville Beachfront
Four Points by Sheraton Jacksonville BeachfrontOceanfront, 4.5 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,010 reviews)
"Awesome stay"
Susan
The price is €182
includes taxes & fees
7 Sept - 8 Sept
17. Springhill Suites By Marriott Jacksonville Beach Oceanfront
Springhill Suites By Marriott Jacksonville Beach OceanfrontOceanfront, 4.7 km from Isle of Palms South
9.0 out of 10, Wonderful, (771 reviews)
"Wonderful property with a great location and friendly staff! I’ve stayed at many Jax beach properties and always go back to this one."
Elizabeth
The price is €166
includes taxes & fees
30 Aug - 31 Aug
18. Seahorse Oceanfront Inn
Seahorse Oceanfront Inn6.8 km from Isle of Palms South
8.8 out of 10, Excellent, (771 reviews)
"Overall it was a great stay."
Controlis
The price is €169
includes taxes & fees
23 Aug - 24 Aug
19. Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass8.8 km from Isle of Palms South
9.2 out of 10, Wonderful, (1,018 reviews)
"Family of 5 stayed comfortably!
Very accommodating and friendly!
Room was clean, pool was also fun!"
Brooke
The price is €122
includes taxes & fees
30 Aug - 31 Aug
20. Homewood Suites by Hilton Jacksonville-South/St. Johns Ctr.
Homewood Suites by Hilton Jacksonville-South/St. Johns Ctr.8.9 km from Isle of Palms South
8.6 out of 10, Excellent, (1,005 reviews)
"Everyone and everything was very nice as usual. We stayed last August 2025 for college move in and stayed this time too, August 2026. Excellent place and people!"
Angela
The price is €95
includes taxes & fees
30 Aug - 31 Aug
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Isle of Palms South
Find the best Isle of Palms South areas for the activities you enjoy most.
Amelia City
While visiting Amelia City, you might make a stop by sights like American Beach and Fernandina Beach.
Oceanfront
While visiting Oceanfront, you might make a stop by sights like Oceanfront Park and Northeast Florida Beaches.
Photo by Ryan Ketterman
Open Photo by Ryan Ketterman
Downtown Jacksonville
The picturesque St. Johns River meanders through the center of this hub of skyscrapers, cultural landmarks and exciting nightlife.
Southside
If you're spending some time in Southside, St. Johns Town Center and Orange Park Place Shopping Center are top sights worth seeing.
Sawgrass
Beaches and riverfront are just a few things travellers like about Sawgrass. A stop by Mickler Beach is also recommended if you've got time to explore the area.
Top Isle of Palms South Hotel Reviews
Scottish Inn Jacksonville Downtown
8/10 Good
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