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Jacksonville Hotel Guide. Hotels in Isle of Palms South, Jacksonville, United States of America

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Check prices for these dates

This weekend
2 Oct - 4 Oct
Next weekend
9 Oct - 11 Oct

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Our top choices for Isle of Palms South hotels

A lobby with a reception desk, seating area, and a staircase.

1. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
2.5 star property
3.7 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,017 reviews)
"wonderful breakfast and friendly staff"
United States
frances
The price is €98
includes taxes & fees
1 Nov - 2 Nov
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
A hotel lobby with a bar area, seating arrangements, and a reception desk.

2. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
2.5 star property
2.9 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,001 reviews)
"Great place to stay."
United States
Patsy
The price is €111
includes taxes & fees
4 Oct - 5 Oct
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
A spacious living area with a high ceiling, a fireplace, and a bar area in the background.

3. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
3.0 star property
Isle of Palms, 2 km from Isle of Palms South
9.4 out of 10, Exceptional, (603 reviews)
"Great stay"
United States
Michaelanne
The price is €138
includes taxes & fees
18 Oct - 19 Oct
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
An outdoor seating area with a fire pit, wicker furniture, and a covered patio.

4. TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East
3.0 star property
2.9 km from Isle of Palms South
9.2 out of 10, Wonderful, (661 reviews)
"Great location close to the beach. Super well maintained facility. Everything was great!"
United States
gregory
The price is €120
includes taxes & fees
25 Oct - 26 Oct
TownePlace Suites by Marriott Jacksonville East
A beach with a sandy shore, waves, and buildings in the background.

5. Best Western Oceanfront

Best Western Oceanfront
3.0 star property
Oceanfront, 4.6 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,002 reviews)
"Big room, clean, great breakfast, right on the beach, staff is friendly."
United States
Svetlana
The price is €132
includes taxes & fees
4 Oct - 5 Oct
Best Western Oceanfront
A modern restaurant with a bar area, wooden ceiling, and large windows.

6. Hilton Jacksonville at Mayo Clinic near Beaches

Hilton Jacksonville at Mayo Clinic near Beaches
4.5 star property
1.9 km from Isle of Palms South
9.2 out of 10, Wonderful, (365 reviews)
"Very nice stay!"
United States
Patricia
The price is €171
includes taxes & fees
17 Oct - 18 Oct
Hilton Jacksonville at Mayo Clinic near Beaches
An outdoor seating area with stone fire pit, wicker furniture, and potted plants.

7. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
3.0 star property
1.5 km from Isle of Palms South
8.4 out of 10, Very good, (798 reviews)
"The staff was very helpful and the parking easy and, in parts, quite shady. It was within easy walking distance of the Mayo Clinic!"
United States
Patricia
The price is €153
includes taxes & fees
10 Oct - 11 Oct
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
A modern dining area with wooden tables and chairs, pendant lighting, and artwork on the walls.

8. Fairfield Inn & Suites by Marriott Jacksonville Beach

Fairfield Inn & Suites by Marriott Jacksonville Beach
3.0 star property
Oceanfront, 5.2 km from Isle of Palms South
8.6 out of 10, Excellent, (987 reviews)
"clean room nice beach location"
United States
Anne
The price is €135
includes taxes & fees
12 Oct - 13 Oct
Fairfield Inn & Suites by Marriott Jacksonville Beach
A hotel room with a large bed, a desk with a chair, a television, and a mirror.

9. Holiday Inn Jacksonville E 295 Baymeadows by IHG

Holiday Inn Jacksonville E 295 Baymeadows by IHG
3.0 star property
9.6 km from Isle of Palms South
8.6 out of 10, Excellent, (1,000 reviews)
"Great Hotel"
United States
Josh
The price is €84
includes taxes & fees
1 Nov - 2 Nov
Holiday Inn Jacksonville E 295 Baymeadows by IHG
A pathway leading to a gated entrance with a sign reading "FEAHORSE."

10. Seahorse Oceanfront Inn

Seahorse Oceanfront Inn
2.5 star property
6.8 km from Isle of Palms South
8.8 out of 10, Excellent, (814 reviews)
"This was a great weekend trip we loved the property and the views from the room."
United States
Steven
The price is €134
includes taxes & fees
12 Oct - 13 Oct
Seahorse Oceanfront Inn
A hotel room with two beds, a desk with a computer, a chair, and a colorful carpet.

11. Holiday Inn Express Jacksonville Beach by IHG

Holiday Inn Express Jacksonville Beach by IHG
3.0 star property
3.5 km from Isle of Palms South
9.2 out of 10, Wonderful, (1,000 reviews)
"Great place to stay"
United States
Bobby
The price is €108
includes taxes & fees
1 Nov - 2 Nov
Holiday Inn Express Jacksonville Beach by IHG
A covered entrance with a dark tiled floor, white columns, and a green bench.

12. Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
2.5 star property
3.8 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,236 reviews)
"Room was clean, staff were very pleasant and helpful. Will definitely stay here again when I come back to Jacksonville."
United States
Robert
The price is €119
includes taxes & fees
11 Oct - 12 Oct
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
A modern outdoor seating area with white wicker chairs, a glass fire pit with burning wood, and a view of palm trees and a building in the background.

13. Element by Marriott Jacksonville Beach

Element by Marriott Jacksonville Beach
3.0 star property
Oceanfront, 4.4 km from Isle of Palms South
9.6 out of 10, Exceptional, (589 reviews)
"Nice lodging a block from the beach. Great food nearby."
United States
Nick
The price is €145
includes taxes & fees
1 Nov - 2 Nov
Element by Marriott Jacksonville Beach
A laptop on a wooden desk with a white mug, a spoon, and a smartphone.

14. Hyatt Studios Jacksonville/St Johns Town Center

Hyatt Studios Jacksonville/St Johns Town Center
2.5 star property
8.7 km from Isle of Palms South
9.4 out of 10, Exceptional, (219 reviews)
"Very nice stay, they have grab and go breakfast as complimentary."
United States
Phi
The price is €111
includes taxes & fees
30 Oct - 31 Oct
Hyatt Studios Jacksonville/St Johns Town Center
A modern cafe with a coffee machine, toaster, and a display of baked goods.

15. Quality Inn Atlantic Beach - Mayo Clinic Jax Area

Quality Inn Atlantic Beach - Mayo Clinic Jax Area
2.5 star property
9.1 km from Isle of Palms South
7.8 out of 10, Good, (1,000 reviews)
"The Lady at the front desk was very helpful and friendly"
United States
John
The price is €76
includes taxes & fees
11 Oct - 12 Oct
Quality Inn Atlantic Beach - Mayo Clinic Jax Area
An outdoor patio with seating, a fire pit, and string lights.

16. Hyatt Place Jacksonville / St. Johns Town Center

Hyatt Place Jacksonville / St. Johns Town Center
3.0 star property
9.5 km from Isle of Palms South
9.2 out of 10, Wonderful, (1,170 reviews)
"Clean rooms great location very nice"
United States
stephanie
The price is €128
includes taxes & fees
5 Oct - 6 Oct
Hyatt Place Jacksonville / St. Johns Town Center
Pool

17. Four Points by Sheraton Jacksonville Beachfront

Four Points by Sheraton Jacksonville Beachfront
3.0 star property
Oceanfront, 4.5 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,011 reviews)
"Awesome stay"
United States
Susan
The price is €171
includes taxes & fees
26 Oct - 27 Oct
Four Points by Sheraton Jacksonville Beachfront
An outdoor patio area with seating, a fire pit, and a barbecue grill.

18. TownePlace Suites by Marriott® Jacksonville Mayport

TownePlace Suites by Marriott® Jacksonville Mayport
3.0 star property
9.8 km from Isle of Palms South
9.6 out of 10, Exceptional, (127 reviews)
"Nice place"
United States
irina
The price is €119
includes taxes & fees
7 Oct - 8 Oct
TownePlace Suites by Marriott® Jacksonville Mayport
A balcony with a view of the beach, a wooden walkway, and a chair.

19. Courtyard by Marriott Jacksonville Beach Oceanfront

Courtyard by Marriott Jacksonville Beach Oceanfront
3.0 star property
Oceanfront, 5.2 km from Isle of Palms South
8.4 out of 10, Very good, (1,002 reviews)
"Great accommodations."
United States
John
The price is €167
includes taxes & fees
13 Oct - 14 Oct
Courtyard by Marriott Jacksonville Beach Oceanfront
A spacious lobby with a glass floor, a reception desk, and a view of the ocean.

20. Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach
2.5 star property
Oceanfront, 4.8 km from Isle of Palms South
8.8 out of 10, Excellent, (4,538 reviews)
"Great location with beautiful views, clean, beautiful rooms and lots to do around the area"
United States
Keisha
The price is €139
includes taxes & fees
1 Nov - 2 Nov
Margaritaville Jacksonville Beach
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Isle of Palms South

Find the best Isle of Palms South areas for the activities you enjoy most.
A city skyline with modern skyscrapers, a prominent Wells Fargo building, and a blue bridge over a river.
Photo by Ryan Ketterman
Open Photo by Ryan Ketterman

Downtown Jacksonville

The picturesque St. Johns River meanders through the center of this hub of skyscrapers, cultural landmarks and exciting nightlife.

A coastal cityscape at dusk with a prominent clock tower, waterfront, and historic buildings.

Amelia City

While visiting Amelia City, you might make a stop by sights like American Beach and Fernandina Beach.

A sunset over a beach with waves and a pier.

Oceanfront

While visiting Oceanfront, you might make a stop by sights like Oceanfront Park and Northeast Florida Beaches.

A city skyline at night with illuminated buildings and a bridge reflecting on the water.

Southside

If you're spending some time in Southside, St. Johns Town Center and Orange Park Place Shopping Center are top sights worth seeing.

A sunset over a beach with fallen trees and a distant shoreline.

American Beach

If you're spending some time in American Beach, American Beach and Spanish Quarter Village are top sights worth seeing.

Top Isle of Palms South Hotel Reviews

Weekly Inn

Weekly Inn

10/10 Excellent
"The place was excellent it was clean the only thing I will say is they need to upgrade their pillows and mattress other than that it was phenomenal for the price"
Wayne 3-night trip
Posted less than an hour ago
Weekly Inn

Frequently asked questions

What is Isle of Palms South like?
Travellers will be sure to find plenty to entertain them in Jacksonville Beach's Isle of Palms South neighbourhood.
How many hotels can I expect to find in Isle of Palms South?
Expedia has 7 Isle of Palms South hotels and other accommodation options, and one might make a good home base for venturing out into the greater Jacksonville Beach area.
If I need to cancel my hotel reservation in Isle of Palms South, will I receive a refund?
Yes, the majority of hotel reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If you have a non-refundable reservation, you might be able to still cancel and receive a refund within a 24-hour period of booking. Enter dates in and click on "Search", then you can filter by "fully refundable" to view the best deals in Isle of Palms South.
What are the top things to see and do in Isle of Palms South?
Cradle Creek Preserve, Windsor Parke Golf Club and Jacksonville Beach Golf Club are just a few of the places to visit in and around Isle of Palms South. Windsor Commons Shopping Center and Harbor City Municipal Golf Course are also worth a visit when you're out sightseeing in Jacksonville Beach.

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