Key West Hotel Guide - Key West National Wildlife Refuge hotels in Key West, United States of America.

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
29 Dec - 30 Dec
Tomorrow
30 Dec - 31 Dec
This weekend
2 Jan - 4 Jan
Next weekend
9 Jan - 11 Jan

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Key West National Wildlife Refuge hotels

Queen Deluxe ADA
Almond Tree Inn Hotel - Adults Only

Almond Tree Inn Hotel - Adults Only

Almond Tree Inn Hotel - Adults Only
3.5 star property
Downtown Key West, 11.8 km from Key West National Wildlife Refuge
10.0 out of 10, Exceptional, (1000)
"Great location, spotless rooms, attentive and friendly staff, great value."
United States
David
The price is €387
includes taxes & fees
4 Jan - 5 Jan 2026
Almond Tree Inn Hotel - Adults Only
King Room D | Balcony
Simonton Court Historic Inn & Cottages

Simonton Court Historic Inn & Cottages

Simonton Court Historic Inn & Cottages
2.5 star property
Historic Seaport, 11.4 km from Key West National Wildlife Refuge
9.8 out of 10, Exceptional, (886)
"I loved staying here! The room was great and the staff was awesome! "
United States
Tiffany
The price is €286
includes taxes & fees
4 Jan - 5 Jan 2026
Simonton Court Historic Inn & Cottages
Restaurant
Artist House Key West

Artist House Key West

Artist House Key West
3.5 star property
Historic Seaport, 11.4 km from Key West National Wildlife Refuge
9.8 out of 10, Exceptional, (422)
"Really great place to stay. Nice rooms and staff. Great location for Devaul street. "
United States
Beth
The price is €300
includes taxes & fees
12 Jan - 13 Jan 2026
Artist House Key West
Carriage House | Terrace/patio
The Gardens Hotel

The Gardens Hotel

The Gardens Hotel
4.0 star property
Downtown Key West, 11.6 km from Key West National Wildlife Refuge
9.8 out of 10, Exceptional, (1002)
"Loved it. The staff were very friendly and the place was classic Key West."
United States
Ben
The price is €386
includes taxes & fees
5 Jan - 6 Jan 2026
The Gardens Hotel
Front of property
Key West Villas

Key West Villas

Key West Villas
3.5 star property
Downtown Key West, 11.6 km from Key West National Wildlife Refuge
9.8 out of 10, Exceptional, (247)
"Awsome staff great location "
United States
Jeffrey
Key West Villas
Exterior
The Marquesa Hotel

The Marquesa Hotel

The Marquesa Hotel
3.5 star property
Historic Seaport, 11.5 km from Key West National Wildlife Refuge
9.8 out of 10, Exceptional, (1000)
"Perfect place to stay. "
United States
Paulette
The price is €429
includes taxes & fees
4 Jan - 5 Jan 2026
The Marquesa Hotel
Exterior
Orchid Key Inn - Adults Only

Orchid Key Inn - Adults Only

Orchid Key Inn - Adults Only
3.5 star property
Uptown - Upper Duval, 11.8 km from Key West National Wildlife Refuge
9.8 out of 10, Exceptional, (1001)
"Staff awesome, good breakfast great location"
United States
Carin helen
The price is €336
includes taxes & fees
5 Jan - 6 Jan 2026
Orchid Key Inn - Adults Only
Outdoor pool, pool loungers
The Conch House Heritage Inn

The Conch House Heritage Inn

The Conch House Heritage Inn
3.5 star property
Old Town Key West, 12 km from Key West National Wildlife Refuge
9.8 out of 10, Exceptional, (146)
"Check in was quick, easy. "
United States
kristen
The price is €342
includes taxes & fees
4 Jan - 5 Jan 2026
The Conch House Heritage Inn
Outdoor pool, pool loungers
The Mermaid & Alligator

The Mermaid & Alligator

The Mermaid & Alligator
3.5 star property
Old Town Key West, 12.1 km from Key West National Wildlife Refuge
9.8 out of 10, Exceptional, (276)
"Great place"
United States
Carol A
The Mermaid & Alligator
Deluxe Suite, 1 King Bed, Private Pool | View from room
H2O Suites - Adults Only

H2O Suites - Adults Only

H2O Suites - Adults Only
3.5 star property
Uptown - Upper Duval, 12.1 km from Key West National Wildlife Refuge
9.8 out of 10, Exceptional, (582)
"Great place!!"
United States
Joel
The price is €534
includes taxes & fees
4 Jan - 5 Jan 2026
H2O Suites - Adults Only
Signature Apartment, 1 Bedroom, Kitchen, Poolside (Room 17) | Terrace/patio
Alexanders Guesthouse - Adult Exclusive, LGBTQ Friendly

Alexanders Guesthouse - Adult Exclusive, LGBTQ Friendly

Alexanders Guesthouse - Adult Exclusive, LGBTQ Friendly
3.5 star property
Old Town Key West, 12.2 km from Key West National Wildlife Refuge
9.8 out of 10, Exceptional, (136)
"We absolutely loved finding this gem to stay on our first visit to Key West. Great location, wonderful staff, and excellent room. "
United States
Sammy
The price is €364
includes taxes & fees
5 Jan - 6 Jan 2026
Alexanders Guesthouse - Adult Exclusive, LGBTQ Friendly
Exterior
Coco Plum Inn

Coco Plum Inn

Coco Plum Inn
3.0 star property
Downtown Key West, 11.4 km from Key West National Wildlife Refuge
9.6 out of 10, Exceptional, (470)
"The Coco Plum Inn is a wonderful place to stay. Staff is fantastic and the location is perfect. We will definitely come back and stay at the Coco Plum Inn."
United States
Brent
The price is €300
includes taxes & fees
4 Jan - 5 Jan 2026
Coco Plum Inn
Garden
Douglas House

Douglas House

Douglas House
3.0 star property
Uptown - Upper Duval, 11.9 km from Key West National Wildlife Refuge
9.6 out of 10, Exceptional, (238)
"Excellent spot, I definitely recommended"
United States
Paul
The price is €257
includes taxes & fees
13 Jan - 14 Jan 2026
Douglas House
Fountain
Island City House Hotel

Island City House Hotel

Island City House Hotel
3.0 star property
Historic Seaport, 11.7 km from Key West National Wildlife Refuge
9.6 out of 10, Exceptional, (1001)
"Excellent stay"
United States
Emily Barbara
The price is €383
includes taxes & fees
11 Jan - 12 Jan 2026
Island City House Hotel
11 Gecko's Garden - Adults Only
Tropical Inn

Tropical Inn

Tropical Inn
3.5 star property
Downtown Key West, 11.7 km from Key West National Wildlife Refuge
9.6 out of 10, Exceptional, (364)
"Nice place to stay "
United States
yulio
The price is €285
includes taxes & fees
4 Jan - 5 Jan 2026
Tropical Inn
Front of property
L'Habitation Guest House

L'Habitation Guest House

L'Habitation Guest House
2.5 star property
Historic Seaport, 11.2 km from Key West National Wildlife Refuge
9.4 out of 10, Exceptional, (925)
"A great no hassle stay."
United States
Gary
The price is €238
includes taxes & fees
4 Jan - 5 Jan 2026
L'Habitation Guest House
Premium bedding, iron/ironing board, free WiFi, bed sheets
Weatherstation Inn

Weatherstation Inn

Weatherstation Inn
2.5 star property
Truman Annex, 11 km from Key West National Wildlife Refuge
9.4 out of 10, Exceptional, (997)
"Wonderful property safe neighborhood convenient to all activities would stay here again."
United States
William
The price is €400
includes taxes & fees
4 Jan - 5 Jan 2026
Weatherstation Inn
Exterior
The Grand Guesthouse

The Grand Guesthouse

The Grand Guesthouse
2.5 star property
Old Town Key West, 12.5 km from Key West National Wildlife Refuge
9.6 out of 10, Exceptional, (1001)
"Great stay"
United States
Ginger
The Grand Guesthouse
View from property
Duval House

Duval House

Duval House
3.0 star property
Downtown Key West, 11.7 km from Key West National Wildlife Refuge
9.4 out of 10, Exceptional, (1003)
"Great place! "
United States
David
The price is €256
includes taxes & fees
6 Jan - 7 Jan 2026
Duval House
Courtyard
Santa Maria Suites

Santa Maria Suites

Santa Maria Suites
4.0 star property
Uptown - Upper Duval, 12.2 km from Key West National Wildlife Refuge
9.6 out of 10, Exceptional, (1001)
"Awesome place we loved it"
United States
Josh
The price is €544
includes taxes & fees
7 Jan - 8 Jan 2026
Santa Maria Suites
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Key West National Wildlife Refuge Hotel Reviews

Pier House Resort & Spa

Pier House Resort & Spa

10/10 Excellent
"The room is beautiful, great private beach."
judith 4-night trip
Posted 2 days ago
Pier House Resort & Spa

Hotels near other Key West National Wildlife Refuge attractions

Truman Beach

Why not spend a lazy afternoon at Truman Beach during your trip to Key West? Stroll along the seaside or discover the area's beautiful sunsets.
See properties
Fort Zachary Taylor Park, Key West. State Park in Florida, USA., Shutterstock ID 761867707, Purchase Order: SP-1891 Wave 0, Client/Licensee: Hotels.com

Fort Zachary Taylor Historic State Park

4.4/5 (1,160 reviews)
The displays of old weapons and interpretive panels in a fort at the heart of the southernmost state park in the continental U.S. provide information about the Civil War.
See properties

Frequently asked questions

What's the area like around Key West National Wildlife Refuge?
Key West National Wildlife Refuge is located in an area of Key West known for its bar scene, cycling and lively festivals. Key West is home to 2776 hotels and other accommodation options, so you can find something that's perfect for your stay.
What's the best hotel to stay close to Key West National Wildlife Refuge?
Pier House Resort & Spa is one of the top choices for your stay based on our traveller data, and this resort offers a full-service spa and a private beach. You'll find it 6.9 mi (11 km) from Key West National Wildlife Refuge. Other good options around the area include Hyatt Centric Key West Resort and Spa and Ocean Key Resort - A Noble House Resort.
If I need to cancel the hotel reservation for my stay near Key West National Wildlife Refuge, will I receive a refund?
Yes, the majority of room reservations are refundable if you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of check in. If you have a reservation that's non-refundable, you might still have the option to cancel and receive a refund within 24 hours of booking. Enter dates in and click on "Search", then use the filter option "fully refundable" to view the best deals available near Key West National Wildlife Refuge.