Lake Nona Medical City Holidays

  • Plan, book, travel with confidence

  • Better together

    Save up to €185 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place
Price found within the past 48 hours. Click for updated prices.
CoCo Key Hotel and Water Resort 

CoCo Key Hotel and Water Resort 

3.5 out of 5
International Drive District
Price was €1,005, price is now €818 per person
€818
per person
26 Dec - 31 Dec
found 8 hours ago
Return flight included
Dublin (DUB) to Orlando (MCO)
8/10 Very Good! (3,633 reviews)
The resort and grounds were very nice. Lush landscaping, beautiful decor. Both pool areas are great! I really loved the deck of the water park and pool area, it’s a rubber type turf, it’s non slip but also nice on the feet.

Reviewed on 9 Nov 2025

Westgate Lakes Resort & Spa Universal Studios Area

Westgate Lakes Resort & Spa Universal Studios Area

4 out of 5
Price was €1,543, price is now €999 per person
€999
per person
26 Dec - 31 Dec
found 8 hours ago
Return flight included
Dublin (DUB) to Orlando (MCO)
8.2/10 Very Good! (5,395 reviews)
everything was Great thank you.

Reviewed on 10 Nov 2025

The Delaney Hotel

The Delaney Hotel

3.5 out of 5
South Orange
Price was €1,448, price is now €1,028 per person
€1,028
per person
5 Jan - 10 Jan
found 1 day ago
Return direct flight included
Dublin (DUB) to Orlando (MCO)
9.6/10 Exceptional! (1,019 reviews)
Really nice and clean space in the middle of Orlando. Will stay here for future Orlando vacations.

Reviewed on 3 Nov 2025

Seasons Florida Resort

Seasons Florida Resort

2 out of 5
Price was €1,095, price is now €844 per person
€844
per person
5 Jan - 10 Jan
found 1 day ago
Return direct flight included
Dublin (DUB) to Orlando (MCO)
8.8/10 Excellent! (3,197 reviews)
It was hard to find the entrance but we got there. Check in fast and easy. The room was clean. Everything great.

Reviewed on 10 Nov 2025

Hyatt Regency Orlando

Hyatt Regency Orlando

4.5 out of 5
International Drive District
Price was €1,104, price is now €884 per person
€884
per person
26 Dec - 31 Dec
found 8 hours ago
Return flight included
Dublin (DUB) to Orlando (MCO)
9.2/10 Wonderful! (1,780 reviews)
I feel Expedia does not offer enough info (check in time) on the property until you’ve already booked buuut The Hyatt was extremely helpful in making my early arrival convenient and accommodating. Although I LOVED my stay and otherwise perfect I’d like to add this info just to help someone who might make the same mistake as me I focused on reading reviews and believing some.. for example : that The Hyatt hotel offers shuttles to and from the airport as well as to and from Disney which are in fact NOT TRUE. Overall the hotel was extremely great during my stay and the spa was divine!!

Reviewed on 9 Nov 2025

Where to stay in Lake Nona Medical City

Find the best Lake Nona Medical City areas and neighborhoods for the activities you enjoy most. Learn more about Lake Nona Medical City
Default Image

International Drive District

1 out of top 10 points of interest in this area

Adventure activities, iconic attractions, shopping and world-class dining destinations make this famous street one of Orlando’s most popular tourist attractions.

Find hotels in International Drive District

Top hotels in Lake Nona Medical City

Universal's Cabana Bay Beach Resort

Universal's Cabana Bay Beach Resort

3.5 out of 5
6550 Adventure Way, Orlando, FL
Fully refundableReserve now, pay when you stay
The price is €129 per night from 12 Nov to 13 Nov
€129
12 Nov - 13 Nov
includes taxes & fees
8.8/10 Excellent! (5,469 reviews)
Amazing place in Orlando for te family

Reviewed on 7 Nov 2025

Universal's Cabana Bay Beach Resort
Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando

Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando

4 out of 5
8800 Vistana Centre Dr, Orlando, FL
Fully refundableReserve now, pay when you stay
The price is €89 per night from 1 Dec to 2 Dec
€89
1 Dec - 2 Dec
includes taxes & fees
9.2/10 Wonderful! (3,854 reviews)
The cascade pool was very nice. We enjoyed the waterfall and the hot tub. Had a great margherita at the bar.

Reviewed on 6 Nov 2025

Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando
Ramada by Wyndham Suites Orlando Airport

Ramada by Wyndham Suites Orlando Airport

3 out of 5
7500 Augusta National Dr, Orlando, FL
Fully refundableReserve now, pay when you stay
The price is €78 per night from 24 Nov to 25 Nov
€78
24 Nov - 25 Nov
includes taxes & fees
8.2/10 Very Good! (5,055 reviews)
The room was clean and comfortable. The staff was very helpful! We enjoyed the breakfast, and the shuttle service was excellent! Picked us up from the airport in a timely manner, and took us back at the reserved time!

Reviewed on 9 Nov 2025

Ramada by Wyndham Suites Orlando Airport
See all 27,312 properties in Lake Nona Medical City
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Lake Nona Medical City holiday package cost?
The cheapest Lake Nona Medical City package is €818, so your dream trip can become a reality — without burning a hole in your pocket. Combine flights, hotels and car rentals to tailor make a package that suits your travel style.
How do I get a cheap travel package to Lake Nona Medical City?
Find flights that fit your busy schedule, add a hotel to your booking and watch the savings rack up with a Lake Nona Medical City holiday package. It's as easy as that! From flights and hotels to tours and rental cars, Expedia makes travelling cheap and easy. And with more than 550 air carriers and 1,000,000 hotel options globally to pick from, you won't be short of choice.
Where should I stay in Lake Nona Medical City?
With loads to explore in Lake Nona Medical City, it'd be convenient for you to stay close to its attractions. Nemours Childrens Hospital, VA Medical Centre at Lake Nona and University of Central Florida College of Medicine are some fascinating ones to add to your to-do list.
What are the top hotels in Lake Nona Medical City?
Make a reservation at Residence Inn Orlando Lake Nona. It's one of the area's most sought-after properties. Another reputable option in Lake Nona Medical City is Courtyard Orlando Lake Nona.
How far in advance should I book my Lake Nona Medical City holiday?
It depends on the airline, but you can generally look up international fares on Expedia up to a year in advance. While it's generally a good idea to book ahead of time, lucky customers occasionally score a cheaper ticket just weeks prior to the date of departure.
What does an Expedia Lake Nona Medical City travel package include?
Expedia has everything you need to organise your Lake Nona Medical City getaway, but what goes into your package is totally up to you. Choose from a combination of hotels, rental cars and flights. In search of some experiences or tours to keep you busy? Once you've made your booking, you can add them too. Whatever your budget or style, there's a deal to match your needs.
What should I know before booking a Lake Nona Medical City travel package?
Locking in all the parts of your escape together is a great way to save. Combine your airfares, rental cars and hotels into one package. But hotels aren't your only option. Expedia has all types of properties, including holiday rentals like beachside villas and city apartments. The list goes on!
Can I choose my airline with a Lake Nona Medical City Expedia holiday package?
Yes — and it's simple too. Expedia has access to more than 550 partner airlines worldwide. Our holiday packages give you the freedom to take your pick of available flight, hotel or activity options that fit your needs.
If I'm not able to travel, can I cancel my Lake Nona Medical City holiday package?
Don't worry if you're rethinking your Lake Nona Medical City holiday package — you can cancel or amend your booking. And if you've booked it within 24 hours, you may be able to do it at no cost. However, bookings made more than 24 hours ago may incur a fee from your airline, hotel or car rental company. We know life can throw the occasional spanner in the works, so look up our Customer Service Portal if that occurs. When you're ready to make changes, we'll be here to help.

Things to do

Universal Orlando Resort

Universal Orlando Resort Theme Park Tickets

€392
per adult
90% of travellers recommend
Universal Orlando Resort Theme Park Tickets
Aquatica Orlando

Aquatica Orlando

€46
per traveller
82% of travellers recommend
Aquatica Orlando
Florida: 90 Minute Everglades Cruise

Florida: 90 Minute Everglades Cruise

€47
per adult
100% of travellers recommend
Florida: 90 Minute Everglades Cruise
See all activities in Orlando
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.