Mayo Clinic Holidays

  • Plan, book, travel with confidence

  • Better together

    Save up to €185 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Where to stay in Mayo Clinic

Find the best Mayo Clinic areas and neighborhoods for the activities you enjoy most. Learn more about Mayo Clinic
Downtown Phoenix

Downtown Phoenix

3 out of top 10 points of interest in this area

Cheer on the Phoenix Suns at an NBA game or walk around the city’s historic precinct as you explore the state capital.

Find hotels in Downtown Phoenix

Top hotels in Mayo Clinic

Hilton Phoenix Tapatio Cliffs Resort

Hilton Phoenix Tapatio Cliffs Resort

4 out of 5
11111 N 7th St Phoenix AZ
Fully refundableReserve now, pay when you stay
The price is €205 per night from 9 May to 10 May
€205
9 May - 10 May
includes taxes & fees
8.6/10 Excellent! (2,517 reviews)
Great breakfast buffet

Reviewed on 14 Apr 2026

Hilton Phoenix Tapatio Cliffs Resort
Hilton Phoenix Resort at the Peak

Hilton Phoenix Resort at the Peak

4 out of 5
7677 N 16th St Phoenix AZ
Fully refundableReserve now, pay when you stay
The price is €191 per night from 19 Apr to 20 Apr
€191
19 Apr - 20 Apr
includes taxes & fees
7.6/10 Good! (3,292 reviews)
A little construxtion, which was expected.. room was nicer than expected. Waterpark is pretty small but adequate. 4* especially at rhe price.

Reviewed on 14 Apr 2026

Hilton Phoenix Resort at the Peak
Talking Stick Resort

Talking Stick Resort

4 out of 5
9800 E. Talking Stick Way Scottsdale AZ
The price is €180 per night from 10 May to 11 May
€180
10 May - 11 May
includes taxes & fees
9.2/10 Wonderful! (4,578 reviews)
Staff and amenities were wonderful. Everyone was so hospitable. Would definitely come back and recommend for anyone wanting to celebrate a birthday, anniversary or getaway!

Reviewed on 14 Apr 2026

Talking Stick Resort
See all 13,249 properties in Mayo Clinic
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Mayo Clinic holiday package cost?
Starting from as low as , a package is your gateway to low-priced travel. Customize your Mayo Clinic trip by choosing from our extensive range of hotels, flights and rental cars.
How do I get a cheap travel package to Mayo Clinic?
Our Mayo Clinic holiday packages promise plenty of savings for the savvy globetrotter. For the best deals, simply combine your flights, hotels and activities into an affordable package. But low prices are just the beginning of your next unforgettable adventure. Book with Expedia and and you'll have over 550 airlines and 1,000,000 properties throughout the world to pick from. No matter your budget or style, there's a holiday package that's perfect for you.
Where should I stay in Mayo Clinic?
Cross Tournament Players Club of Scottsdale off your must-see list and then stay right near it. Soak up the exciting vibe around this terrific attraction and drop by whenever the mood strikes!
What are the top hotels in Mayo Clinic?
Whether you plan to stay for a night or a week in Mayo Clinic, you'll get a great night's rest at Sonesta Select Scottsdale at Mayo Clinic Campus. This option is popular with plenty of travellers.
How far in advance should I book my Mayo Clinic holiday?
Search Expedia to compare international flights as early as possible. In most cases, you can purchase a seat up to 12 months prior to departure. If it's too early for your preferred carrier, or you have to book last minute, don't despair. Cheap fares to Mayo Clinic sometimes occur within weeks of departure.
What does an Expedia Mayo Clinic travel package include?
It all depends on what sort of trip you have in the works. Mayo Clinic holiday deals can include car rentals, hotels and flights. You can mix and match to find the travel package that suits your style and budget. You can also add on activities and experiences after you've booked to score even bigger discounts.
What should I know before booking a Mayo Clinic travel package?
When you book your flights, hotels and car rentals together, you'll walk away with awesome discounts. Whether you're planning a beach break in a villa or want to stay in a fancy hotel in the city, Expedia will help make it happen.
Can I choose my airline with a Mayo Clinic Expedia holiday package?
You can, and with over 550 airlines to choose from all over the world, you've got lots of choice. Take a look at the available options and find out which airline fits your budget and needs.
If I'm not able to travel, can I cancel my Mayo Clinic holiday package?
You sure can, and we'll help you every step of the way. You may be able to cancel and rebook your Mayo Clinic holiday package at no cost if you booked in the last 24 hours. But you may incur a fee from your hotel, airline or car rental company if you booked more than 24 hours ago. If your travel plans suddenly change, have a look at our Customer Service Portal for further information.

Popular places to visit

Phoenix_GrandCanyonUniversity_502345_07

Grand Canyon University

3/5(2 reviews)

Walk around the campus of Grand Canyon University, a well-known university in Phoenix. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.

Grand Canyon University
Phoenix_TalkingStickResortCasino_553248621555612463_02

Talking Stick Resort Casino

Why not try your luck with a visit to Talking Stick Resort Casino where you can enjoy the entertainment at this popular casino in Scottsdale? Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.

Talking Stick Resort Casino
Phoenix_GilaRiverArena_6068401_04

Desert Diamond Arena

5/5(2 reviews)

Catch an event at Desert Diamond Arena during your trip to Glendale. Experience the area's lively festivals and great live music.

Desert Diamond Arena

Things to do

Phoenix Zoo Admission Ticket

Phoenix Zoo Admission Ticket

€35
per adult
92% of travellers recommend
Phoenix Zoo Admission Ticket
Guided Arizona Desert Tour by ATV - Centipede Tour

Guided Arizona Desert Tour by ATV - Centipede Tour

€123
per adult
88% of travellers recommend
Guided Arizona Desert Tour by ATV - Centipede Tour
Phoenix Morning Hot Air Balloon Ride with Bubbly + Breakfast

Phoenix Morning Hot Air Balloon Ride with Bubbly + Breakfast

€208
per adult
96% of travellers recommend
Phoenix Morning Hot Air Balloon Ride with Bubbly + Breakfast
See all activities in Phoenix
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.