A gazebo with columns, a large tree with hanging roots, and a building in the background.

Panama City Hotel Guide. Hotels in Santa Ana, Panama City, Panama

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Check prices for these dates

Next weekend
30 Oct - 1 Nov
In two weeks
6 Nov - 8 Nov

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Our top choices for Santa Ana hotels

A hotel lobby with a large glass window, a wooden bookshelf with colorful items, and a seating area with chairs and a table.

1. Hotel Caracas - Casco Viejo

Hotel Caracas - Casco Viejo
3.0 star property
Santa Ana
7.6 out of 10, Good, (23 reviews)
"great staff"
United States
Keith
The price is €50
includes taxes & fees
2 Nov - 3 Nov
Hotel Caracas - Casco Viejo
A modern indoor pool area with clear blue water, lounge chairs, and a wall of plants.

2. Casco View Life Residences

Casco View Life Residences
4.0 star property
Santa Ana
9.0 out of 10, Wonderful, (112 reviews)
"Amazing location and comfort"
United States
Ruben
The price is €109
includes taxes & fees
25 Oct - 26 Oct
Casco View Life Residences
An indoor dining area with tables and chairs, a mural on the wall, and hanging plants.

3. Hostal La Cigarra

Hostal La Cigarra
2.0 star property
Santa Ana
7.6 out of 10, Good, (76 reviews)
"Excellent staff, close to metro and embassies. A good location, good room for a great price. I would stay again. "
United Kingdom
Mark
The price is €29
includes taxes & fees
6 Nov - 7 Nov
Hostal La Cigarra
A bar area with a curved counter, multiple seating options, and a variety of bottles and glasses on display.

4. Hotel Riazor

Hotel Riazor
3.0 star property
Santa Ana
3.8 out of 10, (11 reviews)
"Rough neighborhood "
Canada
Del
The price is €27
includes taxes & fees
25 Oct - 26 Oct
Hotel Riazor
A hotel room with a large bed, a window with curtains, a city view, and a lamp.

5. Hotel República

Hotel República
2.0 star property
Santa Ana
6.8 out of 10, (197 reviews)
"Good location. Walking distance to shops and public transport."
Canada
Danilo
The price is €82
includes taxes & fees
22 Nov - 23 Nov
Hotel República
Exterior detail

6. Casco View Apartments & Rooftop Pool

Casco View Apartments & Rooftop Pool
3.5 star property
Santa Ana
Casco View Apartments & Rooftop Pool
A modern hotel room with a large bed, a sofa, a TV, and a view of the city.

7. La Manzana Barrio Vivo by Wynwood

La Manzana Barrio Vivo by Wynwood
3.0 star property
Santa Ana
7.6 out of 10, Good, (20 reviews)
"Staff was helpful and its in a great location surrounded by stores and lots of views"
United States
Storme
The price is €97
includes taxes & fees
25 Oct - 26 Oct
La Manzana Barrio Vivo by Wynwood
A hotel entrance with a green facade and a metal fence.

8. ART CASCO The Hotel

ART CASCO The Hotel
2.0 star property
Santa Ana
6.0 out of 10, (15 reviews)
"Walkable location and free secure parking! The price is really affordable, but the condition of the hotel is not the best"
United States
Eldris
The price is €36
includes taxes & fees
25 Oct - 26 Oct
ART CASCO The Hotel
Exterior

9. Room-sofa Bed Stay Rooftop Pool & Gym, A

Room-sofa Bed Stay Rooftop Pool & Gym, A
2.0 star property
Santa Ana
2.0 out of 10, (1 review)
"You pay for a space in the apartment, it’s not the whole apartment be careful. The owner or whoever manages doesn’t give care about you as costumers they just want the money"
United States
Cristian Camilo Betancur
The price is €95
includes taxes & fees
25 Oct - 26 Oct
Room-sofa Bed Stay Rooftop Pool & Gym, A
A rooftop bar with a city skyline view, outdoor seating, and a bar area with bottles and glasses.

10. Tantalo Hotel

Tantalo Hotel
3.5 star property
San Felipe, 0.7 km from Santa Ana
8.8 out of 10, Excellent, (340 reviews)
"Staff was amazing! Rooms are large with all the amenities you would need! Beautiful art and aesthetic to every room!"
United States
Cynthia
The price is €76
includes taxes & fees
22 Nov - 23 Nov
Tantalo Hotel
A modern lobby with a chandelier, seating area, reception desk, and a staircase.

11. The Executive Hotel

The Executive Hotel
3.5 star property
Campo Alegre, 3.2 km from Santa Ana
9.2 out of 10, Wonderful, (1,291 reviews)
"Good location, great breakfast. Clean rooms and helpful staff"
United States
Frank
The price is €78
includes taxes & fees
17 Nov - 18 Nov
The Executive Hotel
A spacious living room with blue sofas, a marble coffee table, and framed pictures on the walls.

12. Hotel Magnolia Boutique

Hotel Magnolia Boutique
2.0 star property
San Felipe, 0.7 km from Santa Ana
8.8 out of 10, Excellent, (533 reviews)
"Fantastic location and very friendly, helpful staff. Highly recommended!"
Canada
Cathy
The price is €95
includes taxes & fees
26 Oct - 27 Oct
Hotel Magnolia Boutique
A hotel named PRINCIPE with a modern facade and large glass windows.

13. Principe Hotel and Suites

Principe Hotel and Suites
3.0 star property
El Cangrejo, 3.9 km from Santa Ana
9.0 out of 10, Wonderful, (2,117 reviews)
"Very large suites, comfortable beds, great A/C"
United States
Willis
The price is €58
includes taxes & fees
25 Oct - 26 Oct
Principe Hotel and Suites
A balcony with a view of a cityscape, including a river and a bridge.

14. Oasis Hotel

Oasis Hotel
3.0 star property
San Felipe, 0.6 km from Santa Ana
8.6 out of 10, Excellent, (160 reviews)
"I enjoyed everything about my stay,the view was amazing and the location was perfect!! I would definitely stay here in the future!!"
United States
Charles
The price is €58
includes taxes & fees
12 Nov - 13 Nov
Oasis Hotel
A rooftop pool with sun loungers and umbrellas, surrounded by palm trees and modern buildings.

15. Hotel Riu Plaza Panama

Hotel Riu Plaza Panama
5.0 star property
Campo Alegre, 3.6 km from Santa Ana
9.0 out of 10, Wonderful, (6,120 reviews)
"Food , staff very nice and helpful, clean room"
United States
Rosa
The price is €117
includes taxes & fees
25 Oct - 26 Oct
Hotel Riu Plaza Panama
A hotel entrance with a covered walkway, large windows, and a well-maintained garden area.

16. Hotel Milan

Hotel Milan
3.0 star property
El Cangrejo, 3.6 km from Santa Ana
9.0 out of 10, Wonderful, (597 reviews)
"Hotel is maintained and managed well, close to many restaurants and transportation."
United States
Michael
The price is €39
includes taxes & fees
2 Nov - 3 Nov
Hotel Milan
A modern hotel room with a large bed, a desk, a flat-screen TV, and a separate seating area.

17. Hotel Ojos del Rio

Hotel Ojos del Rio
3.5 star property
Calidonia, 2.2 km from Santa Ana
8.2 out of 10, Very good, (1,001 reviews)
"Place was nice and quiet and was a comfortable stay."
United States
Sheridan
The price is €50
includes taxes & fees
27 Oct - 28 Oct
Hotel Ojos del Rio
A restaurant with booths, a neon-lit red wall, hanging plants, and pendant lights.

18. Hotel Mio Panama

Hotel Mio Panama
3.0 star property
Campo Alegre, 3.5 km from Santa Ana
8.6 out of 10, Excellent, (273 reviews)
"Great place and great location"
United States
Nfamory
The price is €63
includes taxes & fees
29 Oct - 30 Oct
Hotel Mio Panama
A modern building with a glass facade, a curved structure, and a flat roof.

19. Decapolis Hotel Panama City

Decapolis Hotel Panama City
4.0 star property
Punta Paitilla, 3.6 km from Santa Ana
8.6 out of 10, Excellent, (1,731 reviews)
"Food was limited, but I enjoyed our stay ..3"
United States
Mechalia
The price is €86
includes taxes & fees
31 Oct - 1 Nov
Decapolis Hotel Panama City
A rooftop pool with lounge chairs and a city skyline view.

20. TRYP by Wyndham Panamá Centro

TRYP by Wyndham Panamá Centro
3.5 star property
El Cangrejo, 3.5 km from Santa Ana
9.0 out of 10, Wonderful, (1,002 reviews)
"Room clean staff very welcoming and breakfast was fantastic also Dinner"
United States
Donna
The price is €85
includes taxes & fees
9 Nov - 10 Nov
TRYP by Wyndham Panamá Centro
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in Santa Ana

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A modern indoor pool area with clear blue water, lounge chairs, and a wall of plants.
Casco View Life Residences
4.0 star property
9.0
Wonderful
112 reviews
View
A hotel lobby with a large glass window, a wooden bookshelf with colorful items, and a seating area with chairs and a table.
Hotel Caracas - Casco Viejo
3.0 star property
7.6
Good
23 reviews
View
An indoor dining area with tables and chairs, a mural on the wall, and hanging plants.
Hostal La Cigarra
2.0 star property
7.6
Good
76 reviews
View
A modern hotel room with a large bed, a sofa, a TV, and a view of the city.
La Manzana Barrio Vivo by Wynwood
3.0 star property
7.6
Good
20 reviews
View
A hotel room with a large bed, a window with curtains, a city view, and a lamp.
Hotel República
2.0 star property
6.8
197 reviews
View

Where to stay in Santa Ana

Find the best Santa Ana areas for the activities you enjoy most.
A coastal cityscape with a prominent church tower, a river, and distant mountains.

Casco Viejo

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

A modern, spiraling skyscraper with a unique design, surrounded by other buildings in an urban setting.
Photo by Fabiola Tile
Open Photo by Fabiola Tile

Bella Vista

Travellers love Bella Vista for its popular shops, and you can see more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina Station. You might spend time checking out top sights like Via Espana and Iglesia del Carmen.

A city skyline with modern high-rise buildings and a river in the foreground.

El Cangrejo

The ample dining options and casino gaming are top of the list for many visitors to El Cangrejo. A stop by Via Espana or Crown Casino might round out your trip.

A bridge over a body of water with several boats.

San Francisco

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

A building with three arched windows, a balcony with wrought iron railings, and a tiled roof.

San Felipe

While visiting San Felipe, you might make a stop by sights like Independence Square and Interoceanic Canal Museum.

Top Santa Ana Hotel Reviews

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

8/10 Good
"Place very clean, staff was very helpful, and friendly. I would really stay there again. My family love it there. EA from Brooklyn, new york"
ESAVIA 5-night trip
Posted 5 hours ago
Hotel Riu Plaza Panama

Frequently asked questions

What's it like in Santa Ana?
Santa Ana is a neighbourhood that travellers like for its seafood restaurants, shopping and parks. Are you looking for Santa Ana travel tips? Make sure that you visit Avenida Balboa and El Machetazo Santa Ana while you're in the neighbourhood.
Where is the best hotel for a stay in Santa Ana?
Based on our traveller data, Hotel Caracas - Casco Viejo is one of the top choices for your stay in Santa Ana. This hotel is a short 7-minute walk from Avenida Balboa, and it offers a restaurant and a bar. Another good choice for your stay in the area is Casco View Life Residences.
How many hotels can I expect to find in Santa Ana?
Expedia has 135 hotels and other accommodation options in Santa Ana to choose from, making this an ideal home base for exploring the greater Panama City area.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If you booked a non-refundable reservation, you may still be able to cancel and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to view the best options available in Santa Ana.
What is there to do in this Panama City neighbourhood?
If you're looking forward to a day of shopping in Santa Ana, consider El Machetazo Santa Ana or Avenida Balboa, and pick out the perfect souvenir. When you're sightseeing in Panama City, Albrook Shopping Mall and Avenida Central are also worth a stop.