Santa Ana Holidays

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    Save up to €185 when you book a flight and hotel together*

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    With over 300,000 hotels worldwide, it's easy to create a perfect package

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Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most. Learn more about Santa Ana
View of the Panama City Old Town

Casco Viejo

3.5/5(3 area reviews)

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

Find hotels in Casco Viejo

Top hotels in Santa Ana

Casco View Apartments

Casco View Apartments

3.5 out of 5
C. 16 Oeste Panama City Provincia de Panamá
9/10 Wonderful! (81 reviews)
Quite disappointing. The most obvious reason for the poor review is the immediate area the property is in. I read negative reviews about this but didn’t quite get the full scope of what the neighbouring properties were like until we actually stayed there. When a property is in such a rough area, ...

Reviewed on 24 Mar 2026

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Casco View Apartments
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
The price is €134 per night from 19 Apr to 20 Apr
€134
19 Apr - 20 Apr
includes taxes & fees
9/10 Wonderful! (5,148 reviews)
The hotel stay was good overall, the breakfast was excellent but I had one complaint. There was no coffee machine in the room, and when I reported it to the front desk, it was not addressed.

Reviewed on 24 Mar 2026

Hotel Riu Plaza Panama
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4 out of 5
Ave. Domingo Diaz Tocumen Panama
Fully refundable
The price is €128 per night from 23 Apr to 24 Apr
€128
23 Apr - 24 Apr
includes taxes & fees
8.6/10 Excellent! (2,493 reviews)
Clean room / staff / airport shuttle / outdoor pool

Reviewed on 24 Mar 2026

Crowne Plaza Panama Airport by IHG
See all 1,629 properties in Santa Ana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Santa Ana holiday package cost?
From as little as . Yes, you read that correctly. Our Santa Ana holiday packages are an easy way to stretch your budget further. Combine your favourite hotels, flights and rental car and explore this destination your way.
How do I get a cheap travel package to Santa Ana?
One of the easiest ways to save cash (and time) is to combine your bookings with Expedia. Flights, hotels, activities and rental cars — we've got it all. Pick and choose the combination that best fits you and see your savings grow. We know a package deal is never a one-size-fits-all. That's why Expedia offers over 550 air carriers and 1,000,000 hotels throughout the world, which lets you customize your Santa Ana holiday.
Where should I stay in Santa Ana?
Most who travel to Santa Ana include both Miraflores Locks and Metropolitan Cathedral of Panama on their bucket lists. Why not go for a hotel right near these great attractions?
What are the top hotels in Santa Ana?
If it's your first time in Santa Ana, make a reservation at Hotel Riazor or Hotel Doral. Both hotels will make you feel at home and are favourites among lots of travellers.
How far in advance should I book my Santa Ana holiday?
While prices change from time to time, we generally suggest booking your seats as soon as possible. Most international airfares are available on Expedia up to a year in advance. If circumstances have left you booking late, you might still be in luck. Low prices to Santa Ana sometimes occur only weeks before departure.
What does an Expedia Santa Ana travel package include?
That mostly depends on you. You can select from a range of Santa Ana packages, such as a rental car, flight and hotel. You can also book a hotel and a flight, or a rental car and a flight. Once you've made your booking, you can add on the fun stuff like tours and activities. Whatever your perfect Santa Ana break looks like, get set to save!
What should I know before booking a Santa Ana travel package?
Discover deals to suit your budget with an Expedia package. Hotels, airfares, rental cars — we've got everything you need to plan your getaway. You'll save big dollars just for bundling your bookings. Whether you're taking off on a ski trip or getting some sun on a warm beach, your ideal getaway is only clicks away.
Can I choose my airline with a Santa Ana Expedia holiday package?
Definitely. Expedia has more than 550 airline partners to pick from globally. With all that choice at your fingertips, finding the right carrier to get you to Santa Ana shouldn't be hard.
If I'm not able to travel, can I cancel my Santa Ana holiday package?
We totally get it — life can throw you the odd curveball. If you've booked a Santa Ana holiday package and have to amend or cancel it, we're here to help. It's always worth visiting our Customer Service Portal first for information. But generally, if you've booked your package in the last 24 hours, you may be able to amend or cancel your itinerary at no cost. If it's been longer than 24 hours, your hotel, airline or car rental company may charge a fee.

Things to do

Panama City Visit an Indian town Embera and waterfall with lunch

Panama City Visit an Indian town Embera and waterfall with lunch

€42
per adult
98% of travellers recommend
Panama City Visit an Indian town Embera and waterfall with lunch
Panama Canal Half Transit Experience

Panama Canal Partial Transit

€129
per adult
86% of travellers recommend
Panama Canal Partial Transit
Panama City: POIN Swing Experience

Panama City: POIN Swing Experience

€28
per adult
100% of travellers recommend
Panama City: POIN Swing Experience
See all activities in Panama City
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.