Santa Ana Holidays

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    Save up to €185 when you book a flight and hotel together*

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    With over 300,000 hotels worldwide, it's easy to create a perfect package

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Price found within the past 48 hours. Click for updated prices.
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Bella Vista
Price was €1,013, price is now €780 per person
€780
per person
15 Mar - 19 Mar
found 1 day ago
Return flight included
Chicago (ORD) to Panama City (PTY)
9/10 Wonderful! (4,515 reviews)
Staff, complicated people, not all of them of course. Reservation for 2, only one coffee in the station, asked for two and not decaf, they stated only one packet per room, and we should give the decaf back....

Reviewed on 4 Feb 2026

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Price was €1,452, price is now €1,037 per person
€1,037
per person
15 Mar - 19 Mar
found 1 day ago
Return flight included
Chicago (ORD) to Panama City (PTY)
9/10 Wonderful! (1,002 reviews)
Location, amenities and staff were great.

Reviewed on 3 Feb 2026

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Price was €1,275, price is now €947 per person
€947
per person
15 Mar - 19 Mar
found 1 day ago
Return flight included
Chicago (ORD) to Panama City (PTY)
8.4/10 Very Good! (1,204 reviews)
Excellent service, large rooms and very clean

Reviewed on 28 Jan 2026

Dreams Playa Bonita Panama - All Inclusive

Dreams Playa Bonita Panama - All Inclusive

4 out of 5
Price was €1,670, price is now €1,285 per person
€1,285
per person
15 Mar - 19 Mar
found 1 day ago
Return flight included
Chicago (ORD) to Panama City (PTY)
7.4/10 Good! (1,002 reviews)
The rooms were clean, and the property was very nice and well kept up. The service was slower than I liked, but it’s Panamá time I guess. The food was ok, depending on what you like.

Reviewed on 2 Feb 2026

Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

4 out of 5
Price was €988, price is now €810 per person
€810
per person
15 Mar - 19 Mar
found 1 day ago
Return flight included
Chicago (ORD) to Panama City (PTY)
8.6/10 Excellent! (1,884 reviews)
everything was ok with the exception no hot water in the shower/had it in the sink but shower was without

Reviewed on 3 Feb 2026

Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most. Learn more about Santa Ana
View of the Panama City Old Town

Casco Viejo

3.5/5(3 area reviews)

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

Find hotels in Casco Viejo

Top hotels in Santa Ana

Casco View Apartments

Casco View Apartments

3.5 out of 5
C. 16 Oeste Panama City Provincia de Panamá
9/10 Wonderful! (68 reviews)
The space was very nice.

Reviewed on 1 Feb 2026

Get rates
Casco View Apartments
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
The price is €128 per night from 8 Mar to 9 Mar
€128
8 Mar - 9 Mar
includes taxes & fees
9/10 Wonderful! (4,897 reviews)
Everything was absolutely amazing.

Reviewed on 30 Jan 2026

Hotel Riu Plaza Panama
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4 out of 5
Ave. Domingo Diaz Tocumen Panama
Fully refundable
The price is €110 per night from 3 Mar to 4 Mar
€110
3 Mar - 4 Mar
includes taxes & fees
8.4/10 Very Good! (2,421 reviews)
Clean room, acceptable dining area with good service. Pool area is great

Reviewed on 29 Jan 2026

Crowne Plaza Panama Airport by IHG
See all 1,712 properties in Santa Ana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Santa Ana holiday package cost?
From as little as €780. Yes, you read that correctly. Our Santa Ana holiday packages are an easy way to stretch your budget further. Combine your favourite hotels, flights and rental car and explore this destination your way.
How do I get a cheap travel package to Santa Ana?
One of the easiest ways to save cash (and time) is to combine your bookings with Expedia. Flights, hotels, activities and rental cars — we've got it all. Pick and choose the combination that best fits you and see your savings grow. We know a package deal is never a one-size-fits-all. That's why Expedia offers over 550 air carriers and 1,000,000 hotels throughout the world, which lets you customize your Santa Ana holiday.
Where should I stay in Santa Ana?
Most who travel to Santa Ana include both Miraflores Locks and Metropolitan Cathedral of Panama on their bucket lists. Why not go for a hotel right near these great attractions?
What are the top hotels in Santa Ana?
If it's your first time in Santa Ana, make a reservation at Hotel Riazor or Hotel Doral. Both hotels will make you feel at home and are favourites among lots of travellers.
How far in advance should I book my Santa Ana holiday?
While prices change from time to time, we generally suggest booking your seats as soon as possible. Most international airfares are available on Expedia up to a year in advance. If circumstances have left you booking late, you might still be in luck. Low prices to Santa Ana sometimes occur only weeks before departure.
What does an Expedia Santa Ana travel package include?
That mostly depends on you. You can select from a range of Santa Ana packages, such as a rental car, flight and hotel. You can also book a hotel and a flight, or a rental car and a flight. Once you've made your booking, you can add on the fun stuff like tours and activities. Whatever your perfect Santa Ana break looks like, get set to save!
What should I know before booking a Santa Ana travel package?
Discover deals to suit your budget with an Expedia package. Hotels, airfares, rental cars — we've got everything you need to plan your getaway. You'll save big dollars just for bundling your bookings. Whether you're taking off on a ski trip or getting some sun on a warm beach, your ideal getaway is only clicks away.
Can I choose my airline with a Santa Ana Expedia holiday package?
Definitely. Expedia has more than 550 airline partners to pick from globally. With all that choice at your fingertips, finding the right carrier to get you to Santa Ana shouldn't be hard.
If I'm not able to travel, can I cancel my Santa Ana holiday package?
We totally get it — life can throw you the odd curveball. If you've booked a Santa Ana holiday package and have to amend or cancel it, we're here to help. It's always worth visiting our Customer Service Portal first for information. But generally, if you've booked your package in the last 24 hours, you may be able to amend or cancel your itinerary at no cost. If it's been longer than 24 hours, your hotel, airline or car rental company may charge a fee.

Things to do

Panama City: Poin Glass Observation Deck Ticket with VR Tour

Panama City: Poin Glass Observation Deck Ticket with VR Tour

€27
per adult
100% of travellers recommend
Panama City: Poin Glass Observation Deck Ticket with VR Tour
All-inclusive 8-hour catamaran tour to Isla Taboga from Panama City

All-inclusive 8-hour catamaran tour to Isla Taboga from Panama City

€82
per adult
96% of travellers recommend
All-inclusive 8-hour catamaran tour to Isla Taboga from Panama City
Tower

Archaeological Site. Admission ticket to Panama La Vieja

€12
per adult
Archaeological Site. Admission ticket to Panama La Vieja
See all activities in Panama City
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.