A gazebo with columns, a large tree with hanging roots, and a building in the background.

Panama City Hotel Guide. Hotels in Santa Ana, Panama City, Panama

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
30 Oct - 1 Nov
Next weekend
6 Nov - 8 Nov

Filter by

Property class

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Santa Ana hotels

A hotel hallway with wooden doors, a central staircase, and potted plants.

1. Hotel Caracas - Casco Viejo

Hotel Caracas - Casco Viejo
3.0 star property
Santa Ana
7.6 out of 10, Good, (23 reviews)
"great staff"
United States
Keith
The price is €50
includes taxes & fees
5 Nov - 6 Nov
Hotel Caracas - Casco Viejo
A modern indoor pool area with clear blue water, lounge chairs, and a wall of plants.

2. Casco View Life Residences

Casco View Life Residences
4.0 star property
Santa Ana
9.0 out of 10, Wonderful, (113 reviews)
"Amazing location and comfort"
United States
Ruben
The price is €109
includes taxes & fees
29 Oct - 30 Oct
Casco View Life Residences
A hotel room with a bed, a chair, a painting, and a plant.

3. Hostal La Cigarra

Hostal La Cigarra
2.0 star property
Santa Ana
7.6 out of 10, Good, (76 reviews)
"Excellent staff, close to metro and embassies. A good location, good room for a great price. I would stay again. "
United Kingdom
Mark
The price is €29
includes taxes & fees
28 Oct - 29 Oct
Hostal La Cigarra
A hotel room with two beds, a bathroom, and a shower area.

4. Hotel Riazor

Hotel Riazor
3.0 star property
Santa Ana
3.8 out of 10, (11 reviews)
"Rough neighborhood "
Canada
Del
The price is €27
includes taxes & fees
29 Oct - 30 Oct
Hotel Riazor
A hotel room with a large bed, a window with curtains, a city view, and a lamp.

5. Hotel República

Hotel República
2.0 star property
Santa Ana
6.8 out of 10, (197 reviews)
"Good location. Walking distance to shops and public transport."
Canada
Danilo
The price is €82
includes taxes & fees
28 Oct - 29 Oct
Hotel República
A neatly made bed with a teal bedspread, two pillows, and two towels folded at the foot of the bed. There is a wooden nightstand with a phone and a small table beside the bed.

6. ART CASCO The Hotel

ART CASCO The Hotel
2.0 star property
Santa Ana
6.0 out of 10, (15 reviews)
"Walkable location and free secure parking! The price is really affordable, but the condition of the hotel is not the best"
United States
Eldris
The price is €36
includes taxes & fees
28 Oct - 29 Oct
ART CASCO The Hotel
A rooftop pool with a view of the cityscape, lounge chairs, and potted plants.

7. Casco View Apartments & Rooftop Pool

Casco View Apartments & Rooftop Pool
3.5 star property
Santa Ana
The price is €84
includes taxes & fees
29 Oct - 30 Oct
Casco View Apartments & Rooftop Pool
A modern hotel room with a large bed, a sofa, a TV, and a view of the city.

8. La Manzana Barrio Vivo by Wynwood

La Manzana Barrio Vivo by Wynwood
3.0 star property
Santa Ana
7.6 out of 10, Good, (20 reviews)
"Staff was helpful and its in a great location surrounded by stores and lots of views"
United States
Storme
The price is €104
includes taxes & fees
2 Nov - 3 Nov
La Manzana Barrio Vivo by Wynwood
A high-rise building with a glass balcony overlooking a city skyline and a body of water.

9. Room-sofa Bed Stay Rooftop Pool & Gym, A

Room-sofa Bed Stay Rooftop Pool & Gym, A
2.0 star property
Santa Ana
2.0 out of 10, (1 review)
"You pay for a space in the apartment, it’s not the whole apartment be careful. The owner or whoever manages doesn’t give care about you as costumers they just want the money"
United States
Cristian Camilo Betancur
The price is €95
includes taxes & fees
28 Oct - 29 Oct
Room-sofa Bed Stay Rooftop Pool & Gym, A
A hotel lobby with a reception desk, seating area, and a visible sign for 'PRINCIPES HOTEL & SQUITES'.

10. Principe Hotel and Suites

Principe Hotel and Suites
3.0 star property
El Cangrejo, 3.9 km from Santa Ana
9.0 out of 10, Wonderful, (2,125 reviews)
"Very large suites, comfortable beds, great A/C"
United States
Willis
The price is €58
includes taxes & fees
28 Oct - 29 Oct
Principe Hotel and Suites
A hotel room with a large bed, a painting on the wall, a door, and a small table with a lamp.

11. Tantalo Hotel

Tantalo Hotel
3.5 star property
San Felipe, 0.7 km from Santa Ana
8.8 out of 10, Excellent, (340 reviews)
"Staff was amazing! Rooms are large with all the amenities you would need! Beautiful art and aesthetic to every room!"
United States
Cynthia
The price is €77
includes taxes & fees
22 Nov - 23 Nov
Tantalo Hotel
A spacious living room with blue sofas, a marble coffee table, and framed pictures on the walls.

12. Hotel Magnolia Boutique

Hotel Magnolia Boutique
2.0 star property
San Felipe, 0.7 km from Santa Ana
8.8 out of 10, Excellent, (535 reviews)
"Fantastic location and very friendly, helpful staff. Highly recommended!"
Canada
Cathy
The price is €93
includes taxes & fees
1 Nov - 2 Nov
Hotel Magnolia Boutique
A modern lobby with a chandelier, seating area, reception desk, and a staircase.

13. The Executive Hotel

The Executive Hotel
3.5 star property
Campo Alegre, 3.2 km from Santa Ana
9.2 out of 10, Wonderful, (1,300 reviews)
"Good location, great breakfast. Clean rooms and helpful staff"
United States
Frank
The price is €79
includes taxes & fees
22 Nov - 23 Nov
The Executive Hotel
A balcony with a view of a cityscape, including a river and a bridge.

14. Oasis Hotel

Oasis Hotel
3.0 star property
San Felipe, 0.6 km from Santa Ana
8.6 out of 10, Excellent, (160 reviews)
"I enjoyed everything about my stay,the view was amazing and the location was perfect!! I would definitely stay here in the future!!"
United States
Charles
The price is €58
includes taxes & fees
12 Nov - 13 Nov
Oasis Hotel
A rooftop pool with lounge chairs and a city skyline view.

15. TRYP by Wyndham Panamá Centro

TRYP by Wyndham Panamá Centro
3.5 star property
El Cangrejo, 3.5 km from Santa Ana
9.0 out of 10, Wonderful, (1,007 reviews)
"I love the tryp i was well taken care of and thank you expedia for my voucher ."
United States
Bert
The price is €81
includes taxes & fees
16 Nov - 17 Nov
TRYP by Wyndham Panamá Centro
A hotel entrance with a covered walkway, large windows, and a well-maintained garden area.

16. Hotel Milan

Hotel Milan
3.0 star property
El Cangrejo, 3.6 km from Santa Ana
9.0 out of 10, Wonderful, (598 reviews)
"Hotel is maintained and managed well, close to many restaurants and transportation."
United States
Michael
The price is €39
includes taxes & fees
2 Nov - 3 Nov
Hotel Milan
A modern interior with a colorful mural, hanging plants, and a staircase.

17. Canova

Canova
3.0 star property
Calidonia, 1.4 km from Santa Ana
8.2 out of 10, Very good, (218 reviews)
"A great no frills hotel choice. My first choice when solo traveling to Panama city. The rooms are clean and comfortable and the staff is friendly."
United States
george
The price is €29
includes taxes & fees
28 Oct - 29 Oct
Canova
A modern building with a glass facade, a curved structure, and a flat roof.

18. Decapolis Hotel Panama City

Decapolis Hotel Panama City
4.0 star property
Punta Paitilla, 3.6 km from Santa Ana
8.6 out of 10, Excellent, (1,727 reviews)
"Food was limited, but I enjoyed our stay ..3"
United States
Mechalia
The price is €87
includes taxes & fees
31 Oct - 1 Nov
Decapolis Hotel Panama City
A rooftop pool with sun loungers and umbrellas, surrounded by palm trees and modern buildings.

19. Hotel Riu Plaza Panama

Hotel Riu Plaza Panama
5.0 star property
Campo Alegre, 3.6 km from Santa Ana
9.0 out of 10, Wonderful, (6,142 reviews)
"Great clean hotel! Very nice location"
Canada
Sean
The price is €118
includes taxes & fees
22 Nov - 23 Nov
Hotel Riu Plaza Panama
A rooftop pool with sun loungers and a city skyline in the background.

20. Waymore Hotel Spa & Casino

Waymore Hotel Spa & Casino
4.0 star property
El Cangrejo, 3.5 km from Santa Ana
9.0 out of 10, Wonderful, (1,216 reviews)
"Breakfast, Cafe, was just perfect location"
United States
Bruno
The price is €142
includes taxes & fees
5 Nov - 6 Nov
Waymore Hotel Spa & Casino
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in Santa Ana

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A modern indoor pool area with clear blue water, lounge chairs, and a wall of plants.
Casco View Life Residences
4.0 star property
9.0
Wonderful
113 reviews
View
A hotel hallway with wooden doors, a central staircase, and potted plants.
Hotel Caracas - Casco Viejo
3.0 star property
7.6
Good
23 reviews
View
A hotel room with a bed, a chair, a painting, and a plant.
Hostal La Cigarra
2.0 star property
7.6
Good
76 reviews
View
A modern hotel room with a large bed, a sofa, a TV, and a view of the city.
La Manzana Barrio Vivo by Wynwood
3.0 star property
7.6
Good
20 reviews
View
A hotel room with a large bed, a window with curtains, a city view, and a lamp.
Hotel República
2.0 star property
6.8
197 reviews
View

Where to stay in Santa Ana

Find the best Santa Ana areas for the activities you enjoy most.
A coastal cityscape with a prominent church tower, a river, and distant mountains.

Casco Viejo

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

A modern, spiraling skyscraper with a unique design, surrounded by other buildings in an urban setting.
Photo by Fabiola Tile
Open Photo by Fabiola Tile

Bella Vista

Travellers love Bella Vista for its popular shops, and you can see more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina Station. You might spend time checking out top sights like Via Espana and Iglesia del Carmen.

A city skyline with modern high-rise buildings and a river in the foreground.

El Cangrejo

The ample dining options and casino gaming are top of the list for many visitors to El Cangrejo. A stop by Via Espana or Crown Casino might round out your trip.

A bridge over a body of water with several boats.

San Francisco

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

A building with three arched windows, a balcony with wrought iron railings, and a tiled roof.

San Felipe

While visiting San Felipe, you might make a stop by sights like Independence Square and Interoceanic Canal Museum.

Top Santa Ana Hotel Reviews

Waymore Hotel Spa & Casino

Waymore Hotel Spa & Casino

10/10 Excellent
"Súper lindo, elegante y el desayuno lo mejor 😍"
Vanessa 3-night trip
Posted less than an hour ago
Waymore Hotel Spa & Casino

Frequently asked questions

What's it like in Santa Ana?
Santa Ana is a neighbourhood that travellers like for its seafood restaurants, shopping and parks. Are you looking for Santa Ana travel tips? Make sure that you visit Avenida Balboa and El Machetazo Santa Ana while you're in the neighbourhood.
Where is the best hotel for a stay in Santa Ana?
Based on our traveller data, Hotel Caracas - Casco Viejo is one of the top choices for your stay in Santa Ana. This hotel is a short 7-minute walk from Avenida Balboa, and it offers a restaurant and a bar. Another good choice for your stay in the area is Casco View Life Residences.
How many hotels can I expect to find in Santa Ana?
Expedia has 135 hotels and other accommodation options in Santa Ana to choose from, making this an ideal home base for exploring the greater Panama City area.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If you booked a non-refundable reservation, you may still be able to cancel and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to view the best options available in Santa Ana.
What is there to do in this Panama City neighbourhood?
If you're looking forward to a day of shopping in Santa Ana, consider El Machetazo Santa Ana or Avenida Balboa, and pick out the perfect souvenir. When you're sightseeing in Panama City, Albrook Shopping Mall and Avenida Central are also worth a stop.