A gazebo with columns, a large tree with hanging roots, and a building in the background.

Panama City Hotel Guide. Hotels in Santa Ana, Panama City, Panama

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
18 Sept - 20 Sept
In two weeks
25 Sept - 27 Sept

Filter by

Star rating

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Santa Ana hotels

A modern indoor pool area with clear blue water, lounge chairs, and a wall of plants.

1. Casco View Life Residences

Casco View Life Residences
4.0 star property
Santa Ana
9.0 out of 10, Wonderful, (106 reviews)
"Always an amazing stay"
United States
chris
The price is €81
includes taxes & fees
23 Sept - 24 Sept
Casco View Life Residences
A corridor with a bench, a staircase, and a mural of a bird.

2. Hotel Caracas - Casco Viejo

Hotel Caracas - Casco Viejo
3.0 star property
Santa Ana
8.0 out of 10, Very good, (11 reviews)
"great staff"
United States
Keith
The price is €35
includes taxes & fees
12 Oct - 13 Oct
Hotel Caracas - Casco Viejo
A restaurant with a long counter, chairs, and tables. There are plants and lights decorating the space.

3. Hostal La Cigarra

Hostal La Cigarra
2.0 star property
Santa Ana
7.6 out of 10, Good, (73 reviews)
"Excellent staff, close to metro and embassies. A good location, good room for a great price. I would stay again. "
United Kingdom
Mark
The price is €29
includes taxes & fees
6 Oct - 7 Oct
Hostal La Cigarra
A hotel entrance with a green facade and a metal fence.

4. ART CASCO The Hotel

ART CASCO The Hotel
2.0 star property
Santa Ana
6.2 out of 10, (12 reviews)
"Walkable location and free secure parking! The price is really affordable, but the condition of the hotel is not the best"
United States
Eldris
The price is €23
includes taxes & fees
13 Sept - 14 Sept
ART CASCO The Hotel
A modern hotel room with a large bed, a sofa, a TV, and a view of the city.

5. La Manzana Barrio Vivo by Wynwood

La Manzana Barrio Vivo by Wynwood
3.0 star property
Santa Ana
7.6 out of 10, Good, (18 reviews)
"Very clean and safe property"
United States
Javier Alberto Lindauer
The price is €83
includes taxes & fees
15 Sept - 16 Sept
La Manzana Barrio Vivo by Wynwood
A hotel room with a large bed, a window with curtains, a city view, and a lamp.

6. Hotel República

Hotel República
2.0 star property
Santa Ana
6.8 out of 10, (197 reviews)
"Good location. Walking distance to shops and public transport."
Canada
Danilo
The price is €79
includes taxes & fees
10 Oct - 11 Oct
Hotel República
A bar area with a curved counter, multiple seating options, and a variety of bottles and glasses on display.

7. Hotel Riazor

Hotel Riazor
3.0 star property
Santa Ana
3.8 out of 10, (11 reviews)
"Rough neighborhood "
Canada
Del
Hotel Riazor

8. Room-sofa Bed Stay Rooftop Pool & Gym, A

Room-sofa Bed Stay Rooftop Pool & Gym, A
2.0 star property
Santa Ana
2.0 out of 10, (1 review)
"You pay for a space in the apartment, it’s not the whole apartment be careful. The owner or whoever manages doesn’t give care about you as costumers they just want the money"
United States
Cristian Camilo Betancur
The price is €99
includes taxes & fees
13 Sept - 14 Sept
Room-sofa Bed Stay Rooftop Pool & Gym, A
A spacious living room with blue sofas, a marble coffee table, and framed pictures on the walls.

9. Hotel Magnolia Boutique

Hotel Magnolia Boutique
2.0 star property
San Felipe, 0.7 km from Santa Ana
8.8 out of 10, Excellent, (514 reviews)
"Super nice hotel, very clean and location is amazing"
United States
Boris
The price is €76
includes taxes & fees
14 Sept - 15 Sept
Hotel Magnolia Boutique
A wooden door with a number plate, a black and white striped bag, and a lantern on the ground.

10. Hotel Casa Panamá

Hotel Casa Panamá
4.0 star property
San Felipe, 0.6 km from Santa Ana
7.6 out of 10, Good, (753 reviews)
"Beautifully decorated. Great location! Staff very helpful."
United States
Mariana
The price is €59
includes taxes & fees
13 Oct - 14 Oct
Hotel Casa Panamá
A spacious indoor area with high ceilings, large windows, and multiple dining tables.

11. American Trade Hotel

American Trade Hotel
4.5 star property
San Felipe, 0.7 km from Santa Ana
9.4 out of 10, Exceptional, (809 reviews)
"Wonderful building and location. Spacious room. Wish we could have stayed longer"
United States
James
The price is €176
includes taxes & fees
14 Sept - 15 Sept
American Trade Hotel
A multi-story building with balconies, arched windows, and decorative railings.

12. Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo
4.0 star property
San Felipe, 0.9 km from Santa Ana
9.0 out of 10, Wonderful, (1,013 reviews)
"Great location and nice hotel."
United States
Olga
The price is €174
includes taxes & fees
11 Oct - 12 Oct
Central Hotel Panama Casco Viejo
A spacious outdoor patio with wicker furniture, potted plants, and umbrellas providing shade.

13. Hotel San Felipe

Hotel San Felipe
4.0 star property
San Felipe, 0.7 km from Santa Ana
9.4 out of 10, Exceptional, (452 reviews)
"Everything was excellent"
United States
ORLANDO RICARDO
The price is €120
includes taxes & fees
13 Sept - 14 Sept
Hotel San Felipe
A rooftop bar with a city skyline view, outdoor seating, and a bar area with bottles and glasses.

14. Tantalo Hotel

Tantalo Hotel
3.5 star property
San Felipe, 0.7 km from Santa Ana
8.8 out of 10, Excellent, (332 reviews)
"Great location, friendly and helpful staff, very spacious room, very clean, Great breakfast because we could order straight from the in-house restaurant’s menu. Would definitely stay again."
United States
Cassondra
The price is €94
includes taxes & fees
23 Sept - 24 Sept
Tantalo Hotel
A hotel room with a bed, a desk with a computer, a chair, a mirror, and a staircase.

15. Hotel Bardot Boutique

Hotel Bardot Boutique
3.0 star property
San Felipe, 1.1 km from Santa Ana
9.0 out of 10, Wonderful, (49 reviews)
"Clean room, nice staff!!"
United States
justin
The price is €79
includes taxes & fees
23 Sept - 24 Sept
Hotel Bardot Boutique
A balcony with a view of a cityscape, including a river and a bridge.

16. Oasis Hotel

Oasis Hotel
3.0 star property
San Felipe, 0.6 km from Santa Ana
8.6 out of 10, Excellent, (153 reviews)
"Great stay! Highly recommend"
United States
Gregg
The price is €56
includes taxes & fees
30 Sept - 1 Oct
Oasis Hotel
A restaurant with multiple dining tables, chairs, and a central water feature.

17. Hotel La Compañía Casco Antiguo

Hotel La Compañía Casco Antiguo
4.5 star property
San Felipe, 0.9 km from Santa Ana
9.8 out of 10, Exceptional, (349 reviews)
"One of our favorite stays. Right in old town, walking distance to everything. Beautiful room, beautifal courtyard. Their on-site restaurants were also excellent."
United States
Reid
The price is €265
includes taxes & fees
9 Oct - 10 Oct
Hotel La Compañía Casco Antiguo
A grand, illuminated building with a symmetrical facade, multiple balconies, and a prominent entrance.

18. La Concordia Boutique Hotel

La Concordia Boutique Hotel
4.0 star property
San Felipe, 0.5 km from Santa Ana
9.6 out of 10, Exceptional, (237 reviews)
"Very nice rooms and bathrooms. Great location in Casco Viejo"
Canada
Shrinand
The price is €191
includes taxes & fees
8 Oct - 9 Oct
La Concordia Boutique Hotel
A restaurant interior with checkered flooring, wooden tables, wicker chairs, and hanging wicker lamps.

19. Amarla Boutique Hotel Casco Viejo Adults Only

Amarla Boutique Hotel Casco Viejo Adults Only
3.0 star property
San Felipe, 1 km from Santa Ana
9.6 out of 10, Exceptional, (142 reviews)
"The location was great & staff was cool too!"
United States
Kennedi
The price is €224
includes taxes & fees
13 Sept - 14 Sept
Amarla Boutique Hotel Casco Viejo Adults Only
A resort with a pool area, lounge chairs, and a view of a bridge at night.

20. Radisson Hotel Panama Canal

Radisson Hotel Panama Canal
4.5 star property
Amador, 2.3 km from Santa Ana
8.6 out of 10, Excellent, (1,002 reviews)
"It was a nice getaway if you didn't want to be directly in the city"
United Kingdom
Samantha
The price is €90
includes taxes & fees
25 Sept - 26 Sept
Radisson Hotel Panama Canal
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in Santa Ana

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A modern indoor pool area with clear blue water, lounge chairs, and a wall of plants.
Casco View Life Residences
4.0 star property
9.0
Wonderful
106 reviews
View
A corridor with a bench, a staircase, and a mural of a bird.
Hotel Caracas - Casco Viejo
3.0 star property
8.0
Very good
11 reviews
View
A restaurant with a long counter, chairs, and tables. There are plants and lights decorating the space.
Hostal La Cigarra
2.0 star property
7.6
Good
73 reviews
View
A modern hotel room with a large bed, a sofa, a TV, and a view of the city.
La Manzana Barrio Vivo by Wynwood
3.0 star property
7.6
Good
18 reviews
View
A hotel room with a large bed, a window with curtains, a city view, and a lamp.
Hotel República
2.0 star property
6.8
197 reviews
View

Where to stay in Santa Ana

Find the best Santa Ana areas for the activities you enjoy most.
A coastal cityscape with buildings, a hill with a church, and a clear blue sky.

Casco Viejo

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

A coastal cityscape with high-rise buildings and a curved bay.
Photo by Freddy Dominguez
Open Photo by Freddy Dominguez

Bella Vista

Travellers love Bella Vista for its popular shops, and you can see more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina Station. You might spend time checking out top sights like Via Espana and Iglesia del Carmen.

A city skyline with modern high-rise buildings and a river in the foreground.

El Cangrejo

The ample dining options and casino gaming are top of the list for many visitors to El Cangrejo. A stop by Via Espana or Crown Casino might round out your trip.

A bridge over a body of water with several boats.

San Francisco

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

A coastal cityscape with high-rise buildings, a calm sea, and a rocky shoreline.

Calidonia

Calidonia is a destination travellers like for its shopping, and you might hop aboard the metro at Lotería Station or Santo Tomás Station to explore sights like Via Espana.

Top Santa Ana Hotel Reviews

Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

10/10 Excellent
"Very good hotel if you have an early morning flight. My room and bathroom were spacious. The bed was very comfortable. The free airport shuttle was a bonus. I didn’t use the pool or eat in the restaurant so I can’t comment on these."
Susan 1-night trip
Posted 11 hours ago
Crowne Plaza Panama Airport by IHG

Frequently asked questions

What's it like in Santa Ana?
Santa Ana is a neighbourhood that travellers like for its seafood restaurants, shopping and parks. Are you looking for Santa Ana travel tips? Make sure that you visit Avenida Balboa and El Machetazo Santa Ana while you're in the neighbourhood.
Where is the best hotel for a stay in Santa Ana?
Based on our traveller data, Hotel Caracas - Casco Viejo is one of the top choices for your stay in Santa Ana. This hotel is a short 7-minute walk from Avenida Balboa, and it offers a restaurant and a bar. Another good choice for your stay in the area is Casco View Apartments.
How many hotels can I expect to find in Santa Ana?
Expedia has 128 hotels and other accommodation options in Santa Ana to choose from, making this an ideal home base for exploring the greater Panama City area.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If you booked a non-refundable reservation, you may still be able to cancel and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to view the best options available in Santa Ana.
What is there to do in this Panama City neighbourhood?
If you're looking forward to a day of shopping in Santa Ana, consider El Machetazo Santa Ana or Avenida Balboa, and pick out the perfect souvenir. When you're sightseeing in Panama City, Albrook Shopping Mall and Avenida Central are also worth a stop.