Portsmouth Hotel Guide - Portsmouth Regional Hospital hotels in Portsmouth, United States of America.

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Our top choices for Portsmouth Regional Hospital hotels

Reception
Hotel Thaxter

Hotel Thaxter

Hotel Thaxter
4.0 star property
Downtown, 2.7 km from Portsmouth Regional Hospital
9.8 out of 10, Exceptional, (227)
"Hotel Thaxter is very nice. The room was clean, modern with a very nice bathroom, large shower, comfortable bed, and friendly, attentive staff."
United States
Paul
Hotel Thaxter
Exterior
Martin Hill Inn

Martin Hill Inn

Martin Hill Inn
3.5 star property
West End, 2 km from Portsmouth Regional Hospital
9.4 out of 10, Exceptional, (139)
"Great hotel with cute garden ! We stayed in the cathedral room. Very spacious, nicely decorated and comfortable!"
United States
Maria
Martin Hill Inn
Reception
Hampton Inn & Suites Portsmouth Downtown

Hampton Inn & Suites Portsmouth Downtown

Hampton Inn & Suites Portsmouth Downtown
3.0 star property
Downtown, 2.8 km from Portsmouth Regional Hospital
9.6 out of 10, Exceptional, (1091)
"Pleasant staff, clean room, nice gym facilities. "
United States
Danielle
The price is €113
includes taxes & fees
28 Dec - 29 Dec
Hampton Inn & Suites Portsmouth Downtown
Front of property
The Davenport Inn

The Davenport Inn

The Davenport Inn
4.0 star property
Downtown, 2.7 km from Portsmouth Regional Hospital
9.8 out of 10, Exceptional, (45)
"Absolutely loved this place! Our room was stunning, the staff was wonderful, and had such a great selection of little snacks. I can’t wait for another opportunity to stay here! "
United States
Mariana
The price is €323
includes taxes & fees
22 Dec - 23 Dec
The Davenport Inn
Free daily buffet breakfast
Fairfield Inn by Marriott Portsmouth-Seacoast

Fairfield Inn by Marriott Portsmouth-Seacoast

Fairfield Inn by Marriott Portsmouth-Seacoast
2.5 star property
0.9 km from Portsmouth Regional Hospital
8.6 out of 10, Excellent, (1003)
"Breakfast was great, staff friendly, and room comfortable "
United States
Linda
The price is €84
includes taxes & fees
28 Dec - 29 Dec
Fairfield Inn by Marriott Portsmouth-Seacoast
Front of property
The Hotel Portsmouth

The Hotel Portsmouth

The Hotel Portsmouth
3.0 star property
Downtown, 2.7 km from Portsmouth Regional Hospital
9.4 out of 10, Exceptional, (1002)
"Great location, easy parking, friendly staff. nice property!"
United States
Ralph
The price is €149
includes taxes & fees
1 Jan - 2 Jan 2026
The Hotel Portsmouth
Premier Apartment, 1 King Bed with Sofa bed, Non Smoking, Kitchen | Private kitchen
The Inn Downtown

The Inn Downtown

The Inn Downtown
3.5 star property
Downtown, 2.9 km from Portsmouth Regional Hospital
9.6 out of 10, Exceptional, (108)
"We stayed in the penthouse suite. The room was very spacious and clean. The bed was very comfortable as well. We will definitely be staying here again. "
United States
Mark
The price is €179
includes taxes & fees
6 Jan - 7 Jan 2026
The Inn Downtown
54-inch flat-screen TV with cable channels, TV, Netflix
The Sailmaker's House

The Sailmaker's House

The Sailmaker's House
3.5 star property
Downtown, 3.1 km from Portsmouth Regional Hospital
9.6 out of 10, Exceptional, (368)
"beautiful and historic architecture! "
United States
RICHARD PHILLIPS
The Sailmaker's House
Lobby
Howard Johnson by Wyndham Portsmouth

Howard Johnson by Wyndham Portsmouth

Howard Johnson by Wyndham Portsmouth
2.0 star property
1.5 km from Portsmouth Regional Hospital
8.6 out of 10, Excellent, (1001)
"An awesome place to stay!"
United States
Nicholas
The price is €79
includes taxes & fees
23 Dec - 24 Dec
Howard Johnson by Wyndham Portsmouth
Restaurant
AC Hotel by Marriott Portsmouth

AC Hotel by Marriott Portsmouth

AC Hotel by Marriott Portsmouth
3.5 star property
North End, 2.8 km from Portsmouth Regional Hospital
9.2 out of 10, Wonderful, (952)
"Very nice hotel "
United States
Yoanny
The price is €148
includes taxes & fees
23 Dec - 24 Dec
AC Hotel by Marriott Portsmouth
Exterior
Port Inn and Suites Portsmouth, an Ascend Collection Hotel

Port Inn and Suites Portsmouth, an Ascend Collection Hotel

Port Inn and Suites Portsmouth, an Ascend Collection Hotel
3.0 star property
1 km from Portsmouth Regional Hospital
8.2 out of 10, Very good, (1003)
"Nice location and really close to downtown. "
United States
Claire
The price is €83
includes taxes & fees
1 Jan - 2 Jan 2026
Port Inn and Suites Portsmouth, an Ascend Collection Hotel
Reception
Courtyard by Marriott in Portsmouth

Courtyard by Marriott in Portsmouth

Courtyard by Marriott in Portsmouth
3.0 star property
1.8 km from Portsmouth Regional Hospital
8.6 out of 10, Excellent, (932)
"This is my favorite place to stay in the Portsmouth area. "
United States
Gwendolyne
The price is €103
includes taxes & fees
28 Dec - 29 Dec
Courtyard by Marriott in Portsmouth
Indoor pool, pool loungers
Hampton Inn Portsmouth Central

Hampton Inn Portsmouth Central

Hampton Inn Portsmouth Central
2.5 star property
2.6 km from Portsmouth Regional Hospital
8.8 out of 10, Excellent, (1002)
"Great room & pool."
United States
Cathy
The price is €90
includes taxes & fees
27 Dec - 28 Dec
Hampton Inn Portsmouth Central
Desk, laptop workspace, blackout curtains, iron/ironing board
Residence Inn by Marriott Portsmouth Downtown/ Waterfront

Residence Inn by Marriott Portsmouth Downtown/ Waterfront

Residence Inn by Marriott Portsmouth Downtown/ Waterfront
3.0 star property
Downtown, 2.9 km from Portsmouth Regional Hospital
9.0 out of 10, Wonderful, (1001)
"Will definitely stay here again!"
United States
Mary
The price is €118
includes taxes & fees
28 Dec - 29 Dec
Residence Inn by Marriott Portsmouth Downtown/ Waterfront
Outdoor dining
Homewood Suites By Hilton Portsmouth Downtown

Homewood Suites By Hilton Portsmouth Downtown

Homewood Suites By Hilton Portsmouth Downtown
3.0 star property
Downtown, 2.6 km from Portsmouth Regional Hospital
8.8 out of 10, Excellent, (33)
"Clean ever where, knowledgeable and friendly staff and great breakfast."
United States
Brenda
The price is €98
includes taxes & fees
1 Jan - 2 Jan 2026
Homewood Suites By Hilton Portsmouth Downtown
Business centre
Quality Inn Portsmouth West End

Quality Inn Portsmouth West End

Quality Inn Portsmouth West End
2.5 star property
Elwyn Park, 2.4 km from Portsmouth Regional Hospital
8.6 out of 10, Excellent, (1001)
"Nice clean hotel. "
United States
Michael
The price is €107
includes taxes & fees
22 Dec - 23 Dec
Quality Inn Portsmouth West End
Individually furnished, blackout curtains, iron/ironing board
Holiday Inn Portsmouth by IHG

Holiday Inn Portsmouth by IHG

Holiday Inn Portsmouth by IHG
3.0 star property
1.4 km from Portsmouth Regional Hospital
8.0 out of 10, Very good, (1002)
"Great stay"
United States
Kim
The price is €80
includes taxes & fees
25 Dec - 26 Dec
Holiday Inn Portsmouth by IHG
Terrace/patio
Homewood Suites by Hilton Portsmouth

Homewood Suites by Hilton Portsmouth

Homewood Suites by Hilton Portsmouth
3.0 star property
2.9 km from Portsmouth Regional Hospital
8.6 out of 10, Excellent, (1000)
"Very nice staff, very clean, nice breakfast and modern amenities."
United States
Paul
The price is €87
includes taxes & fees
4 Jan - 5 Jan 2026
Homewood Suites by Hilton Portsmouth
Meeting facility
Sheraton Portsmouth Harborside Hotel

Sheraton Portsmouth Harborside Hotel

Sheraton Portsmouth Harborside Hotel
3.5 star property
Downtown, 2.9 km from Portsmouth Regional Hospital
8.6 out of 10, Excellent, (1001)
"Friendly staff, great view and the best clam chowder I have ever had. And I am big fan of clam chowder. "
United States
Tim
The price is €141
includes taxes & fees
28 Dec - 29 Dec
Sheraton Portsmouth Harborside Hotel
Aerial view
Hilton Garden Inn Portsmouth Downtown

Hilton Garden Inn Portsmouth Downtown

Hilton Garden Inn Portsmouth Downtown
3.0 star property
Downtown, 2.9 km from Portsmouth Regional Hospital
8.4 out of 10, Very good, (190)
"Clean and great location "
United States
Maria
The price is €106
includes taxes & fees
11 Jan - 12 Jan 2026
Hilton Garden Inn Portsmouth Downtown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Portsmouth Regional Hospital Hotel Reviews

Hilton Garden Inn Portsmouth Downtown

Hilton Garden Inn Portsmouth Downtown

10/10 Excellent
"Clean and great location "
Maria 1-night trip
Posted 4 days ago
Hilton Garden Inn Portsmouth Downtown

Hotels near other Portsmouth Regional Hospital attractions

Portsmouth_JacksonHouseMuseum_6079673_04

Jackson House Museum

You can browse the exhibits at Jackson House Museum, a museum with a storied past, during your travels to Portsmouth. Stroll along the seaside or visit the shops in the area.
See properties
Portsmouth_RundletMayHouse_6333288_02

Rundlet-May House

Learn about the local history of Portsmouth when you take a trip to Rundlet-May House. Stroll along the waterfront or visit the shops in the area.
See properties

Frequently asked questions

What's the area like around Portsmouth Regional Hospital?
Portsmouth Regional Hospital is located in Portsmouth. This historic area is known for its beautiful beaches and major shopping area. If you're looking for a convenient place to stay, take a look at the 8 hotels and other accommodation options you'll find within a mile.
Where is the best place to stay near Portsmouth Regional Hospital?
Fairfield Inn by Marriott Portsmouth-Seacoast is one of the top choices for your stay based on our traveller data, and this hotel offers free breakfast and free parking. It's located just a short 0.5 mi (0.9 km) from Portsmouth Regional Hospital. Other good options within a short distance include Howard Johnson by Wyndham Portsmouth and Port Inn and Suites Portsmouth, an Ascend Collection Hotel.
How many hotels will I be able to find close to Portsmouth Regional Hospital?
Expedia has 8 hotels and other accommodation options within a mile from Portsmouth Regional Hospital.
If I need to cancel the hotel reservation for my stay near Portsmouth Regional Hospital, will I receive a refund?
Yes, most room reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If you have a non-refundable reservation, it may still be possible to cancel it and receive a refund within a 24-hour period of booking. Plug in your dates, click on "Search", then filter by "fully refundable" to review top deals close to Portsmouth Regional Hospital.
What can I see and do near Portsmouth Regional Hospital?
Study the collections at Strawbery Banke Museum, Discover Portsmouth or Portsmouth Athenaeum. Some landmarks that you won't want to miss include Market Square, Portsmouth Harbor Lighthouse and Portsmouth Harbor Trail. You can check out the local talent at The Music Hall, Seacoast Repertory Theatre and Players Ring Theatre.