Sanctuary Holidays

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    Save up to €185 when you book a flight and hotel together*

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    With over 300,000 hotels worldwide, it's easy to create a perfect package

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Price found within the past 48 hours. Click for updated prices.
Hampton Inn & Suites Fort Myers-Estero/FGCU

Hampton Inn & Suites Fort Myers-Estero/FGCU

2.5 out of 5
Price was €677, price is now €505 per person
€505
per person
2 Jan - 6 Jan
found 21 hours ago
Return flight included
Toronto (YYZ) to Fort Myers (RSW)
18.4/10 Exceptional! (1,001 reviews)
The hotel is clean. Great staff. Easy in easy out

Reviewed on 15 Nov 2025

Matanzas Inn Bayside Resort and Marina

Matanzas Inn Bayside Resort and Marina

3 out of 5
Price was €1,021, price is now €599 per person
€599
per person
2 Jan - 6 Jan
found 21 hours ago
Return flight included
Toronto (YYZ) to Fort Myers (RSW)
18.4/10 Exceptional! (1,001 reviews)
Nice room and was perfect for a 2 night stay

Reviewed on 20 Nov 2025

Flamingo Inn

Flamingo Inn

3 out of 5
Mid Island
Price was €730, price is now €519 per person
€519
per person
2 Jan - 6 Jan
found 21 hours ago
Return flight included
Toronto (YYZ) to Fort Myers (RSW)
15.6/10 Exceptional! (981 reviews)
Wonderful and cozy stay. Just right for two. Spotless, clean and updated in good taste. The bed was nice a big with crisp clean white sheets. We slept very well. The fridge and shower were a little small. Beach towels and beach chairs were a bonus. No fault to property but we were disappointed with the bugs Labor Day Weekend. Unfortunately we got eaten alive by swarms of mosquitos on the way to and back from the beach the first time. We tried going for sunset but had to run back flailing. We had to kill the ones that followed us back to the room. Literally a slapping contest. Next morning we ran to the car to find breakfast and a new beach. Ended up going to Lovers Key for the rest of the trip (no bugs there). We attempted one more cautious walk to Flamingo Beach and couldn't. Must be better in the winter. We will be back!

Reviewed on 1 Sept 2025

Marriott Sanibel Harbour Resort & Spa

Marriott Sanibel Harbour Resort & Spa

4 out of 5
Punta Rassa
Price was €988, price is now €735 per person
€735
per person
2 Jan - 6 Jan
found 21 hours ago
Return flight included
Toronto (YYZ) to Fort Myers (RSW)
16.8/10 Exceptional! (1,005 reviews)
Staff was great. The room smelled like poop

Reviewed on 18 Nov 2025

Sundial Beach Resort & Spa

Sundial Beach Resort & Spa

5 out of 5
Mid Island
Price was €1,314, price is now €989 per person
€989
per person
2 Jan - 6 Jan
found 21 hours ago
Return flight included
Toronto (YYZ) to Fort Myers (RSW)
17.2/10 Exceptional! (2,581 reviews)
Staff was very nice, pool was warm & clean. Mike the bartender at Turtles Was Fabulous!!!

Reviewed on 11 Nov 2025

Where to stay in Sanctuary

Find the best Sanctuary areas and neighborhoods for the activities you enjoy most. Learn more about Sanctuary
Fort Myers showing a sandy beach

West End

3 out of top 10 points of interest in this area

If you're spending some time in West End, J. N. Ding Darling National Wildlife Refuge and Bowman's Beach are top sights worth seeing.

Find hotels in West End

Top hotels in Sanctuary

Margaritaville Beach Resort Fort Myers

Margaritaville Beach Resort Fort Myers

4 out of 5
251 Crescent Street Fort Myers Beach FL
The price is €208 per night from 1 Dec to 2 Dec
€208
1 Dec - 2 Dec
includes taxes & fees
8.8/10 Excellent! (1,649 reviews)
The view was nice

Reviewed on 21 Nov 2025

Margaritaville Beach Resort Fort Myers
Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Holiday Inn Express Cape Coral-Fort Myers Area by IHG

2.5 out of 5
1538 Cape Coral Pkwy E Cape Coral FL
Fully refundableReserve now, pay when you stay
The price is €77 per night from 16 Dec to 17 Dec
€77
16 Dec - 17 Dec
includes taxes & fees
9.2/10 Wonderful! (1,014 reviews)
Breakfast was excellent

Reviewed on 18 Nov 2025

Holiday Inn Express Cape Coral-Fort Myers Area by IHG
Lani Kai Beachfront Resort

Lani Kai Beachfront Resort

3.5 out of 5
1400 Estero Blvd Fort Myers Beach FL
Fully refundableReserve now, pay when you stay
The price is €224 per night from 4 Dec to 5 Dec
€224
4 Dec - 5 Dec
includes taxes & fees
8.8/10 Excellent! (1,005 reviews)
Breakfast was great but not included with the room price The 29 drink credit we had to ask them about it as we didn’t receive it upon check in. But they gave us a rum barrell drink ticket snd domestic beer drink ticket and he tossed in a couple of xtras. We don’t care for the rum drinks. But overall ...

Reviewed on 15 Nov 2025

Lani Kai Beachfront Resort
See all 12,747 properties in Sanctuary
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Sanctuary holiday package cost?
Starting from as little as €505, you can tailor your Sanctuary package the way you want. Simply combine hotels, flights and car rentals and we'll reward you with discounts.
How do I get a cheap travel package to Sanctuary?
Booking a flight and hotel together with Expedia won't just save you time — it'll save you a pretty penny too. A Sanctuary holiday package makes it easy to organise your dream adventure. With more than 550 airlines across the world to choose from, finding convenient flights that suit your schedule won't be hard. On top of that, we've got over 1,000,000 properties globally to select from. Now that's what we call choice. No matter who you are, Expedia brings the world within your reach.
Where should I stay in Sanctuary?
A getaway to Sanctuary wouldn't be complete without seeing Bowmans Beach, Blind Pass Beach and Castaways Marina. Spend your evenings close to these top attractions and make sightseeing a breeze.
How far in advance should I book my Sanctuary holiday?
Reward yourself with the biggest variety at the lowest prices by booking your holiday to Sanctuary early. Airlines typically release flight tickets around 12 months prior to departure, so start your planning ASAP. That said, Expedia is committed to providing you with the best deals around, so it's never a bad time to book your dream holiday!
What does an Expedia Sanctuary travel package include?
That depends on what you're after. If you're travelling by yourself, you might decide to bundle flights and hotels. Taking the whole family to Sanctuary? A travel package that includes hotels, rental cars and flights might suit you better. Expedia gives you the freedom and flexibility to tailor-make your travel package.
What should I know before booking a Sanctuary travel package?
Booking all the parts of your escape together is a terrific way to save. Bundle your car rentals, airfares and hotels into one package. But you're not limited to hotels. Expedia offers all types of properties, including holiday rentals like beachfront villas and spacious residences. The list goes on!
Can I choose my airline with a Sanctuary Expedia holiday package?
Most definitely. Expedia has over 550 partner airlines to choose from globally. With so much choice, finding the perfect carrier to whisk you away to Sanctuary won't be difficult.
If I'm not able to travel, can I cancel my Sanctuary holiday package?
Don't stress if you're rethinking your Sanctuary holiday package — it's possible to change or amend your booking. And if you've booked it within the last 24 hours, you may be able to do it for free. However, bookings made more than 24 hours ago may incur fees from your hotel, airline or car rental company. We totally understand life can sometimes throw you a curveball, so make your way to our Customer Service Portal if that happens. When you're ready to make changes, we'll be here to help.

Popular places to visit

Sanibel Island Lighthouse

Sanibel Island Lighthouse

4/5(23 reviews)

You can find out about the history of Sanibel with a trip to Sanibel Island Lighthouse. Wander through the beautiful beaches and seaside in this family-friendly area.

Sanibel Island Lighthouse
Periwinkle Way

Periwinkle Way

The island’s spine is also its commercial hub. Drive or bike the road’s length to find attractions and discover many stores and restaurants.

Periwinkle Way

Things to do

Copacetic Day Sail

Copacetic Day Sail

€61
per adult
100% of travellers recommend
Copacetic Day Sail
Southwest Florida Sunset Sail

Southwest Florida Sunset Sail

€61
per adult
100% of travellers recommend
Southwest Florida Sunset Sail
Dolphin Wildlife Cruise Fort Myers Beach

Dolphin Wildlife Cruise Fort Myers Beach

€55
per adult
Dolphin Wildlife Cruise Fort Myers Beach
See all activities in Sanibel
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.