Sanibel Hotel Guide. Hotels in Sanctuary, Sanibel, United States of America

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Our top choices for Sanctuary hotels

OYO Waterfront Hotel - Cape Coral/Fort Myers, FL

OYO Waterfront Hotel - Cape Coral/Fort Myers, FL
2.5 star property
25.2 km from Sanctuary
5.8 out of 10, (1,005 reviews)
"Staff was amazing. Rooms were clean "
United States
Brandi
The price is €59
includes taxes & fees
26 Apr - 27 Apr
OYO Waterfront Hotel - Cape Coral/Fort Myers, FL

Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL

Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL
2.5 star property
22.6 km from Sanctuary
8.8 out of 10, Excellent, (1,001 reviews)
"Room was clean and staff was fantastic "
United States
Wayne
The price is €93
includes taxes & fees
19 Apr - 20 Apr
Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL

Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Holiday Inn Express Cape Coral-Fort Myers Area by IHG
2.5 star property
23.9 km from Sanctuary
9.2 out of 10, Wonderful, (1,386 reviews)
"Great location, clean rooms, wonderful basic breakfast and coffee, I will be back again."
United States
Eduardo
The price is €98
includes taxes & fees
28 Apr - 29 Apr
Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Allure Suites

Allure Suites
3.0 star property
27.2 km from Sanctuary
7.6 out of 10, Good, (1,003 reviews)
"We had a great stay,friendly staff, etc...."
United States
Dale
The price is €75
includes taxes & fees
27 Apr - 28 Apr
Allure Suites

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
3.0 star property
19.9 km from Sanctuary
8.2 out of 10, Very good, (1,100 reviews)
"Rooms were perfect, bigger than most and very comfortable. Staff was incredibly friendly and the breakfast had a waffle maker! "
United States
Emily
The price is €93
includes taxes & fees
3 May - 4 May
La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral
3.0 star property
30.1 km from Sanctuary
8.6 out of 10, Excellent, (855 reviews)
"Nice free breakfast"
United States
Janet
The price is €88
includes taxes & fees
26 Apr - 27 Apr
Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

Homewood Suites by Hilton - Fort Myers

Homewood Suites by Hilton - Fort Myers
3.0 star property
30.9 km from Sanctuary
9.2 out of 10, Wonderful, (1,017 reviews)
"Great room and the breakfast was delicious "
United States
Jackeline
The price is €109
includes taxes & fees
10 May - 11 May
Homewood Suites by Hilton - Fort Myers

Candlewood Suites Fort Myers Sanibel Gateway by IHG

Candlewood Suites Fort Myers Sanibel Gateway by IHG
3.0 star property
25.4 km from Sanctuary
7.6 out of 10, Good, (1,003 reviews)
"The location was great for access to beaches"
United States
Shelly
The price is €76
includes taxes & fees
22 Apr - 23 Apr
Candlewood Suites Fort Myers Sanibel Gateway by IHG

Doubletree by Hilton Fort Myers at Bell Tower Shops

Doubletree by Hilton Fort Myers at Bell Tower Shops
4.0 star property
30.8 km from Sanctuary
8.8 out of 10, Excellent, (1,064 reviews)
"Wonderful staff, pool and on site restaurant "
United States
Lori
The price is €108
includes taxes & fees
5 May - 6 May
Doubletree by Hilton Fort Myers at Bell Tower Shops

Dolphin Key Resort

Dolphin Key Resort
3.0 star property
23.8 km from Sanctuary
8.8 out of 10, Excellent, (1,243 reviews)
"Staff was wonderful…guests staying were awesome !!! We will be back"
United States
Kaia
The price is €86
includes taxes & fees
14 Apr - 15 Apr
Dolphin Key Resort

Hilton Garden Inn Ft Myers

Hilton Garden Inn Ft Myers
3.0 star property
29.5 km from Sanctuary
8.8 out of 10, Excellent, (1,006 reviews)
"Clean room, friendly staff, convenient to everything "
United States
Tracy
The price is €106
includes taxes & fees
1 May - 2 May
Hilton Garden Inn Ft Myers

Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway
3.0 star property
22.9 km from Sanctuary
8.6 out of 10, Excellent, (1,010 reviews)
"This hotel was super clean and the staff was so friendly, I would absolutely stay here again!!"
United States
Abigail
The price is €93
includes taxes & fees
26 Apr - 27 Apr
Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
2.5 star property
23.1 km from Sanctuary
9.2 out of 10, Wonderful, (1,015 reviews)
"Amazing property! Ernesto was an absolute gem helping has throughout our stay"
Canada
Carlton
The price is €91
includes taxes & fees
23 Apr - 24 Apr
Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

Latitude 26 Waterfront Resort & Marina

Latitude 26 Waterfront Resort & Marina
3.0 star property
22 km from Sanctuary
8.6 out of 10, Excellent, (988 reviews)
"We enjoyed bike riding, the pool, and the many outdoor amenities that were available. The restaurant next door was great too! Staff was very friendly and helpful!"
United States
Cindy
The price is €97
includes taxes & fees
15 Apr - 16 Apr
Latitude 26 Waterfront Resort & Marina

TriLuxe Inn & Studios

TriLuxe Inn & Studios
2.0 star property
22.7 km from Sanctuary
8.2 out of 10, Very good, (22 reviews)
"Great mattress, enjoyed the recliners, we prefer no doors on the closet making it fast & easy to access our wardrobe, liked the Roku TV, liked the induction stove top and drainer for washing our dishes daily as opposed to having a dishwasher. "
United States
Bobbi
The price is €106
includes taxes & fees
12 May - 13 May
TriLuxe Inn & Studios

Residence Inn by Marriott Fort Myers Sanibel

Residence Inn by Marriott Fort Myers Sanibel
3.0 star property
19.3 km from Sanctuary
8.8 out of 10, Excellent, (1,003 reviews)
"Everything was nice in room. & clean. Nice place to stay"
United States
Laura
The price is €113
includes taxes & fees
3 May - 4 May
Residence Inn by Marriott Fort Myers Sanibel

InTown Suites Extended Stay Fort Myers

InTown Suites Extended Stay Fort Myers
2.0 star property
29.9 km from Sanctuary
4.8 out of 10, (1,000 reviews)
"The room was clean"
United States
Deirdre
InTown Suites Extended Stay Fort Myers

Lazy Cuckoo Inn

Lazy Cuckoo Inn
2.0 star property
22.1 km from Sanctuary
8.8 out of 10, Excellent, (278 reviews)
"Great location just a couple miles from the beach, close to stores and restaurants"
United States
Kayla
The price is €107
includes taxes & fees
7 May - 8 May
Lazy Cuckoo Inn

Golf Getaway: Cape Coral Condo 1 Mi to River!

Golf Getaway: Cape Coral Condo 1 Mi to River!
3.0 star property
29.2 km from Sanctuary
The price is €279
includes taxes & fees
25 Apr - 26 Apr
Golf Getaway: Cape Coral Condo 1 Mi to River!

Lovers Key Resort

Lovers Key Resort
3.0 star property
30.3 km from Sanctuary
8.8 out of 10, Excellent, (1,046 reviews)
"Beautiful view and the room was great!"
United States
Seana A
The price is €259
includes taxes & fees
1 May - 2 May
Lovers Key Resort
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Sanctuary

Find the best Sanctuary areas for the activities you enjoy most.

Mid Island

If you're spending some time in Mid Island, Periwinkle Way and Sanibel Island Southern Beach are top sights worth seeing.

West End

If you're spending some time in West End, J. N. Ding Darling National Wildlife Refuge and Bowman's Beach are top sights worth seeing.

East End

While visiting East End, you might make a stop by sights like Sanibel Island Northern Beach and Sanibel Island Lighthouse.

Beachview Country Club Estates

While visiting Beachview Country Club Estates, you might make a stop by sights like Periwinkle Way and Sanibel Island Golf Club.

Shell Harbor

While Shell Harbor isn't home to many top sights, Sanibel Moorings Botanical Gardens and Sanibel Sea School are some notable places to visit nearby.

Top Sanctuary Hotel Reviews

Frequently asked questions

What is Sanctuary like?
Travellers are sure to enjoy a stay in Sanibel's Sanctuary neighbourhood. Consider a visit to J. N. Ding Darling National Wildlife Refuge as part of your Sanctuary travel plans.
How many hotels will I be able to find in the Sanctuary area?
With 10 Expedia hotels and other accommodation options in Sanctuary to choose from, this is a good starting point for exploring the greater Sanibel area.
If I need to cancel my hotel reservation in Sanctuary, will I receive a refund?
Yes, the majority of hotel room reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and receive a refund within a 24-hour period of booking. Enter dates in and click on "Search", then you can filter by "fully refundable" to get the best deals available in Sanctuary.
What is there to do around this Sanibel neighbourhood?
J. N. Ding Darling National Wildlife Refuge is an attraction you might want to check out while you're in Sanctuary. Castaways Marina and Blind Pass Beach are also worth a visit when you're out sightseeing in Sanibel.