Panama City Hotel Guide. Hotels in Santa Ana, Panama City, Panama

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Our top choices for Santa Ana hotels

Hostal La Cigarra

Hostal La Cigarra
2.0 star property
Santa Ana
7.4 out of 10, Good, (61 reviews)
"Excelente "
Mexico
David
Hostal La Cigarra

Casco View Apartments

Casco View Apartments
3.5 star property
Santa Ana
9.0 out of 10, Wonderful, (68 reviews)
"We live this property and stay here whenever we are in town."
United States
chris
Casco View Apartments

La Manzana by Wynwood House

La Manzana by Wynwood House
3.0 star property
Santa Ana
7.2 out of 10, Good, (15 reviews)
"Great hotel. Very close to Casco viejo"
United States
LUCILA
The price is €84
includes taxes & fees
6 Feb - 7 Feb
La Manzana by Wynwood House

Hotel República

Hotel República
2.0 star property
Santa Ana
6.6 out of 10, (183 reviews)
"Super outdated. Looks dangerous in the area"
United States
Nina Kristine
Hotel República

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama
5.0 star property
Campo Alegre, 3.6 km from Santa Ana
9.0 out of 10, Wonderful, (4,915 reviews)
" Nice hotel and great location "
United States
Wajdi
The price is €128
includes taxes & fees
8 Mar - 9 Mar
Hotel Riu Plaza Panama

The Executive Hotel

The Executive Hotel
3.5 star property
Campo Alegre, 3.2 km from Santa Ana
9.2 out of 10, Wonderful, (1,018 reviews)
"Breakfast was excellent, Rooms are lovely "
United States
Kera Michele Naomi
The Executive Hotel

Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG
4.0 star property
21.1 km from Santa Ana
8.6 out of 10, Excellent, (2,414 reviews)
"Very nice hotel and good restaurant "
United States
Allen
The price is €110
includes taxes & fees
3 Mar - 4 Mar
Crowne Plaza Panama Airport by IHG

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
5.0 star property
Juan Diaz, 12.7 km from Santa Ana
9.6 out of 10, Exceptional, (660 reviews)
"As usual the stay was amazing in this hotel"
United States
Jose
The price is €210
includes taxes & fees
7 Mar - 8 Mar
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino
4.0 star property
19.8 km from Santa Ana
8.6 out of 10, Excellent, (1,854 reviews)
"Very nice staff and confortable stay"
United States
MARIA
The price is €116
includes taxes & fees
24 Feb - 25 Feb
Riande Aeropuerto Hotel & Casino

ORHO HOTEL BOUTIQUE PANAMA Airport

ORHO HOTEL BOUTIQUE PANAMA Airport
2.5 star property
20.5 km from Santa Ana
9.0 out of 10, Wonderful, (64 reviews)
"Clean room, friendly staff."
United States
Richard
The price is €132
includes taxes & fees
6 Feb - 7 Feb
ORHO HOTEL BOUTIQUE PANAMA Airport

JW Marriott Panama

JW Marriott Panama
5.0 star property
Punta Pacifica, 4.3 km from Santa Ana
9.0 out of 10, Wonderful, (1,006 reviews)
"Beautiful hotel, great service. Breakfast buffet is amazing. "
United States
Tamara
The price is €213
includes taxes & fees
7 Mar - 8 Mar
JW Marriott Panama

W Panama

W Panama
5.0 star property
Campo Alegre, 3.2 km from Santa Ana
9.0 out of 10, Wonderful, (1,000 reviews)
"Second time staying and it was flawless."
United States
Anthony
The price is €171
includes taxes & fees
7 Mar - 8 Mar
W Panama

Radisson Hotel Panama Canal

Radisson Hotel Panama Canal
4.5 star property
Amador, 2.3 km from Santa Ana
8.6 out of 10, Excellent, (1,005 reviews)
"Unbeatable location if your visit is all about the Panama Canal. "
United States
Vitaliy
The price is €70
includes taxes & fees
21 Feb - 22 Feb
Radisson Hotel Panama Canal

Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica
4.0 star property
San Francisco, 5.1 km from Santa Ana
9.6 out of 10, Exceptional, (1,156 reviews)
"Great staff, breakfast and location "
Canada
Corinne
The price is €85
includes taxes & fees
8 Mar - 9 Mar
Ramada Plaza by Wyndham Panama Punta Pacifica

Courtyard by Marriott Panama Metromall

Courtyard by Marriott Panama Metromall
4.0 star property
14.7 km from Santa Ana
8.8 out of 10, Excellent, (1,006 reviews)
"Staff was good rooms clean just a good experience "
United States
Adrian
The price is €98
includes taxes & fees
23 Feb - 24 Feb
Courtyard by Marriott Panama Metromall

Hyatt Regency Panama City

Hyatt Regency Panama City
4.5 star property
Campo Alegre, 3.3 km from Santa Ana
9.8 out of 10, Exceptional, (190 reviews)
"Very clean modern rooms, spacious hotel, delicious breakfast, very friendly staff!"
Canada
Sheldon
The price is €153
includes taxes & fees
21 Feb - 22 Feb
Hyatt Regency Panama City

Magnolia Inn

Magnolia Inn
2.0 star property
San Felipe, 0.7 km from Santa Ana
8.8 out of 10, Excellent, (438 reviews)
"Great customer service, wonderful room and great location. "
Canada
Sharon
The price is €91
includes taxes & fees
22 Feb - 23 Feb
Magnolia Inn

Decapolis Hotel Panama City

Decapolis Hotel Panama City
4.0 star property
Punta Paitilla, 3.6 km from Santa Ana
8.6 out of 10, Excellent, (1,535 reviews)
"Nice comfortable hotel and very friendly staff."
Canada
norah
The price is €106
includes taxes & fees
27 Feb - 28 Feb
Decapolis Hotel Panama City

The Westin Playa Bonita Panama

The Westin Playa Bonita Panama
5.0 star property
7.5 km from Santa Ana
8.0 out of 10, Very good, (1,009 reviews)
"Beautiful property and amazing staff"
United States
CARMEN
The price is €229
includes taxes & fees
8 Mar - 9 Mar
The Westin Playa Bonita Panama

Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel
3.5 star property
Punta Paitilla, 3.4 km from Santa Ana
9.4 out of 10, Exceptional, (2,168 reviews)
"Hotel was very clean, the staff was very helpful and the breakfast was very good!"
United States
Monty
The price is €112
includes taxes & fees
18 Feb - 19 Feb
Plaza Paitilla Inn Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Santa Ana

Find the best Santa Ana areas for the activities you enjoy most.

Casco Viejo

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

Bella Vista

Travellers love Bella Vista for its popular shops, and you can see more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina. You might spend time checking out top sights like Via Espana and Crown Casino.

El Cangrejo

The ample dining options and casino gaming are top of the list for many visitors to El Cangrejo. A stop by Crown Casino or Luxor Towers might round out your trip.

San Felipe

While visiting San Felipe, you might make a stop by sights like Independence Square and Interoceanic Canal Museum.

San Francisco

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

Top Santa Ana Hotel Reviews

Frequently asked questions

What's it like in Santa Ana?
Santa Ana is a neighbourhood that travellers like for its seafood restaurants, shopping and parks. Are you looking for Santa Ana travel tips? Make sure that you visit Cinta Costera and Avenida Balboa while you're in the neighbourhood.
Where is the best hotel for a stay in Santa Ana?
Expedia customers rank Hostal La Cigarra the highest for a stay in Santa Ana.
How many hotels can I expect to find in Santa Ana?
Expedia has 110 hotels and other accommodation options in Santa Ana to choose from, making this an ideal home base for exploring the greater Panama City area.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If you booked a non-refundable reservation, you may still be able to cancel and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to view the best options available in Santa Ana.
What is there to do in this Panama City neighbourhood?
If you're looking forward to a day of shopping in Santa Ana, consider Avenida Central or Avenida Balboa, and pick out the perfect souvenir. A visit to Cinta Costera is also worth the trip while you're discovering the neighbourhood. Albrook Shopping Mall, Amador Theater and Museum of Contemporary Art Panama are just a few of the places to visit in and around Santa Ana. When you're sightseeing in Panama City, Mi Pueblito and Iglesia de la Merced are also worth a stop.