Santa Cruz Hotel Guide - Luxury Hotels in Santa Cruz, Seville

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Our top choices for Santa Cruz luxury hotels

Hotel Alfonso XIII, a Luxury Collection Hotel, Seville

Hotel Alfonso XIII, a Luxury Collection Hotel, Seville
5.0 star property
Historical Center
9.4 out of 10, Exceptional, (1001)
"Amazing and beautiful historic building but with modernised fittings with really helpful staff and great facilities. And all the key historic sites are within an easy walk of the hotel"
United Kingdom
Christopher
The price is €397
includes taxes & fees
21 Jan - 22 Jan 2026
Hotel Alfonso XIII, a Luxury Collection Hotel, Seville

EME Catedral Mercer Hotel

EME Catedral Mercer Hotel
5.0 star property
Historical Center
8.8 out of 10, Excellent, (1000)
"Great location, and thank you to all the staff for making our stay so enjoyable. "
United Kingdom
Samir
The price is €180
includes taxes & fees
6 Jan - 7 Jan 2026
EME Catedral Mercer Hotel

El Rey Moro Hotel Boutique

El Rey Moro Hotel Boutique
4.0 star property
Historical Center
9.4 out of 10, Exceptional, (895)
"The location is A+! The staff is extremely attentive and knowledgeable their rooms where pristine and comfortable. The bed is very good. Breakfast is amazing. This hotel delivers a great experience."
United States
WALDECTOR
The price is €140
includes taxes & fees
21 Jan - 22 Jan 2026
El Rey Moro Hotel Boutique

Hotel Boutique Casa del Poeta Sevilla

Hotel Boutique Casa del Poeta Sevilla
4.0 star property
Historical Center
9.8 out of 10, Exceptional, (870)
"The hotel was centrally located and The staff was a pleasure and informative . The room was spacious and clean .. perfect overnight stay "
United States
isabel
The price is €206
includes taxes & fees
23 Jan - 24 Jan 2026
Hotel Boutique Casa del Poeta Sevilla

Las Casas de la Judería, Sevilla Historic City Center

Las Casas de la Judería, Sevilla Historic City Center
4.0 star property
Historical Center
9.2 out of 10, Wonderful, (1000)
"The property had real historic character - in a great location with helpful and friendly staff "
United Kingdom
Caroline Jane
The price is €114
includes taxes & fees
13 Jan - 14 Jan 2026
Las Casas de la Judería, Sevilla Historic City Center

Hotel Fernando III

Hotel Fernando III
4.0 star property
Historical Center
9.6 out of 10, Exceptional, (1529)
"Great location, breakfast & staff "
United States
Anup
The price is €109
includes taxes & fees
11 Jan - 12 Jan 2026
Hotel Fernando III

Hotel Amadeus Sevilla

Hotel Amadeus Sevilla
4.0 star property
Historical Center
9.6 out of 10, Exceptional, (1098)
"Fantastic stay"
United Kingdom
Amélie
The price is €113
includes taxes & fees
27 Jan - 28 Jan 2026
Hotel Amadeus Sevilla

Hotel Boutique Palacio Pinello

Hotel Boutique Palacio Pinello
4.0 star property
Historical Center
9.4 out of 10, Exceptional, (685)
"The hotel is centric"
United States
javier
The price is €119
includes taxes & fees
8 Jan - 9 Jan 2026
Hotel Boutique Palacio Pinello

Hotel Rey Alfonso X

Hotel Rey Alfonso X
4.0 star property
Historical Center
9.6 out of 10, Exceptional, (1117)
"Lovely hotel in a great location. Friendly staff. Couldn’t be better. "
United States
Alan
The price is €119
includes taxes & fees
12 Jan - 13 Jan 2026
Hotel Rey Alfonso X

U-Sense Sevilla Centro

U-Sense Sevilla Centro
3.0 star property
Historical Center
9.4 out of 10, Exceptional, (416)
"Nice location and very nice room"
United States
isabella
U-Sense Sevilla Centro
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find out more about Santa Cruz

Santa Cruzand its attractions for luxury travelers

In the charming Santa Cruz neighbourhood of Spain, luxury travellers can indulge in a blend of culture, gastronomy, and relaxation. Begin your day with a visit to the stunning Plaza de la Catedral, where the magnificent cathedral showcases intricate architecture, perfect for a leisurely stroll or a sophisticated photo op. For art enthusiasts, the nearby Museo de Bellas Artes offers a captivating collection of Spanish masterpieces, providing an ideal backdrop for an afternoon of cultural enrichment. After soaking in the sights, unwind at the picturesque Parque García Sanabria, a lush oasis featuring exotic plants and a beautiful lake, perfect for a picnic or a quiet moment. When it comes to dining, Santa Cruz boasts high-end restaurants such as La Casa de la Pasta, where you can savour exquisite local flavours in an elegant setting. After a day of exploration, retreat to one of the luxury hotels in the area, where you can expect personalised service and lavish amenities. For instance, hotels like Iberostar Grand Mencey offer opulent spa facilities and gourmet dining options, ensuring that your stay is as relaxing as it is memorable. Experience the perfect blend of comfort and sophistication, all while being just steps away from the vibrant life of Santa Cruz.

Top Santa Cruz Hotel Reviews

Frequently asked questions

Are you searching for a great accommodation for your luxury trip to Santa Cruz?
While you're visiting, you might want to think about enjoying the monuments and museums, which Santa Cruz is known for.
What's the best luxury place to stay in Santa Cruz?
EME Catedral Mercer Hotel is a luxury hotel with 2 restaurants and a full-service spa, and it's a popular choice for Expedia travellers looking for an elegant place to stay. Hotel Alfonso XIII, a Luxury Collection Hotel, Seville and El Rey Moro Hotel Boutique are other upscale choices for your trip.
What's there to see and do in Santa Cruz?
Take in the sights and attractions that Santa Cruz offers with a visit to Convent of the Incarnation, Giralda Tower and General Archive of the Indies. If you have a little extra time during your trip, you might want to make a stop at Murillo Gardens and Archbishop's Palace.
How can I get around Santa Cruz?
It's easier to get around town comfortably when you know your options. Head to Puerta Jerez Tram Stop for metro travel.

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