Downtown
Seneca
Visit Downtown
Stay near popular Downtown attractions
Top hotels in Downtown
Quality Inn Seneca Clemson Area US-123
226 Hi Tech Rd Seneca SC
The price is €84 per night from 30 Jul to 31 Jul
€84
30 Jul - 31 Jul
includes taxes & fees
Stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff and the clean rooms in ...
Days Inn by Wyndham Anderson
1007 George Smith Mill Rd Anderson SC
The price is €59 per night from 9 Aug to 10 Aug
€59
9 Aug - 10 Aug
includes taxes & fees
Stay at this business-friendly motel in Anderson. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff and the clean rooms ...
8/10 Very good! (1,012 reviews)
"Room was good, ice maker broken and toilet was clogged upon check in and no one from maintenence was available so I had to plunge the toilet."
Reviewed on 25 Jul 2026
Best Western Plus Clemson Hotel & Conference Center
1310 Tiger Blvd Clemson SC
The price is €107 per night from 28 Jul to 29 Jul
€107
28 Jul - 29 Jul
includes taxes & fees
Stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free parking and an outdoor pool. Our guests praise the helpful staff and the clean rooms ...
8.2/10 Very good! (1,005 reviews)
"Great location near Clemson University"
Reviewed on 25 Jul 2026
The Shepherd Hotel Downtown Clemson
110 Sloan St Clemson SC
The price is €165 per night from 28 Jul to 29 Jul
€165
28 Jul - 29 Jul
includes taxes & fees
Stay at this hotel in Clemson. Enjoy free Wi-Fi, breakfast (surcharge) and room service. Our guests praise the helpful staff and the clean rooms in their reviews. ...
Lakeside Lodge Clemson
13500 Clemson Blvd Seneca SC
The price is €119 per night from 27 Jul to 28 Jul
€119
27 Jul - 28 Jul
includes taxes & fees
Stay at this hotel in Seneca. Enjoy free Wi-Fi, free parking and an outdoor pool. Our guests praise the helpful staff and the clean rooms in their reviews. Popular ...
Comfort Inn & Suites Clemson - University Area
1305 Tiger Blvd Clemson SC
The price is €103 per night from 19 Aug to 20 Aug
€103
19 Aug - 20 Aug
includes taxes & fees
Stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff and the clean rooms in ...
8.4/10 Very good! (1,003 reviews)
"Great cheaper options for families complete with free breakfast. The hotel is on the older side and it’s not as up to date, but it’s a great option if you don’t want to break the bank. It’s cheaper than similar options that are more up to date. So we always choose to just stay here instead since ..."
Reviewed on 25 Jul 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Downtown
Find the best Downtown areas for the activities you enjoy most.
Serenity Bay
When in Serenity Bay, you can plan a visit to Keowee Key Golf Course and Lake Keowee, some noteworthy sights in the nearby area.
Pine Ridge Point
If you're looking for some top things to see and do in Pine Ridge Point and surrounding area, you can visit South Beach and Lake Keowee.
Indian Oaks
While Indian Oaks may not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Oconee County Library Seneca Branch and Keowee Reservoir.
Keowee Plantation
While Keowee Plantation isn't home to many top sights, Keowee Reservoir and Oconee County Library Seneca Branch are some notable places to visit nearby.
