Photo by Cindy Keese

Seneca Hotel Guide - Hotels with Spa in Seneca, South Carolina

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Top Seneca Hotels with Spa

Lakeside Lodge Clemson
2.5 star property
9.0 out of 10, Wonderful, (737)
"Everyone was friendly. The room was very clean and nicely updated. The grounds were immaculate."
The price is €124
includes taxes & fees
3 Nov - 4 Nov
Lakeside Lodge Clemson
Tru by Hilton Seneca Clemson
2.5 star property
9.2 out of 10, Wonderful, (637)
"Very modern and clean hotel. The beds were comfortable and happy with the free breakfast. It was a nice hotel to rest during our 14 hour move across the country with a dog and two young children. Friendly staff and nice hotel to stay at!"
The price is €113
includes taxes & fees
3 Nov - 4 Nov
Tru by Hilton Seneca Clemson
Quality Inn Seneca US-123
2.5 star property
8.0 out of 10, Very good, (549)
"Very nice for an-old fashion hotel. Well maintained. Very clean. The room is basic but provides everything we need. Friendly, helpful staff. Convenient location. Pricey for this level of hotel, but virtually all hotels are outrageously expensive nowadays."
The price is €98
includes taxes & fees
1 Dec - 2 Dec
Quality Inn Seneca US-123
Days Inn by Wyndham Seneca / Clemson Area
2.0 star property
6.8 out of 10, (642)
"I didn't like that there was 2 lines going up and down on my TV sceen"
The price is €69
includes taxes & fees
1 Dec - 2 Dec
Days Inn by Wyndham Seneca / Clemson Area
5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!
10.0 out of 10, Exceptional, (78)
"Pictures in the listing looked amazing but it’s hard to capture how awesome the home, views and location truly are. Cloudwalker was the perfect place for our family vacation and communication with the owner was seamless. We can’t wait to book this property again!"
The price is €1,484
includes taxes & fees
3 Nov - 4 Nov
5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!
What a family lake house should be! Natural Beauty w/ space for each to enjoy!!!
9.2 out of 10, Wonderful, (28)
"Overall, I highly recommend this place for anyone looking to unwind and enjoy some beautiful scenery. The house was exactly as described in the listing, which made our stay even more enjoyable. Waking up to those stunning views of the lake every morning was such a treat—it really set the perfect tone for our days. Communication with the owner was a breeze. They were super responsive and made sure we had everything we needed. Plus, the check-in and check-out process was incredibly easy, which...
What a family lake house should be! Natural Beauty w/ space for each to enjoy!!!
Best Western Seneca-Clemson
2.5 star property
8.4 out of 10, Very good, (551)
"I don't think there's much unique about the Best Western in Seneca. But It scored very high for me. The room was spacious and very comfortable. The bathroom facilities, including the tub/shower were above average. The included breakfast was great. (I was only sorry that I couldn't partake on both mornings of my stay.) The staff was very friendly and very helpful. The only negative, and it was tiny and eventually resolves by the staff, was that the TV remote in the room was basically...
The price is €99
includes taxes & fees
7 Nov - 8 Nov
Best Western Seneca-Clemson
Lakefront home w/covered dock*Pool table*Kayak/SUP*11mi to Clemson*Hot tub
9.8 out of 10, Exceptional, (38)
"Great family house, lots of room!"
Lakefront home w/covered dock*Pool table*Kayak/SUP*11mi to Clemson*Hot tub
Serenity Bay, Keowee Lakefront Cabin, Covered Dock, Kayaks, Clean, Near Clemson
10.0 out of 10, Exceptional, (193)
"I’ve stayed at several homes on Lake Keowee. This is my favorite stay so far. Beautiful home - right on the lake. I will definitely be returning. Loved it. "
Serenity Bay, Keowee Lakefront Cabin, Covered Dock, Kayaks, Clean, Near Clemson
Lakefront Lake Keowee Home with flat lawn & private dock. 14 miles to Clemson!
10.0 out of 10, Exceptional, (101)
"Perfect house to stay at if you are going to a Clemson game. Host was communicative and the house was adorable. We fished off the dock, roasted s’mores and watched lots of football. Would definitely rent again. "
Lakefront Lake Keowee Home with flat lawn & private dock. 14 miles to Clemson!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

Looking for a spa hotel in Seneca?
Book one of our lush spa hotels and pamper yourself from the moment you arrive. Discover the lakeside setting in Seneca—worth a picture or two! Make sure you enjoy the coffee shops during your stay. Hotels with spas are the perfect way to take a break from your routine and add a layer of luxury to your weekend away.
What is the best spa hotel in Seneca?
Hampton Inn & Suites Seneca-Clemson Area, SC is a top spa hotel featuring a pool and a 24-hour fitness centre.
How many spa hotels will I find in Seneca?
Among Expedia’s 147 accommodation options in Seneca, there is 1 spa hotel.
What's there to see and do in Seneca?
Take in the sights and attractions that Seneca offers with a visit to Lake Keowee, Keowee Key and Lake Hartwell. If you have some spare time during your trip, you might want to check out Keowee Reservoir and Memorial Stadium.
What is a Seneca spa hotel?
Spa hotels in Seneca provide lodging and have an on-site spa offering services such as therapies as well as beauty treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation and relaxation.