A calm lake with mountains in the background.

Seneca Hotel Guide - Hotels with Spa in Seneca, South Carolina

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Seneca Hotels with Spa

Tonight
23 Oct - 24 Oct
Tomorrow
24 Oct - 25 Oct
This weekend
23 Oct - 25 Oct
Next weekend
30 Oct - 1 Nov
No exact matches found, but these alternatives could be just right

Recommended hotels in Seneca

A restaurant interior with a counter, seating area, and a TV mounted on the wall.
A modern bathroom with a vanity, a shower with a glass door, and a towel rack.
A spacious lobby with a high ceiling, a chandelier, framed artwork, a lamp, a sofa, and a view through large glass doors to an outdoor area.
A hotel room with a TV on a wooden cabinet, a desk with a lamp, a framed picture, and a chair.

1. Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
€89
includes taxes & fees
29 Oct - 30 Oct
Quality Inn Seneca US-123
A hotel room with a bed, a desk, a chair, a large window with curtains, a bathroom with a bathtub, and a flat-screen TV.
A reception area with a brick wall, a reception desk, and a glass door leading outside.
A rectangular swimming pool with a metal ladder, surrounded by lounge chairs and tables, with a wooded area in the background.
A breakfast bar with waffle makers, coffee machines, and a clock on the wall.

2. Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
€92
includes taxes & fees
26 Oct - 27 Oct
Best Western Seneca-Clemson
A poolside area with outdoor seating and a view of a lake and forested hills.
A modern lobby with a reception desk, seating area, and a vending machine.
A modern cafe interior with round tables and chairs, a counter with a beverage dispenser, and a wall-mounted TV.
A modern lounge area with a round table, two green armchairs, a sofa, and a TV mounted on the wall.

3. Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
Seneca
€118
includes taxes & fees
1 Nov - 2 Nov
Fairfield Inn & Suites Seneca Clemson Univ Area
A hotel dining area with a long table, multiple chairs, and a bar in the background.
A hotel room with a bed, a desk, a chair, a TV, and a bathroom visible through an open door.
A Hampton Inn & Suites hotel with a well-lit entrance, a parking lot, and a clear view of the building's exterior.
A long, narrow hallway with white walls and a light-colored floor, leading to a door at the end.

4. Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
Seneca
€131
includes taxes & fees
22 Nov - 23 Nov
Hampton Inn & Suites Seneca-Clemson Area
An outdoor patio area with a fire pit, seating, and string lights.
A modern indoor space with a mix of seating options, including a sofa and tables, under stylish pendant lighting.
A food court with a beverage display, seating area, and a Clemson University sign.
A modern hotel with a prominent 'tru by Hilton' sign, a well-lit entrance, and a parking area.

5. Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
Seneca
€100
includes taxes & fees
19 Nov - 20 Nov
Tru by Hilton Seneca Clemson
A multi-story hotel with a swimming pool, landscaped grounds, and a parking area.
An aerial view of a multi-story hotel with a central courtyard, outdoor pool, and lounge area.
A swimming pool with lounge chairs and a covered patio area, surrounded by trees and a view of a lake.
A spacious lobby with a stone fireplace, modern lighting fixtures, and a seating area with sofas and a coffee table.

6. Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
€120
includes taxes & fees
27 Oct - 28 Oct
Lakeside Lodge Clemson
A cabin with a cozy interior, a wooden exterior, and a view of the forest.
A wooden cabin bedroom with a bed, a desk, and a window overlooking a forest.
Private kitchen
A wooden interior with a table, chair, and a hanging lantern.

7. Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Seneca
€130
includes taxes & fees
28 Oct - 29 Oct
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
A modern dining area with a high ceiling, large windows, and a buffet setup.
A modern hotel room with a large bed, bedside tables with lamps, a wall-mounted air conditioner, and a large window with curtains.
A modern hotel lobby with a high ceiling, comfortable seating, large windows, and a view of the parking lot.
A modern bathroom with a large mirror, a sink, and a shower.

8. Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
€72
includes taxes & fees
26 Oct - 27 Oct
Days Inn by Wyndham Seneca / Clemson Area
A hallway with a wooden floor, a large mirror, and framed pictures on the walls.
A modern dining area with a large table, wicker chairs, and a television in the background.
A hotel room with two beds, wooden flooring, and a brick wall.
A modern living room with a large dining table, white chairs, a sofa, and a television.

9. Boutique hotel in historic downtown Seneca. Room #5, two King beds.

Boutique hotel in historic downtown Seneca. Room #5, two King beds.
Downtown
€184
includes taxes & fees
26 Oct - 27 Oct
Boutique hotel in historic downtown Seneca. Room #5, two King beds.
A hallway with a wooden floor, a large mirror, and framed pictures on the walls.
A modern living room with a sectional sofa, a coffee table, and a television.
A hotel room with a tufted headboard, a nightstand with a lamp, and a bed with white bedding and decorative pillows.
A modern dining area with a large table, wicker chairs, and a television in the background.

10. Private Room #3

Private Room #3
Downtown
€184
includes taxes & fees
26 Oct - 27 Oct
Private Room #3
View all properties

Choose what matters most at spa hotels in Seneca

Pool
Breakfast included
Hot tub
4 stars
5 stars

Top Seneca Hotel Reviews

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area

10/10 Excellent
"Room was clean and staff was friendly and helpful."
Sasha 1-night trip
Posted 3 days ago
Hampton Inn & Suites Seneca-Clemson Area

Frequently asked questions

Looking for a spa hotel in Seneca?
Book one of our lush spa hotels and pamper yourself from the moment you arrive. Discover the lakeside setting in Seneca—worth a picture or two! Make sure you enjoy the coffee shops during your stay. Hotels with spas are the perfect way to take a break from your routine and add a layer of luxury to your weekend away.
What's there to see and do in Seneca?
Take in the sights and attractions that Seneca offers with a visit to Lake Keowee, Keowee Key Golf Course and Lake Hartwell. If you have extra time while you're in the area, you might want to see Oconee County Library Seneca Branch and Keowee Reservoir.
What is a Seneca spa hotel?
Spa hotels in Seneca provide lodging and have an on-site spa offering services such as therapies as well as beauty treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation and relaxation.

Explore a world of travel with Expedia