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21 Aug - 22 Aug
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Top 10 trending Seneca hotels

Postcard Cabins Lake Hartwell
Exterior

Postcard Cabins Lake Hartwell

2.0 star property
9.8 out of 10, Exceptional, (23)
"It was perfect very clean everything was well thought out using the space very efficiently. Will stay again. It was quiet and a wonderful getaway with beautiful scenery! The big window and amazing bed had the best sleep.."
The price is €117
includes taxes & fees
24 Aug - 25 Aug
Postcard Cabins Lake Hartwell
Lakeside Lodge Clemson
Aerial view

Lakeside Lodge Clemson

2.5 star property
9.0 out of 10, Wonderful, (997)
"Great place to stay in Clemson"
The price is €117
includes taxes & fees
22 Aug - 23 Aug
Lakeside Lodge Clemson
Fairfield Inn & Suites Seneca Clemson Univ Area
Balcony

Fairfield Inn & Suites Seneca Clemson Univ Area

2.5 star property
9.4 out of 10, Exceptional, (184)
"Beautiful clean hotel. Staff was very welcoming. Breakfast area was very clean with many options. The river view is so beautiful. "
The price is €122
includes taxes & fees
24 Aug - 25 Aug
Fairfield Inn & Suites Seneca Clemson Univ Area
Hampton Inn & Suites Seneca-Clemson Area
Exterior

Hampton Inn & Suites Seneca-Clemson Area

2.5 star property
9.4 out of 10, Exceptional, (629)
"The staff were very friendly and helpful. The room was clean and the breakfast was great!"
The price is €114
includes taxes & fees
24 Aug - 25 Aug
Hampton Inn & Suites Seneca-Clemson Area
Days Inn by Wyndham Seneca / Clemson Area
Room, 1 King Bed, Non Smoking

Days Inn by Wyndham Seneca / Clemson Area

2.0 star property
6.8 out of 10, (693)
"The property was near the area that I needed to be in. It has ample shops and restaurants in the area "
The price is €66
includes taxes & fees
24 Aug - 25 Aug
Days Inn by Wyndham Seneca / Clemson Area
Tru by Hilton Seneca Clemson
Lobby

Tru by Hilton Seneca Clemson

2.5 star property
9.2 out of 10, Wonderful, (761)
"Staff and property were top-notch! "
The price is €105
includes taxes & fees
7 Sept - 8 Sept
Tru by Hilton Seneca Clemson
Quality Inn Seneca Clemson Area US-123
Free daily on-the-go breakfast

Quality Inn Seneca Clemson Area US-123

2.5 star property
8.0 out of 10, Very good, (632)
"Ok hotel for a quick stay "
The price is €84
includes taxes & fees
31 Aug - 1 Sept
Quality Inn Seneca Clemson Area US-123
Best Western Seneca-Clemson
Lobby

Best Western Seneca-Clemson

2.5 star property
8.4 out of 10, Very good, (601)
"We liked the location. It was easy to explore Lake Keowee from here. The blackout window shades were nice too! The room was so humid that it even made the sheets feel damp. "
The price is €96
includes taxes & fees
14 Sept - 15 Sept
Best Western Seneca-Clemson
Inn @ Clemson
Lobby lounge

Inn @ Clemson

2.5 star property
8.0 out of 10, Very good, (1012)
"It was very clean. A nice place to stay "
The price is €85
includes taxes & fees
1 Sept - 2 Sept
Inn @ Clemson
Woodspring Suites Anderson North I-85
Exterior

Woodspring Suites Anderson North I-85

2.5 star property
6.6 out of 10, (21)
"Very nice and clean property. Staff was so nice and helpful. Made check in so easy"
The price is €75
includes taxes & fees
24 Aug - 25 Aug
Woodspring Suites Anderson North I-85
Days Inn by Wyndham Anderson
Free daily continental breakfast

Days Inn by Wyndham Anderson

2.0 star property
7.4 out of 10, Good, (1001)
"Great stay "
The price is €57
includes taxes & fees
24 Aug - 25 Aug
Days Inn by Wyndham Anderson
Best Western Plus Clemson Hotel & Conference Center
Lobby

Best Western Plus Clemson Hotel & Conference Center

2.5 star property
8.2 out of 10, Very good, (1005)
"The hotel was very quiet, clean and staff was very friendly!"
The price is €100
includes taxes & fees
3 Sept - 4 Sept
Best Western Plus Clemson Hotel & Conference Center
Comfort Inn & Suites Clemson - University Area
Lobby

Comfort Inn & Suites Clemson - University Area

2.5 star property
8.2 out of 10, Very good, (1003)
"Awesome place to stay"
The price is €96
includes taxes & fees
13 Sept - 14 Sept
Comfort Inn & Suites Clemson - University Area
Baymont by Wyndham Anderson Clemson
Outdoor pool

Baymont by Wyndham Anderson Clemson

2.5 star property
7.0 out of 10, Good, (812)
"Excellent stay "
The price is €65
includes taxes & fees
12 Sept - 13 Sept
Baymont by Wyndham Anderson Clemson
Quality Inn Clemson near University
Reception

Quality Inn Clemson near University

2.5 star property
7.0 out of 10, Good, (861)
"Great customer service "
The price is €57
includes taxes & fees
24 Aug - 25 Aug
Quality Inn Clemson near University
Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG
Reception

Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG

2.5 star property
9.0 out of 10, Wonderful, (558)
"My daughter and I stayed at the property for one night, as we traveled back home. The room was wonderfully clean, the beds comfortable, and the front desk staff was warm and accommodating. I noticed that the hotel even offered board games to play with friends or family. "
The price is €98
includes taxes & fees
24 Aug - 25 Aug
Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG
Country Inn & Suites by Radisson, Anderson, SC
Free buffet breakfast

Country Inn & Suites by Radisson, Anderson, SC

2.5 star property
8.4 out of 10, Very good, (1000)
"It was a good place to stay good people "
The price is €104
includes taxes & fees
2 Sept - 3 Sept
Country Inn & Suites by Radisson, Anderson, SC
Comfort Suites Anderson-Clemson
Coffee service

Comfort Suites Anderson-Clemson

2.5 star property
8.4 out of 10, Very good, (995)
"RESTAURANTS, HOTEL WAS GREAT STAFF WAS AWESOME I WOULD DEFINITELY RECOMMEND. "
The price is €106
includes taxes & fees
7 Sept - 8 Sept
Comfort Suites Anderson-Clemson
Microtel Inn & Suites by Wyndham Anderson/Clemson
Lobby

Microtel Inn & Suites by Wyndham Anderson/Clemson

2.0 star property
8.2 out of 10, Very good, (1000)
"Great place to stay!"
The price is €76
includes taxes & fees
24 Aug - 25 Aug
Microtel Inn & Suites by Wyndham Anderson/Clemson
The Shepherd Hotel Downtown Clemson
Superior Room, 2 Queen Beds

The Shepherd Hotel Downtown Clemson

4.0 star property
9.8 out of 10, Exceptional, (665)
"Exceptional property and amenities, great for a quick trip or an extended stay. We highly recommend The Shepherd Hotel for any occasion."
The price is €171
includes taxes & fees
1 Sept - 2 Sept
The Shepherd Hotel Downtown Clemson
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Check out pet-friendly hotels in Seneca

Postcard Cabins Lake Hartwell
Exterior

Postcard Cabins Lake Hartwell

2.0 star property
9.8 out of 10, Exceptional, (23)
The price is €117
includes taxes & fees
24 Aug - 25 Aug
Postcard Cabins Lake Hartwell

Hotels with a pool in Seneca you'll enjoy

Lakeside Lodge Clemson
Aerial view

Lakeside Lodge Clemson

2.5 star property
9.0 out of 10, Wonderful, (997)
The price is €117
includes taxes & fees
22 Aug - 23 Aug
Lakeside Lodge Clemson

These family-friendly hotels in Seneca may fit your trip

Fairfield Inn & Suites Seneca Clemson Univ Area
Balcony

Fairfield Inn & Suites Seneca Clemson Univ Area

2.5 star property
9.4 out of 10, Exceptional, (184)
The price is €122
includes taxes & fees
24 Aug - 25 Aug
Fairfield Inn & Suites Seneca Clemson Univ Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Seneca

Find the best Seneca areas for the activities you enjoy most.
Boat Ride on Lake Hartwell

Downtown

2 out of top 10 points of interest in this area

City centre Seneca captures the essence of small-town Southern charm with its well-preserved railway heritage and historic brick buildings. Tree-lined streets lead to charming shops and local eateries housed in structures dating back to the 1800s. Ram Cat Alley's colourful murals tell stories of local history while the old courthouse square hosts community gatherings. This walkable district offers a peaceful retreat from big city life. Visitors can browse antique stores for railway memorabilia, sample authentic Southern comfort food, or explore the cultural exhibits at the Bertha Lee Strickland Museum. The nearby Lake Keowee provides outdoor recreation just minutes away.

Serenity Bay

Serenity Bay offers a peaceful retreat within Saxony Forest's coastal embrace. The quiet residential streets wind through mature trees, creating a tranquil atmosphere away from tourist crowds. Nature lovers can explore nearby Lake Keowee or enjoy the neighborhood's forest trails. The area perfectly balances woodland serenity with beach proximity. Visitors should plan for self-contained holiday rentals rather than hotels. While dining options are limited within the area, the natural surroundings provide ideal conditions for relaxation and outdoor recreation.

Female Kayaker on Lake Keowee at Sunset

Pine Ridge Point

Lake Keowee's serene waters lap against the shores of Pine Ridge Point, a tranquil residential haven in Seneca. Private docks stretch into crystal-clear waters where boats gently bob. Towering pines create natural privacy between lakefront homes. Visitors enjoy peaceful mornings watching mist rise over the water. This area offers an authentic lakeside living experience without tourist crowds. Holiday rentals range from cosy cabins to luxury estates with private boat slips. Days revolve around swimming, fishing, and water sports on Lake Keowee. Nature trails wind through mature forests for hiking and birdwatching.

Indian Oaks

Indian Oaks offers a tranquil retreat in suburban Seneca where mature oak trees create natural canopies over peaceful residential streets. This family-oriented community provides an authentic glimpse into American suburban living without tourist crowds. Landscaped yards and community green spaces showcase South Carolina's native beauty. Visitors can enjoy quiet morning walks on spacious pavements while listening to birdsong. Lake Keowee lies just beyond the area boundaries for those seeking water activities. With minimal commercial presence, Indian Oaks delivers a genuinely restful experience away from urban bustle.

Learn more about Seneca

Nestled along Lake Keowee's shoreline, this charming town offers spectacular waterfront activities from kayaking to fishing at South Cove County Park. Nearby Stumphouse Tunnel and Issaqueena Falls provide fascinating historical exploration and refreshing natural beauty, especially during summer's humid afternoons.

See all hotels in Seneca
Photo by Cindy Keese
Open Photo by Cindy Keese

Top Seneca Hotel Reviews

Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center

10/10 Excellent
"Great place to stay for me while working at the University. Quiet, great staff, clean and a great breakfast selection. As well as a restaurant on site. Made it easy. Also a par 30 golf course only 10 minutes away. And a gas station/ convenience store essentially in the parking lot. "
Jeffrey 2-night trip
Posted 2 days ago
Best Western Plus Clemson Hotel & Conference Center

Frequently asked questions

Where is the best place for a stay in Seneca?

Tru by Hilton Seneca Clemson is ranked highly by Expedia customers. This hotel is a short 5-minute walk from Lake Hartwell, and it offers free breakfast and free parking. Traveller reviews also recommend Lakeside Lodge Clemson and Hampton Inn & Suites Seneca-Clemson Area as top choices for your visit. See all available top hotels, or vacation rentals in Seneca.

What are some of the best holiday rentals that Seneca has to offer?

4/3 Waterfront Home w/ Covered Dock, 2 Decks, Pet Friendly. Long view on lake. : This highly rated holiday home rental in Seneca is located on a lake, and has a fireplace, a balcony and a BBQ to put you at ease in your new surroundings. It has 4 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. Kick off your shoes and enjoy yourself with a garden and an arcade/games room. Some other homes for rent in Seneca include Large family home with dock on Lake Keowee! and 6 Bedrooms and 3 docks on a Lake Hartwell cove, 3 miles from Clemson by water.. See all vacation rentals in Seneca.

If I need to cancel my hotel reservation in Seneca, will I receive a refund?

Yes! You'll find that most room reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If you have a reservation that's non-refundable, you might still have the option to cancel and get a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in Seneca.

What's the best family accommodation in Seneca?

Fairfield Inn & Suites Seneca Clemson Univ Area is a hotel with an outdoor pool and free parking, and it's a top choice on Expedia for families. Also, attractions in the area such as Ultimate Action Sports are fun for the whole family. Find more child-friendly accommodations in Seneca.

What is the top LGBTQ-friendly accommodation in Seneca?

Hampton Inn & Suites Seneca-Clemson Area is a top LGBTQ-friendly hotel that features free breakfast and free Wi-Fi. Tru by Hilton Seneca Clemson is another good choice for your trip. See all available hotels listed as LGBTQ-friendly in Seneca.

What's the best dog-friendly hotel in Seneca?

Lakeside Lodge Clemson is a top hotel for people travelling with their pets, and offers a restaurant and a seasonal outdoor pool for its human guests. Other good choices for you and your pet's trip include Tru by Hilton Seneca Clemson and Days Inn by Wyndham Seneca / Clemson Area. See more pet-friendly hotel accommodations in Seneca.

What are some hotels with pools in Seneca?

Lakeside Lodge Clemson: Hotel, 7-minute walk from Lake Hartwell. Features free self parking, a seasonal outdoor pool and complimentary wireless Internet access. Fairfield Inn & Suites Seneca Clemson Univ Area and Hampton Inn & Suites Seneca-Clemson Area are two additional hotels that feature an on-site pool. View all hotels with pools in Seneca.

What is staying in Seneca like?

Visitors to Seneca will definitely enjoy the sporting events, lakeside setting and university setting. Welcoming and scenic, this city also attracts tourists with its cafes. In Seneca, there are 287 hotels and other accommodation options to choose from. Find out more about Seneca.

What should I see while I'm in Seneca?

Cultural venues include The Gauntlet and Oconee Community Theatre. Natural beauty is on display at Keowee Reservoir, Lake Keowee and Lake Hartwell. Exploring the waterfront is a great activity, and Keowee Key Golf Course is one place to visit. Take a look at what more there is to see and do in Expedia's Seneca guide.

What's the seasonal weather in Seneca?

The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 8°C. Average annual precipitation for Seneca is 1565 mm.