Name: Hotel Murillo
Price range: €121
Rating: 9

Stay near popular Santa Cruz attractions

A courtyard with a central water feature, surrounded by columns and potted trees.

Royal Alcázar of Seville

9.6/10 (8,220 reviews)

Discover a millennium’s worth of royal treasures in this architectural masterpiece in the heart of Seville.

See properties

Things to do

a narrow dirt road leading to a town in Spain

White Villages & Ronda Day Trip from Seville

€79

per adult

92% of travellers recommend

Skip the line combo tour to Alcazar & Cathedral of Seville

Cathedral & Alcázar of Seville Guided Tour Combo

€20

per adult

88% of travellers recommend

Landscape of Guadalquivir river area with several buildings in view.

Guadalquivir River Criuse Tour

€19

per adult

80% of travellers recommend

Three Cities in One Day: Córdoba, White Villages and Ronda from Sevilla

€110

per adult

Seville: Guadalquivir River Cruise

€18

per adult

80% of travellers recommend

Seville Cathedral and Giralda Guided Tour (Skip-The-Line Ticket Included)

€35

per adult

72% of travellers recommend

See all activities in Seville

Top hotels in Santa Cruz

Las Casas de la Judería, Sevilla Historic City Center

Calle Santa Maria La Blanca 5 Seville Seville

€215

25 Oct - 26 Oct

includes taxes & fees

Stay at this spa hotel in Seville. Enjoy free Wi-Fi, an outdoor pool and a full-service spa. Our guests praise the pool and the helpful staff in their reviews. ...

9.4/10 Exceptional! (1,013 reviews)

"Nice and interesting concept,"

Reviewed on 29 Sept 2026

Hotel Alfonso XIII, a Luxury Collection Hotel, Seville

San Fernando 2 Seville Seville

€742

30 Oct - 31 Oct

includes taxes & fees

Stay at this luxury hotel in Seville. Enjoy 2 restaurants, breakfast (surcharge) and 24-hour room service. Our guests praise the helpful staff in their reviews. ...

9.4/10 Exceptional! (1,005 reviews)

"Beautiful hotel with classic features."

Reviewed on 26 Sept 2026

Hotel Fernando III

San Jose 21 Seville Seville

€228

4 Oct - 5 Oct

includes taxes & fees

Stay at this business-friendly hotel in Seville. Enjoy free Wi-Fi, an outdoor pool and a rooftop terrace. Our guests praise the breakfast and the pool in their ...

9.6/10 Exceptional! (1,427 reviews)

"Magnifique hôtel, très bien situé pour tout faire à pieds. Piscine et terrasse sur le toit. Superbe lobby et salle à manger avec déjeuner diversifié. Chambre propre mais simple pour le prix"

Reviewed on 24 Sept 2026

Hotel Amadeus Sevilla

Calle Farnesio 6 Seville Seville

€184

25 Oct - 26 Oct

includes taxes & fees

Stay at this boutique hotel in Seville. Enjoy free Wi-Fi, a rooftop terrace and breakfast (surcharge). Our guests praise the breakfast and the bar in their reviews. ...

9.6/10 Exceptional! (1,285 reviews)

"Hotel Amadeus is charming and unique. The location is great and the amenities are lovely. We arrived early before our room was ready so they held our bags while we had breakfast. Love the breakfast! When we returned from exploring Sevilla our room was ready. Small room but very clean and cozy. They ..."

Reviewed on 30 Sept 2026

Hotel Rey Alfonso X

Calle Ximenez De Enciso, 35 Seville Seville

€242

26 Oct - 27 Oct

includes taxes & fees

Stay at this hotel in Seville. Enjoy free Wi-Fi, an outdoor pool and a rooftop terrace. Our guests praise the breakfast and the pool in their reviews. Popular ...

9.4/10 Exceptional! (1,225 reviews)

"Staff was super helpful and nice. Room was nice but a little noisy."

Reviewed on 29 Sept 2026

Hotel Murillo

Calle Lope de Rueda, 7-9 Seville Seville

€121

4 Oct - 5 Oct

includes taxes & fees

Stay at this family-friendly hotel in Seville. Enjoy free Wi-Fi, a rooftop terrace and breakfast (surcharge). Our guests praise the helpful staff and the clean ...

9/10 Wonderful! (1,065 reviews)

"When in Seville stay at Murillo Hotel. Great facility, staff and location."

Reviewed on 29 Sept 2026

See all 417 properties in Santa Cruz

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Santa Cruz

Find the best Santa Cruz areas for the activities you enjoy most.

A bustling urban street lined with historic buildings and trees.

Historical Center

Known for its fantastic nightlife, stunning cathedral and popular shops, there's plenty to explore in Historical Center. Top attractions like Casa de la Memoria Cultural Center and Calle Sierpes are major draws. Catch the metro at Plaza Nueva Tram Stop or Archivo de Indias Tram Stop to see more of the city.

A river with boats, a historic tower, and a cityscape with trees and buildings.

El Arenal

Travellers choose El Arenal for its abundant dining options. Hop aboard the metro at Plaza Nueva Tram Stop or Archivo de Indias Tram Stop and check out top sights like Teatro Maestranza.

A bustling outdoor café area with people dining and walking.

Alfalfa

Unique features of Alfalfa include the bars and historical sites. Make a stop by Calle Sierpes or Casa de la Memoria Cultural Center while you're exploring the area.

A riverside promenade with a bridge, historic buildings, and a calm river.

Triana

Known for its abundant dining options and stunning river views, there's plenty to explore in Triana. Top attractions like Triana Market and Triana Bridge are major draws, and you can catch the metro at Plaza de Cuba Station or Cartuja Station to see more of the city.

See properties