Sikeston Hotel Guide - Sikeston Depot Museum hotels in Sikeston, United States of America.

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Tonight
18 Dec - 19 Dec
Tomorrow
19 Dec - 20 Dec
This weekend
19 Dec - 21 Dec
Next weekend
26 Dec - 28 Dec

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Our top choices for Sikeston Depot Museum hotels

Exterior
Hampton Inn Sikeston

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
2.2 km from Sikeston Depot Museum
9.0 out of 10, Wonderful, (445)
"Friendly staff clean rooms "
United States
Christopher
The price is €94
includes taxes & fees
28 Dec - 29 Dec
Hampton Inn Sikeston
Exterior
Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
2.1 km from Sikeston Depot Museum
8.6 out of 10, Excellent, (443)
"Staff was great. Hotel was clean. Great sleep. "
United States
Jeffrey
The price is €90
includes taxes & fees
11 Jan - 12 Jan 2026
Holiday Inn Express & Suites Sikeston Southwest by IHG
Property amenity
Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
2.5 star property
2.4 km from Sikeston Depot Museum
9.4 out of 10, Exceptional, (40)
"THE ROOM WAS SPOTLESS, CLEAN LOBBY, WARM AND LOT OF VARITY BREAKFAST, STAFF IS SO NICE."
United States
AHMAD
The price is €98
includes taxes & fees
2 Jan - 3 Jan 2026
Fairfield Inn & Suites by Marriott Sikeston
Property amenity
TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston
3.0 star property
2.4 km from Sikeston Depot Museum
9.0 out of 10, Wonderful, (8)
"Great hotel! Very clean, quiet, plenty of amenities, pool was clean, breakfast in the morning was good with lots of options. I would definitely stay here again. "
United States
Scott
The price is €122
includes taxes & fees
15 Jan - 16 Jan 2026
TownePlace Suites by Marriott Sikeston
Indoor pool, outdoor pool
Pear Tree Inn Sikeston

Pear Tree Inn Sikeston

Pear Tree Inn Sikeston
2.5 star property
5 km from Sikeston Depot Museum
9.4 out of 10, Exceptional, (1001)
"Everything was clean, staff was friendly "
United States
Matthew
The price is €73
includes taxes & fees
23 Dec - 24 Dec
Pear Tree Inn Sikeston
Indoor pool, outdoor pool
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
5.1 km from Sikeston Depot Museum
9.4 out of 10, Exceptional, (1000)
"Clean room, great location and friendly staff"
United States
Mark
The price is €88
includes taxes & fees
23 Dec - 24 Dec
Drury Inn & Suites Sikeston, MO
Exterior
Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55
2.5 star property
4.9 km from Sikeston Depot Museum
8.4 out of 10, Very good, (282)
"Room was clean, breakfast was very good. "
United States
Connie
The price is €82
includes taxes & fees
18 Jan - 19 Jan 2026
Comfort Inn & Suites Sikeston I-55
Individually decorated, individually furnished, desk, blackout curtains
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
5 km from Sikeston Depot Museum
8.4 out of 10, Very good, (719)
"Stayed one night. Good rate for the Hotel "
United States
Paul
The price is €54
includes taxes & fees
21 Dec - 22 Dec
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Free daily full breakfast
Best Western Plus Sikeston

Best Western Plus Sikeston

Best Western Plus Sikeston
2.5 star property
5.4 km from Sikeston Depot Museum
8.4 out of 10, Very good, (1005)
"Easy parking , quiet and comfortable bed , we’ll stop again on our way back "
United States
joseph
The price is €73
includes taxes & fees
21 Dec - 22 Dec
Best Western Plus Sikeston
1 bedroom, desk, laptop workspace, blackout curtains
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston
2.0 star property
5.4 km from Sikeston Depot Museum
7.2 out of 10, Good, (1001)
"A great stay in every aspect. "
United States
Gertrude
The price is €61
includes taxes & fees
21 Dec - 22 Dec
Days Inn and Suites by Wyndham Sikeston
Room, 1 King Bed, Accessible, Non Smoking
Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area
2.0 star property
4.7 km from Sikeston Depot Museum
6.6 out of 10, (564)
"Awesomeness "
United States
Rick
The price is €58
includes taxes & fees
21 Dec - 22 Dec
Super 8 by Wyndham Sikeston/Miner Area
Iron/ironing board, free WiFi, bed sheets
Country Yard Inn and Suite

Country Yard Inn and Suite

Country Yard Inn and Suite
2.0 star property
5.5 km from Sikeston Depot Museum
6.8 out of 10, (120)
"Great spot en route home from Mississippi. Staff put me in a room that ended up being in a quiet section of the hotel. Great sleep."
United States
Andrew
The price is €54
includes taxes & fees
20 Dec - 21 Dec
Country Yard Inn and Suite
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Sikeston Depot Museum Hotel Reviews

Hampton Inn Sikeston

Hampton Inn Sikeston

10/10 Excellent
"Friendly staff clean rooms "
Christopher 2-night trip
Posted 1 day ago
Hampton Inn Sikeston

Hotels near other Sikeston Depot Museum attractions

Central Park

3.8/5 (36 reviews)
Explore the great outdoors at Central Park, a lovely green space in Sikeston. While in this relaxing area, you can savour the top-notch restaurants.
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City of Miner Convention Center

Learn about the events happening in City of Miner Convention Center during your trip to Miner. While in this relaxing area, you can savour the top-notch restaurants.
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Frequently asked questions

What's the area like around Sikeston Depot Museum?
Sikeston Depot Museum is located in a welcoming area of Sikeston known for its array of dining options. You'll find 15 hotels and other accommodations within a few miles for a convenient home base.
What's the best place to stay near Sikeston Depot Museum?
Hampton Inn Sikeston is one of the top choices for your stay based on our traveller data, and this hotel offers free breakfast and an indoor pool. It's located 1.4 mi (2.2 km) from Sikeston Depot Museum. Other good choices within 5 miles include Drury Inn & Suites Sikeston, MO and Fairfield Inn & Suites by Marriott Sikeston.
How many hotels will I find close to Sikeston Depot Museum?
Expedia has 15 hotels and other accommodation options a few miles from Sikeston Depot Museum.
If I need to cancel the hotel reservation for my stay near Sikeston Depot Museum, will I receive a refund?
Yes! The majority of hotel room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you have a non-refundable reservation, you might be able to still cancel and get a refund within a 24-hour period of booking. Put your dates in and click on "Search", then you can use the "fully refundable" filter to view the best options available near Sikeston Depot Museum.