Cape Girardeau Hotel Guide - Southeast Missouri Hospital hotels in Cape Girardeau, United States of America.

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25 Dec - 26 Dec
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26 Dec - 27 Dec
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26 Dec - 28 Dec
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2 Jan - 4 Jan

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Our top choices for Southeast Missouri Hospital hotels

Lobby
Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
3.0 star property
1.6 km from Southeast Missouri Hospital
9.6 out of 10, Exceptional, (468)
"The staff was very helpful and friendly. The rooms were modern and clean. The downtown location was perfect for us. "
United States
Deborah
The price is €120
includes taxes & fees
11 Jan - 12 Jan 2026
Courtyard by Marriott Cape Girardeau Downtown
Lobby sitting area
The Riverview

The Riverview

The Riverview
4.0 star property
2.1 km from Southeast Missouri Hospital
9.4 out of 10, Exceptional, (477)
"The room was clean and the mattress was extremely comfortable "
United States
Stacy
The price is €92
includes taxes & fees
29 Dec - 30 Dec
The Riverview
Desk, free WiFi
Town House Inn Cape Giradreau

Town House Inn Cape Giradreau

Town House Inn Cape Giradreau
2.5 star property
1.2 km from Southeast Missouri Hospital
6.0 out of 10, (206)
"Along a main street but not a lot of noise, especially in the rooms. Rooms exit to the outdoors."
United States
Gary
The price is €54
includes taxes & fees
4 Jan - 5 Jan 2026
Town House Inn Cape Giradreau
Standard Room, 1 Queen Bed, Non Smoking, Garden View
Rockwood Inn

Rockwood Inn

Rockwood Inn
2.0 star property
0.7 km from Southeast Missouri Hospital
10.0 out of 10, Exceptional, (18)
"We came into town for a concert and had a blast! The hotel was super comfy, and the staff were friendly. The rooms were very clean and the decor was beautiful! "
United States
Vanessa
The price is €144
includes taxes & fees
28 Dec - 29 Dec
Rockwood Inn
Courtyard
Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
2.5 star property
3.3 km from Southeast Missouri Hospital
9.6 out of 10, Exceptional, (785)
"Excellent stay"
United States
Christina
The price is €97
includes taxes & fees
31 Dec - 1 Jan 2026
Hampton Inn Cape Girardeau I 55 East
Lobby
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
3.5 km from Southeast Missouri Hospital
9.6 out of 10, Exceptional, (1001)
"Great place and staff, very accommodating!"
United States
Megan
The price is €86
includes taxes & fees
29 Dec - 30 Dec
Drury Plaza Hotel Cape Girardeau Conference Center
Room, 2 Queen Beds
Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
2.5 star property
6.8 km from Southeast Missouri Hospital
9.6 out of 10, Exceptional, (103)
"It was a nice stay"
United States
Douglas
The price is €86
includes taxes & fees
4 Jan - 5 Jan 2026
Tru By Hilton Cape Girardeau
Exterior
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
3.4 km from Southeast Missouri Hospital
9.4 out of 10, Exceptional, (1000)
"We like to stay at this hotel on our way to New Orleans and on our return trip to Wisconsin. It is convenient, clean, breakfast options are excellent and the 8 pm cookie time is always a hit. Staff are also very friendly. "
United States
Brian
The price is €87
includes taxes & fees
4 Jan - 5 Jan 2026
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Lobby
Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
2.5 star property
3.7 km from Southeast Missouri Hospital
9.4 out of 10, Exceptional, (142)
"Nice hotel, clean and comfortable "
United States
Laura
The price is €84
includes taxes & fees
1 Jan - 2 Jan 2026
Fairfield Inn & Suites by Marriott Cape Girardeau
Business centre
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
3.0 star property
3.8 km from Southeast Missouri Hospital
9.4 out of 10, Exceptional, (1000)
"Very friendly staff and great breakfast"
United States
Ray
The price is €86
includes taxes & fees
29 Dec - 30 Dec
Drury Inn & Suites Cape Girardeau
Lobby
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center
2.5 star property
3.3 km from Southeast Missouri Hospital
9.0 out of 10, Wonderful, (1002)
"Nice place for a stay at a reasonable price."
United States
Arthur
The price is €67
includes taxes & fees
29 Dec - 30 Dec
Pear Tree Inn Cape Girardeau Near the Medical Center
Lobby
Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
3.0 star property
15.9 km from Southeast Missouri Hospital
9.6 out of 10, Exceptional, (1002)
"Breakfast was great- staff was welcoming. Will stay there again."
United States
Laura
The price is €74
includes taxes & fees
28 Dec - 29 Dec
Drury Inn & Suites Jackson MO
Property amenity
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
7.9 km from Southeast Missouri Hospital
8.8 out of 10, Excellent, (674)
"Great place "
United States
GUY
The price is €77
includes taxes & fees
7 Jan - 8 Jan 2026
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Exterior
Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG
2.5 star property
3.7 km from Southeast Missouri Hospital
8.2 out of 10, Very good, (885)
"Room was clean and spacious."
United States
George
The price is €72
includes taxes & fees
25 Jan - 26 Jan 2026
Candlewood Suites Cape Girardeau by IHG
Lobby
Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau
2.5 star property
7.9 km from Southeast Missouri Hospital
8.2 out of 10, Very good, (740)
"Room was clean and affordable for one night. The morning person could have been more attentive to me being there for breakfast. No greeting at all and sat on her phone. I was the only one down in the breakfast area. Be more aware of her surroundings while working alone. "
United States
Lori
The price is €73
includes taxes & fees
28 Dec - 29 Dec
Comfort Suites Jackson-Cape Girardeau
Lobby
Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North
2.5 star property
4.6 km from Southeast Missouri Hospital
7.2 out of 10, Good, (686)
"Overall was wonderful customer service and breakfast"
United States
Stephanie
The price is €55
includes taxes & fees
31 Dec - 1 Jan 2026
Quality Inn Cape Girardeau North
Economy Single Room, 1 Queen Bed, Kitchenette
Town House Inn

Town House Inn

Town House Inn
2.5 star property
13.1 km from Southeast Missouri Hospital
7.6 out of 10, Good, (426)
"The staff member Tim was very friendly and nice. "
United States
Julie
The price is €64
includes taxes & fees
1 Jan - 2 Jan 2026
Town House Inn
Lobby
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
2.5 star property
3.7 km from Southeast Missouri Hospital
9.0 out of 10, Wonderful, (1000)
"Great stay"
United States
Heather
The price is €67
includes taxes & fees
29 Dec - 30 Dec
Pear Tree Inn Cape Girardeau West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Southeast Missouri Hospital Hotel Reviews

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent
"The room was great. Very clean and the bed was comfortable. "
Josh 1-night trip
Posted 4 days ago
Drury Plaza Hotel Cape Girardeau Conference Center

Hotels near other Southeast Missouri Hospital attractions

Panorama of Academic Hall, Southeast Missouri State University

Southeast Missouri State University

4.4/5 (137 reviews)
Take a campus tour or just explore the area of Southeast Missouri State University during your trip to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.
See properties
View of the Christopher S. Bond Bridge over Missouri River in Kansas City, from the riverfront park

Riverfront Bridge Park

4.4/5 (74 reviews)
Riverfront Bridge Park is just one of the places to see in Cape Girardeau, so why not enjoy the other things to explore during your travels? While in this family-friendly area, you can savour the top-notch restaurants.
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Frequently asked questions

What's the area like around Southeast Missouri Hospital?
Southeast Missouri Hospital is located in Cape Girardeau. This family-friendly area is known for its array of dining options. If you're looking for a convenient place to stay, take a look at the 13 hotels and other accommodation options you'll find within a mile.
Where is the best place to stay near Southeast Missouri Hospital?
Drury Plaza Hotel Cape Girardeau Conference Center is one of the top choices for your stay based on our traveller data, and this hotel offers free breakfast and a restaurant. It's located 2.2 mi (3.5 km) from Southeast Missouri Hospital. Other good options within 5 miles include The Riverview and Courtyard by Marriott Cape Girardeau Downtown.
How many hotels are there near Southeast Missouri Hospital?
Expedia has 13 hotels and other accommodation options within a mile from Southeast Missouri Hospital.
If I need to cancel the hotel reservation for my stay near Southeast Missouri Hospital, will I receive a refund?
Yes, the majority of hotel bookings are fully refundable provided that you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you have a reservation that's non-refundable, you might still have the option to cancel and be given a refund within 24 hours of booking. Enter dates in and click on "Search", then filter by "fully refundable" to view the best deals near Southeast Missouri Hospital.
What can I see and do near Southeast Missouri Hospital?
You might spend a leisurely day outdoors at Cape Rock Park and Fort D Historic Site. Create some family memories at Cape Splash Family Aquatic Center and Cape Girardeau Conservation Nature Center. You might plan a visit to Show Me Center or eDen Spa & Salon while you're in the area.