A bench, a bicycle, and a lake surrounded by trees.

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Go beyond your typical stay in Upstate South Carolina

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Our top choices for Upstate South Carolina hotels

Carolina Inn Anderson Clemson Area

Anderson

Luis Fernando

includes taxes & fees

16 Jul - 17 Jul

Best Western Plus Clemson Hotel & Conference Center

Clemson

Tammy

includes taxes & fees

20 Jul - 21 Jul

Premium bedding, in-room safe, individually furnished, laptop workspace

Carolina Camp Cedar

Pickens

Katlynn

includes taxes & fees

15 Jul - 16 Jul

Tru by Hilton Seneca Clemson

Seneca

Jason

includes taxes & fees

21 Jul - 22 Jul

Clemson University's James F. Martin Inn

Clemson

Jesse

includes taxes & fees

26 Jul - 27 Jul

Hampton Inn Greer Greenville, SC

Greer

Trina

includes taxes & fees

26 Jul - 27 Jul

Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG

Anderson

Edna

includes taxes & fees

2 Aug - 3 Aug

Lakeside Lodge Clemson

Seneca

JEFFREY

includes taxes & fees

26 Jul - 27 Jul

Best Western Spartanburg Northwest

Spartanburg

Sonia

includes taxes & fees

20 Jul - 21 Jul

The Inn at Patrick Square

Clemson

Karyn

includes taxes & fees

15 Jul - 16 Jul

Hampton Inn Spartanburg-North I-85

Spartanburg

Stephanie

includes taxes & fees

9 Aug - 10 Aug

Best Western Plus Greenville I-385 Inn & Suites

Greenville

Shabana

includes taxes & fees

26 Jul - 27 Jul

Aloft by Marriott Greenville Downtown

Greenville Downtown

Johari

includes taxes & fees

26 Jul - 27 Jul

Microtel Inn & Suites by Wyndham Anderson/Clemson

Anderson

Kathryn A

includes taxes & fees

22 Jul - 23 Jul

Embassy Suites Greenville Golf Resort & Conference Center

Greenville

Janet

includes taxes & fees

2 Aug - 3 Aug

Fairfield Inn & Suites by Marriott Greenville Simpsonville

Simpsonville

Carole

includes taxes & fees

2 Aug - 3 Aug

Holiday Inn Express Hotel & Suites Spartanburg-North by IHG

Spartanburg

Thomas

includes taxes & fees

26 Jul - 27 Jul

Standard Room, 2 Queen Beds, Non Smoking, Refrigerator & Microwave

Clarion Greenville Airport Inn

Greenville

Gladys

includes taxes & fees

3 Aug - 4 Aug

Best Western Spartanburg I-26

Spartanburg

Daniel

includes taxes & fees

25 Jul - 26 Jul

SpringHill Suites by Marriott Greenville Downtown

Greenville Downtown

Samir

includes taxes & fees

2 Aug - 3 Aug

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Holiday Rentals in Upstate South Carolina

Cabin

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

"Awesome place "

Apartment

Deluxe Two Bedroom (Self Check-in with Virtual Front Desk) | Living area

Mint House Greenville Downtown by Kasa

Greenville Downtown

"Love the location. Room was great."

Cottage

< 3 Mi to Dtwn: Modern Cottage in Greenville!

Greenville

Aparthotel

Full-sized fridge, microwave, oven, stovetop

stayAPT Suites Greenville-Haywood Mall

Greenville

"This is a great hotel for the price!!"

Cottage

2 Mi to Downtown: Luxe Greenville Retreat!

Greenville

"Great house! Very clean and comfortable. Outstanding amenities. Conveniently located. "

Cottage

Claires Cottage ~ 4 Mi to Downtown Greenville!

Greenville

"Great trip. The small cottage was perfect for my wife and I and the owner was very responsive."

Cottage

Waterfront Seneca Cabin ~ 4 Mi to Boat Launch!

Seneca

"Beautiful and quaint cabin! Highly recommend, great view of the lake."

Apartment

Serene Travelers Rest Apartment: 7 Mi to Downtown!

Travelers Rest

"The best time ever. My wife and I enjoyed our Honeymoon and stay here. We will come back every year for our Anniversary now and also to vacation here. The area was beautiful, quiet, and safe. We had everything we needed. No other vacation spot in South Carolina can compete. Thank you for our wonderful stay and perfect memories! "

Cottage

Cozy Home in Historic Area ~ 2 Mi to Main St!

Greenville

"Absolutely adorable property. Little bit of an interesting part of town. We weren’t spending a bunch of time on property so it didn’t mater. Super close to down town and the house is well kept. "

Cottage

Serene Cabin w/ Pond & Creek on South Saluda River

Cleveland

"I chose this cabin due to its close proximity to the pretty place chapel. The property was BEAUTIFUL and tucked away. The silence and change of scenery was well needed and felt like we were at home. I honestly don’t have enough good things to say about the host Mr. Steve and his generosity and professionalism!"

Cottage

Stay at Jos Taylor Retreat: 9 Mi to Greenville!

Taylors

Cottage

Cleveland Home w/ South Saluda Fishing Access

Cleveland

"This was a fishing trip that myself and a couple of my friends went on. The cabin was exactly as described in the listing and then some. Very clean and had every amenity you could think of. The host lives next door and went above and beyond making sure we had everything we needed and were comfortable. He even lent us his state pass to get into the parks and supplied his vast knowledge of where and what to use for fishing in the creeks. Will definitely be going back sometime in the near future."

Cottage

Families Welcome, Fenced Yard: Inviting Greer Home

Greer

"This property is such an amazing find. Three large bedrooms, very clean and well maintained. Close to town of Greer and all amenities. Very easy check-in. Beds very comfortable. Kitchen well equipped for the week we were there."

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Stay near popular Upstate South Carolina attractions

A historic building with a clock tower, surrounded by a well-maintained lawn with a paw print design.

Clemson University

9.6/10 (1,439 reviews)

Enjoy the student vibe around Clemson University, a top university in Clemson. Experience the area's theatre scene or attend a football match.

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Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, sports teams and sights from Discovery Island Water Park to Frankie's Fun Park.

See all hotels in Upstate South Carolina

An aerial view of a park with a winding path, trees in autumn colors, and a bridge.

Top Upstate South Carolina Hotel Reviews

Aloft by Marriott Greenville Downtown

8/10 Good

"We always love Aloft! Not having a fridge in our room was a bit inconvenient, but we made it work!"

Courtyard by Marriott Greenville Haywood Mall

8/10 Good

"The hotel is nice, not the top notch Marriott. Since they don't offer breakfast, they should at least have free coffee in the lounge. It's crazy to pay $10 a night for self-parking in their lot. We didn't see any sign of security around. Room was comfortable."

Hyatt Regency Greenville

10/10 Excellent

"We really enjoyed our stay at this hotel! The hotel has a restaurant, café, and bar, which was very convenient. The staff at check-in were very kind and helpful, and the room was nice as well! I do wish breakfast had been included in the room rate, but otherwise, it was a great place to stay!"