
Uptown Greenville Holidays
- Plan, book, travel with confidence
Better together
Save up to €185 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place
Where to stay in Uptown Greenville
Find the best Uptown Greenville areas and neighborhoods for the activities you enjoy most. Learn more about Uptown Greenville

Medical District
1 out of top 10 points of interest in this area
If you're looking for some top things to see and do in Medical District and surrounding area, you can visit Arlington Crossing and Town Common.
Top hotels in Uptown Greenville

Hilton Garden INN Greenville University
423 EVANS ST, Greenville, NC
Fully refundableReserve now, pay when you stay
The price is €122 per night from 24 Aug to 25 Aug
€122
24 Aug - 25 Aug
includes taxes & fees
9.2/10 Wonderful! (54 reviews)
"Very clean-friendly staff. Great location!"
Reviewed on 9 Aug 2025

Staybridge Suites Greenville Medical Center by IHG
930 Crosswind Street, Greenville, NC
Fully refundable
The price is €101 per night from 14 Sept to 15 Sept
€101
14 Sept - 15 Sept
includes taxes & fees
9.2/10 Wonderful! (71 reviews)
Highly recommend
"It was absolutely amazing, had your standard continental breakfast, but the bed, oh my lord, extremely comfortable!"
Reviewed on 9 Aug 2025

Microtel Inn & Suites by Wyndham Greenville/University Medic
450 Moye Blvd, Greenville, NC
Fully refundableReserve now, pay when you stay
The price is €65 per night from 21 Aug to 22 Aug
€65
21 Aug - 22 Aug
includes taxes & fees
7/10 Good! (1,003 reviews)
"The housekeeping staff was excellent. The young lady called "TT"was very exceptional due to her"
Reviewed on 11 Aug 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.