Cheap Flights from Madrid to Panama City

View €488 flight on Mon, 11 Aug 2025Opens in a new window

Popular airlines from Madrid to Panama City

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Cheap flights from Madrid to Panama City (MAD-PTY)

Prices were available within the past 7 days and start at €488 for one-way flights and €584 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

United
Thu, 15 Jan - Sun, 1 Feb
MAD
Madrid
PTY
Panama City
€584 Return, found 6 days ago
€584
Return
found 6 days ago
Select United flight, departing Thu, 15 Jan from Madrid to Panama City, returning Sun, 1 Feb, priced at €584 found 6 days ago
United
Sat, 6 Sep - Mon, 22 Sep
MAD
Madrid
PTY
Panama City
€585 Return, found 2 days ago
€585
Return
found 2 days ago
Select United flight, departing Sat, 6 Sep from Madrid to Panama City, returning Mon, 22 Sep, priced at €585 found 2 days ago
Lufthansa
Thu, 15 Jan - Wed, 28 Jan
MAD
Madrid
PTY
Panama City
€608 Return, found 6 days ago
€608
Return
found 6 days ago
Select Lufthansa flight, departing Thu, 15 Jan from Madrid to Panama City, returning Wed, 28 Jan, priced at €608 found 6 days ago
Iberia
Mon, 16 Mar - Thu, 30 Apr
MAD
Madrid
PTY
Panama City
€611 Return, found 6 days ago
€611
Return
found 6 days ago
Select Iberia flight, departing Mon, 16 Mar from Madrid to Panama City, returning Thu, 30 Apr, priced at €611 found 6 days ago
Air Canada
Thu, 15 Jan - Sun, 1 Feb
MAD
Madrid
PTY
Panama City
€619 Return, found 6 days ago
€619
Return
found 6 days ago
Select Air Canada flight, departing Thu, 15 Jan from Madrid to Panama City, returning Sun, 1 Feb, priced at €619 found 6 days ago
KLM
Fri, 16 Jan - Sun, 1 Feb
MAD
Madrid
PTY
Panama City
€628 Return, found 6 days ago
€628
Return
found 6 days ago
Select KLM flight, departing Fri, 16 Jan from Madrid to Panama City, returning Sun, 1 Feb, priced at €628 found 6 days ago

Find the cheapest month to fly from Madrid (MAD) to Panama City (PTY)

May is typically the cheapest month to fly

From €457 - €785 per traveller.

Graph displaying average flight prices per month

*Available to Expedia members.