€182 Cheap Flights Medellín to Panama City (MDE-PTY)

View €182 flight on Fri, 5 Dec 2025Opens in a new window

Popular airlines from Jose Maria Cordova Intl. Airport (MDE) to Tocumen Intl. Airport (PTY)

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Cheap flights from Medellín to Panama City (MDE-PTY)

Prices were available within the past 7 days and start at €182 for one-way flights and €319 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Copa
Thu, 6 Nov - Tue, 11 Nov
MDE
Medellin
PTY
Panama City
€319 Return, found 3 days ago
€319
Return
found 3 days ago
Select Copa flight, departing Thu, 6 Nov from Medellin to Panama City, returning Tue, 11 Nov, priced at €319 found 3 days ago
Copa
Thu, 4 Sep - Thu, 11 Sep
MDE
Medellin
PTY
Panama City
€320 Return, found 6 days ago
€320
Return
found 6 days ago
Select Copa flight, departing Thu, 4 Sep from Medellin to Panama City, returning Thu, 11 Sep, priced at €320 found 6 days ago
Copa
Thu, 4 Sep - Thu, 11 Sep
MDE
Medellin
PTY
Panama City
€340 Return, found 6 days ago
€340
Return
found 6 days ago
Select Copa flight, departing Thu, 4 Sep from Medellin to Panama City, returning Thu, 11 Sep, priced at €340 found 6 days ago
Copa
Thu, 4 Sep - Thu, 11 Sep
MDE
Medellin
PTY
Panama City
€359 Return, found 6 days ago
€359
Return
found 6 days ago
Select Copa flight, departing Thu, 4 Sep from Medellin to Panama City, returning Thu, 11 Sep, priced at €359 found 6 days ago
Copa
Thu, 4 Sep - Thu, 11 Sep
MDE
Medellin
PTY
Panama City
€377 Return, found 6 days ago
€377
Return
found 6 days ago
Select Copa flight, departing Thu, 4 Sep from Medellin to Panama City, returning Thu, 11 Sep, priced at €377 found 6 days ago
Copa
Thu, 4 Sep - Thu, 11 Sep
MDE
Medellin
PTY
Panama City
€473 Return, found 6 days ago
€473
Return
found 6 days ago
Select Copa flight, departing Thu, 4 Sep from Medellin to Panama City, returning Thu, 11 Sep, priced at €473 found 6 days ago
Copa
Thu, 4 Sep - Thu, 11 Sep
MDE
Medellin
PTY
Panama City
€491 Return, found 6 days ago
€491
Return
found 6 days ago
Select Copa flight, departing Thu, 4 Sep from Medellin to Panama City, returning Thu, 11 Sep, priced at €491 found 6 days ago
Copa
Thu, 4 Sep - Thu, 11 Sep
MDE
Medellin
PTY
Panama City
€510 Return, found 6 days ago
€510
Return
found 6 days ago
Select Copa flight, departing Thu, 4 Sep from Medellin to Panama City, returning Thu, 11 Sep, priced at €510 found 6 days ago
Copa
Thu, 6 Nov - Tue, 11 Nov
MDE
Medellin
PTY
Panama City
€632 Return, found 3 days ago
€632
Return
found 3 days ago
Select Copa flight, departing Thu, 6 Nov from Medellin to Panama City, returning Tue, 11 Nov, priced at €632 found 3 days ago
Aeromexico
Thu, 4 Sep - Thu, 11 Sep
MDE
Medellin
PTY
Panama City
€671 Return, found 6 days ago
€671
Return
found 6 days ago
Select Aeromexico flight, departing Thu, 4 Sep from Medellin to Panama City, returning Thu, 11 Sep, priced at €671 found 6 days ago

Find the cheapest month to fly from Medellín (MDE) to Panama City (PTY)

March is typically the cheapest month to fly

From €175 - €353 per traveller.

Graph displaying average flight prices per month

Medellín to Panama City route information
Origin airport
José María Córdova Intl.
Destination airport
Tocumen Intl.
Return price
€319
Distance
539 km
Average flight time
1 hour 23 mins

Perfect flights from Medellín to Panama City

Embark on an unforgettable journey without breaking the bank with Expedia's incredible deals on cheap flights from Medellín to Panama City. Whether you're aching for a romantic escape with your partner, craving an adventurous solo expedition, or yearning to immerse yourself in the local history and culture, we've got you covered.
 
Picture yourself strolling through the streets of Tocumen, surrounded by breathtaking architecture and absorbing the vibrant atmosphere of this captivating city. Indulge in the mouth-watering local specialties, from tantalizing street food to exquisite fine dining. With Expedia, you can experience all of this and more, without sacrificing your budget.
 
Our flexible José María Córdova Intl. to Tocumen Intl. ticket options cater to your travel preferences, with incredible one-way fares from €182 and roundtrip prices from €319. Whether you're planning a short city break or a longer adventure, our dynamic pricing ensures that you find the best deals for your journey.
 
But the magic doesn't stop there. Expedia offers a range of partner services to enhance your trip. Rent a car at Tocumen Intl. and explore Tocumen and its surrounding areas at your own pace. Discover hidden gems off the beaten path, and create unforgettable memories. We also provide a handpicked selection of accommodations, from charming bed and breakfasts to luxury hotels, ensuring that you have a comfortable and memorable stay.
 
Planning your next great adventure is a breeze with Expedia. Our user-friendly platform, unbeatable prices, and round-the-clock customer support are designed to make your travel experience seamless and stress-free. So, why wait? Book your MDE to PTY travel arrangements today and embark on the journey of a lifetime in Panama City.

Frequently asked questions

How much is a flight from Medellin Airport to Tocumen Intl. Airport (PTY)?
Start packing your bags, because round-trip flights from Jose Maria Cordova Intl. Airport (MDE) to Panama Airport start from €319. That's based on fares listed within the last 7 days on Expedia for flights departing within the next year. Prices can move quickly, so book now to score the best deal. Prices and availability are subject to change. Additional terms apply.
Do I need to pay a cancellation fee if I cancel my flight from MDE to PTY?
The majority of flights can be cancelled online, but whether you incur a fee all comes down to your airline. If you do have to cancel your break, follow the easy instructions in the Customer Service Portal.
How do I find cheap flights from Medellin Airport to Panama Airport that have flexible change policies?
Many airlines offer the option to reschedule your flight without a change fee. All you pay is the difference between the original flight and the new flight. When you're searching for Medellin Airport to PTY flights, you'll see a "no change fees" filter for you to select.
How far is the flight from Medellin Airport to Panama Airport?
A flight distance of just 540 kilometres separates Rionegro and Tocumen. Once you're in the air, you won't get a chance to do much more than browse the magazine in your seat-back pocket.
Which airlines fly direct from Jose Maria Cordova Intl. Airport (MDE) to Tocumen Intl. Airport (PTY)?
Copa Airlines (CM) is one of the preferred choices for many travellers flying between Medellin Airport and Tocumen Intl. Airport (PTY). Choose from the 199 flights it offers on this route each month. You could also have a look at fares with Copa Airlines Colombia (P5). It operates 13 flights a month between Rionegro and Tocumen.
Are MDE to Panama Airport flight tickets cheaper when they're purchased at the last minute?
Booking your trip from Jose Maria Cordova Intl. Airport (MDE) to Panama Airport last minute could be your ticket to an awesome deal. However, it might cost you a whole lot more! If you'd rather not take any chances, book well ahead of your departure date. In fact, Expedia has some of the biggest bargains up to 12 months in advance. If your preferred carrier hasn't released tickets yet, check back regularly as deals are updated on Expedia all the time.
*Available to Expedia members.