A calm river with boats, lush greenery, and a clear blue sky.

4 Star Hotels in Big Pine Key, Florida

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Check availability on Big Pine Key 4 Star Hotels

Next weekend
13 Nov - 15 Nov
In two weeks
20 Nov - 22 Nov

Our top choices for Big Pine Key 4-star hotels

A swimming pool surrounded by palm trees and lounge chairs.

1. Tranquility Bay Beachfront Hotel and Resort

Tranquility Bay Beachfront Hotel and Resort
4.0 star property
Marathon
8.8 out of 10, Excellent, (1,002 reviews)
"Perfect place for a family vacation. We loved everything about it"
United States
Shauna
The price is €267
includes taxes & fees
1 Dec - 2 Dec
Tranquility Bay Beachfront Hotel and Resort
A marina with boats docked, a swimming pool, and a building with a blue roof.

2. Faro Blanco Resort Marathon Florida Keys, Curio by Hilton

Faro Blanco Resort Marathon Florida Keys, Curio by Hilton
4.0 star property
Marathon
8.6 out of 10, Excellent, (1,135 reviews)
"Great resort, restaurant and bar!"
United States
Rick
The price is €174
includes taxes & fees
15 Nov - 16 Nov
Faro Blanco Resort Marathon Florida Keys, Curio by Hilton
A wooden deck with a pool and chairs overlooking a beach with palm trees.

3. Grassy Flats Resort & Beach Club

Grassy Flats Resort & Beach Club
4.0 star property
Marathon
9.4 out of 10, Exceptional, (504 reviews)
"Loved everything about this place!"
United States
Amanda
The price is €229
includes taxes & fees
7 Dec - 8 Dec
Grassy Flats Resort & Beach Club
A large hotel with a pool, multiple balconies, and palm trees.

4. Marlin Bay Resort & Marina

Marlin Bay Resort & Marina
4.5 star property
Marathon
10.0 out of 10, Exceptional, (3 reviews)
"Wonderful vacation!"
United States
Chardell
Marlin Bay Resort & Marina
A covered outdoor area with a wooden deck, white railings, and a view of the ocean.

5. Waterfront Luxury Villa

Waterfront Luxury Villa
4.0 star property
Marathon Shores
Waterfront Luxury Villa
Property grounds

6. Indigo Reef Marina Homes Close to Boat Slip by Pack and Relax

Indigo Reef Marina Homes Close to Boat Slip by Pack and Relax
4.0 star property
Marathon Shores
Indigo Reef Marina Homes Close to Boat Slip by Pack and Relax
Pool

7. Indigo Reef Marina Homes by Pack and Relax

Indigo Reef Marina Homes by Pack and Relax
4.0 star property
Marathon
Indigo Reef Marina Homes by Pack and Relax
Pool

8. Indigo Reef Marina Pet Friendly Homes by Pack and Relax

Indigo Reef Marina Pet Friendly Homes by Pack and Relax
4.0 star property
Marathon
Indigo Reef Marina Pet Friendly Homes by Pack and Relax
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Explore similar 5-star hotels

Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Big Pine Key.
Isla Bella Beach Resort & Spa

Isla Bella Beach Resort & Spa

1 Knights Key Boulevard Marathon FL
The price is €281 per night from 15 Nov to 16 Nov
€281
15 Nov - 16 Nov
includes taxes & fees
9.2/10 Wonderful! (1,302 reviews)
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Big Pine Key

Snorkel crystal-clear waters teeming with colourful fish, then spot adorable Key deer at the National Key Deer Refuge. Unwind on pristine beaches like Calusa or Sandspur, where soft sand meets turquoise waves.

See all hotels in Big Pine Key
A coastal town with a beach, clear waters, a pier, and lush greenery.

Top Big Pine Key Hotel Reviews

Tranquility Bay Beachfront Hotel and Resort

Tranquility Bay Beachfront Hotel and Resort

10/10 Excellent
"I enjoyed the hotel ."
Madileny 1-night trip
Posted 1 hour ago
Tranquility Bay Beachfront Hotel and Resort
Faro Blanco Resort Marathon Florida Keys, Curio by Hilton

Faro Blanco Resort Marathon Florida Keys, Curio by Hilton

10/10 Excellent
"We only stayed here for two nights and booked a family room. It was well equipped and the beds were super comfy. The resort was immaculate and the staff are so friendly. We would love to return and stay longer to enjoy the resort next time."
Amy 2-night trip
Posted 6 hours ago
Faro Blanco Resort Marathon Florida Keys, Curio by Hilton

Frequently asked questions

What are the best 4-star hotels in Big Pine Key?
Create unforgettable holiday memories in Big Pine Key at Little Palm Island Resort & Spa - A Noble House Resort. A favourite with our guests, this 4-star hotel offers loads of conveniences for a relaxing and comfortable stay.
How much does it cost to stay in a 4-star hotel in Big Pine Key?
To find a 4-star hotel in Big Pine Key that fits your budget, use Expedia's handy filters. Take a look at the available options during your holiday dates and use our pricing filter to set your limit. You can also list your results by the most budget-friendly stay first.

  • Search for the lowest price from €281

What's the difference between 5-star and 4-star hotels in Big Pine Key?
Treat yourself to luxury living during your Big Pine Key getaway by checking in to a 4-star hotel. As well as featuring upscale accommodation, these retreats are usually packed with amenities like large beds, complimentary bathrobes and plenty more. A 5-star hotel will go above and beyond to make your stay an even more indulgent and unforgettable one. 24-hour concierge assistance, elegant furnishings and world-class dining are only the start of the exclusive services and conveniences you'll likely have access to.