A calm river with boats, lush greenery, and a clear blue sky.

4 Star Hotels in Big Pine Key, Florida

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Our top choices for Big Pine Key 4-star hotels

2 bars/lounges, poolside bar

Faro Blanco Resort Marathon Florida Keys, Curio by Hilton

Faro Blanco Resort Marathon Florida Keys, Curio by Hilton
4.0 star property
Marathon
8.6 out of 10, Excellent, (1,174 reviews)
"Great location!"
United States
Frank
The price is €160
includes taxes & fees
16 Aug - 17 Aug
Faro Blanco Resort Marathon Florida Keys, Curio by Hilton
3 outdoor pools, pool loungers

Tranquility Bay Beachfront Hotel and Resort

Tranquility Bay Beachfront Hotel and Resort
4.0 star property
Marathon
8.8 out of 10, Excellent, (1,006 reviews)
"Property was well maintained, staff was super helpful and kind!"
United States
Brittany
The price is €248
includes taxes & fees
20 Aug - 21 Aug
Tranquility Bay Beachfront Hotel and Resort
Balcony view

Grassy Flats Resort & Beach Club

Grassy Flats Resort & Beach Club
4.0 star property
Marathon
9.4 out of 10, Exceptional, (475 reviews)
"Great location, beautiful room with sea view balcony. Would stay again"
United Kingdom
Katherine
The price is €230
includes taxes & fees
22 Jul - 23 Jul
Grassy Flats Resort & Beach Club
Exterior

The Reef at Marathon, Florida Keys

The Reef at Marathon, Florida Keys
2.5 star property
Marathon
9.2 out of 10, Wonderful, (34 reviews)
"Wonderful stay! "
United States
Jennifer
The Reef at Marathon, Florida Keys
Exterior

Marlin Bay Resort & Marina

Marlin Bay Resort & Marina
4.5 star property
Marathon
10.0 out of 10, Exceptional, (3 reviews)
"Wonderful vacation!"
United States
Chardell
Marlin Bay Resort & Marina
Luxury Villa, 3 Bedrooms, Balcony, Overwater | Terrace/patio

Waterfront Luxury Villa

Waterfront Luxury Villa
4.0 star property
Marathon Shores
Waterfront Luxury Villa
Villa, 3 Bedrooms | Property grounds

Indigo Reef Marina Homes Close to Boat Slip by Pack and Relax

Indigo Reef Marina Homes Close to Boat Slip by Pack and Relax
4.0 star property
Marathon Shores
Indigo Reef Marina Homes Close to Boat Slip by Pack and Relax
Outdoor pool

Indigo Reef Marina Homes by Pack and Relax

Indigo Reef Marina Homes by Pack and Relax
4.0 star property
Marathon
Indigo Reef Marina Homes by Pack and Relax
Outdoor pool

Indigo Reef Marina Pet Friendly Homes by Pack and Relax

Indigo Reef Marina Pet Friendly Homes by Pack and Relax
4.0 star property
Marathon
Indigo Reef Marina Pet Friendly Homes by Pack and Relax
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Explore similar 5-star hotels

Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Big Pine Key.
Isla Bella Beach Resort & Spa

Isla Bella Beach Resort & Spa

1 Knights Key Boulevard Marathon FL
The price is €283 per night from 4 Aug to 5 Aug
€283
4 Aug - 5 Aug
includes taxes & fees
9.2/10 Wonderful! (1,205 reviews)
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PoolSpaHot tubBreakfast includedWaterpark
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Big Pine Key

Snorkel crystal-clear waters teeming with colourful fish, then spot adorable Key deer at the National Key Deer Refuge. Unwind on pristine beaches like Calusa or Sandspur, where soft sand meets turquoise waves.

See all hotels in Big Pine Key
A beach with clear turquoise water, a red umbrella, and a bridge in the background.

Top Big Pine Key Hotel Reviews

Faro Blanco Resort Marathon Florida Keys, Curio by Hilton

Faro Blanco Resort Marathon Florida Keys, Curio by Hilton

10/10 Excellent
"Excelente hotel y atención"
Daliane 1-night trip
Posted 13 hours ago
Faro Blanco Resort Marathon Florida Keys, Curio by Hilton
Tranquility Bay Beachfront Hotel and Resort

Tranquility Bay Beachfront Hotel and Resort

10/10 Excellent
"Super clean room ,beitiful garden, and soo quiet, relax"
Carmen 3-night trip
Posted 2 days ago
Tranquility Bay Beachfront Hotel and Resort

Frequently asked questions

What are the best 4-star hotels in Big Pine Key?
Create unforgettable holiday memories in Big Pine Key at Little Palm Island Resort & Spa - A Noble House Resort. A favourite with our guests, this 4-star hotel offers loads of conveniences for a relaxing and comfortable stay.
How much does it cost to stay in a 4-star hotel in Big Pine Key?
To find a 4-star hotel in Big Pine Key that fits your budget, use Expedia's handy filters. Take a look at the available options during your holiday dates and use our pricing filter to set your limit. You can also list your results by the most budget-friendly stay first.

  • Search for the lowest price from €283

What's the difference between 5-star and 4-star hotels in Big Pine Key?
Treat yourself to luxury living during your Big Pine Key getaway by checking in to a 4-star hotel. As well as featuring upscale accommodation, these retreats are usually packed with amenities like large beds, complimentary bathrobes and plenty more. A 5-star hotel will go above and beyond to make your stay an even more indulgent and unforgettable one. 24-hour concierge assistance, elegant furnishings and world-class dining are only the start of the exclusive services and conveniences you'll likely have access to.