4 Star Hotels in Upstate South Carolina, South Carolina
Change your mind
Book hotels with free cancellation
Be picky
Search almost a million properties worldwide
Check availability on Upstate South Carolina 4 Star Hotels
Top Upstate South Carolina 4 Star Hotels

Grand Bohemian Lodge Greenville, Autograph Collection
Grand Bohemian Lodge Greenville, Autograph Collection
9.6 out of 10, Exceptional, (369)
The price is €228
includes taxes & fees
1 Sept - 2 Sept

The Westin Poinsett Greenville
The Westin Poinsett Greenville
9.2 out of 10, Wonderful, (1000)
The price is €169
includes taxes & fees
17 Aug - 18 Aug

The Shepherd Hotel Downtown Clemson
The Shepherd Hotel Downtown Clemson
9.8 out of 10, Exceptional, (653)
The price is €170
includes taxes & fees
1 Sept - 2 Sept

Hotel Hartness
Hotel Hartness
9.8 out of 10, Exceptional, (575)
The price is €197
includes taxes & fees
10 Aug - 11 Aug

Greenville Marriott
Greenville Marriott
8.6 out of 10, Excellent, (584)
The price is €125
includes taxes & fees
17 Aug - 18 Aug

Mint House Greenville - Downtown
Mint House Greenville - Downtown
9.2 out of 10, Wonderful, (708)
The price is €104
includes taxes & fees
17 Aug - 18 Aug

The Abernathy of Clemson
The Abernathy of Clemson
9.6 out of 10, Exceptional, (537)

Park Place Apartments by Landing
Park Place Apartments by Landing
7.8 out of 10, Good, (37)
Save an average of 15% on thousands of hotels when you're signed in
Learn more about Upstate South Carolina
Experience the family-friendly area of Upstate South Carolina—live music, sports teams and sights from Discovery Island Water Park to Frankie's Fun Park.

Photo by South Carolina Department of Parks, Recreation & Tourism
Open Photo by South Carolina Department of Parks, Recreation & Tourism
Top Upstate South Carolina Hotel Reviews

Grand Bohemian Lodge Greenville, Autograph Collection
10/10 Excellent
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Hotel Theme
- Adventure Sport Hotels in Upstate South Carolina
- Beach Hotels in Upstate South Carolina
- Boutique Hotels in Upstate South Carolina
- Business Hotels in Upstate South Carolina
- Cheap Hotels in Upstate South Carolina
- Family Friendly Hotels in Upstate South Carolina
- Golf Hotels in Upstate South Carolina
- Historic Hotels in Upstate South Carolina
- Hotels with Air Conditioning in Upstate South Carolina
- Hotels with Bar in Upstate South Carolina
- Hotels with Breakfast in Upstate South Carolina
- Hotels with Childcare in Upstate South Carolina
- Hotels with Connecting Rooms in Upstate South Carolina
- Hotels with Parking in Upstate South Carolina
- Hotels with Pool in Upstate South Carolina
- Hotels with Restaurant in Upstate South Carolina
- Hotels with Spa in Upstate South Carolina
- Hotels with WiFi in Upstate South Carolina
- Luxury Hotels in Upstate South Carolina
- Pet Friendly Hotels in Upstate South Carolina
- Romantic Hotels in Upstate South Carolina
- Ski Hotels in Upstate South Carolina
- Wedding Hotels in Upstate South Carolina
More accommodation types in Upstate South Carolina
- Holiday Homes in Upstate South Carolina
- Apartments in Upstate South Carolina
- Cottages in Upstate South Carolina
- Cabin Rentals in Upstate South Carolina
- Condo Rentals in Upstate South Carolina
- Motels in Upstate South Carolina
- Farmstay in Upstate South Carolina
- Villas in Upstate South Carolina
- B&B in Upstate South Carolina
- Caravan Parks in Upstate South Carolina
- Aparthotels in Upstate South Carolina
- Guest Houses in Upstate South Carolina
- Chalets in Upstate South Carolina
- Lodges in Upstate South Carolina
- Condo Resorts in Upstate South Carolina
- Resorts in Upstate South Carolina
- Houseboats in Upstate South Carolina
More top Upstate South Carolina Hotels
- SpringHill Suites by Marriott Greenville Downtown
- Embassy Suites Greenville Golf Resort & Conference Center
- Wingate by Wyndham - Greenville-Airport
- Comfort Inn Greenville - Haywood Mall
- Aloft Greenville Downtown
- Lakeside Lodge Clemson
- Hyatt Place Greenville Downtown
- Inn @ Clemson
- Midtown Suites-Greenville
- Comfort Inn & Suites Clemson - University Area
- ECHO Suites Extended Stay by Wyndham Spartanburg
- Comfort Suites At WestGate Mall
- Spartanburg Marriott
- Holiday Inn Express Gaffney by IHG
- Quality Inn Seneca Clemson Area US-123
Expedia's Latest Trends
Hotels
Flights
Cars
Activities
Packages
Holiday Rentals