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5 Star Hotels in Vatican City, Rome

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Check availability on Vatican City 5 Star Hotels

Tonight
26 Dec - 27 Dec
Tomorrow
27 Dec - 28 Dec
This weekend
26 Dec - 28 Dec
Next weekend
2 Jan - 4 Jan

Our top choices for Vatican City 5-star hotels

Sauna, steam room, Turkish bath/hammam, body treatments, aromatherapy
The Westin Excelsior, Rome

The Westin Excelsior, Rome

The Westin Excelsior, Rome
5.0 star property
Rome City Centre
8.2 out of 10, Very good, (746)
"Spacious rooms!!!"
United States
Milana
The price is €322
includes taxes & fees
21 Jan - 22 Jan 2026
The Westin Excelsior, Rome
Exterior
NH Collection Roma Palazzo Cinquecento

NH Collection Roma Palazzo Cinquecento

NH Collection Roma Palazzo Cinquecento
5.0 star property
Rome City Centre
9.0 out of 10, Wonderful, (1000)
"The hotel was the best location to be at. Amazing stay and so convenient."
United States
Jalin
The price is €275
includes taxes & fees
10 Jan - 11 Jan 2026
NH Collection Roma Palazzo Cinquecento
Restaurant
Sofitel Rome Villa Borghese

Sofitel Rome Villa Borghese

Sofitel Rome Villa Borghese
5.0 star property
Rome City Centre
9.2 out of 10, Wonderful, (968)
"Professional staff, luxurious surroundings, excellent location, very nice accommodations - all in all a great experience. "
Sweden
Daniel
The price is €305
includes taxes & fees
18 Jan - 19 Jan 2026
Sofitel Rome Villa Borghese
2 restaurants, Italian cuisine
Anantara Palazzo Naiadi Rome Hotel - A Leading Hotel of the World

Anantara Palazzo Naiadi Rome Hotel - A Leading Hotel of the World

Anantara Palazzo Naiadi Rome Hotel - A Leading Hotel of the World
5.0 star property
Rome City Centre
9.2 out of 10, Wonderful, (1003)
"incredible, no hotel compares to it. everything was perfect "
United States
Sana
The price is €601
includes taxes & fees
12 Jan - 13 Jan 2026
Anantara Palazzo Naiadi Rome Hotel - A Leading Hotel of the World
Exterior
InterContinental Rome Ambasciatori Palace by IHG

InterContinental Rome Ambasciatori Palace by IHG

InterContinental Rome Ambasciatori Palace by IHG
5.0 star property
Rome City Centre
9.6 out of 10, Exceptional, (160)
"Great Staff Great Location"
Canada
cristina
The price is €504
includes taxes & fees
9 Jan - 10 Jan 2026
InterContinental Rome Ambasciatori Palace by IHG
Property amenity
W Rome

W Rome

W Rome
5.0 star property
Rome City Centre
9.6 out of 10, Exceptional, (205)
"Amazing hotel, wonderful staff, convenience "
Canada
Anna
The price is €460
includes taxes & fees
14 Jan - 15 Jan 2026
W Rome
Exterior
Baglioni Hotel Regina - The Leading Hotels of the World

Baglioni Hotel Regina - The Leading Hotels of the World

Baglioni Hotel Regina - The Leading Hotels of the World
5.0 star property
Rome City Centre
9.0 out of 10, Wonderful, (501)
"Excellent hotel with great sraff"
United Kingdom
Gary
The price is €429
includes taxes & fees
7 Jan - 8 Jan 2026
Baglioni Hotel Regina - The Leading Hotels of the World
2 bars/lounges
Radisson Collection Hotel, Roma Antica

Radisson Collection Hotel, Roma Antica

Radisson Collection Hotel, Roma Antica
5.0 star property
Rome City Centre
9.6 out of 10, Exceptional, (148)
"Great staff clean rooms "
United States
Anthony
The price is €288
includes taxes & fees
18 Jan - 19 Jan 2026
Radisson Collection Hotel, Roma Antica
Restaurant
Six Senses Rome

Six Senses Rome

Six Senses Rome
5.0 star property
Rome City Centre
9.6 out of 10, Exceptional, (58)
"Amazing staff, beautifully decorated hotel, super amenities. Truly wonderful find in the heart of Rome."
United States
Sergio Alfonso
The price is €1,120
includes taxes & fees
4 Jan - 5 Jan 2026
Six Senses Rome
Garden
Villa Agrippina Gran Meliá - The Leading Hotels of the World

Villa Agrippina Gran Meliá - The Leading Hotels of the World

Villa Agrippina Gran Meliá - The Leading Hotels of the World
5.0 star property
Rome City Centre
9.2 out of 10, Wonderful, (935)
"Beautiful hotel, very clean, staff so friendly and helpful Would definitely stay again!"
United Kingdom
debra jane
The price is €462
includes taxes & fees
8 Jan - 9 Jan 2026
Villa Agrippina Gran Meliá - The Leading Hotels of the World
View from property
Sina Bernini Bristol, Autograph Collection

Sina Bernini Bristol, Autograph Collection

Sina Bernini Bristol, Autograph Collection
5.0 star property
Rome City Centre
8.2 out of 10, Very good, (542)
"Amazing staff service and beautiful room "
United States
Samantha
The price is €376
includes taxes & fees
8 Jan - 9 Jan 2026
Sina Bernini Bristol, Autograph Collection
Property entrance
Grand Hotel Palace

Grand Hotel Palace

Grand Hotel Palace
5.0 star property
Rome City Centre
9.0 out of 10, Wonderful, (1000)
"The location was amazing and the staff was really friendly. The restaurant in the hotel was really good too. "
United States
Anuj
The price is €227
includes taxes & fees
11 Jan - 12 Jan 2026
Grand Hotel Palace
Terrace/patio
Hotel Raphaël – Relais & Châteaux

Hotel Raphaël – Relais & Châteaux

Hotel Raphaël – Relais & Châteaux
5.0 star property
Rome City Centre
9.2 out of 10, Wonderful, (1000)
"Exceptional service, rooms and ambiance. Loved it. "
United States
Angela and Calvin
The price is €258
includes taxes & fees
18 Jan - 19 Jan 2026
Hotel Raphaël – Relais & Châteaux
Terrace/patio
Hotel Locarno

Hotel Locarno

Hotel Locarno
5.0 star property
Rome City Centre
9.8 out of 10, Exceptional, (524)
"Great location Friendly "
United States
anthony yunchin
The price is €445
includes taxes & fees
14 Jan - 15 Jan 2026
Hotel Locarno
Property amenity
Aleph Rome Hotel Curio Collection by Hilton

Aleph Rome Hotel Curio Collection by Hilton

Aleph Rome Hotel Curio Collection by Hilton
5.0 star property
Rome City Centre
9.4 out of 10, Exceptional, (465)
"great stay! Hotel was perfect!"
United States
Ernest
The price is €339
includes taxes & fees
7 Jan - 8 Jan 2026
Aleph Rome Hotel Curio Collection by Hilton
Restaurant
Palazzo Roma - The Leading Hotels of the World

Palazzo Roma - The Leading Hotels of the World

Palazzo Roma - The Leading Hotels of the World
5.0 star property
Rome City Centre
10.0 out of 10, Exceptional, (106)
"Great location, beautiful property, very well run and managed. "
United Kingdom
John
Palazzo Roma - The Leading Hotels of the World
Banquet hall
Hassler Roma

Hassler Roma

Hassler Roma
5.0 star property
Rome City Centre
9.6 out of 10, Exceptional, (154)
"We loved every minute of our stay. "
United States
Holly Goldberg
The price is €1,360
includes taxes & fees
4 Jan - 5 Jan 2026
Hassler Roma
Suite
Palazzo Montemartini Rome, A Radisson Collection Hotel

Palazzo Montemartini Rome, A Radisson Collection Hotel

Palazzo Montemartini Rome, A Radisson Collection Hotel
5.0 star property
Rome City Centre
8.8 out of 10, Excellent, (714)
"Room was amazing and the service was top notch. Staff was attentive and friendly. Lorenzo was an exceptional staff. He remembered us during our stay and constantly checked in on us when he was on shift. "
Singapore
Alvin
The price is €240
includes taxes & fees
16 Jan - 17 Jan 2026
Palazzo Montemartini Rome, A Radisson Collection Hotel
Terrace/patio
NH Collection Roma Fori Imperiali

NH Collection Roma Fori Imperiali

NH Collection Roma Fori Imperiali
5.0 star property
Rome City Centre
9.4 out of 10, Exceptional, (212)
"Location"
United States
Trevon
The price is €402
includes taxes & fees
5 Jan - 6 Jan 2026
NH Collection Roma Fori Imperiali
Lobby lounge
Palazzo Ripetta

Palazzo Ripetta

Palazzo Ripetta
5.0 star property
Rome City Centre
10.0 out of 10, Exceptional, (99)
"Absolutely top notch service and accommodation. Definitely would recommend!!"
United States
Linda
Palazzo Ripetta
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Vatican City.
Bettoja Hotel Mediterraneo

Bettoja Hotel Mediterraneo

Via Cavour 15 Rome RM
Get rates
8.6/10 Excellent! (995 reviews)
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Learn more about Vatican City

Marvel at Michelangelo's masterpiece ceiling in the Sistine Chapel before climbing St. Peter's Basilica dome for panoramic views. Reserve tickets for the Vatican Museums well in advance to explore one of the world's greatest art collections without the longest lines.

See all hotels in Vatican City
Piazza San Pietro featuring a statue or sculpture, a city and a square or plaza

Top Vatican City Hotel Reviews

Frequently asked questions

What are the best 5-star hotels in Vatican City?
Get ready for 5-star pampering at Villa Agrippina Gran Meliá - The Leading Hotels of the World, Hotel Indigo Rome - St. George, an IHG Hotel or DOM Hotel. These are some of the leading properties in Vatican City based on Expedia traveller reviews. Choose your favourite and get a taste of the good life!
How much does it cost to stay in a 5-star hotel in Vatican City?
There are a range of pricing options for a 5-star hotel in Vatican City on Expedia. The amount you pay will depend on when you plan to travel, trip length and other factors. Compare all of the available properties for your preferred dates and use our pricing and other filters to land the ideal upscale stay.

  • Search for the lowest price per night from €147

What makes a hotel 5 stars in Vatican City?
In Vatican City, a hotel needs to offer a specific level of upscale amenities to be designated 5 stars. These can include on-site gyms, gourmet restaurants, saunas and spas, complimentary luxury toiletries, premium bedding and more. What also sets 5-star hotels apart is their extraordinary service. You'll enjoy things like in-room massages, concierge services and nightly turn-down services. Some may even offer extra touches like a welcome gift.