Byron Hotels

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
In two weeks

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Byron hotels

Residence Inn by Marriott Rochester Mayo Clinic Area

Residence Inn by Marriott Rochester Mayo Clinic Area
3.0 star property
Downtown Rochester
8.4 out of 10, Very good, (202 reviews)
"Wonderful room, staff, breakfast, and location! Thank you so much!"
United States
Olivia
The price is €145
includes taxes & fees
13 Feb - 14 Feb
Residence Inn by Marriott Rochester Mayo Clinic Area

Broadway Plaza, Trademark Collection by Wyndham

Broadway Plaza, Trademark Collection by Wyndham
3.0 star property
Downtown Rochester
9.2 out of 10, Wonderful, (170 reviews)
  • cleanliness
    Convenient Mayo Clinic access with pool, hot tub, and apartment-style amenities.
"Great staff, clean room, spacious kitchen and living room."
United States
silvia
The price is €173
includes taxes & fees
13 Feb - 14 Feb
Broadway Plaza, Trademark Collection by Wyndham

The Towers At Kahler Grand Hotel

The Towers At Kahler Grand Hotel
4.0 star property
Downtown Rochester
9.4 out of 10, Exceptional, (96 reviews)
  • cleanliness
    Located near Mayo Clinic with indoor pool and Lord Essex restaurant on-site.
"Excellent accommodations, amazing staff"
United States
Shannon
The price is €398
includes taxes & fees
8 Feb - 9 Feb
The Towers At Kahler Grand Hotel

Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys
3.0 star property
Kutzky Park
9.2 out of 10, Wonderful, (781 reviews)
"Room was clean and the housekeeping person very helpful and courteous "
United States
Dawn
The price is €101
includes taxes & fees
20 Feb - 21 Feb
Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

TownePlace Suites by Marriott Rochester

TownePlace Suites by Marriott Rochester
3.0 star property
Rochester
8.8 out of 10, Excellent, (547 reviews)
"My kids really enjoyed the pool, and so did I! Room was nice & clean. Staff were nice. I really appreciated the late checkout. (At least compared to other hotels, 12pm is late!) "
United States
Ashley
The price is €95
includes taxes & fees
15 Feb - 16 Feb
TownePlace Suites by Marriott Rochester

Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys
2.5 star property
Kutzky Park
9.6 out of 10, Exceptional, (687 reviews)
  • cleanliness
    A comfortable stay near Mayo Clinic with convenient shuttle service and amenities.
"Good place to stay when traveling to Mayo apots"
United States
Carolyn
The price is €95
includes taxes & fees
20 Feb - 21 Feb
Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

Home2 Suites by Hilton Rochester Mayo Clinic Area

Home2 Suites by Hilton Rochester Mayo Clinic Area
3.0 star property
Rochester
9.6 out of 10, Exceptional, (910 reviews)
  • cleanliness
    Modern suites with indoor pools just 5 minutes from Mayo Clinic facilities.
"Staff, room and breakfast were wonderful!"
United States
DeLaine
The price is €119
includes taxes & fees
20 Feb - 21 Feb
Home2 Suites by Hilton Rochester Mayo Clinic Area

Marriott Rochester Mayo Clinic

Marriott Rochester Mayo Clinic
3.5 star property
Downtown Rochester
8.4 out of 10, Very good, (533 reviews)
  • cleanliness
    Perfectly located minutes from Mayo Clinic, this hotel offers pool and dining options.
"it was a fantastic "
United States
Paul
The price is €184
includes taxes & fees
13 Feb - 14 Feb
Marriott Rochester Mayo Clinic

Quality Inn & Suites Mayo Clinic Area

Quality Inn & Suites Mayo Clinic Area
2.5 star property
Rochester
8.8 out of 10, Excellent, (845 reviews)
  • cleanliness
    Enjoy a peaceful stay near Mayo Clinic with convenient access to Rochester attractions.
"Great stay!"
United States
William
The price is €63
includes taxes & fees
21 Feb - 22 Feb
Quality Inn & Suites Mayo Clinic Area

Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG

Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG
2.5 star property
Kutzky Park
8.8 out of 10, Excellent, (774 reviews)
  • cleanliness
    Stay close to Mayo Clinic in Rochester with free breakfast and parking.
"the staff was friendly and helpful/ and the room was clean/ and good amenities"
United States
carol
The price is €104
includes taxes & fees
1 Mar - 2 Mar
Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys
3.0 star property
Kutzky Park
8.6 out of 10, Excellent, (961 reviews)
"Friendly staff, good breakfast."
United States
Missy
The price is €92
includes taxes & fees
14 Feb - 15 Feb
SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

Red Carpet Inn Rochester

Red Carpet Inn Rochester
2.0 star property
Rochester
7.6 out of 10, Good, (535 reviews)
  • cleanliness
    Convenient hotel near Mayo Clinic with free parking and housekeeping service.
"Quiet and affordable. Comfortable beds."
United States
Amy
Red Carpet Inn Rochester

Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG
3.5 star property
Downtown Rochester
8.8 out of 10, Excellent, (928 reviews)
  • cleanliness
    Peaceful stay near Mayo Clinic, featuring rooftop terrace and fitness centre.
"Great stay as always! "
United States
Misty
The price is €101
includes taxes & fees
5 Mar - 6 Mar
Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hilton Garden Inn Rochester Downtown, MN

Hilton Garden Inn Rochester Downtown, MN
3.0 star property
Downtown Rochester
8.8 out of 10, Excellent, (873 reviews)
  • cleanliness
    Convenient city centre Rochester lodging, minutes from Mayo Clinic.
"The staff was excellent, the room was clean,would recommend to all our friends"
United States
Jan
The price is €111
includes taxes & fees
14 Feb - 15 Feb
Hilton Garden Inn Rochester Downtown, MN

TownePlace Suites by Marriott Rochester Mayo Clinic Area

TownePlace Suites by Marriott Rochester Mayo Clinic Area
3.0 star property
Kutzky Park
9.6 out of 10, Exceptional, (494 reviews)
  • cleanliness
    Contemporary hotel near Mayo Clinic with free breakfast and area shuttle service.
"Staff was very helpful. Room was spacious and beds were very comfortable. "
United States
Lisa
The price is €124
includes taxes & fees
14 Feb - 15 Feb
TownePlace Suites by Marriott Rochester Mayo Clinic Area

Comfort Inn & Suites West - Medical Center

Comfort Inn & Suites West - Medical Center
3.0 star property
Rochester
9.0 out of 10, Wonderful, (545 reviews)
  • cleanliness
    Just a short drive from Mayo Clinic, with an indoor pool for year-round comfort.
"Was a nice place to stay"
United States
Pam
The price is €70
includes taxes & fees
14 Feb - 15 Feb
Comfort Inn & Suites West - Medical Center

Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys
3.0 star property
Kutzky Park
9.2 out of 10, Wonderful, (493 reviews)
  • cleanliness
    Perfect for medical stays with a complimentary breakfast and indoor pool.
"We have stayed here often in the past year. The staff is so kind. Rooms are extremely comfortable and clean. Breakfast is excellent. "
United States
Annie
The price is €103
includes taxes & fees
14 Feb - 15 Feb
Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

Sleep Inn & Suites West-Near Medical Center

Sleep Inn & Suites West-Near Medical Center
2.5 star property
Rochester
9.0 out of 10, Wonderful, (604 reviews)
  • cleanliness
    Convenient access to Mayo Clinic, with indoor pool and free breakfast for travellers.
"It was a quiet place to stay. The rooms were clean and the staff was polite."
United States
Laurie
The price is €89
includes taxes & fees
15 Feb - 16 Feb
Sleep Inn & Suites West-Near Medical Center

Staybridge Suites Rochester - Commerce Dr NW by IHG

Staybridge Suites Rochester - Commerce Dr NW by IHG
3.0 star property
Rochester
8.8 out of 10, Excellent, (517 reviews)
  • cleanliness
    Stay close to Mayo Clinic with a refreshing pool and free breakfast awaits.
"Staff very helpful and friendly. Room clean and spacious for our four adults and a baby."
United States
Amanda
The price is €109
includes taxes & fees
20 Feb - 21 Feb
Staybridge Suites Rochester - Commerce Dr NW by IHG

Hampton Inn & Suites Rochester-North

Hampton Inn & Suites Rochester-North
2.5 star property
Rochester
9.2 out of 10, Wonderful, (1,000 reviews)
  • cleanliness
    Explore Mayo Clinic then unwind in this modern Rochester hotel's heated pool.
"Good staff great place "
United States
Juan
The price is €95
includes taxes & fees
15 Feb - 16 Feb
Hampton Inn & Suites Rochester-North
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Stay near popular Byron attractions

Top Byron Hotel Reviews

More cheap stays in Byron

Frequently asked questions

Where is the best place to stay in Byron?
Located 9 mi (14.4 km) from the heart of Byron, Kahler Grand Hotel is a top choice for your stay, based on our traveller data. Two other choices for your visit to the area are AmericInn by Wyndham Rochester Near Mayo Clinic and Aspen Suites. See all available top hotels, or vacation rentals in Byron.
What are some of the best holiday rentals that Byron has to offer?
Discounted Oasis! 5 Star-3 Bedroom Showstopping Duplex 4 Minutes to Mayo Clinic!: This holiday home rental outside of Byron offers a fireplace, a patio and a BBQ to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. You and your friends and family can relax into your holiday with amenities such as a selection of games. See all vacation rentals in Byron.
If I need to cancel my hotel reservation in Byron, will I receive a refund?
Yes! The majority of hotel bookings are fully refundable if you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your arrival date. If you have a reservation that's non-refundable, you might still have the option to cancel and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Byron.
How is it to stay in Byron?
Visitors can enjoy all that Byron has to offer, including the zoo, golf courses and bars. Tourists can also enjoy the city's parks and art. In Byron, there are 2 hotels and other accommodation options to choose from. Find out more about Byron.
What should I see while I'm in Byron?
Favourite places to visit include Putting Green, Kalmar Town Hall and Links of Byron Mini Golf. A couple of additional sights to add to your itinerary are Cheery Meadows Center and High Point Shopping Center. Take a look at what more there is to see and do in Expedia's Byron guide.
What's the seasonal weather in Byron?
The hottest months are usually July and August, with an average temperature of 20°C, while the coldest months are January and February, with an average of -6°C. The snowiest months in Byron are January, March, April and February, with each month seeing an average of 19 cm of snowfall.

Explore a world of travel with Expedia