St. Charles Hotels from €53 - Fully Refundable Options

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Our top choices for St. Charles hotels

A hotel room with a large bed, a desk, a chair, a television, and a window with curtains.

1. Econo Lodge Mayo Clinic Area

Rochester

Lorraine

includes taxes & fees

4 Dec - 5 Dec

A modern hotel lobby with a reception desk, seating area, and a kitchenette.

2. Spark by Hilton Rochester South

Rochester

Stanton

includes taxes & fees

22 Nov - 23 Nov

A spacious living area with a high ceiling, wooden beams, a blue armchair, a sofa, and a glass coffee table.

3. Stone Mill Hotel & Suites

Lanesboro

Bernie

includes taxes & fees

13 Nov - 14 Nov

A modern hotel lobby with a reception desk, seating area, and a dining space.

4. Holiday Inn Express Rochester South - Mayo Area by IHG

Rochester

Rick

includes taxes & fees

14 Nov - 15 Nov

A modern living room with a sofa, coffee table, and a TV mounted on a stone wall.

5. Quality Inn & Suites Mayo Clinic Area

Rochester

Mark

includes taxes & fees

4 Dec - 5 Dec

A Comfort Inn & Suites hotel with a modern design, featuring a prominent signage and a parking lot.

6. Comfort Inn & Suites Rochester South Mayo Clinic

Rochester

LeeAnn

includes taxes & fees

11 Dec - 12 Dec

A La Quinta Inn & Suites hotel with a well-lit entrance, a parking area, and a clear view of the building's facade.

7. La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

Rochester

Joseph

includes taxes & fees

15 Nov - 16 Nov

8. AmericInn by Wyndham Rochester Near Mayo Clinic

Rochester

Madelyn

includes taxes & fees

6 Dec - 7 Dec

A hotel lobby with a reception desk, seating area, and a bar.

9. Super 8 by Wyndham Rochester Mayo Clinic Area

Rochester

Rick

includes taxes & fees

22 Nov - 23 Nov

A two-story house with a porch and a covered entryway.

10. The Wen Inn formerly Andor Wenneson

Peterson

Daniel

includes taxes & fees

15 Nov - 16 Nov

A modern interior with a bar area, seating, and a large window.

11. Hotel Indigo Rochester – Mayo Clinic Area by IHG

Downtown Rochester

Kathleen

includes taxes & fees

28 Nov - 29 Nov

A hotel room with two beds, a desk, a chair, and a lamp.

12. Country Trails Inn & Suites

Preston

Jeannie

includes taxes & fees

12 Nov - 13 Nov

A hotel room with two beds, a large landscape painting above the headboard, a bedside table with a phone, and a blue patterned rug.

13. Days Inn by Wyndham Winona

Winona

William

includes taxes & fees

8 Dec - 9 Dec

14. Birch Hill Suite Rochester – Med City

Rochester

PAPILLON

includes taxes & fees

12 Nov - 13 Nov

An outdoor seating area with a fire feature, blue cushioned chairs, and a modern building with large windows in the background.

15. Hyatt House Rochester/Mayo Clinic Area

Downtown Rochester

Robert Blaise

includes taxes & fees

27 Nov - 28 Nov

A hotel room with two beds, a desk, a chair, a TV, a wardrobe, and a window with curtains.

16. MainStay Suites Rochester South Mayo Clinic

Rochester

Stephen

includes taxes & fees

29 Nov - 30 Nov

A reception area with a wooden reception desk, a "Welcome to the Bread & Butter State" sign, and a "Please Center" sign.

17. Hampton Inn Rochester-South

Rochester

Susan

includes taxes & fees

29 Nov - 30 Nov

A hotel room with a large bed, a desk with a chair, a television, and a view of the outdoors through a door.

18. Baymont by Wyndham Rochester Mayo Clinic Area

Rochester

Scottie

includes taxes & fees

6 Dec - 7 Dec

A Comfort Inn hotel with a stone facade, a covered entrance, and a parking area.

19. Comfort Inn & Suites West - Medical Center

Rochester

Tammy

includes taxes & fees

11 Dec - 12 Dec

A modern living room with a fireplace, comfortable seating, and large windows.

20. Staybridge Suites Rochester - Mayo Clinic Area by IHG

Kutzky Park

Sheri

includes taxes & fees

25 Nov - 26 Nov

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St. Charles awaits: its natural setting and more!

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Top St. Charles Hotel Reviews

Kahler Inn and Suites - Mayo Clinic Area

10/10 Excellent

"The room and bathroom needs a bit of remodeling, but in general it was big and spacious. The cleaning staff was very helpful. The included breakfast is very complete, but in long stays it might become a bit tedious to eat the same style of eggs everyday. The Chinese restaurant in the lobby was excelent and provides a hot meal after a long day in the hospital."

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

10/10 Excellent

"Everything was quite clean. Staff was extremely accommodating. It was nice to have the fireplace in the lobby, shuttle, and hot tub. The on site restaurant, Twigs, is absolutely amazing! Great GF and regular food and drinks!"

Quality Inn near Medical Center

10/10 Excellent

"I just love them to death! They were so kind, helpful and flexible with me. I do highly recommend them. I also thought their breakfast was particularly good this time too. As a solo woman traveler, it was also very safe for me there. The housekeepers were trustworthy as well. The Manager Nick is also a very nice gentleman whom I happy to like, and other staff were also top notch to me too. The city of Rochester was, however, quite another matter for me. But during times of disrespect from agencies and being canceled for job interviews (plus scam interviews and more, this hotel was a peaceful, quiet place for me. Much love ❤️ to them."

Hyatt House Rochester/Mayo Clinic Area

8/10 Good

"Stay was as usual. The property has been sold to new owners, resulting in some changes. 1) They now charge for parking- $20 per night. It didn’t get charged earlier. But they now restrict access to parking via room keys so hopefully vehicles are safer. 2) Saw an upgrade in breakfast- it was visibly better from how it used to be earlier. 3) Room was the same, albeit saw water blockage in the sink- housekeeping needs better controls. All in all, will recommend the property- it’s walking distance from Meyo; you can also take a shuttle. Courteous staff; good pricing, comfortable rooms and convenient location."

More cheap stays in St. Charles

Super 8 by Wyndham Winona MN

1025 Sugar Loaf Rd Winona MN

€61

3 Dec - 4 Dec

includes taxes & fees

Frequently asked questions

Where is the best place to stay in St. Charles?

AmericInn by Wyndham Rochester Near Mayo Clinic, located 20.5 mi (32.9 km) from the heart of St. Charles, is a top choice for your stay, based on our traveller data. Two other options for your stay in the area are Kahler Grand Hotel and Kahler Inn and Suites - Mayo Clinic Area. See all available top hotels, or vacation rentals in St. Charles.

What are some of the best holiday rentals that St. Charles has to offer?

Clean, fun, comfy ranch home near parks, 2.5 mi to Mayo w Pingpong and Playroom: This holiday home rental outside of St. Charles offers a patio, a garden and a BBQ to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. Make the most of games in this rental home to help you unwind. See all vacation rentals in St. Charles.

If I need to cancel my hotel reservation in St. Charles, will I receive a refund?

Yes! The majority of room reservations are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you have a non-refundable reservation, you might be able to cancel it and get a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in St. Charles.

What's it like to stay in St. Charles?

Visitors can enjoy all that St. Charles has to offer, including its parks. This city also attracts tourists with its welcoming locals. In St. Charles, there are 3 hotels and other accommodation options to choose from. Find out more about St. Charles.

What is there to see in St. Charles?

A couple of favourite places to visit are Whitewater State Park and Whitewater River. You'll also find Regional Sports Center and National Volleyball Center in the area. Take a look at what more there is to see and do in Expedia's St. Charles guide.

What's the weather like in St. Charles?

The hottest months are usually July and August, with an average temperature of 19°C, while the coldest months are January and February, with an average of -6°C. The snowiest months in St. Charles are January, March, February and April, with each month seeing an average of 20 cm of snowfall.

St. Charles Hotels

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Our top choices for St. Charles hotels

1. Econo Lodge Mayo Clinic Area

2. Spark by Hilton Rochester South

3. Stone Mill Hotel & Suites

4. Holiday Inn Express Rochester South - Mayo Area by IHG

5. Quality Inn & Suites Mayo Clinic Area

6. Comfort Inn & Suites Rochester South Mayo Clinic

7. La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

8. AmericInn by Wyndham Rochester Near Mayo Clinic

9. Super 8 by Wyndham Rochester Mayo Clinic Area

10. The Wen Inn formerly Andor Wenneson

11. Hotel Indigo Rochester – Mayo Clinic Area by IHG

12. Country Trails Inn & Suites

13. Days Inn by Wyndham Winona

14. Birch Hill Suite Rochester – Med City

15. Hyatt House Rochester/Mayo Clinic Area

16. MainStay Suites Rochester South Mayo Clinic

17. Hampton Inn Rochester-South

18. Baymont by Wyndham Rochester Mayo Clinic Area

19. Comfort Inn & Suites West - Medical Center

20. Staybridge Suites Rochester - Mayo Clinic Area by IHG

Learn more about St. Charles

Top St. Charles Hotel Reviews

Kahler Inn and Suites - Mayo Clinic Area

More cheap stays in St. Charles

Super 8 by Wyndham Winona MN

Frequently asked questions

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