Cape Girardeau Holidays
Photo by Skyy
- Plan, book, travel with confidence
Better together
Save up to €185 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place
Top hotels in Cape Girardeau
Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
The price is €86 per night from 12 Oct to 13 Oct
€86
12 Oct - 13 Oct
includes taxes & fees
9.4/10 Exceptional! (1,023 reviews)
"Clean, friendly staff and business friendly"
Reviewed on 28 Sept 2025
The Riverview
777 Main St, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
The price is €118 per night from 19 Oct to 20 Oct
€118
19 Oct - 20 Oct
includes taxes & fees
9.2/10 Wonderful! (426 reviews)
"Great view."
Reviewed on 28 Sept 2025
Pear Tree Inn Cape Girardeau Near the Medical Center
3248 William St, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
The price is €67 per night from 5 Oct to 6 Oct
€67
5 Oct - 6 Oct
includes taxes & fees
8.8/10 Excellent! (1,009 reviews)
"Staff was friendly, room was clean, good location, good rate."
Reviewed on 22 Sept 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Popular places to visit
eDen Spa & Salon
You can take time to visit eDen Spa & Salon during your travels to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.
More trip options
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
