Central San Diego Hotel Guide - Business Hotels in Central San Diego, San Diego
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check availability on Central San Diego Business Hotels
Our top choices for Central San Diego business-friendly hotels
DoubleTree by Hilton Hotel San Diego - Mission Valley
DoubleTree by Hilton Hotel San Diego - Mission ValleyMission Valley
8.4 out of 10, Very good, (1425)
"Great hotel in a great area - would definitely stay here again."
Bhupinder
The price is €110
includes taxes & fees
3 Jan - 4 Jan 2026
8.8 out of 10, Excellent, (1319)
"Checking in was easy and friendly staff."
Elvira
The price is €95
includes taxes & fees
25 Jan - 26 Jan 2026
8.8 out of 10, Excellent, (1003)
"Check in was great, employees were so nice"
Noel
The price is €176
includes taxes & fees
30 Dec - 31 Dec
Holiday Inn Express Mira Mesa-San Diego by IHG
Holiday Inn Express Mira Mesa-San Diego by IHGScripps Ranch
8.4 out of 10, Very good, (1001)
"Beds were comfy "
Dave
The price is €99
includes taxes & fees
4 Jan - 5 Jan 2026
9.2 out of 10, Wonderful, (2933)
"Great boutique hotel!!"
Maksim
Hilton Garden Inn San Diego Mission Valley Stadium
Hilton Garden Inn San Diego Mission Valley StadiumKearny Mesa
8.0 out of 10, Very good, (1001)
"The room was clean and staff was courteous "
Jessica
The price is €101
includes taxes & fees
11 Jan - 12 Jan 2026
Best Western Plus Hacienda Hotel Old Town
Best Western Plus Hacienda Hotel Old TownOld Town San Diego
8.4 out of 10, Very good, (1870)
"Excellent location, courteous staff, great airport shuttle, delicious on-site restaurant."
Kathleen
The price is €113
includes taxes & fees
4 Jan - 5 Jan 2026
8.2 out of 10, Very good, (2247)
"Room and staff were excellent"
Bryant
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Central San Diego Hotel Reviews
Homewood Suites by Hilton San Diego Hotel Circle/SeaWorld Area
10/10 Excellent
Frequently asked questions
Explore a world of travel with Expedia
- 3 Star Hotels in Pacific Beach
- 5 Star Hotels in La Jolla Village
- Allied Gardens Hotels
- Bay Park Hotels
- Condo Rentals in Beach Cities San Diego County
- Bird Rock Hotels
- Clairemont Hotels
- Hotels near Crystal Pier
- Beach Hotels in San Diego County
- Casino Hotels in San Diego County
- Golf Hotels in San Diego County
- Cheap Hotels in Downtown San Diego
- Hilton Hotels in Fiesta Island
- Hotels near Hotel Circle
- Kearny Mesa Hotels
- Beach Hotels in La Jolla
- Luxury Hotels in La Jolla
- La Jolla Hotels
- Linda Vista Hotels
- Motel 6 Hotels in Mira Mesa
- Hotels with Spa in Mira Mesa
- Mira Mesa Hotels
- Hotels with Restaurant in Miramar
- Miramar Hotels
- Hotels near Mission Bay
- Lgbt-Friendly Hotels in Mission Beach
- Casino Hotels in Mission Valley
- Cheap Hotels in Mission Valley
- Mission Valley Hotels
- Pet Friendly Hotels in North Mission Beach
- Beach Hotels in North Park
- Hotels with Bar in Ocean Beach
- Beach Hotels in Pacific Beach
- Boutique Hotels in Pacific Beach
- Cheap Hotels in Pacific Beach
- Family Friendly Hotels in Pacific Beach
- Hotels with Restaurant in Pacific Beach
- Luxury Hotels in Pacific Beach
- Pet Friendly Hotels in Pacific Beach
- Pacific Beach Hotels
- Cheap Hotels in San Diego
- Business Hotels in San Diego
- Green / Sustainable Hotels in San Diego
- Hotels with Bar in San Diego
- Hotels with Breakfast in San Diego
- Luxury Hotels in San Diego
- Wedding Hotels in San Diego
- Hotels near San Diego State University
- Cheap Hotels in Sorrento Valley
- Sorrento Valley Hotels
- Hotels near Stadium Golf Center & Batting Cages
- Beach Hotels in Torrey Pines
- Flights to Beach Cities San Diego County
- Flights to La Jolla
- Flights from Montgomery Field
- Flights from Auckland (AKL) to San Diego (MYF)
- Flights from Amman (AMM) to San Diego (MYF)
- Flights from Atlanta (ATL) to San Diego (MYF)
- Flights from Chico (CIC) to San Diego (MYF)
- Flights from Concord (CON) to San Diego (MYF)
- Flights from Fort Lauderdale (FLL) to San Diego (MYF)
- Flights from New York (JFK) to San Diego (MYF)
- Flights from Lake Charles (LCH) to San Diego (MYF)
- Flights from Manta (MEC) to San Diego (MYF)
- Flights from Modesto (MOD) to San Diego (MYF)
- Flights from Mesa (MSC) to San Diego (MYF)
- Flights from Oceanside (OCN) to San Diego (MYF)
- Flights from Pago Pago (PPG) to San Diego (MYF)
- Flights from Richland (RLD) to San Diego (MYF)
- Flights from San Francisco (SFO) to San Diego (MYF)
- Flights from Santa Monica (SMO) to San Diego (MYF)
- Flights from Orange County (SNA) to San Diego (MYF)
- Flights from Santa Ynez (SQA) to San Diego (MYF)
- Flights from Thermal (TRM) to San Diego (MYF)
- Birch Aquarium
- Fashion Valley Mall
- Hillcrest Holidays
- La Jolla Cove
- Visit La Jolla Farms
- Visit La Jolla Village
- Visit La Jolla
- Cheap Holiday Packages Fiesta Island
- Marine Corps Air Station Miramar
- Mission Bay
- Visit North Mission Beach
- Pacific Beach Park
- Visit Linda Vista
- Visit Miramar
- Visit Mission Hills
- Scripps Ranch Holidays
- Avis Rental Cars in Pacific Beach
- Budget Rental Cars in La Jolla
- Car hire near La Jolla Village
- Car hire La Jolla
- Dollar Rental Cars in Central San Diego
- Dollar Rent A Car Rental Cars in Beach Cities San Diego County
- Enterprise Rental Cars in Fiesta Island
- Hertz Rental Cars in Central San Diego
- Mex Rent A Car Rental Cars in Central San Diego