
Central San Diego Hotel Guide - Luxury Hotels in Central San Diego, San Diego
- Change your mindBook hotels with free cancellation
- Be pickySearch almost a million properties worldwide
Check availability on Central San Diego Luxury Hotels
Our top choices for Central San Diego luxury hotels

1. Hampton Inn San Diego-Kearny Mesa
Hampton Inn San Diego-Kearny MesaKearny Mesa
9.2 out of 10, Wonderful, (1,010 reviews)
The price is €117
includes taxes & fees
15 Nov - 16 Nov

2. TownePlace Suites by Marriott San Diego Central
TownePlace Suites by Marriott San Diego CentralKearny Mesa
9.0 out of 10, Wonderful, (645 reviews)
The price is €185
includes taxes & fees
28 Nov - 29 Nov

3. Courtyard by Marriott San Diego Central
Courtyard by Marriott San Diego CentralKearny Mesa
8.8 out of 10, Excellent, (1,005 reviews)
The price is €139
includes taxes & fees
22 Nov - 23 Nov

4. Four Points by Sheraton San Diego
Four Points by Sheraton San DiegoKearny Mesa
8.4 out of 10, Very good, (1,001 reviews)
The price is €149
includes taxes & fees
10 Nov - 11 Nov

5. Hilton Garden Inn San Diego Mission Valley Stadium
Hilton Garden Inn San Diego Mission Valley StadiumKearny Mesa
8.0 out of 10, Very good, (1,009 reviews)
The price is €126
includes taxes & fees
22 Nov - 23 Nov

6. Extended Stay America Suites San Diego Mission Valley Stadium
Extended Stay America Suites San Diego Mission Valley StadiumKearny Mesa
6.6 out of 10, (1,003 reviews)
The price is €107
includes taxes & fees
17 Nov - 18 Nov

7. Lafayette Hotel & Club
Lafayette Hotel & ClubUniversity Heights
9.4 out of 10, Exceptional, (2,132 reviews)
The price is €282
includes taxes & fees
9 Nov - 10 Nov

8. HYATT house San Diego/Sorrento Mesa
HYATT house San Diego/Sorrento MesaSorrento Valley
9.2 out of 10, Wonderful, (1,004 reviews)
The price is €135
includes taxes & fees
15 Nov - 16 Nov

9. Legacy Resort Hotel & Spa
Legacy Resort Hotel & SpaMission Valley
9.2 out of 10, Wonderful, (3,099 reviews)
The price is €167
includes taxes & fees
30 Nov - 1 Dec

10. City24 Hotel Little Italy Mission Hills
City24 Hotel Little Italy Mission HillsMiddletown
9.6 out of 10, Exceptional, (242 reviews)
The price is €148
includes taxes & fees
2 Dec - 3 Dec

11. Country Inn & Suites by Radisson, San Diego North, CA
Country Inn & Suites by Radisson, San Diego North, CASorrento Valley
9.0 out of 10, Wonderful, (1,761 reviews)
The price is €139
includes taxes & fees
22 Nov - 23 Nov

12. Holiday Inn Express San Diego Airport - Old Town by IHG
Holiday Inn Express San Diego Airport - Old Town by IHGMission Hills
9.2 out of 10, Wonderful, (1,101 reviews)
The price is €140
includes taxes & fees
15 Nov - 16 Nov

13. Courtyard by Marriott San Diego Miramar
Courtyard by Marriott San Diego MiramarMiramar
8.8 out of 10, Excellent, (1,002 reviews)
The price is €148
includes taxes & fees
15 Nov - 16 Nov

14. Cosmopolitan Hotel & Restaurant
Cosmopolitan Hotel & RestaurantOld Town San Diego
9.2 out of 10, Wonderful, (773 reviews)
The price is €222
includes taxes & fees
17 Nov - 18 Nov

15. Homewood Suites by Hilton San Diego Central
Homewood Suites by Hilton San Diego CentralScripps Ranch
8.6 out of 10, Excellent, (1,000 reviews)
The price is €131
includes taxes & fees
15 Nov - 16 Nov

16. Hyatt Regency La Jolla
Hyatt Regency La JollaUniversity City
9.0 out of 10, Wonderful, (1,002 reviews)
The price is €243
includes taxes & fees
20 Nov - 21 Nov

17. San Diego Marriott Mission Valley
San Diego Marriott Mission ValleyMission Valley
8.8 out of 10, Excellent, (1,016 reviews)
The price is €164
includes taxes & fees
15 Nov - 16 Nov

18. Element by Marriott San Diego Mission Valley
Element by Marriott San Diego Mission ValleyMission Valley
8.8 out of 10, Excellent, (129 reviews)
The price is €166
includes taxes & fees
15 Nov - 16 Nov

19. Kings Inn San Diego
Kings Inn San DiegoMission Valley
8.8 out of 10, Excellent, (3,845 reviews)
The price is €80
includes taxes & fees
9 Nov - 10 Nov

20. Embassy Suites by Hilton San Diego La Jolla
Embassy Suites by Hilton San Diego La JollaUniversity City
8.8 out of 10, Excellent, (2,134 reviews)
The price is €173
includes taxes & fees
20 Nov - 21 Nov
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Central San Diego Hotel Reviews

Country Inn & Suites by Radisson, San Diego North, CA
10/10 Excellent
Explore a world of travel with Expedia
- 3 Star Hotels in Pacific Beach
- 5 Star Hotels in La Jolla Village
- Allied Gardens Hotels
- Bay Park Hotels
- Clairemont Hotels
- Crown Point Hotels
- Beach Hotels in San Diego County
- Casino Hotels in San Diego County
- Golf Hotels in San Diego County
- Green / Sustainable Hotels in San Diego County
- Wedding Hotels in San Diego County
- Resorts in Fiesta Island
- Hillcrest Hotels
- Kearny Mesa Hotels
- Cottages in La Jolla
- Hostels in La Jolla
- Beach Hotels in La Jolla
- Boutique Hotels in La Jolla
- Luxury Hotels in La Jolla
- Motels in La Jolla
- Linda Vista Hotels
- Beach Hotels in Little Italy
- Motel 6 Hotels in Mira Mesa
- Hotels with Spa in Mira Mesa
- Mira Mesa Hotels
- Hotels with Restaurant in Miramar
- Miramar Hotels
- Hotels near Mission Bay
- Lgbt-Friendly Hotels in Mission Beach
- Casino Hotels in Mission Valley
- Cheap Hotels in Mission Valley
- Mission Valley Hotels
- Beach Hotels in North Park
- North Park Hotels
- Holiday Homes in Old Town Transit Center
- Beach Hotels in Pacific Beach
- Boutique Hotels in Pacific Beach
- Cheap Hotels in Pacific Beach
- Family Friendly Hotels in Pacific Beach
- Hotels with Restaurant in Pacific Beach
- Luxury Hotels in Pacific Beach
- Pet Friendly Hotels in Pacific Beach
- Cheap Hotels in San Diego
- Hotels with Parking in San Diego
- Hotels with Breakfast in San Diego
- Lgbt-Friendly Hotels in San Diego
- Luxury Hotels in San Diego
- Romantic Hotels in San Diego
- Hotels near San Diego Zoo
- Cheap Hotels in Sorrento Valley
- Sorrento Valley Hotels
- Hotels near Stadium Golf Center & Batting Cages
- Hotels near Torrey Pines Golf Course
- Beach Hotels in Torrey Pines
- Flights to Beach Cities San Diego County
- Flights from Montgomery Field
- Flights from Auckland (AKL) to San Diego (MYF)
- Flights from Amman (AMM) to San Diego (MYF)
- Flights from Atlanta (ATL) to San Diego (MYF)
- Flights from Chico (CIC) to San Diego (MYF)
- Flights from Concord (CON) to San Diego (MYF)
- Flights from Fort Lauderdale (FLL) to San Diego (MYF)
- Flights from New York (JFK) to San Diego (MYF)
- Flights from Lake Charles (LCH) to San Diego (MYF)
- Flights from Manta (MEC) to San Diego (MYF)
- Flights from Modesto (MOD) to San Diego (MYF)
- Flights from Mesa (MSC) to San Diego (MYF)
- Flights from Oceanside (OCN) to San Diego (MYF)
- Flights from Pago Pago (PPG) to San Diego (MYF)
- Flights from Richland (RLD) to San Diego (MYF)
- Flights from San Francisco (SFO) to San Diego (MYF)
- Flights from Santa Monica (SMO) to San Diego (MYF)
- Flights from Orange County (SNA) to San Diego (MYF)
- Flights from Santa Ynez (SQA) to San Diego (MYF)
- Flights from Thermal (TRM) to San Diego (MYF)
- Balboa Park
- Birch Aquarium
- Fashion Valley Mall
- Hotel Circle
- Visit Beach Barber Tract
- La Jolla Cove
- Visit La Jolla Farms
- Visit La Jolla Village
- Visit Torrey Pines
- Cheap Holiday Packages Fiesta Island
- Marine Corps Air Station Miramar
- Pacific Beach Holidays
- Pechanga Arena
- Visit Hillcrest
- Visit Linda Vista
- Visit Miramar
- Visit Pacific Beach
- Scripps Ranch Holidays
































































