Hotels in Mississippi County

Top Cities in Mississippi County

A sunset over a calm lake with tall trees reflected in the water.

A tree-lined landscape with a river and fields.

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Our top choices for Mississippi County hotels

A building with a fountain and flower beds in front.

1. The Riverstone Hotel Charleston-Sikeston

Charleston

Kathleen

includes taxes & fees

29 Oct - 30 Oct

A hotel room with a large bed, two bedside lamps, a framed picture of a bridge, and a wooden nightstand with a phone.

2. Super 8 by Wyndham Charleston/Sikeston East MO

Charleston

zandra

includes taxes & fees

22 Nov - 23 Nov

A hotel room with a large bed, a desk, a television, and a bathroom visible through an open door.

3. Eagle Inn Charleston

Charleston

Jackson

includes taxes & fees

28 Oct - 29 Oct

A hotel lobby with a reception desk, seating area, and a large window.

4. Quality Inn Cairo I-57

Cairo

Santiago

includes taxes & fees

15 Nov - 16 Nov

A hot tub with a wooden deck and outdoor seating area.

5. The Roost | Hot Tub, Ponds & Farm Views

Carlisle County

A hot tub in an outdoor setting with a wooden deck and lounge chairs.

6. Perfect Couples Retreat - firepit

Carlisle County

includes taxes & fees

28 Oct - 29 Oct

View all properties

Compare top hotels in Mississippi County

The Riverstone Hotel Charleston-Sikeston 2.5 star property Charleston View	Super 8 by Wyndham Charleston/Sikeston East MO 2.0 star property Charleston View	Eagle Inn Charleston 2.0 star property Charleston View	Quality Inn Cairo I-57 2.5 star property Cairo View
6.8 443 reviews	6.8 680 reviews	6.6 107 reviews	6.4 296 reviews
The price is €66 includes taxes & fees 29 Oct - 30 Oct	The price is €59 includes taxes & fees 22 Nov - 23 Nov	The price is €66 includes taxes & fees 28 Oct - 29 Oct	The price is €68 includes taxes & fees 15 Nov - 16 Nov
Yes, Breakfast included Yes, Pool No Spa Yes, Pet-friendly Yes, WiFi included Yes, Parking	Yes, Breakfast included No Pool No Spa Yes, Pet-friendly Yes, WiFi included Yes, Parking	No Breakfast included No Pool No Spa Yes, Pet-friendly Yes, WiFi included Yes, Parking	Yes, Breakfast included No Pool No Spa Yes, Pet-friendly Yes, WiFi included Yes, Parking

Hotels recommended for families in Mississippi County

An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.

Drury Inn & Suites Sikeston, MO

Sikeston

includes taxes & fees

3 Nov - 4 Nov

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Top Mississippi County Hotel Reviews

Drury Inn & Suites Sikeston, MO

8/10 Good

"We had a two-room room king suite. The only complaint I had was that it took 5-10 minutes for the hot water to get hot. They did offer to give me points for a free stay if I wanted to sign-up for their rewards program. We will there next year when we go through Sikeston MO."

Holiday Inn Express & Suites Sikeston Southwest by IHG

10/10 Excellent

"We had a nice overnight stay here. The sleeper/sofa was not comfortable, but very few are. It was a good selection of foods for the breakfast. We especially enjoyed the coffee machine that freshly grinds the coffee beans and brews it immediately. We also liked the style of the luggage carts. They were less bulky and easier to handle."