East Prairie Hotels

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Guest rating
Guest rating
Star rating

Our top choices for East Prairie hotels

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1,004 reviews)
"Very nice for overnight stay"
United States
Scott
The price is €101
includes taxes & fees
4 May - 5 May
Drury Inn & Suites Sikeston, MO

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (534 reviews)
"Great stay"
United States
grant
The price is €102
includes taxes & fees
26 Apr - 27 Apr
Hampton Inn Sikeston

Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America
2.5 star property
Union City
9.2 out of 10, Wonderful, (375 reviews)
"Great stay. "
United States
Paul
The price is €87
includes taxes & fees
10 May - 11 May
Sleep Inn at Discovery Park of America

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (71 reviews)
"Nice quiet hotel "
United States
Steven
The price is €106
includes taxes & fees
30 Apr - 1 May
Fairfield Inn & Suites by Marriott Sikeston

Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very good, (1,003 reviews)
"Very nice folks who manage the hotel!!"
United States
Jane
The price is €88
includes taxes & fees
19 Apr - 20 Apr
Best Western Plus Sikeston I-55

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.6 out of 10, Excellent, (457 reviews)
"Clean rooms, friendly staff and convenient location."
United States
Mark
The price is €101
includes taxes & fees
26 Apr - 27 Apr
Holiday Inn Express & Suites Sikeston Southwest by IHG

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very good, (763 reviews)
"Very nice place, very nice stay! They were out of cream cheese for the bagels at breakfast though.:-)"
United States
Mark
The price is €60
includes taxes & fees
16 Apr - 17 Apr
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Super 8 By Wyndham Marston

Super 8 By Wyndham Marston
2.0 star property
Marston
8.2 out of 10, Very good, (60 reviews)
"The property is beautiful! The rooms are terrific! Staff is amazing! Totally recommend!! "
United States
Sue
The price is €71
includes taxes & fees
18 Apr - 19 Apr
Super 8 By Wyndham Marston

The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
2.5 star property
Charleston
6.8 out of 10, (411 reviews)
"Clean "
United States
Chris
The price is €78
includes taxes & fees
16 Apr - 17 Apr
The Riverstone Hotel Charleston-Sikeston

Quality Inn Union City US 51

Quality Inn Union City US 51
2.5 star property
Union City
8.4 out of 10, Very good, (502 reviews)
"Overall, a decent stay. No fancy bells or whistles, exactly what was advertised and delivered. Only issue of note was that the room smelled of body odder when we stayed. "
United States
John
The price is €72
includes taxes & fees
26 Apr - 27 Apr
Quality Inn Union City US 51

Hospitality House Union City I 69 / US 51

Hospitality House Union City I 69 / US 51
2.5 star property
Union City
6.8 out of 10, (390 reviews)
"Easy to check in.. Clean Room..Lots of food options near by.. "
United States
Pooran
The price is €58
includes taxes & fees
16 Apr - 17 Apr
Hospitality House Union City I 69 / US 51

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston
2.0 star property
Sikeston
7.2 out of 10, Good, (1,003 reviews)
"Business friendly, clean room staff very friendly, accommodating."
United States
Janice
The price is €66
includes taxes & fees
26 Apr - 27 Apr
Days Inn and Suites by Wyndham Sikeston

Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.6 out of 10, (284 reviews)
"Amenities, microwave, refrigerator,iron and iron board,Shower soap options "
United States
Maurice
The price is €71
includes taxes & fees
22 Apr - 23 Apr
Quality Inn Cairo I-57

Country Hearth Inn & Suites Union City

Country Hearth Inn & Suites Union City
2.5 star property
Union City
8.6 out of 10, Excellent, (561 reviews)
"Very clean nice staff and well run "
United States
zach
The price is €64
includes taxes & fees
15 Apr - 16 Apr
Country Hearth Inn & Suites Union City

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.8 out of 10, (629 reviews)
"Affordable for a quick one night stay. Restaurant and gas station next to hotel."
United States
Annette
The price is €62
includes taxes & fees
19 Apr - 20 Apr
Super 8 by Wyndham Charleston/Sikeston East MO

Holiday Inn Express & Suites Union City by IHG

Holiday Inn Express & Suites Union City by IHG
2.5 star property
Union City
9.4 out of 10, Exceptional, (318 reviews)
"The room was spacious & clean. The complimentary breakfast was nice. Very quiet place and next to a unique tourist attraction."
United States
Angela
The price is €132
includes taxes & fees
26 Apr - 27 Apr
Holiday Inn Express & Suites Union City by IHG

Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very good, (293 reviews)
"nice room, clean. breakfast was great and lady keeping it full, hot, and clean!"
United States
Fred
The price is €90
includes taxes & fees
7 May - 8 May
Comfort Inn & Suites Sikeston I-55

TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (16 reviews)
"This hotel was great. Good location. Awesome staff. Hopefully I get the opportunity to stay here again."
United States
Jason
The price is €114
includes taxes & fees
7 May - 8 May
TownePlace Suites by Marriott Sikeston

MainStay Suites Union City, TN

MainStay Suites Union City, TN
2.5 star property
Union City
8.6 out of 10, Excellent, (45 reviews)
"Very clean room, friendly staff! I would highly recommend this place! "
United States
Lydia
The price is €107
includes taxes & fees
8 May - 9 May
MainStay Suites Union City, TN

Hampton Inn Union City

Hampton Inn Union City
2.5 star property
Union City
9.6 out of 10, Exceptional, (178 reviews)
"Spotless , friendly staff."
United States
Gail
The price is €124
includes taxes & fees
19 Apr - 20 Apr
Hampton Inn Union City
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Stay near popular East Prairie attractions

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artefacts tell the storey of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

The Mississippi River near Hannibal, Missouri, USA

Top East Prairie Hotel Reviews

More cheap stays in East Prairie

Frequently asked questions

What's the best place for a stay in East Prairie?
Drury Inn & Suites Sikeston, MO, located 11.4 mi (18.4 km) from the heart of East Prairie, is a top choice for your stay, based on our traveller data. Other good choices for your trip to the area are Hampton Inn Sikeston and Best Western Plus Sikeston I-55. See all available top hotels, or vacation rentals in East Prairie.
What are some of the best holiday rentals that East Prairie has to offer?
Duck Hunting, Fishing or Relaxing Family Vacation: This holiday home rental outside of East Prairie is located on a lake, and has a patio, a garden and a BBQ to put you at ease in your new surroundings. It has 3 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. See all vacation rentals in East Prairie.
If I need to cancel my hotel reservation in East Prairie, will I receive a refund?
Yes, you'll find most room reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If your reservation is non-refundable, you might still have the option to cancel and get a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in East Prairie.
How is it staying in East Prairie?
Visitors will definitely enjoy all that East Prairie has to offer. There are 32 hotels and other accommodation options in the surrounding area. Find out more about East Prairie.
What are the top places to visit in East Prairie?
The picturesque setting of Big Oak Tree State Park and Mississippi River exemplify the area's natural beauty. You'll also find Sikeston Depot Museum and River Ridge Winery in the area. Take a look at what more there is to see and do in Expedia's East Prairie guide.
What's the weather like in East Prairie?
The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for East Prairie is 1522 mm.