East Prairie Hotels

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
23 Aug - 24 Aug
Tomorrow
24 Aug - 25 Aug
Next weekend
29 Aug - 31 Aug
In two weeks
5 Sept - 7 Sept

Filter by

Guest rating
Guest rating
Property class

Top 10 trending East Prairie hotels

Drury Inn & Suites Sikeston, MO
Property amenity

Drury Inn & Suites Sikeston, MO

3.0 star property
9.4 out of 10, Exceptional, (1001)
"Great location "
The price is €88
includes taxes & fees
21 Sept - 22 Sept
Drury Inn & Suites Sikeston, MO
Pear Tree Inn Sikeston
Lobby

Pear Tree Inn Sikeston

2.5 star property
9.4 out of 10, Exceptional, (1004)
"Very nice property Friendly helpful staff"
The price is €76
includes taxes & fees
5 Sept - 6 Sept
Pear Tree Inn Sikeston
Super 8 By Wyndham Marston
Suite, 1 King Bed, Non Smoking

Super 8 By Wyndham Marston

2.0 star property
7.8 out of 10, Good, (25)
"Nice place, staff great"
The price is €66
includes taxes & fees
24 Aug - 25 Aug
Super 8 By Wyndham Marston
Best Western Plus Sikeston
Free daily full breakfast

Best Western Plus Sikeston

2.5 star property
8.4 out of 10, Very good, (1003)
"Staff was friendly and room was very clean. A very comfortable stay"
The price is €82
includes taxes & fees
14 Sept - 15 Sept
Best Western Plus Sikeston
Sleep Inn at Discovery Park of America
Lobby

Sleep Inn at Discovery Park of America

2.5 star property
9.0 out of 10, Wonderful, (264)
"This place must be brand new, the pillows and bed were perfect, everything was spotlessly clean, and the complementary breakfast was wonderful!"
The price is €85
includes taxes & fees
21 Sept - 22 Sept
Sleep Inn at Discovery Park of America
Reelfoot Lake Inn
Handicap Room

Reelfoot Lake Inn

2.0 star property
7.2 out of 10, Good, (446)
"Staff was amazing and available anytime. Other than incredible bug problem my only real issue is the pet fee is $20 not $10 and having a pet forces you in a smoking room which had i known certainly would have changed my plans. Location though is perfect"
The price is €62
includes taxes & fees
9 Sept - 10 Sept
Reelfoot Lake Inn
Country Hearth Inn & Suites Union City
Reception

Country Hearth Inn & Suites Union City

2.5 star property
8.6 out of 10, Excellent, (530)
"Very good!"
The price is €73
includes taxes & fees
26 Aug - 27 Aug
Country Hearth Inn & Suites Union City
Fairfield Inn & Suites by Marriott Sikeston
Bar (on property)

Fairfield Inn & Suites by Marriott Sikeston

2.5 star property
9.4 out of 10, Exceptional, (18)
"Nice hotel "
The price is €110
includes taxes & fees
7 Sept - 8 Sept
Fairfield Inn & Suites by Marriott Sikeston
Quality Inn Union City US 51
Lobby

Quality Inn Union City US 51

2.5 star property
8.4 out of 10, Very good, (463)
"Nice place. Everything went as should and no hidden fees. "
The price is €81
includes taxes & fees
21 Sept - 22 Sept
Quality Inn Union City US 51
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Hallway

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

2.5 star property
8.4 out of 10, Very good, (669)
"Everything was nice"
The price is €59
includes taxes & fees
18 Sept - 19 Sept
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Hampton Inn Sikeston
Exterior

Hampton Inn Sikeston

2.5 star property
8.8 out of 10, Excellent, (374)
"Great location and clean room. Plenty of food and shopping nearby."
The price is €103
includes taxes & fees
7 Sept - 8 Sept
Hampton Inn Sikeston
Hampton Inn Union City
Terrace/patio

Hampton Inn Union City

2.5 star property
9.4 out of 10, Exceptional, (148)
"It was peaceful and quiet"
The price is €113
includes taxes & fees
31 Aug - 1 Sept
Hampton Inn Union City
New Orleans Inn Portageville
Premier Room, 1 Bedroom, Non Smoking

New Orleans Inn Portageville

2.5 star property
8.2 out of 10, Very good, (683)
"Very nice stay"
New Orleans Inn Portageville
Comfort Inn & Suites Sikeston I-55
Exterior

Comfort Inn & Suites Sikeston I-55

2.5 star property
8.4 out of 10, Very good, (271)
"The facility was very nice. "
The price is €85
includes taxes & fees
31 Aug - 1 Sept
Comfort Inn & Suites Sikeston I-55
Quality Inn Cairo I-57
Lobby

Quality Inn Cairo I-57

2.5 star property
6.6 out of 10, (264)
"The hotel is in need of some serious upkeep and cleaning. It is in fairly poor condition, but it the only hotel in town."
The price is €65
includes taxes & fees
11 Sept - 12 Sept
Quality Inn Cairo I-57
Days Inn and Suites by Wyndham Sikeston
1 bedroom, desk, laptop workspace, blackout curtains

Days Inn and Suites by Wyndham Sikeston

2.0 star property
7.2 out of 10, Good, (1002)
"The room was awesome and the building had a historical thing about it."
The price is €61
includes taxes & fees
26 Aug - 27 Aug
Days Inn and Suites by Wyndham Sikeston
Holiday Inn Express & Suites Union City by IHG
Free daily buffet breakfast

Holiday Inn Express & Suites Union City by IHG

2.5 star property
9.4 out of 10, Exceptional, (286)
"This hotel was directly across from the Discovery Park of America. Definitely recommend staying there!"
The price is €119
includes taxes & fees
7 Sept - 8 Sept
Holiday Inn Express & Suites Union City by IHG
Super 8 by Wyndham Charleston/Sikeston East MO
Front of property – evening/night

Super 8 by Wyndham Charleston/Sikeston East MO

2.0 star property
6.6 out of 10, (585)
"Rooms was clean "
The price is €55
includes taxes & fees
8 Sept - 9 Sept
Super 8 by Wyndham Charleston/Sikeston East MO
Super 8 by Wyndham Sikeston/Miner Area
Room, 1 King Bed, Accessible, Non Smoking

Super 8 by Wyndham Sikeston/Miner Area

2.0 star property
6.6 out of 10, (552)
"I enjoyed our stay"
The price is €61
includes taxes & fees
24 Aug - 25 Aug
Super 8 by Wyndham Sikeston/Miner Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artefacts tell the storey of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

See all hotels in East Prairie

Top East Prairie Hotel Reviews

Hospitality House Union City I 69 / US 51

Hospitality House Union City I 69 / US 51

10/10 Excellent
"The Staff"
Ricky 1-night trip
Posted 1 day ago
Hospitality House Union City I 69 / US 51

Frequently asked questions

What's the best place for a stay in East Prairie?

Best Western Plus Sikeston, located 11.1 mi (17.9 km) from the heart of East Prairie, is a top choice for your stay, based on our traveller data. Other good choices for your trip to the area are Drury Inn & Suites Sikeston, MO and Days Inn and Suites by Wyndham Sikeston. See all available top hotels, or vacation rentals in East Prairie.

What are some of the best holiday rentals that East Prairie has to offer?

Duck Hunting, Fishing or Relaxing Family Vacation: This holiday home rental outside of East Prairie is located on a lake, and has a patio, a garden and a BBQ to put you at ease in your new surroundings. It has 3 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. See all vacation rentals in East Prairie.

If I need to cancel my hotel reservation in East Prairie, will I receive a refund?

Yes, you'll find most room reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If your reservation is non-refundable, you might still have the option to cancel and get a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in East Prairie.

How is it staying in East Prairie?

Visitors will definitely enjoy all that East Prairie has to offer. There are 30 hotels and other accommodation options in the surrounding area. Find out more about East Prairie.

What are the top places to visit in East Prairie?

The picturesque setting of Big Oak Tree State Park and Mississippi River exemplify the area's natural beauty. You'll also find Sikeston Depot Museum and New Madrid Historical Museum in the area. Take a look at what more there is to see and do in Expedia's East Prairie guide.

What's the weather like in East Prairie?

The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for East Prairie is 1522 mm.