A tree-lined landscape with a river and fields.

East Prairie Hotels

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Check prices for these dates

Tonight
14 Oct - 15 Oct
Tomorrow
15 Oct - 16 Oct
This weekend
16 Oct - 18 Oct
Next weekend
23 Oct - 25 Oct

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Our top choices for East Prairie hotels

A building with a fountain and flower beds in front.
A reception area with a stone wall, wooden cabinets, and a sign for The Riverstone Hotel.
A hotel room with a beige sofa, two patterned armchairs, a ceiling fan, a flat-screen TV, and a window with curtains.
A hotel room with a large bed, two bedside tables with lamps, a chair, a small table, and a picture on the wall.

1. The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
Charleston
United States
Kathleen
€66
includes taxes & fees
17 Oct - 18 Oct
The Riverstone Hotel Charleston-Sikeston
A hotel lobby with a central bar area, multiple dining tables and chairs, large windows, and a patterned carpet.
A reception area with a wooden reception desk, a large painting on the wall, and a potted plant.
A hotel with a covered entrance, a sign indicating a restaurant, and a well-lit parking area.
Room

2. Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55
Sikeston
United States
Shelley
€85
includes taxes & fees
15 Oct - 16 Oct
Best Western Plus Sikeston I-55
A hotel room with a large bed, a desk with a computer, a chair, a window with a view, and a wall-mounted TV.
A reception area with a sign for 'Travel Inn and Suites' and a counter with a computer and a phone.
A modern kitchen with stainless steel appliances, wooden cabinets, and a bright yellow accent wall.
A living room with a sofa, two chairs, a coffee table, a television, and a window with blinds.

3. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Sikeston
United States
Craig
€71
includes taxes & fees
15 Oct - 16 Oct
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.
A hotel room with a patterned sofa, a yellow ottoman, a desk with a TV, and a framed picture on the wall.
A spacious dining area with high tables and chairs, a bar counter, and large windows providing natural light.
A spacious lobby with a polished floor, seating areas, and modern lighting fixtures.

4. Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
Sikeston
United States
Tim
€96
includes taxes & fees
1 Nov - 2 Nov
Drury Inn & Suites Sikeston, MO
A hotel room with a bed, a desk with a chair, a TV, two bedside lamps, and a large window.
A motel with a covered entrance, multiple rooms, and a parking lot.
A hotel room with a flat-screen TV, a microwave, a coffee maker, a dining table, and two sofas.
A hotel kitchen with a long counter, various appliances, and a tiled backsplash.

5. Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area
Sikeston
United States
Laura
€58
includes taxes & fees
10 Nov - 11 Nov
Super 8 by Wyndham Sikeston/Miner Area
A Hampton Inn with a stone facade, outdoor seating area, and a fire pit.
A hotel lobby with a bar area, seating arrangements, and a large window providing natural light.
A conference room with a large rectangular table, six chairs with patterned upholstery, two modern ceiling lights, a bowl of fruit on the table, and large windows with curtains.
A Hampton Inn hotel with a modern facade, a stone entrance, and a well-lit entrance area.

6. Hampton Inn Sikeston

Hampton Inn Sikeston
Sikeston
United States
Lori
€107
includes taxes & fees
18 Oct - 19 Oct
Hampton Inn Sikeston
A hotel room with two beds, a desk with a chair, a TV, and a window with curtains.
A buffet with various food items, including omelets and baked goods, served in metal containers.
A kitchenette with a coffee machine, a kettle, and storage shelves.
A Holiday Inn Express & Suites building with a covered entrance, multiple windows, and a parking lot.

7. Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
Sikeston
United States
Melissa
€95
includes taxes & fees
18 Oct - 19 Oct
Holiday Inn Express & Suites Sikeston Southwest by IHG
A modern hotel room with a large bed, a smaller bed, a desk, and a chair. There is a window with curtains and a painting on the wall.
A spacious room with a large dining table and chairs, a kitchenette area, and a television mounted on the wall.
A spacious lobby with a central atrium, a piano, and a reception desk.
A Days Inn hotel with a brick facade, large windows, and a sign above the entrance.

8. Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston
Sikeston
United States
David
€67
includes taxes & fees
1 Nov - 2 Nov
Days Inn and Suites by Wyndham Sikeston
An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.
A modern lobby with a green sofa, two armchairs, a wooden coffee table, and a patterned rug.
An outdoor bar area with a modern design, featuring a counter, seating, and a view of the interior.
A modern indoor swimming pool with clear glass walls, a tiled deck, and multiple lounge chairs.

9. Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
Sikeston
United States
Allen
€103
includes taxes & fees
1 Nov - 2 Nov
Fairfield Inn & Suites by Marriott Sikeston
Property amenity
A modern hotel with a sign reading "Towneplace Suites by Marriott Fairfield." It features a flat roof, large windows, and a well-lit entrance.
A modern hotel room with a large window, a gray sofa, a small round table, a white chair, and a bed.
A modern lobby with a green sofa, two armchairs, a wooden coffee table, and a patterned rug.

10. TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston
Sikeston
United States
Rubin
€111
includes taxes & fees
25 Oct - 26 Oct
TownePlace Suites by Marriott Sikeston
A hotel room with two beds, a desk, a chair, a TV, and a mirror.
A reception area with a sofa, a small table, a trash bin, a microwave, and a book display.
A bathroom with a bathtub, toilet, and shower curtain.
A reception area with a counter, a coffee machine, and seating.

11. Country Yard Inn and Suite

Country Yard Inn and Suite
Sikeston
United States
William
€62
includes taxes & fees
15 Oct - 16 Oct
Country Yard Inn and Suite
A modern hotel room with a large bed, bedside tables, a nightstand, a wall-mounted lamp, a window with a view of a road, and a wall-mounted air conditioner.
A modern kitchen with a built-in microwave, a black refrigerator, and a wooden countertop.
A hotel with a central entrance, multiple parking spaces, and a well-lit facade.
A modern kitchen with a stone backsplash, a dining area with red chairs, and a red accent wall with a framed picture.

12. Super 8 By Wyndham Marston

Super 8 By Wyndham Marston
Marston
United States
Brenda
€57
includes taxes & fees
21 Oct - 22 Oct
Super 8 By Wyndham Marston
A hotel room with a large bed, a desk, a television, and a bathroom visible through an open door.
A motel with a sign reading "Eagle Inn" and a parking lot with several cars.
A hotel room with two beds, a nightstand, a lamp, and a window with curtains.
A bathroom with a sink, mirror, towel rack, shower, and toilet.

13. Eagle Inn Charleston

Eagle Inn Charleston
Charleston
United States
Jackson
€66
includes taxes & fees
15 Oct - 16 Oct
Eagle Inn Charleston
A Comfort Inn & Suites hotel with a clear entrance, a covered parking area, and a sign indicating a 12' clearance.
A living room with two sofas, a coffee table, a TV, and a cabinet.
A hotel room with a bed, a desk with a TV, a chair, a bathroom with a bathtub, and a window with curtains.
A hotel lobby with a reception desk, seating area, and large windows offering a view of the outdoors.

14. Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55
Sikeston
United States
Kathryn
€81
includes taxes & fees
8 Nov - 9 Nov
Comfort Inn & Suites Sikeston I-55
A hotel room with a large bed, two bedside lamps, a framed picture of a bridge, and a wooden nightstand with a phone.
A restaurant with wooden cabinets, a refrigerator, and a counter with various items. There are tables and chairs for dining.
A hotel with a covered entrance, a sign for the brand, and a parking lot with cars.
A reception area with a sofa, a coffee table, a potted plant, and a framed picture on the wall.

15. Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
Charleston
United States
William
€60
includes taxes & fees
15 Oct - 16 Oct
Super 8 by Wyndham Charleston/Sikeston East MO
A reception area with a reception desk, two blue armchairs, a round table, and a glass door leading outside.
A corridor with a vending machine displaying various beverages and a wall with hanging products.
A modern building with a covered entrance, a nameplate, and a landscaped area with shrubs and a street lamp.
A large indoor swimming pool with a tiled floor, surrounded by seating areas and tables.

16. Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America
Union City
United States
Ben
€76
includes taxes & fees
8 Nov - 9 Nov
Sleep Inn at Discovery Park of America
A fireplace with a framed painting above it, flanked by two vases of flowers.
A restaurant with yellow walls, a red carpet, a chandelier, a ceiling fan, and Christmas decorations.
A hotel room with a wooden desk, a television, a bed with a patterned bedspread, a "No Smoking" sign, and a ceiling fan.
A reception desk with a wooden counter, a chandelier, and a plant on the right.

17. Country Hearth Inn & Suites Union City

Country Hearth Inn & Suites Union City
Union City
United States
Jade
€73
includes taxes & fees
15 Oct - 16 Oct
Country Hearth Inn & Suites Union City
A hotel lobby with a reception desk, seating area, and a large window.
A Quality Inn hotel with a green sign, a covered outdoor area, and a parking lot.
A hotel room with two beds, a desk with a computer, a television, and a window with curtains.
A hotel lobby with a reception desk, two armchairs, a coffee table, and large windows with potted plants.

18. Quality Inn Cairo I-57

Quality Inn Cairo I-57
Cairo
United States
Santiago
€68
includes taxes & fees
10 Nov - 11 Nov
Quality Inn Cairo I-57
A living room with a sofa, chairs, a glass coffee table, and a TV.
Room
A swimming pool with a clear blue sky and clouds above.
A modern bathroom with a large sink, towel rack, and a mirror reflecting a dining area.

19. Hospitality House Union City I 69 / US 51

Hospitality House Union City I 69 / US 51
Union City
United States
Joan
€59
includes taxes & fees
15 Oct - 16 Oct
Hospitality House Union City I 69 / US 51
A hotel room with two beds, a television, a desk, and a mirror.
A bathroom with a sink, mirror, and chair.
A hotel room with a bed, a desk, a television, and a seating area with a small table.
A motel with a covered outdoor seating area and a parking lot.

20. Travel Inn Marston I-55 by Hotel O

Travel Inn Marston I-55 by Hotel O
Marston
United States
Frank
€45
includes taxes & fees
25 Oct - 26 Oct
Travel Inn Marston I-55 by Hotel O
View all properties

Hotels recommended for families in East Prairie

A hotel lobby with a central bar area, multiple dining tables and chairs, large windows, and a patterned carpet.
A reception area with a wooden reception desk, a large painting on the wall, and a potted plant.
A hotel with a covered entrance, a sign indicating a restaurant, and a well-lit parking area.
Room

Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55
Sikeston
€85
includes taxes & fees
15 Oct - 16 Oct
Best Western Plus Sikeston I-55
A Hampton Inn with a stone facade, outdoor seating area, and a fire pit.
A hotel lobby with a bar area, seating arrangements, and a large window providing natural light.
A conference room with a large rectangular table, six chairs with patterned upholstery, two modern ceiling lights, a bowl of fruit on the table, and large windows with curtains.
A Hampton Inn hotel with a modern facade, a stone entrance, and a well-lit entrance area.

Hampton Inn Sikeston

Hampton Inn Sikeston
Sikeston
€107
includes taxes & fees
18 Oct - 19 Oct
Hampton Inn Sikeston
An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.
A hotel room with a patterned sofa, a yellow ottoman, a desk with a TV, and a framed picture on the wall.
A spacious dining area with high tables and chairs, a bar counter, and large windows providing natural light.
A spacious lobby with a polished floor, seating areas, and modern lighting fixtures.

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
Sikeston
€96
includes taxes & fees
1 Nov - 2 Nov
Drury Inn & Suites Sikeston, MO
A hotel room with a large bed, a desk with a computer, a chair, a window with a view, and a wall-mounted TV.
A reception area with a sign for 'Travel Inn and Suites' and a counter with a computer and a phone.
A modern kitchen with stainless steel appliances, wooden cabinets, and a bright yellow accent wall.
A living room with a sofa, two chairs, a coffee table, a television, and a window with blinds.

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Sikeston
€71
includes taxes & fees
15 Oct - 16 Oct
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
A hotel room with two beds, a desk with a chair, a TV, and a window with curtains.
A buffet with various food items, including omelets and baked goods, served in metal containers.
A kitchenette with a coffee machine, a kettle, and storage shelves.
A Holiday Inn Express & Suites building with a covered entrance, multiple windows, and a parking lot.

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
Sikeston
€95
includes taxes & fees
18 Oct - 19 Oct
Holiday Inn Express & Suites Sikeston Southwest by IHG
An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.
A modern lobby with a green sofa, two armchairs, a wooden coffee table, and a patterned rug.
An outdoor bar area with a modern design, featuring a counter, seating, and a view of the interior.
A modern indoor swimming pool with clear glass walls, a tiled deck, and multiple lounge chairs.

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
Sikeston
€116
includes taxes & fees
21 Oct - 22 Oct
Fairfield Inn & Suites by Marriott Sikeston
Property amenity
A modern hotel with a sign reading "Towneplace Suites by Marriott Fairfield." It features a flat roof, large windows, and a well-lit entrance.
A modern hotel room with a large window, a gray sofa, a small round table, a white chair, and a bed.
A modern lobby with a green sofa, two armchairs, a wooden coffee table, and a patterned rug.

TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston
Sikeston
€111
includes taxes & fees
25 Oct - 26 Oct
TownePlace Suites by Marriott Sikeston
A hotel room with a bed, a desk with a chair, a TV, two bedside lamps, and a large window.
A motel with a covered entrance, multiple rooms, and a parking lot.
A hotel room with a flat-screen TV, a microwave, a coffee maker, a dining table, and two sofas.
A hotel kitchen with a long counter, various appliances, and a tiled backsplash.

Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area
Sikeston
€58
includes taxes & fees
12 Nov - 13 Nov
Super 8 by Wyndham Sikeston/Miner Area
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Stay near popular East Prairie attractions

Big Oak Tree State Park

8.0/10 (20 reviews)
You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.
See properties

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artefacts tell the storey of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

See all hotels in East Prairie
A tree-lined landscape with a river and fields.

Top East Prairie Hotel Reviews

Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

10/10 Excellent
"good, clean, affordable :)"
Nicholas 1-night trip
Posted 14 hours ago
Super 8 by Wyndham Sikeston/Miner Area
Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America

8/10 Good
"Everything was nice. Bed very comfortable."
ROBERT 6-night trip
Posted 21 hours ago
Sleep Inn at Discovery Park of America
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

10/10 Excellent
"Everything perfect. Drury Inns sweat the details."
Richard 1-night trip
Posted 1 day ago
Drury Inn & Suites Sikeston, MO
Reelfoot Lake Inn

Reelfoot Lake Inn

8/10 Good
"Dated but descent."
Lisa 1-night trip
Posted 3 days ago
Reelfoot Lake Inn
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

8/10 Good
"Easy parking, our bathroom sink was leaning forward and we had to place our soap in the sink so it didn't slide on the floor."
Ronda 1-night trip
Posted 4 days ago
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Holiday Inn Express & Suites Union City by IHG

Holiday Inn Express & Suites Union City by IHG

10/10 Excellent
"It was the perfect stay."
Kevin 2-night trip
Posted 4 days ago
Holiday Inn Express & Suites Union City by IHG
Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

10/10 Excellent
"Clean, comfortable room. Nice staff and good breakfast choices."
Antoinette 1-night trip
Posted 5 days ago
Holiday Inn Express & Suites Sikeston Southwest by IHG
Hampton Inn Union City

Hampton Inn Union City

10/10 Excellent
"The room was pretty spacious and very clean with updated furniture. Breakfast was great!"
Debra 2-night trip
Posted 5 days ago
Hampton Inn Union City
The Dragonfly - Sleeps up to 8, Lake views.

The Dragonfly - Sleeps up to 8, Lake views.

10/10 Excellent
"This was the perfect place for us to stay when we were in town for the real foot art and craft show the house was clean. Nice size. We loved the views we had. A a fire that we sat around with and did some mores. It was just wonderful Kristi the host was awesome, very responsive and helpful. Hope to stay there again in the future!"
Andena F. 4-night trip
Posted 6 days ago
The Dragonfly - Sleeps up to 8, Lake views.

More cheap stays in East Prairie

Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

2609 E Malone Ave Sikeston MO
€58
12 Nov - 13 Nov
includes taxes & fees
7/10 Good! (687 reviews)
Super 8 by Wyndham Sikeston/Miner Area
Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

310 S Story St Charleston MO
€60
15 Oct - 16 Oct
includes taxes & fees
Super 8 by Wyndham Charleston/Sikeston East MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO
€67
1 Nov - 2 Nov
includes taxes & fees
Days Inn and Suites by Wyndham Sikeston
Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America

1111 BLue Heron Lane Union City TN
€76
8 Nov - 9 Nov
includes taxes & fees
9.2/10 Wonderful! (438 reviews)
Sleep Inn at Discovery Park of America
Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55

120 S Interstate Drive Sikeston MO
€85
15 Oct - 16 Oct
includes taxes & fees
8.4/10 Very good! (1,000 reviews)
Best Western Plus Sikeston I-55
Hampton Inn Sikeston

Hampton Inn Sikeston

1240 Commerce Drive Sikeston MO
€107
18 Oct - 19 Oct
includes taxes & fees
Hampton Inn Sikeston

Frequently asked questions

What's the best place for a stay in East Prairie?
Drury Inn & Suites Sikeston, MO, located 11.4 mi (18.4 km) from the heart of East Prairie, is a top choice for your stay, based on our traveller data. Other good choices for your trip to the area are Days Inn and Suites by Wyndham Sikeston and Best Western Plus Sikeston I-55. See all available top hotels, or vacation rentals in East Prairie.
What are some of the best holiday rentals that East Prairie has to offer?
Duck Hunting, Fishing or Relaxing Family Vacation: This holiday home rental outside of East Prairie is located on a lake, and has a patio, a garden and a BBQ to put you at ease in your new surroundings. It has 3 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. See all vacation rentals in East Prairie.
If I need to cancel my hotel reservation in East Prairie, will I receive a refund?
Yes, you'll find most room reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If your reservation is non-refundable, you might still have the option to cancel and get a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in East Prairie.
How is it staying in East Prairie?
Visitors will definitely enjoy all that East Prairie has to offer. There are 36 hotels and other accommodation options in the surrounding area. Find out more about East Prairie.
What are the top places to visit in East Prairie?
The picturesque setting of Big Oak Tree State Park and Mississippi River exemplify the area's natural beauty. You'll also find Columbus-Belmont State Park and Fort Defiance State Park in the area. Take a look at what more there is to see and do in Expedia's East Prairie guide.
What's the weather like in East Prairie?
The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for East Prairie is 1522 mm.

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