South Main
Houston
Visit South Main
Popular places to visit
NRG Stadium
Catch an event at NRG Stadium during your trip to Houston. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.
George R. Brown Convention Center
During your trip, find out what's happening in George R. Brown Convention Center, a top convention centre in Houston. Experience the entertainment choices and acclaimed art galleries in this vibrant area.
Daikin Park
Catch an event at Daikin Park during your trip to Houston. Experience the entertainment choices and lively festivals in this vibrant area.
Toyota Center
Catch an event at Toyota Center during your trip to Houston. Experience the acclaimed theatre scene and entertainment choices in this vibrant area.
NASA Johnson Space Center
After visiting NASA Johnson Space Center, make a plan to see the other sights and activities in Houston. Amble around the area's lakeside or attend a sporting event.
Space Center Houston
This iconic “mission control” was immortalized for its role in the first moon landing.
Things to do
Space Center Houston Admission Ticket
Houston: Houston Botanic Garden Entry Ticket
Houston Museum of Natural Science General Admission Ticket
Astroville Tunnel Tour of Downtown Houston (Air-Conditioned)
Top hotels in South Main
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Great stay. Got upgraded for free and got cookies for dessert. Great location and stay
Reviewed on 10 Mar 2026
Hotel Zaza Houston Museum District
Ashley is the best, she offered us a list of things to do like locals
Reviewed on 10 Mar 2026
The Royal Sonesta Houston Galleria
NA
Reviewed on 9 Mar 2026
Club Quarters Hotel Downtown, Houston
Good stay centered location
Reviewed on 10 Mar 2026
Blossom Hotel Houston, Curio Collection by Hilton
Enjoyed our stay. We had several meals. Food was good and wait staff was outstanding.
Reviewed on 10 Mar 2026
The Whitehall Houston
Small rooms , uncomfortable beds by no means a 4 star hotel . Lobby is nice but really needs an update .bath is tiny . Not good Staff was really friendly. In not cheap either
Reviewed on 9 Mar 2026
Other neighbourhoods around South Main
Astrodome
While you're in Astrodome, take in top sights like NRG Stadium or NRG Astrodome, and hop on the metro to see more of the city at Stadium Park/Astrodome Station or Smith Lands Station.
Texas Medical Center
Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.
Museum District
Known for its abundant dining options and interesting museums, there's plenty to explore in Museum District. Top attractions like Children's Museum of Houston and Houston Natural Science Museum are major draws, and you can catch the metro at Museum District Station or Hermann Park/Rice U Station to see more of the city.
Greenway Plaza-Upper Kirby
Greenway Plaza-Upper Kirby is known for its abundant dining options, and you can plan a trip to Highland Village and Richmond Avenue while you're in town.
South Central Houston
If you're spending time in South Central Houston, check out sights like Children's Museum of Houston or Houston Natural Science Museum and hop on the metro to see more of the city at Elgin/Third Ward Station or TSU/UH Athletics District Station.
Montrose
Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
